← All .science files
pmid:37691822
Molecular subtyping of acute myeloid leukemia through ferroptosis signatures predicts prognosis and deciphers the immune microenvironment.
Denggang Fu · Biyu Zhang · Shiyong Wu · Jueping Feng · Hua Jiang
Frontiers in cell and developmental biology · 2023 doi:10.3389/fcell.2023.1207642
Paper
complete
Experiment
complete
Data
partial
Analysis
complete
Execution
absent
Execution evidence has not yet been added to this .science file. Explore its methods, data and open questions to plan the next step.
Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
paper object · 10 fields
authors array · 5 items
claims array · 3 items
[0] object · 6 fields
[1] object · 6 fields
[2] object · 6 fields
evidence array · 1 item
[0] object · 3 fields
gaps array · 0 items
experiment object · 8 fields
steps array · 3 items
[0] object · 13 fields
parameters object · 0 fields
inputs array · 1 item
outputs array · 1 item
instruments array · 0 items
reagents array · 0 items
[1] object · 13 fields
parameters object · 0 fields
inputs array · 1 item
outputs array · 1 item
instruments array · 0 items
reagents array · 0 items
[2] object · 13 fields
parameters object · 0 fields
inputs array · 1 item
outputs array · 1 item
instruments array · 0 items
reagents array · 0 items
materials array · 0 items
instruments array · 0 items
reagents array · 0 items
conditions object · 0 fields
gaps array · 0 items
data object · 3 fields
assets array · 7 items
[0] object · 15 fields
structure object · 4 fields
[1] object · 15 fields
structure object · 15 fields
sample_accessions array · 304 items
[2] object · 15 fields
structure object · 15 fields
sample_accessions array · 250 items
[3] object · 15 fields
structure object · 15 fields
sample_accessions array · 83 items
[4] object · 15 fields
structure object · 15 fields
sample_accessions array · 405 items
[5] object · 15 fields
structure object · 15 fields
sample_accessions array · 19 items
[6] object · 15 fields
structure object · 15 fields
sample_accessions array · 984 items
gaps array · 12 items
analysis object · 4 fields
methods array · 2 items
[0] object · 10 fields
dsl_operations array · 1 item
missing_operations array · 0 items
parameters object · 0 fields
data_shapes array · 1 item
[1] object · 10 fields
dsl_operations array · 1 item
missing_operations array · 0 items
parameters object · 0 fields
data_shapes array · 1 item
targets array · 0 items
gaps array · 0 items
capability object · 3 fields
requirements array · 1 item
[0] object · 6 fields
assay_families array · 9 items
gaps array · 0 items
readiness object · 8 fields
axes object · 3 fields
method object · 5 fields
required_operations array · 1 item
missing_operations array · 0 items
capability object · 4 fields
data object · 6 fields
accessions array · 6 items
resolved_accessions array · 6 items
statements array · 1 item
can_run object · 3 fields
dsl_operations array · 1 item
assets array · 2 items
steps array · 1 item
must_build object · 5 fields
dsl_operations array · 0 items
converters array · 0 items
readers array · 0 items
capabilities array · 0 items
data_gaps array · 1 item
gaps array · 0 items
review object · 5 fields
machine_critique object · 5 fields
reader object · 5 fields
evidence_check object · 2 fields
usage object · 3 fields
stages array · 1 item
[0] object · 4 fields
gaps array · 3 items
provenance object · 7 fields
entities array · 3 items
activities array · 3 items
[0] object · 4 fields
used array · 3 items
[0] object · 3 fields
[1] object · 3 fields
[2] object · 3 fields
[1] object · 4 fields
agents array · 2 items
lineage object · 4 fields
gaps array · 16 items
assays array · 1 item
[0] object · 11 fields
required_operations array · 1 item
source_hashes object · 1 field
evidence array · 1 item
Complete file
{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:37691822", "kind": "science-record", "revision": 3, "content_hash": "sha256:2c27198ccd4d7e45ff01266a3c2a543d20f2f3583c9559495391633605b1c8cd", "created_at": "2026-11-01T19:02:29Z", "updated_at": "2026-11-01T21:31:31Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Molecular subtyping of acute myeloid leukemia through ferroptosis signatures predicts prognosis and deciphers the immune microenvironment.", "doi": "10.3389/fcell.2023.1207642", "pmid": "37691822", "authors": ["Denggang Fu", "Biyu Zhang", "Shiyong Wu", "Jueping Feng", "Hua Jiang"], "journal": "Frontiers in cell and developmental biology", "year": 2023, "abstract": "Acute myeloid leukemia (AML) is one of the most aggressive hematological malignancies with a low 5-year survival rate and high rate of relapse. Developing more efficient therapies is an urgent need for AML treatment. Accumulating evidence showed that ferroptosis, an iron-dependent form of programmed cell death, is closely correlated with cancer initiation and clinical outcome through reshaping the tumor microenvironment. However, understanding of AML heterogeneity based on extensive profiling of ferroptosis signatures remains to be investigated yet. Herein, five independent AML transcriptomic datasets (TCGA-AML, GSE37642, GSE12417, GSE10358, and GSE106291) were obtained from the GEO and TCGA databases. Then, we identified two ferroptosis-related molecular subtypes (C1 and C2) with distinct prognosis and tumor immune microenvironment (TIME) by consensus clustering. Patients in the C1 subtype were associated with favorable clinical outcomes and increased cytotoxic immune cell infiltration, including CD8+/central memory T cells, natural killer (NK) cells, and