Role of PPAR-related genes in chronic heart failure: evidence from large populations.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:37950149", "kind": "science-record", "revision": 3, "content_hash": "sha256:cabf9de60af565d3668f07571632328e95c3a092f20f9c2c93229bbc4db01c77", "created_at": "2026-11-01T19:02:50Z", "updated_at": "2026-11-01T22:10:37Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Role of PPAR-related genes in chronic heart failure: evidence from large populations.", "doi": "10.1186/s12872-023-03554-8", "pmid": "37950149", "authors": ["Zun-Ping Ke", "Wen-Qi Tao", "Gang Zhao", "Kuan Cheng"], "journal": "BMC cardiovascular disorders", "year": 2023, "abstract": "BACKGROUND: The role of PPAR signaling and its associated genes in the pathogenesis and progression of chronic heart failure (CHF) remains elusive.\nMETHODS: We accessed the gene expression profile and relevant baseline information of CHF samples from the Gene Expression Omnibus (GEO) database, specifically from the GSE57338 project.\nRESULTS: From GSE57338 project, we derived the expression value of 126 PPAR-related genes. A protein-protein interaction network was then established to illustrate potential protein interactions. ClueGO analysis results revealed that these genes predominantly participate in functions such as export across plasma membrane, regulation of lipid metabolic process, fatty acid metabolism, circulatory system vascular processes, alcohol metabolism, triglyceride metabolism and regulation of lipid localization and response to nutrient. Using the cytohubba plug-in in Cytoscape, we pinpointed ACADM, PPARG and CPT2 as potential central molecules in HF pathogenesis and progression. Subsequent Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis delved into the potential biological role of these three genes in CHF. Immune infiltration analysis suggested that the infiltration level of neutrophils and M2 macrophages might be notably influenced by these genes, thereby playing a role in the CHF mechanism.\nCONCLUSIONS: Our research provides a comprehensive insight into the significance of PPAR associated genes in CHF development. Notably, the genes ACADM, PPARG and CPT2 emerged as potential targets for clinical interventions.", "claims": [{"id": "claim-method", "statement": "Correlation analysis showed that there is a significant expression correlation between ACADM, PPARG, and CP2 pairwise (Figure S2, ACADM-PPARG: cor = -0.309, P < 0.001; ACADM-CPT2: cor = 0.427, P < 0.001; PPARG-CPT2: cor = -0.143, P = 0.011).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37950149", "locator": "sections[12] \"Identification of the hub nodes and their biological role\" paragraph 2", "quote": "Correlation analysis showed that there is a significant expression correlation between ACADM, PPARG, and CP2 pairwise (Figure S2, ACADM-PPARG: cor = -0.309, P < 0.001; ACADM-CPT2: cor = 0.427, P < 0.001; PPARG-CPT2: cor = -0.143, P = 0.011)."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The original data of GSE57338 can be obtained from https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE57338. All data are available from the corresponding author on reasonable request.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37950149", "locator": "sections[22] \"notes\" paragraph 1", "quote": "The original data of GSE57338 can be obtained from https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE57338. All data are available from the corresponding author on reasonable request."}], "state": "complete"}, {"id": "claim-target-result", "statement": "ACADM, PPARG, and CPT2 showed significant pairwise expression correlations in the GSE57338 CHF cohort.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:37950149", "locator": "sections[12] \"Identification of the hub nodes and their biological role\" paragraph 2", "quote": "Correlation analysis showed that there is a significant expression correlation between ACADM, PPARG, and CP2 pairwise (Figure S2, ACADM-PPARG: cor = -0.309, P < 0.001; ACADM-CPT2: cor = 0.427, P < 0.001; PPARG-CPT2: cor = -0.143, P = 0.011)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "ACADM, PPARG, and CPT2 showed significant pairwise expression correlations in the GSE57338 CHF cohort.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:37950149"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE57338"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE57338"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:37950149", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.1186/s12872-023-03554-8", "sha256": "sha256:63cd05673dff794c779663038df102713de4c8208e8bde90dfdd62125567c231", "bytes": 20371, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.1186/s12872-023-03554-8", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC10638691", "source": "europe_pmc_fulltext", "coverage": "whole_body_without_references", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE57338", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE57338", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE57338", "version": null, "note": "The original data of GSE57338 can be obtained from https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE57338. 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