CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:37927958", "kind": "science-record", "revision": 4, "content_hash": "sha256:805c2d9dd0689a83be4c0140fef742819b635be2b9f4dbf570515b235e5512f0", "created_at": "2026-11-01T19:02:49Z", "updated_at": "2026-11-01T22:10:35Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients.", "doi": "10.2147/JIR.S431212", "pmid": "37927958", "authors": ["Yingli Liu", "Dan Si", "Pingping Bai", "Li Zhu", "Lili Zhang", "Qi Chen", "Yong Qi"], "journal": "Journal of inflammation research", "year": 2023, "abstract": "Background: Although the potential of coronavirus disease 2019 (COVID-19) patients to develop pulmonary embolism (PE) is widely recognized, the underlying mechanism has not been completely elucidated. This study aimed to identify genes common to COVID-19 and PE to reveal the underlying pathogenesis of susceptibility to PE in COVID-19 patients.\nMethods: COVID-19 genes were obtained from the GEO database and the OMIM, CTD, GeneCards, and DisGeNET databases; PE genes were obtained from the OMIM, CTD, GeneCards, and DisGeNET databases. We overlapped the genes of COVID-19 and PE to obtain common genes for additional analysis, including functional enrichment, protein-protein interaction, and immune infiltration analysis. Hub genes were identified using cytoHubba, a plugin of Cytoscape, and validated using the independent datasets GSE167000 and GSE13535. The genes validated by the above datasets were further validated in clinical samples.\nResults: We obtained 36 genes shared by PE and COVID-19. Functional enrichment and immune infiltration analyses revealed the involvement of cytokines and immune activation. Five genes (CCL2, CXCL10, ALB, EGF, and MKI67) were identified as hub genes common to COVID-19 and PE. CXCL10 was validated in both independent datasets (GSE167000 and GSE13535). Serum levels of CXCL10 in the COVID-19 group and the COVID-19 combined with PE group were significantly higher than those in the healthy control group (P<0.001). In addition, there were significant differences between the COVID-19 group and the COVID-19 combined with PE group (P<0.01).\nConclusion: Our study reveals common genes shared by PE and COVID-19 and identifies CXCL10 as a possible cause of susceptibility to PE in COVID-19 patients.", "claims": [{"id": "claim-method", "statement": "Differences between the two groups were compared by an unpaired Student′s t-test. 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A two-tailed p-value < 0.05 was considered statistically significant."}], "state": "complete"}, {"id": "claim-data-access", "statement": "We provide details of the materials and methods in our manuscript.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37927958", "locator": "sections[23] \"Data Sharing Statement\" paragraph 2", "quote": "We provide details of the materials and methods in our manuscript."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Serum levels of CXCL10 in the COVID-19 group and the COVID-19 combined with PE group were significantly higher than those in the healthy control group (P<0.001).", "kind": "quantitative", "target": {"value": 0.001, "unit": "p-value", "tolerance": null, "source": "Serum levels of CXCL10 in the COVID-19 group and the COVID-19 combined with PE group were significantly higher than those in the healthy control group (P<0.001)."}, "evidence": [{"asset": "source:pmid:37927958", "locator": "sections[0] \"Abstract\" paragraph 3", "quote": "Serum levels of CXCL10 in the COVID-19 group and the COVID-19 combined with PE group were significantly higher than those in the healthy control group (P<0.001)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "Serum levels of CXCL10 in the COVID-19 group and the COVID-19 combined with PE group were significantly higher than those in the healthy control group (P<0.001).", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:37927958"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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