non-regulatory CD4+ T cells while showing decreased suppressive immune subsets such as M2 macrophages, neutrophils, and monocytes. Functional enrichment analysis of differentially expressed genes (DEGs) implied that cell activation involved in immune response, leukocyte cell-cell adhesion and migration, and cytokine production were the main biological processes. Phagosome, antigen processing and presentation, cytokine-cytokine receptor interaction, B-cell receptor, and chemokine were identified as the major pathways. To seize the distinct landscape in C1 vs. C2 subtypes, a 5-gene prognostic signature (LSP1, IL1R2, MPO, CRIP1, and SLC24A3) was developed using LASSO Cox stepwise regression analysis and further validated in independent AML cohorts. Patients were divided into high- and low-risk groups, and decreased survival rates were observed in high- vs. low-risk groups. The TIME between high- and low-risk groups has a similar scenery in C1 vs. C2 subtypes. Single-cell-level analysis verified that LSP1 and CRIP1 were upregulated in AML and exhausted CD8+ T cells. Dual targeting of these two markers might present a promising immunotherapeutic for AML. In addition, potential effective chemical drugs for AML were predicted. Thus, we concluded that molecular subtyping using ferroptosis signatures could characterize the TIME and provide implications for monitoring clinical outcomes and predicting novel therapies.", "claims": [{"id": "claim-method", "statement": "OS-related FAGs in AML with p < 0.05 were identified through univariate Cox regression analysis.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37691822", "locator": "sections[6] \"Identification of overall survival (OS)-related FAGs\" paragraph 2", "quote": "OS-related FAGs in AML with p < 0.05 were identified through univariate Cox regression analysis."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding authors.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37691822", "locator": "sections[21] \"Data availability statement\" paragraph 2", "quote": "The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding authors."}], "state": "complete"}, {"id": "claim-target-result", "statement": "To seize the distinct landscape in C1 vs. C2 subtypes, a 5-gene prognostic signature (LSP1, IL1R2, MPO, CRIP1, and SLC24A3) was developed using LASSO Cox stepwise regression analysis and further validated in independent AML cohorts.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:37691822", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "To seize the distinct landscape in C1 vs. C2 subtypes, a 5-gene prognostic signature (LSP1, IL1R2, MPO, CRIP1, and SLC24A3) was developed using LASSO Cox stepwise regression analysis and further validated in independent AML cohorts."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "To seize the distinct landscape in C1 vs. C2 subtypes, a 5-gene prognostic signature (LSP1, IL1R2, MPO, CRIP1, and SLC24A3) was developed using LASSO Cox stepwise regression analysis and further validated in independent AML cohorts.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:37691822"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE10358"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE10358"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:37691822", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.3389/fcell.2023.1207642", "sha256": "sha256:6959fdbe1ffebc3eed388f753dc13c9697903b2effcda7b1d450cb2ecc6f2290", "bytes": 67265, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.3389/fcell.2023.1207642", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC10483833", "source": "europe_pmc_fulltext", "coverage": "whole_body", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE10358", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE10358", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE10358", "version": null, "note": "The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM1226121", "GSM1254265", "GSM1254266", "GSM1254267", "GSM1254268", "GSM1254269", "GSM1254270", "GSM1254271", "GSM1254272", "GSM1254273", "GSM1254274", "GSM1254275", "GSM1254276", "GSM1254277", "GSM1254278", "GSM1254279", "GSM1254280", "GSM1254281", "GSM1254282", "GSM1254283", "GSM1254284", "GSM1254285", "GSM1254286", "GSM1254287", "GSM1254288", "GSM262030", "GSM262031", "GSM262032", "GSM262033", "GSM262034", "GSM262035", "GSM262036", "GSM262037", "GSM262038", "GSM262039", "GSM262040", "GSM262041", "GSM262042", "GSM262043", "GSM262044", "GSM262045", "GSM262046", "GSM262047", "GSM262048", "GSM262049", "GSM262050", "GSM262051", "GSM262052", "GSM262053", "GSM262054", "GSM262055", "GSM262056", "GSM262057", "GSM262058", "GSM262059", "GSM262060", "GSM262061", "GSM262062", "GSM262063", "GSM262064", "GSM262065", "GSM262066", "GSM262067", "GSM262068", "GSM262069", "GSM262070", "GSM262071", "GSM262072", "GSM262073", "GSM262074", "GSM262075", "GSM262076", "GSM262077", "GSM262078", "GSM262079", "GSM262080", "GSM262090", "GSM262091", "GSM262092", "GSM262093", "GSM262094", "GSM262095", "GSM262096", "GSM262097", "GSM262098", "GSM262099", "GSM262100", "GSM262101", "GSM262102", "GSM262103", "GSM262104", "GSM262105", "GSM262106", "GSM262107", "GSM262108", "GSM262109", "GSM262110", "GSM262111", "GSM262112", "GSM262113", "GSM262114", "GSM262115", "GSM262116", "GSM262117", "GSM262118", "GSM262119", "GSM262120", "GSM262121", "GSM262122", "GSM262123", "GSM262124", "GSM262125", "GSM262126", "GSM262127", "GSM262128", "GSM262129", "GSM262130", "GSM262131", "GSM262132", "GSM262133", "GSM262134", "GSM262135", "GSM262136", "GSM262137", "GSM262138", "GSM262139", "GSM262140", "GSM262141", "GSM262142", "GSM262143", "GSM262144", "GSM262145", "GSM262146", "GSM262147", "GSM262148", "GSM262149", "GSM262150", "GSM262151", "GSM262152", "GSM262153", "GSM262154", "GSM262155", "GSM262156", "GSM262157", "GSM262158", "GSM262159", "GSM262160", "GSM262161", "GSM262162", "GSM262163", "GSM262164", "GSM262165", "GSM262166", "GSM262167", "GSM262168", "GSM262169", "GSM262170", "GSM262171", "GSM262172", "GSM262173", "GSM262174", "GSM262175", "GSM262176", "GSM262177", "GSM262178", "GSM262179", "GSM262180", "GSM262181", "GSM262182", "GSM262183", "GSM262184", "GSM262185", "GSM262186", "GSM262187", "GSM262188", "GSM262189", "GSM262190", "GSM262191", "GSM262192", "GSM262193", "GSM262194", "GSM262195", "GSM262196", "GSM262197", "GSM262198", "GSM262199", "GSM262200", "GSM262201", "GSM262202", "GSM262203", "GSM262204", "GSM262205", "GSM262206", "GSM262207", "GSM262208", "GSM262209", "GSM262210", "GSM262211", "GSM262212", "GSM262213", "GSM262214", "GSM262215", "GSM262216", "GSM262217", "GSM262218", "GSM262219", "GSM262220", "GSM262221", "GSM262222", "GSM262254", "GSM262255", "GSM262256", "GSM262257", "GSM726172", "GSM726173", "GSM726174", "GSM726175", "GSM726176", "GSM726177", "GSM726178", "GSM726179", "GSM726180", "GSM726181", "GSM726182", "GSM726183", "GSM726184", "GSM726185", "GSM726186", "GSM726187", "GSM726188", "GSM726189", "GSM726190", "GSM726191", "GSM726192", "GSM726193", "GSM726194", "GSM726195", "GSM726196", "GSM726197", "GSM726198", "GSM726199", "GSM726200", "GSM726201", "GSM726202", "GSM726203", "GSM726204", "GSM726205", "GSM726206", "GSM726207", "GSM726208", "GSM726209", "GSM726210", "GSM726211", "GSM726212", "GSM726213", "GSM726214", "GSM726215", "GSM726216", "GSM726217", "GSM726218", "GSM726219", "GSM726220", "GSM726221", "GSM726222", "GSM726223", "GSM726224", "GSM726225", "GSM726226", "GSM726227", "GSM726228", "GSM726229", "GSM726230", "GSM726231", "GSM726232", "GSM726233", "GSM726234", "GSM726235", "GSM726236", "GSM726237", "GSM726238", "GSM726239", "GSM726240", "GSM726241", "GSM726242", "GSM726243", "GSM726244", "GSM726245", "GSM726246", "GSM726247", "GSM726248", "GSM726249", "GSM726250", "GSM726251", "GSM726252", "GSM726253", "GSM726254", "GSM726255", "GSM726256", "GSM726257", "GSM726258", "GSM726259", "GSM726260", "GSM726261", "GSM726262"], "sample_count": 304, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Discovery and validation of expression data for the Genomics of Acute Myeloid Leukemia Program at Washington University", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE106291", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE106291", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE106291", "version": null, "note": "The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM2835244", "GSM2835245", "GSM2835246", "GSM2835247", "GSM2835248", "GSM2835249", "GSM2835250", "GSM2835251", "GSM2835252", "GSM2835253", "GSM2835254", "GSM2835255", "GSM2835256", "GSM2835257", "GSM2835258", "GSM2835259", "GSM2835260", "GSM2835261", "GSM2835262", "GSM2835263", "GSM2835264", "GSM2835265", "GSM2835266", "GSM2835267", "GSM2835268", "GSM2835269", "GSM2835270", "GSM2835271", "GSM2835272", "GSM2835273", "GSM2835274", "GSM2835275", "GSM2835276", "GSM2835277", "GSM2835278", "GSM2835279", "GSM2835280", "GSM2835281", "GSM2835282", "GSM2835283", "GSM2835284", "GSM2835285", "GSM2835286", "GSM2835287", "GSM2835288", "GSM2835289", "GSM2835290", "GSM2835291", "GSM2835292", "GSM2835293", "GSM2835294", "GSM2835295", "GSM2835296", "GSM2835297", "GSM2835298", "GSM2835299", "GSM2835300", "GSM2835301", "GSM2835302", "GSM2835303", "GSM2835304", "GSM2835305", "GSM2835306", "GSM2835307", "GSM2835308", "GSM2835309", "GSM2835310", "GSM2835311", "GSM2835312", "GSM2835313", "GSM2835314", "GSM2835315", "GSM2835316", "GSM2835317", "GSM2835318", "GSM2835319", "GSM2835320", "GSM2835321", "GSM2835322", "GSM2835323", "GSM2835324", "GSM2835325", "GSM2835326", "GSM2835327", "GSM2835328", "GSM2835329", "GSM2835330", "GSM2835331", "GSM2835332", "GSM2835333", "GSM2835334", "GSM2835335", "GSM2835336", "GSM2835337", "GSM2835338", "GSM2835339", "GSM2835340", "GSM2835341", "GSM2835342", "GSM2835343", "GSM2835344", "GSM2835345", "GSM2835346", "GSM2835347", "GSM2835348", "GSM2835349", "GSM2835350", "GSM2835351", "GSM2835352", "GSM2835353", "GSM2835354", "GSM2835355", "GSM2835356", "GSM2835357", "GSM2835358", "GSM2835359", "GSM2835360", "GSM2835361", "GSM2835362", "GSM2835363", "GSM2835364", "GSM2835365", "GSM2835366", "GSM2835367", "GSM2835368", "GSM2835369", "GSM2835370", "GSM2835371", "GSM2835372", "GSM2835373", "GSM2835374", "GSM2835375", "GSM2835376", "GSM2835377", "GSM2835378", "GSM2835379", "GSM2835380", "GSM2835381", "GSM2835382", "GSM2835383", "GSM2835384", "GSM2835385", "GSM2835386", "GSM2835387", "GSM2835388", "GSM2835389", "GSM2835390", "GSM2835391", "GSM2835392", "GSM2835393", "GSM2835394", "GSM2835395", "GSM2835396", "GSM2835397", "GSM2835398", "GSM2835399", "GSM2835400", "GSM2835401", "GSM2835402", "GSM2835403", "GSM2835404", "GSM2835405", "GSM2835406", "GSM2835407", "GSM2835408", "GSM2835409", "GSM2835410", "GSM2835411", "GSM2835412", "GSM2835413", "GSM2835414", "GSM2835415", "GSM2835416", "GSM2835417", "GSM2835418", "GSM2835419", "GSM2835420", "GSM2835421", "GSM2835422", "GSM2835423", "GSM2835424", "GSM2835425", "GSM2835426", "GSM2835427", "GSM2835428", "GSM2835429", "GSM2835430", "GSM2835431", "GSM2835432", "GSM2835433", "GSM2835434", "GSM2835435", "GSM2835436", "GSM2835437", "GSM2835438", "GSM2835439", "GSM2835440", "GSM2835441", "GSM2835442", "GSM2835443", "GSM2835444", "GSM2835445", "GSM2835446", "GSM2835447", "GSM2835448", "GSM2835449", "GSM2835450", "GSM2835451", "GSM2835452", "GSM2835453", "GSM2835454", "GSM2835455", "GSM2835456", "GSM2835457", "GSM2835458", "GSM2835459", "GSM2835460", "GSM2835461", "GSM2835462", "GSM2835463", "GSM2835464", "GSM2835465", "GSM2835466", "GSM2835467", "GSM2835468", "GSM2835469", "GSM2835470", "GSM2835471", "GSM2835472", "GSM2835473", "GSM2835474", "GSM2835475", "GSM2835476", "GSM2835477", "GSM2835478", "GSM2835479", "GSM2835480", "GSM2835481", "GSM2835482", "GSM2835483", "GSM2835484", "GSM2835485", "GSM2835486", "GSM2835487", "GSM2835488", "GSM2835489", "GSM2835490", "GSM2835491", "GSM2835492", "GSM2835493"], "sample_count": 