Kinesin superfamily member KIFC2 as an independent prognostic biomarker of colon adenocarcinoma associated with poor immune response.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:37904433", "kind": "science-record", "revision": 4, "content_hash": "sha256:2ef36287c14a8c68342d519c1b355315b98ac529ae8961049259c64e79a59f8c", "created_at": "2026-11-01T19:02:46Z", "updated_at": "2026-11-01T22:52:59Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Kinesin superfamily member KIFC2 as an independent prognostic biomarker of colon adenocarcinoma associated with poor immune response.", "doi": "10.1097/MD.0000000000035491", "pmid": "37904433", "authors": ["Tao Chen", "Yunqian Chu", "Haiyuan Xu", "Hanjue Dai", "Yuxi Zhou", "Haiwei Du", "Wenyu Zhu"], "journal": "Medicine", "year": 2023, "abstract": "Clinical outcomes of colon adenocarcinoma (COAD) exhibit heterogeneity among different patients, highlighting the need for novel prognostic biomarkers. Kinesin superfamily members have been shown to play a crucial role in tumors and can predict cancer diagnosis and prognosis. However, the role of kinesin family member C2 (KIFC2) in tumors, particularly its prognostic value in COAD, remains poorly understood. Our bioinformatics analysis of the cancer genome atlas and GEO databases revealed significantly higher expression of KIFC2 in COAD, correlating with a worse prognosis in the cancer genome atlas-COAD and GSE17536 cohorts. Additionally, differentially expressed genes in COAD were enriched in immune-related pathways, and patients with higher KIFC2 expression showed fewer activated CD4 + T cells. These findings suggest KIFC2 as a potential prognostic biomarker for COAD, warranting further validation in clinical studies.", "claims": [{"id": "claim-method", "statement": "Kaplan–Meier method was applied for survival analysis and the log-rank test was used to estimate statistical significance. Multivariate Cox regression analysis was used to screen potential prognostic factors.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37904433", "locator": "sections[7] \"2.5. Statistical analysis\" paragraph 2", "quote": "Kaplan–Meier method was applied for survival analysis and the log-rank test was used to estimate statistical significance. Multivariate Cox regression analysis was used to screen potential prognostic factors."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets generated during and/or analyzed during the current study are publicly available.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37904433", "locator": "sections[18] \"fn-group\" paragraph 1", "quote": "The datasets generated during and/or analyzed during the current study are publicly available."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Our bioinformatics analysis of the cancer genome atlas and GEO databases revealed significantly higher expression of KIFC2 in COAD, correlating with a worse prognosis in the cancer genome atlas-COAD and GSE17536 cohorts.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:37904433", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "Our bioinformatics analysis of the cancer genome atlas and GEO databases revealed significantly higher expression of KIFC2 in COAD, correlating with a worse prognosis in the cancer genome atlas-COAD and GSE17536 cohorts."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "Our bioinformatics analysis of the cancer genome atlas and GEO databases revealed significantly higher expression of KIFC2 in COAD, correlating with a worse prognosis in the cancer genome atlas-COAD and GSE17536 cohorts.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:37904433"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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