Immunological characterization of stroke-heart syndrome and identification of inflammatory therapeutic targets.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:37965346", "kind": "science-record", "revision": 3, "content_hash": "sha256:d93d070e6eb4b12e697c2850f5632050fea41811c79da6f944dd1dfe7ee67b2d", "created_at": "2026-11-01T19:02:52Z", "updated_at": "2026-11-01T21:31:57Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Immunological characterization of stroke-heart syndrome and identification of inflammatory therapeutic targets.", "doi": "10.3389/fimmu.2023.1227104", "pmid": "37965346", "authors": ["Junyi Zheng", "Yilin Ma", "Xukun Guo", "Jialing Wu"], "journal": "Frontiers in immunology", "year": 2023, "abstract": "Acute cardiac dysfunction caused by stroke-heart syndrome (SHS) is the second leading cause of stroke-related death. The inflammatory response plays a significant role in the pathophysiological process of cardiac damage. However, the mechanisms underlying the brain-heart interaction are poorly understood. Therefore, we aimed to analysis the immunological characterization and identify inflammation therapeutic targets of SHS. We analyzed gene expression data of heart tissue 24 hours after induction of ischemia stoke by MCAO or sham surgery in a publicly available dataset (GSE102558) from Gene Expression Omnibus (GEO). Bioinformatics analysis revealed 138 differentially expressed genes (DEGs) in myocardium of MCAO-treated compared with sham-treated mice, among which, immune and inflammatory pathways were enriched. Analysis of the immune cells infiltration showed that the natural killer cell populations were significantly different between the two groups. We identified five DIREGs, Aplnr, Ccrl2, Cdkn1a, Irak2, and Serpine1 and found that their expression correlated with specific populations of infiltrating immune cells in the cardiac tissue. RT-qPCR and Western blot methods confirmed significant changes in the expression levels of Aplnr, Cdkn1a, Irak2, and Serpine1 after MCAO, which may serve as therapeutic targets to prevent cardiovascular complications after stroke.", "claims": [{"id": "claim-method", "statement": "DEGs were identified using the GEO2R (http://www.ncbi.nlm.nih.gov/geo/geo2r) online web tool provided by the GEO database.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37965346", "locator": "sections[9] \"Identification of differentially expressed genes\" paragraph 2", "quote": "DEGs were identified using the GEO2R (http://www.ncbi.nlm.nih.gov/geo/geo2r) online web tool provided by the GEO database."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number(s) can be found in the article/supplementary material.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37965346", "locator": "sections[26] \"Data availability statement\" paragraph 2", "quote": "The datasets presented in this study can be found in online repositories. 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