250, "group_sizes": null, "group_sizes_basis": null, "platform": "18460", "taxon": "Homo sapiens", "title": "A 29-Gene and Cytogenetic Score for the Prediction of Resistance to Induction Treatment in Acute Myeloid Leukemia", "resolution_checked_at": "2026-11-01T18:06:43Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE116256", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE116256", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE116256", "version": null, "note": "The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM3587923", "GSM3587924", "GSM3587925", "GSM3587926", "GSM3587927", "GSM3587928", "GSM3587929", "GSM3587930", "GSM3587931", "GSM3587932", "GSM3587933", "GSM3587934", "GSM3587935", "GSM3587936", "GSM3587937", "GSM3587938", "GSM3587939", "GSM3587940", "GSM3587941", "GSM3587942", "GSM3587943", "GSM3587944", "GSM3587945", "GSM3587946", "GSM3587947", "GSM3587948", "GSM3587949", "GSM3587950", "GSM3587951", "GSM3587952", "GSM3587953", "GSM3587954", "GSM3587955", "GSM3587956", "GSM3587957", "GSM3587958", "GSM3587959", "GSM3587960", "GSM3587961", "GSM3587962", "GSM3587963", "GSM3587964", "GSM3587965", "GSM3587966", "GSM3587967", "GSM3587968", "GSM3587969", "GSM3587970", "GSM3587971", "GSM3587972", "GSM3587973", "GSM3587974", "GSM3587975", "GSM3587976", "GSM3587977", "GSM3587978", "GSM3587979", "GSM3587980", "GSM3587981", "GSM3587982", "GSM3587983", "GSM3587984", "GSM3587985", "GSM3587986", "GSM3587987", "GSM3587988", "GSM3587989", "GSM3587990", "GSM3587991", "GSM3587992", "GSM3587993", "GSM3587994", "GSM3587995", "GSM3587996", "GSM3587997", "GSM3587998", "GSM3587999", "GSM3588000", "GSM3588001", "GSM3588002", "GSM3588003", "GSM3588004", "GSM3588005"], "sample_count": 83, "group_sizes": null, "group_sizes_basis": null, "platform": "24106;18573", "taxon": "Homo sapiens", "title": "Single-cell RNA-seq reveals AML hierarchies relevant to disease progression and immunity", "resolution_checked_at": "2026-11-01T17:30:42Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE12417", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE12417", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE12417", "version": null, "note": "The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM311598", "GSM311599", "GSM311600", "GSM311601", "GSM311602", "GSM311603", "GSM311604", "GSM311605", "GSM311606", "GSM311607", "GSM311608", "GSM311609", "GSM311610", "GSM311611", "GSM311612", "GSM311613", "GSM311614", "GSM311615", "GSM311616", "GSM311617", "GSM311618", "GSM311619", "GSM311620", "GSM311621", "GSM311622", "GSM311623", "GSM311624", "GSM311625", "GSM311626", "GSM311627", "GSM311628", "GSM311629", "GSM311630", "GSM311631", "GSM311632", "GSM311633", "GSM311634", "GSM311635", "GSM311636", "GSM311637", "GSM311638", "GSM311639", "GSM311640", "GSM311641", "GSM311642", "GSM311643", "GSM311644", "GSM311645", "GSM311646", "GSM311647", "GSM311648", "GSM311649", "GSM311650", "GSM311651", "GSM311652", "GSM311653", "GSM311654", "GSM311655", "GSM311656", "GSM311657", "GSM311658", "GSM311659", "GSM311660", "GSM311661", "GSM311662", "GSM311663", "GSM311664", "GSM311665", "GSM311666", "GSM311667", "GSM311668", "GSM311669", "GSM311670", "GSM311671", "GSM311672", "GSM311673", "GSM311674", "GSM311675", "GSM311676", "GSM311677", "GSM311678", "GSM311679", "GSM311680", "GSM311681", "GSM311682", "GSM311683", "GSM311684", "GSM311685", "GSM311686", "GSM311687", "GSM311688", "GSM311689", "GSM311690", "GSM311691", "GSM311692", "GSM311693", "GSM311694", "GSM311695", "GSM311696", "GSM311697", "GSM311698", "GSM311699", "GSM311700", "GSM311701", "GSM311702", "GSM311703", "GSM311704", "GSM311705", "GSM311706", "GSM311707", "GSM311708", "GSM311709", "GSM311710", "GSM311711", "GSM311712", "GSM311713", "GSM311714", "GSM311715", "GSM311716", "GSM311717", "GSM311718", "GSM311719", "GSM311720", "GSM311721", "GSM311722", "GSM311723", "GSM311724", "GSM311725", "GSM311726", "GSM311727", "GSM311728", "GSM311729", "GSM311730", "GSM311731", "GSM311732", "GSM311733", "GSM311734", "GSM311735", "GSM311736", "GSM311737", "GSM311738", "GSM311739", "GSM311740", "GSM311741", "GSM311742", "GSM311743", "GSM311744", "GSM311745", "GSM311746", "GSM311747", "GSM311748", "GSM311749", "GSM311750", "GSM311751", "GSM311752", "GSM311753", "GSM311754", "GSM311755", "GSM311756", "GSM311757", "GSM311758", "GSM311759", "GSM311760", "GSM311761", "GSM311762", "GSM311763", "GSM311764", "GSM311765", "GSM311766", "GSM311767", "GSM311768", "GSM311769", "GSM311770", "GSM311771", "GSM311772", "GSM311773", "GSM311774", "GSM311775", "GSM311776", "GSM311777", "GSM311778", "GSM311779", "GSM311780", "GSM311781", "GSM311782", "GSM311783", "GSM311784", "GSM311785", "GSM311786", "GSM311787", "GSM311788", "GSM311789", "GSM311790", "GSM311791", "GSM311792", "