Bioinformatics and Systems Biology Approach to Identify the Pathogenetic Link between Heart Failure and Sarcopenia.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:37909603", "kind": "science-record", "revision": 4, "content_hash": "sha256:a300d7783a5af2f13a7465fbd7e9a0098740fb562d41020dfdf62bc54750cf13", "created_at": "2026-11-01T19:02:47Z", "updated_at": "2026-11-01T22:10:34Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Bioinformatics and Systems Biology Approach to Identify the Pathogenetic Link between Heart Failure and Sarcopenia.", "doi": "10.36660/abc.20220874", "pmid": "37909603", "authors": ["Rui Xu", "Ling-Ling Ma", "Shuai Cui", "Ling Chen", "Hong Xu"], "journal": "Arquivos brasileiros de cardiologia", "year": 2023, "abstract": "Despite increasing evidence that patients with heart failure (HF) are susceptible to sarcopenia, the reason for the association is not well understood. The purpose of this study is to explore further the molecular mechanism of the occurrence of this complication. Gene expression datasets for HF (GSE57345) and Sarcopenia (GSE1428) were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified using 'edgeR' and \"limma\" packages of R, and their functions were analyzed using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). Protein-protein interaction (PPI) networks were constructed and visualized using Search Tool for the Retrieval of Interacting Genes (STRING) and Cytoscape. Hub genes were selected using the plugin cytoHubba and validation with GSE76701 for HF and GSE136344 for Sarcopenia. The related pathways and molecular mechanisms of the hub genes were performed by Gene set enrichment analysis (GSEA). The statistical analyses were performed using R software. P < 0.05 was considered statistically significant. A total of 114 common DEGs were found. Pathways related to growth factor, Insulin secretion and cGMP-PKG were enriched in both HF and Sarcopenia. CYP27A1, KCNJ8, PIK3R5, TIMP2, CXCL12, KIT, and VCAM1 were found to be significant hub genes after validation, with GSEA emphasizing the importance of the hub genes in the regulation of the inflammatory response. Our study reveals that HF and Sarcopenia share common pathways and pathogenic mechanisms. These findings may suggest new directions for future research into the underlying pathogenesis.", "claims": [{"id": "claim-data-access", "statement": "O conjunto de dados GSE57345 incluiu dados de sequenciamento de RNA de 177 pacientes com IC e 136 controles saudáveis da Filadélfia", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37909603", "locator": "sections[3] \"Desenho do estudo e coleta de dados\" paragraph 2", "quote": "O conjunto de dados GSE57345 incluiu dados de sequenciamento de RNA de 177 pacientes com IC e 136 controles saudáveis da Filadélfia"}], "state": "complete"}, {"id": "claim-target-result", "statement": "Foram identificados 114 genes diferencialmente expressos comuns à insuficiência cardíaca e à sarcopenia.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:37909603", "locator": "sections[0] \"Abstract\" paragraph 5", "quote": "Foram encontrados 114 DEGs comuns."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "Foram identificados 114 genes diferencialmente expressos comuns à insuficiência cardíaca e à sarcopenia.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:37909603"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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