The Prognostic and Therapeutic Role of Histone Acetylation Modification in LIHC Development and Progression.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:37763801", "kind": "science-record", "revision": 2, "content_hash": "sha256:e0ddad4bc3a6150b3b5320d0ac4faf378113dd3e8a219cb09ad11e9f8f1a7e6d", "created_at": "2026-11-01T19:02:36Z", "updated_at": "2026-11-01T21:31:38Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "The Prognostic and Therapeutic Role of Histone Acetylation Modification in LIHC Development and Progression.", "doi": "10.3390/medicina59091682", "pmid": "37763801", "authors": ["Ji Gao", "Sheng Han", "Jian Gu", "Chen Wu", "Xiaoxin Mu"], "journal": "Medicina (Kaunas, Lithuania)", "year": 2023, "abstract": "Background and Objectives: The modification of histone acetylation plays a vital role in regulating tumor occurrence and development, but the interaction between histone acetylation modulator genes and the liver hepatocellular carcinoma (LIHC) microenvironment, as well as immunotherapy, has not been investigated. Materials and Methods: Analysis of all statistical data was carried out using R software (Version 4.2.0) and the online tool Sangerbox. Comprehensive bioinformatics analysis, including signature construction and validation, functional analyses, immune and genomic features analyses, and immunotherapy prediction analyses, were performed to explore the prognostic and therapeutic role of histone acetylation modulator genes in LIHC development and progression. Results: The LIHC cohort from The Cancer Genome Atlas (TCGA) database was selected as the training cohort; the GSE76427 cohort from the Gene Expression Omnibus (GEO) database and the LIRI-JP cohort from the International Cancer Genome Consortium (ICGC) database were selected as the validation cohorts. The histone acetylation modulator gene-based prognostic signature was constructed and validated successfully. Immune infiltration analysis showed that most immune cells and immune functions were enriched in patients with high histone acetylation risk scores (HARS). Additionally, high levels of checkpoint inhibitors (ICIs) and human leukocyte antigens (HLAs) were also observed in high HARS patients. Meanwhile, TIDE algorithm analysis was conducted to explore the relationship between HARS and immunotherapy response, and submap algorithm analysis was used for the verification of the results, from which we found that high HAPS patients were more likely to respond to immunotherapy. Conclusions: Our findings revealed that the histone acetylation modulator genes, particularly for KAT21, SIRT6, and HAT1, may have the potential to function as a new prognostic marker and therapeutic target for LIHC.", "claims": [{"id": "claim-data-access", "statement": "All the data used in our study are included in the article/Supplementary Material, and further inquiries can be directed to the corresponding author.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37763801", "locator": "sections[21] \"notes\" paragraph 1", "quote": "All the data used in our study are included in the article/Supplementary Material, and further inquiries can be directed to the corresponding author."}], "state": "complete"}, {"id": "claim-target-result", "statement": "The histone acetylation modulator gene-based prognostic signature was constructed and validated successfully, with time-dependent ROC AUCs of 0.75, 0.71, and 0.81 at 1, 3, and 5 years in the TCGA cohort.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:37763801", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "The histone acetylation modulator gene-based prognostic signature was constructed and validated successfully."}, {"asset": "source:pmid:37763801", "locator": "sections[11] \"3.3. Verification and Evaluation of the Signature\" paragraph 2", "quote": "Time-dependent ROC curve analyses showed the overall accuracy was excellent among all three cohorts, with a satisfactory predicted efficacy on patient prognosis in the TCGA group (Figure 3A; 1-year AUC = 0.75, 3-year AUC = 0.71, 5-year AUC = 0.81)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "The histone acetylation modulator gene-based prognostic signature was constructed and validated successfully, with time-dependent ROC AUCs of 0.75, 0.71, and 0.81 at 1, 3, and 5 years in the TCGA cohort.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:37763801"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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