GSM311793", "GSM311794", "GSM311795", "GSM311796", "GSM311797", "GSM311798", "GSM311799", "GSM311800", "GSM311801", "GSM311802", "GSM311803", "GSM311804", "GSM311805", "GSM311806", "GSM311807", "GSM311808", "GSM311809", "GSM311810", "GSM311811", "GSM311812", "GSM311813", "GSM311814", "GSM311815", "GSM311816", "GSM311817", "GSM311818", "GSM311819", "GSM311820", "GSM311821", "GSM311822", "GSM311823", "GSM311824", "GSM311825", "GSM311826", "GSM311827", "GSM311828", "GSM311829", "GSM311830", "GSM311831", "GSM311832", "GSM311833", "GSM311834", "GSM311835", "GSM311836", "GSM311837", "GSM311838", "GSM311839", "GSM311840", "GSM311841", "GSM311842", "GSM311843", "GSM311844", "GSM311845", "GSM311846", "GSM311847", "GSM311848", "GSM311849", "GSM311850", "GSM311851", "GSM311852", "GSM311853", "GSM311854", "GSM311855", "GSM311856", "GSM311857", "GSM311858", "GSM311859", "GSM311860", "GSM311861", "GSM311862", "GSM311863", "GSM311864", "GSM311865", "GSM311866", "GSM311867", "GSM311868", "GSM311869", "GSM311870", "GSM311871", "GSM311872", "GSM311873", "GSM311874", "GSM311875", "GSM311876", "GSM311877", "GSM311878", "GSM311879", "GSM311880", "GSM311881", "GSM311882", "GSM311883", "GSM311884", "GSM311885", "GSM311886", "GSM311887", "GSM311888", "GSM311889", "GSM311890", "GSM311891", "GSM311892", "GSM311893", "GSM311894", "GSM311895", "GSM311896", "GSM311897", "GSM311898", "GSM311899", "GSM311900", "GSM311901", "GSM311902", "GSM311903", "GSM311904", "GSM311905", "GSM311906", "GSM311907", "GSM311908", "GSM311909", "GSM311910", "GSM311911", "GSM311912", "GSM311913", "GSM311914", "GSM311915", "GSM311916", "GSM311917", "GSM311918", "GSM311919", "GSM311920", "GSM311921", "GSM311922", "GSM311923", "GSM316652", "GSM316653", "GSM316654", "GSM316655", "GSM316656", "GSM316657", "GSM316658", "GSM316659", "GSM316660", "GSM316661", "GSM316662", "GSM316663", "GSM316664", "GSM316665", "GSM316666", "GSM316667", "GSM316668", "GSM316669", "GSM316670", "GSM316671", "GSM316672", "GSM316673", "GSM316674", "GSM316675", "GSM316676", "GSM316677", "GSM316678", "GSM316679", "GSM316680", "GSM316681", "GSM316682", "GSM316683", "GSM316684", "GSM316685", "GSM316686", "GSM316687", "GSM316688", "GSM316689", "GSM316690", "GSM316691", "GSM316692", "GSM316693", "GSM316694", "GSM316695", "GSM316696", "GSM316697", "GSM316698", "GSM316699", "GSM316700", "GSM316701", "GSM316702", "GSM316703", "GSM316704", "GSM316705", "GSM316706", "GSM316707", "GSM316708", "GSM316709", "GSM316710", "GSM316711", "GSM316712", "GSM316713", "GSM316714", "GSM316715", "GSM316716", "GSM316717", "GSM316718", "GSM316719", "GSM316720", "GSM316721", "GSM316722", "GSM316723", "GSM316724", "GSM316725", "GSM316726", "GSM316727", "GSM316728", "GSM316729", "GSM316730"], "sample_count": 405, "group_sizes": null, "group_sizes_basis": null, "platform": "570;96;97", "taxon": "Homo sapiens", "title": "Prognostic gene signature for normal karyotype AML", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE154109", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE154109", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE154109", "version": null, "note": "The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM4664009", "GSM4664010", "GSM4664011", "GSM4664012", "GSM4664013", "GSM4664014", "GSM4664015", "GSM4664016", "GSM4664017", "GSM4664018", "GSM4664019", "GSM4664020", "GSM4664021", "GSM4664022", "GSM4664023", "GSM4664024", "GSM4664025", "GSM4664026", "GSM4664027"], "sample_count": 19, "group_sizes": null, "group_sizes_basis": null, "platform": "16791", "taxon": "Homo sapiens", "title": "Risk-associated alterations in marrow T cells in pediatric leukemia", "resolution_checked_at": "2026-11-01T19:09:46Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE37642", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE37642", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE37642", "version": null, "note": "The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM923596", "GSM923597", "GSM923598", "GSM923599", "GSM923600", "GSM923601", "GSM923602", "GSM923603", "GSM923604", "GSM923605", "GSM923606", "GSM923607", "GSM923608", "GSM923609", "GSM923610", "GSM923611", "GSM923612", "GSM923613", "GSM923614", "GSM923615", "GSM923616", "GSM923617", "GSM923618", "GSM923619", "GSM923620", "GSM923621", "GSM923622", "GSM923623", "GSM923624", "GSM923625", "GSM923626", "GSM923627", "GSM923628", "GSM923629", "GSM923630", "GSM923631", "GSM923632", "GSM923633", "GSM923634", "GSM923635", "GSM923636", "GSM923637", "GSM923638", "GSM923639", "GSM923640", "GSM923641", "GSM923642", "GSM923643", "GSM923644", "GSM923645", "GSM923646", "GSM923647", "GSM923648", "GSM923649", "GSM923650", "GSM923651", "GSM923652", "GSM923653", "GSM923654", "GSM923655", "GSM923656", "GSM923657", "GSM923658", "GSM923659", "GSM923660", "GSM923661", "GSM923662", "GSM923663", "GSM923664", "GSM923665", "GSM923666", "GSM923667", "GSM923668", "GSM923669", "GSM923670", "GSM923671", "GSM923672", "GSM923673", "GSM923674", "GSM923675", "GSM923676", "GSM923677", "GSM923678", "GSM923679", "GSM923680", "GSM923681", "GSM923682", "GSM923683", "GSM923684", "GSM923685", "GSM923686", "GSM923687", "GSM923688", "GSM923689", "GSM923690", "GSM923691", "GSM923692", "GSM923693", "GSM923694", "GSM923695", "GSM923696", "GSM923697", "GSM923698", "GSM923699", "GSM923700", "GSM923701", "GSM923702", "GSM923703", "GSM923704", "GSM923705", "GSM923706", "GSM923707", "GSM923708", "GSM923709", "GSM923710", "GSM923711", "GSM923712", "GSM923713", "GSM923714", "GSM923715", "GSM923716", "GSM923717", "GSM923718", "GSM923719", "