Significance of LINC02082 and LOC105369812 in differentiating papillary thyroid cancer from benign nodules.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:37932992", "kind": "science-record", "revision": 3, "content_hash": "sha256:5419208118f00e87852f4eb7d8701914b519da71d7e2130fdc441d27c3548b4f", "created_at": "2026-11-01T19:02:49Z", "updated_at": "2026-11-01T22:10:36Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Significance of LINC02082 and LOC105369812 in differentiating papillary thyroid cancer from benign nodules.", "doi": "10.1097/MD.0000000000035542", "pmid": "37932992", "authors": ["Jingya Xu", "Wenya Liu", "Ruiqi Li", "Youmin Wang"], "journal": "Medicine", "year": 2023, "abstract": "OBJECTIVE: To explore the significance of LINC02082 and LOC105369812 in the differential diagnosis of papillary thyroid carcinoma (PTC) and benign nodules.\nMETHODS: Cancer tissues and benign nodules from 8 patients were sequenced and constructed using high-throughput sequencing. Differentially expressed mRNAs (DEmRNAs) and lncRNAs (DElncRNAs) with significant differences were screened. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed on the mRNAs co-expressed by DEmRNAs and DElncRNAs. LncRNAs with significant differences, good consistency, and enrichment in the PI3K-AKt signaling pathway were selected as candidate lncRNAs, and the target lncRNAs were screened by correlation analysis. Target lncRNAs and co-expressed mRNAs enriched in the PI3K-AKt signaling pathway and microRNAs (miRNAs) interacting with each other were used to construct a competing endogenous RNA (ceRNA) network. Finally, the PTC-related gene set (GSE33630) was downloaded from the GEO database and the expression of the genes obtained by sequencing was compared. Differential expression was verified using quantitative real-time PCR (qRT-PCR). Finally, the receiver operating characteristic (ROC) curve was used to evaluate the value of the target lncRNAs in diagnosis, when used alone or in combination.\nRESULTS: A total of 1113 differential RNAs (DE RNAs) were identified, of which 338 were DElncRNAs and 775 were DEmRNAs. Three lncRNAs enriched in the PI3K-AKt signaling pathway, LINC02082, LOC105369812, and LOC105375170, were used as candidate lncRNAs. After correlation analysis with known biomarkers, LINC02082 and LOC105369812 were selected as the target lncRNAs. The qRT-PCR results showed that the target lncRNAs were significantly different among the 3 tissues. The ROC curve showed that LOC105369812 could be used to differentiate PTC from benign thyroid nodules, whereas LINC02082 and its combination had lower predictive value.\nCONCLUSIONS: LOC105369812 is valuable for differentiating benign from malignant thyroid nodules, whereas LINC02082 has lower diagnostic value.", "claims": [{"id": "claim-method", "statement": "Receiver operating characteristic (ROC) analysis was performed on LINC02082 and LOC105369812 and logistic regression analysis was performed on the 2 target lncRNAs to obtain the area under the curve to assess the results.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37932992", "locator": "sections[8] \"2.6. Statistical analysis\" paragraph 4", "quote": "Receiver operating characteristic (ROC) analysis was performed on LINC02082 and LOC105369812 and logistic regression analysis was performed on the 2 target lncRNAs to obtain the area under the curve to assess the results."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets generated during and/or analyzed during the current study are not publicly available, but are available from the corresponding author on reasonable request.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37932992", "locator": "sections[22] \"(untitled)\" paragraph 1", "quote": "The datasets generated during and/or analyzed during the current study are not publicly available, but are available from the corresponding author on reasonable request."}], "state": "complete"}, {"id": "claim-target-result", "statement": "LOC105369812 showed diagnostic value for differentiating PTC from benign thyroid nodules, with an AUC of 0.6952, compared with 0.5829 for LINC02082 and 0.6301 for their combination.", "kind": "quantitative", "target": {"value": 95.0, "unit": "per cent", "tolerance": null, "source": "The cutoff value and AUC were 0.0274 and 0.5829 (95% confidence interval (CI): 0.4305–0.7353) for LINC02082, and 0.0021 and 0.6952 (95% CI: 0.5530–0.8373) for LOC105369812, respectively."}, "evidence": [{"asset": "source:pmid:37932992", "locator": "sections[18] \"3.7.2. Diagnostic value of target lncRNAs.\" paragraph 2", "quote": "The ROC curves indicated that LOC105369812 could be used to identify PTC and BN, whereas the combined predictive identification values of both LOC105369812 and LINC02082 were lower (Fig. 9)."}, {"asset": "source:pmid:37932992", "locator": "sections[18] \"3.7.2. Diagnostic value of target lncRNAs.\" paragraph 2", "quote": "The cutoff value and AUC were 0.0274 and 0.5829 (95% confidence interval (CI): 0.4305–0.7353) for LINC02082, and 0.0021 and 0.6952 (95% CI: 0.5530–0.8373) for LOC105369812, respectively."}, {"asset": "source:pmid:37932992", "locator": "sections[18] \"3.7.2. Diagnostic value of target lncRNAs.\" paragraph 2", "quote": "The joint predicted cutoff value and AUC were 0.5845 and 0.6301 (95% CI: 0.4829–0.7773), respectively."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "LOC105369812 showed diagnostic value for differentiating PTC from benign thyroid nodules, with an AUC of 0.6952, compared with 0.5829 for LINC02082 and 0.6301 for their combination.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:37932992"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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