GSM923720", "GSM923721", "GSM923722", "GSM923723", "GSM923724", "GSM923725", "GSM923726", "GSM923727", "GSM923728", "GSM923729", "GSM923730", "GSM923731", "GSM923732", "GSM923733", "GSM923734", "GSM923735", "GSM923736", "GSM923737", "GSM923738", "GSM923739", "GSM923740", "GSM923741", "GSM923742", "GSM923743", "GSM923744", "GSM923745", "GSM923746", "GSM923747", "GSM923748", "GSM923749", "GSM923750", "GSM923751", "GSM923752", "GSM923753", "GSM923754", "GSM923755", "GSM923756", "GSM923757", "GSM923758", "GSM923759", "GSM923760", "GSM923761", "GSM923762", "GSM923763", "GSM923764", "GSM923765", "GSM923766", "GSM923767", "GSM923768", "GSM923769", "GSM923770", "GSM923771", "GSM923772", "GSM923773", "GSM923774", "GSM923775", "GSM923776", "GSM923777", "GSM923778", "GSM923779", "GSM923780", "GSM923781", "GSM923782", "GSM923783", "GSM923784", "GSM923785", "GSM923786", "GSM923787", "GSM923788", "GSM923789", "GSM923790", "GSM923791", "GSM923792", "GSM923793", "GSM923794", "GSM923795", "GSM923796", "GSM923797", "GSM923798", "GSM923799", "GSM923800", "GSM923801", "GSM923802", "GSM923803", "GSM923804", "GSM923805", "GSM923806", "GSM923807", "GSM923808", "GSM923809", "GSM923810", "GSM923811", "GSM923812", "GSM923813", "GSM923814", "GSM923815", "GSM923816", "GSM923817", "GSM923818", "GSM923819", "GSM923820", "GSM923821", "GSM923822", "GSM923823", "GSM923824", "GSM923825", "GSM923826", "GSM923827", "GSM923828", "GSM923829", "GSM923830", "GSM923831", "GSM923832", "GSM923833", "GSM923834", "GSM923835", "GSM923836", "GSM923837", "GSM923838", "GSM923839", "GSM923840", "GSM923841", "GSM923842", "GSM923843", "GSM923844", "GSM923845", "GSM923846", "GSM923847", "GSM923848", "GSM923849", "GSM923850", "GSM923851", "GSM923852", "GSM923853", "GSM923854", "GSM923855", "GSM923856", "GSM923857", "GSM923858", "GSM923859", "GSM923860", "GSM923861", "GSM923862", "GSM923863", "GSM923864", "GSM923865", "GSM923866", "GSM923867", "GSM923868", "GSM923869", "GSM923870", "GSM923871", "GSM923872", "GSM923873", "GSM923874", "GSM923875", "GSM923876", "GSM923877", "GSM923878", "GSM923879", "GSM923880", "GSM923881", "GSM923882", "GSM923883", "GSM923884", "GSM923885", "GSM923886", "GSM923887", "GSM923888", "GSM923889", "GSM923890", "GSM923891", "GSM923892", "GSM923893", "GSM923894", "GSM923895", "GSM923896", "GSM923897", "GSM923898", "GSM923899", "GSM923900", "GSM923901", "GSM923902", "GSM923903", "GSM923904", "GSM923905", "GSM923906", "GSM923907", "GSM923908", "GSM923909", "GSM923910", "GSM923911", "GSM923912", "GSM923913", "GSM923914", "GSM923915", "GSM923916", "GSM923917", "GSM923918", "GSM923919", "GSM923920", "GSM923921", "GSM923922", "GSM923923", "GSM923924", "GSM923925", "GSM923926", "GSM923927", "GSM923928", "GSM923929", "GSM923930", "GSM923931", "GSM923932", "GSM923933", "GSM923934", "GSM923935", "GSM923936", "GSM923937", "GSM923938", "GSM923939", "GSM923940", "GSM923941", "GSM923942", "GSM923943", "GSM923944", "GSM923945", "GSM923946", "GSM923947", "GSM923948", "GSM923949", "GSM923950", "GSM923951", "GSM923952", "GSM923953", "GSM923954", "GSM923955", "GSM923956", "GSM923957", "GSM923958", "GSM923959", "GSM923960", "GSM923961", "GSM923962", "GSM923963", "GSM923964", "GSM923965", "GSM923966", "GSM923967", "GSM923968", "GSM923969", "GSM923970", "GSM923971", "GSM923972", "GSM923973", "GSM923974", "GSM923975", "GSM923976", "GSM923977", "GSM923978", "GSM923979", "GSM923980", "GSM923981", "GSM923982", "GSM923983", "GSM923984", "GSM923985", "GSM923986", "GSM923987", "GSM923988", "GSM923989", "GSM923990", "GSM923991", "GSM923992", "GSM923993", "GSM923994", "GSM923995", "GSM923996", "GSM923997", "GSM923998", "GSM923999", "GSM924000", "GSM924001", "GSM924002", "GSM924003", "GSM924004", "GSM924005", "GSM924006", "GSM924007", "GSM924008", "GSM924009", "GSM924010", "GSM924011", "GSM924012", "GSM924013", "GSM924014", "GSM924015", "GSM924016", "GSM924017", "GSM924018", "GSM924019", "GSM924020", "GSM924021", "GSM924022", "GSM924023", "GSM924024", "GSM924025", "GSM924026", "GSM924027", "GSM924028", "GSM924029", "GSM924030", "GSM924031", "GSM924032", "GSM924033", "GSM924034", "GSM924035", "GSM924036", "GSM924037", "GSM924038", "GSM924039", "GSM924040", "GSM924041", "GSM924042", "GSM924043", "GSM924044", "GSM924045", "GSM924046", "GSM924047", "GSM924048", "GSM924049", "GSM924050", "GSM924051", "GSM924052", "GSM924053", "GSM924054", "GSM924055", "GSM924056", "GSM924057", "GSM924058", "GSM924059", "GSM924060", "GSM924061", "GSM924062", "GSM924063", "GSM924064", "GSM924065", "GSM924066", "GSM924067", "GSM924068", "GSM924069", "GSM924070", "GSM924071", "GSM924072", "GSM924073", "GSM924074", "GSM924075", "GSM924076", "GSM924077", "GSM924078", "GSM924079", "GSM924080", "GSM924081", "GSM924082", "GSM924083", "GSM924084", "GSM924085", "GSM924086", "GSM924087", "GSM924088", "GSM924089", "GSM924090", "GSM924091", "GSM924092", "GSM924093", "GSM924094", "GSM924095", "GSM924096", "GSM924097", "GSM924098", "GSM924099", "GSM924100", "GSM924101", "GSM924102", "GSM924103", "GSM924104", "GSM924105", "GSM924106", "GSM924107", "GSM924108", "GSM924109", "GSM924110", "GSM924111", "GSM924112", "GSM924113", "GSM924114", "GSM924115", "GSM924116", "GSM924117", "GSM924118", "GSM924119", "GSM924120", "GSM924121", "GSM924122", "GSM924123", "GSM924124", "GSM924125", "GSM924126", "GSM924127", "GSM924128", "GSM924129", "GSM924130", "GSM924131", "GSM924132", "GSM924133", "GSM924134", "GSM924135", "GSM924136", "GSM924137", "GSM924138", "GSM924139", "GSM924140", "GSM924141", "GSM924142", "GSM924143", "GSM924144", "GSM924145", "GSM924146", "GSM924147", "GSM924148", "GSM924149", "GSM924150", "GSM924151", "GSM924152", "GSM924153", "GSM924154", "GSM924155", "GSM924156", "GSM924157", "GSM924158", "GSM924159", "GSM924160", "GSM924161", "GSM924162", "GSM924163", "GSM924164", "GSM924165", "GSM924166", "GSM924167", "GSM924168", "GSM924169", "GSM924170", "GSM924171", "GSM924172", "GSM924173", "GSM924174", "GSM924175", "GSM924176", "GSM924177", "GSM924178", "GSM924179", "GSM924180", "GSM924181", "GSM924182", "GSM924183", "GSM924184", "GSM924185", "GSM924186", "GSM924187", "GSM924188", "GSM924189", "GSM924190", "GSM924191", "GSM924192", "GSM924193", "GSM924194", "GSM924195", "GSM924196", "GSM924197", "GSM924198", "GSM924199", "GSM924200", "GSM924201", "GSM924202", "GSM924203", "GSM924204", "GSM924205", "GSM924206", "GSM924207", "GSM924208", "GSM924209", "GSM924210", "GSM924211", "GSM924212", "GSM924213", "GSM924214", "GSM924215", "GSM924216", "GSM924217", "GSM924218", "GSM924219", "GSM924220", "GSM924221", "GSM924222", "GSM924223", "GSM924224", "GSM924225", "GSM924226", "GSM924227", "GSM924228", "GSM924229", "GSM924230", "GSM924231", "GSM924232", "GSM924233", "GSM924234", "GSM924235", "GSM924236", "GSM924237", "GSM924238", "GSM924239", "GSM924240", "GSM924241", "GSM924242", "GSM924243", "GSM924244", "GSM924245", "GSM924246", "GSM924247", "GSM924248", "GSM924249", "GSM924250", "GSM924251", "GSM924252", "GSM924253", "GSM924254", "GSM924255", "GSM924256", "GSM924257", "GSM924258", "GSM924259", "GSM924260", "GSM924261", "GSM924262", "GSM924263", "GSM924264", "GSM924265", "GSM924266", "GSM924267", "GSM924268", "GSM924269", "GSM924270", "GSM924271", "GSM924272", "GSM924273", "GSM924274", "GSM924275", "GSM924276", "GSM924277", "GSM924278", "GSM924279", "GSM924280", "GSM924281", "GSM924282", "GSM924283", "GSM924284", "GSM924285", "GSM924286", "GSM924287", "GSM924288", "GSM924289", "GSM924290", "GSM924291", "GSM924292", "GSM924293", "GSM924294", "GSM924295", "GSM924296", "GSM924297", "GSM924298", "GSM924299", "GSM924300", "GSM924301", "GSM924302", "GSM924303", "GSM924304", "GSM924305", "GSM924306", "GSM924307", "GSM924308", "GSM924309", "GSM924310", "GSM924311", "GSM924312", "GSM924313", "GSM924314", "GSM924315", "GSM924316", "GSM924317", "GSM924318", "GSM924319", "GSM924320", "GSM924321", "GSM924322", "GSM924323", "GSM924324", "GSM924325", "GSM924326", "GSM924327", "GSM924328", "GSM924329", "GSM924330", "GSM924331", "GSM924332", "GSM924333", "GSM924334", "GSM924335", "GSM924336", "GSM924337", "GSM924338", "GSM924339", "GSM924340", "GSM924341", "GSM924342", "GSM924343", "GSM924344", "GSM924345", "GSM924346", "GSM924347", "GSM924348", "GSM924349", "GSM924350", "GSM924351", "GSM924352", "GSM924353", "GSM924354", "GSM924355", "GSM924356", "GSM924357", "GSM924358", "GSM924359", "GSM924360", "GSM924361", "GSM924362", "GSM924363", "GSM924364", "GSM924365", "GSM924366", "GSM924367", "GSM924368", "GSM924369", "GSM924370", "GSM924371", "GSM924372", "GSM924373", "GSM924374", "GSM924375", "GSM924376", "GSM924377", "GSM924378", "GSM924379", "GSM924380", "GSM924381", "GSM924382", "GSM924383", "GSM924384", "GSM924385", "GSM924386", "GSM924387", "GSM924388", "GSM924389", "GSM924390", "GSM924391", "GSM924392", "GSM924393", "GSM924394", "GSM924395", "GSM924396", "GSM924397", "GSM924398", "GSM924399", "GSM924400", "GSM924401", "GSM924402", "GSM924403", "GSM924404", "GSM924405", "GSM924406", "GSM924407", "GSM924408", "GSM924409", "GSM924410", "GSM924411", "GSM924412", "GSM924413", "GSM924414", "GSM924415", "GSM924416", "GSM924417", "GSM924418", "GSM924419", "GSM924420", "GSM924421", "GSM924422", "GSM924423", "GSM924424", "GSM924425", "GSM924426", "GSM924427", "GSM924428", "GSM924429", "GSM924430", "GSM924431", "GSM924432", "GSM924433", "GSM924434", "GSM924435", "GSM924436", "GSM924437", "GSM924438", "GSM924439", "GSM924440", "GSM924441", "GSM924442", "GSM924443", "GSM924444", "GSM924445", "GSM924446", "GSM924447", "GSM924448", "GSM924449", "GSM924450", "GSM924451", "GSM924452", "GSM924453", "GSM924454", "GSM924455", "GSM924456", "GSM924457", "GSM924458", "GSM924459", "GSM924460", "GSM924461", "GSM924462", "GSM924463", "GSM924464", "GSM924465", "GSM924466", "GSM924467", "GSM924468", "GSM924469", "GSM924470", "GSM924471", "GSM924472", "GSM924473", "GSM924474", "GSM924475", "GSM924476", "GSM924477", "GSM924478", "GSM924479", "GSM924480", "GSM924481", "GSM924482", "GSM924483", "GSM924484", "GSM924485", "GSM924486", "GSM924487", "GSM924488", "GSM924489", "GSM924490", "GSM924491", "GSM924492", "GSM924493", "GSM924494", "GSM924495", "GSM924496", "GSM924497", "GSM924498", "GSM924499", "GSM924500", "GSM924501", "GSM924502", "GSM924503", "GSM924504", "GSM924505", "GSM924506", "GSM924507", "GSM924508", "GSM924509", "GSM924510", "GSM924511", "GSM924512", "GSM924513", "GSM924514", "GSM924515", "GSM924516", "GSM924517", "GSM924518", "GSM924519", "GSM924520", "GSM924521", "GSM924522", "GSM924523", "GSM924524", "GSM924525", "GSM924526", "GSM924527", "GSM924528", "GSM924529", "GSM924530", "GSM924531", "GSM924532", "GSM924533", "GSM924534", "GSM924535", "GSM924536", "GSM924537", "GSM924538", "GSM924539", "GSM924540", "GSM924541", "GSM924542", "GSM924543", "GSM924544", "GSM924545", "GSM924546", "GSM924547", "GSM924548", "GSM924549", "GSM924550", "GSM924551", "GSM924552", "GSM924553", "GSM924554", "GSM924555", "GSM924556", "GSM924557", "GSM924558", "GSM924559", "GSM924560", "GSM924561", "GSM924562", "GSM924563", "GSM924564", "GSM924565", "GSM924566", "GSM924567", "GSM924568", "GSM924569", "GSM924570", "GSM924571", "GSM924572", "GSM924573", "GSM924574", "GSM924575", "GSM924576", "GSM924577", "GSM924578", "GSM924579"], "sample_count": 984, "group_sizes": null, "group_sizes_basis": null, "platform": "570;96;97", "taxon": "Homo sapiens", "title": "Prognostic gene signature for AML", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}], "gaps": ["asset:data:geo:GSE10358 not downloaded", "asset:data:geo:GSE10358 licence not read", "asset:data:geo:GSE106291 not downloaded", "asset:data:geo:GSE106291 licence not read", "asset:data:geo:GSE116256 not downloaded", "asset:data:geo:GSE116256 licence not read", "asset:data:geo:GSE12417 not downloaded", "asset:data:geo:GSE12417 licence not read", "asset:data:geo:GSE154109 not downloaded", "asset:data:geo:GSE154109 licence not read", "asset:data:geo:GSE37642 not downloaded", "asset:data:geo:GSE37642 licence not read"]}, "analysis": {"state": "complete", "methods": [{"id": "method-1", "family": "survival_analysis", "specific": "cox_proportional_hazards", "label": "Survival analysis", "dsl_operations": ["cox_ph"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 1.0, "band": "verbatim", "quote": "OS-related FAGs in AML with p < 0.05 were identified through univariate Cox regression analysis."}}, {"id": "method-2", "family": "principal_component_analysis", "specific": "pca", "label": "Principal component analysis", "dsl_operations": ["pca_fit"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["wide_numeric_matrix"], "evidence": {"score": 0.8, "band": "high", "quote": "Principal component analysis"}}], "targets": [], "gaps": []}, "capability": {"state": "complete", "requirements": [{"capability_id": "capability:computational_analysis", "label": "Computational analysis platform", "assay_families": ["meta_analysis", "machine_learning", "survival_analysis", "statistical_regression", "pca", "molecular_docking", "network_analysis", "differential_expression", "gwas"], "availability_state": "owned", "tier_unlocked": "R1", "candidate": "Automated Assays Laravel application and simulated adapters"}], "gaps": []}, "readiness": {"state": "complete", "tier": "R1", "blocking_axis": "none", "blocked_on": "nothing:replicable_now", "axes": {"method": {"tier": "R1", "expressible": true, "required_operations": ["cox_ph"], "missing_operations": [], "basis": "The paper names the method it used and the corpus's method extractor maps it onto the DSL catalogue: cox_proportional_hazards."}, "capability": {"tier": "R1", "capability_id": "capability:computational_analysis", "availability_state": "owned", "basis": "The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE37642", "GSE12417", "GSE10358", "GSE106291", "GSE116256", "GSE154109"], "resolved_accessions": ["GSE37642", "GSE12417", "GSE10358", "GSE106291", "GSE116256", "GSE154109"], "statements": ["The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding authors."], "basis": "The paper names GSE37642, GSE12417, GSE10358, GSE106291, GSE116256, GSE154109 in Gene Expression Omnibus (GEO) and the accession resolves in the repository. No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": ["cox_ph"], "assets": ["source:pmid:37691822", "data:geo:GSE10358"], "steps": ["run_analysis"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:GSE10358"]}, "gaps": []}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": "2026-11-01T18:53:12Z", "independence": "single_reader"}, "evidence_check": {"method": "verbatim", "availability": "verbatim"}, "calls": 5, "usage": {"prompt_tokens": 18633, "completion_tokens": 3545, "cached_tokens": 264}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:37691822", "type": "paper", "label": "pmid:37691822"}, {"id": "source:pmid:37691822", "type": "manuscript", "label": "PMID 37691822 full text"}, {"id": "data:geo:GSE10358", "type": "dataset", "label": "GEO GSE10358"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:37691822", "type": "paper", "label": "pmid:37691822"}, {"id": "source:pmid:37691822", "type": "manuscript", "label": "PMID 37691822 full text"}, {"id": "data:geo:GSE10358", "type": "dataset", "label": "GEO GSE10358"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-37691822", "type": "extraction", "used": ["source:pmid:37691822"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-GSE10358", "type": "accession_resolution", "used": ["data:geo:GSE10358"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:37691822", "parent_hash": "sha256:d363136365b39529078db57705458424e908fe11e8769e3fe8cc7e27c7c26af5", "fork_of": null, "generation": 2}, "gaps": ["asset:data:geo:GSE10358 licence not read", "asset:data:geo:GSE10358 not downloaded", "asset:data:geo:GSE106291 licence not read", "asset:data:geo:GSE106291 not downloaded", "asset:data:geo:GSE116256 licence not read", "asset:data:geo:GSE116256 not downloaded", "asset:data:geo:GSE12417 licence not read", "asset:data:geo:GSE12417 not downloaded", "asset:data:geo:GSE154109 licence not read", "asset:data:geo:GSE154109 not downloaded", "asset:data:geo:GSE37642 licence not read", "asset:data:geo:GSE37642 not downloaded", "execution.not_run", "review.human_critique", "review.independent_reader", "review.machine_critique"], "assays": [{"role": "analysis", "definition_id": "survival_analysis", "definition_version": "f2132e96ae6c7a4e", "definition_digest": null, "required_operations": ["cox_ph"], "support_state": "supported", "source_hashes": {"dsl_catalogue": "f2132e96ae6c7a4e"}, "confidence": 1.0, "evidence": ["OS-related FAGs in AML with p < 0.05 were identified through univariate Cox regression analysis."], "order_basis": "analysis_only", "id": "assay:1"}]}