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pmid:37994961
ALOX5AP is a new prognostic indicator in acute myeloid leukemia.
Xin-Yi Chen · Xiang-Mei Wen · Wei Zhao · Ming-Qiang Chu · Yu Gu · Hai-Hui Huang · Qian Yuan · Zi-Jun Xu · Jun Qian · Jiang Lin
Discover oncology · 2023 doi:10.1007/s12672-023-00826-9
Paper
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Experiment
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Data
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Analysis
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Execution
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Complete file
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This study aimed to identify the expression and methylation patterns of ALOX5AP in bone marrow (BM) samples of AML patients, and further explore its clinical significance.\nMETHODS: Eighty-two de novo AML patients and 20 healthy donors were included in the study. Meanwhile, seven public datasets from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) were included to confirm the alteration of ALOX5AP. Receiver operating characteristic (ROC) curve analysis was applied to determine the discriminative capacity of ALOX5AP expression to discriminate AML. The prognostic value of ALOX5AP was identified by the Kaplan-Meier method and log-rank test. It was further validated in four independent cohorts (n = 1186). Significantly different genes associated with ALOX5AP expression were subsequently compared by LinkedOmics, and Metascape database.\nRESULTS: The level of ALOX5AP expression was significantly increased in bone marrow cells of AML patients compared with healthy donors (P < 0.05). ROC curve analysis suggested that ALOX5AP expression might be a potential biomarker to discriminate AML from controls. ALOX5AP overexpression was associated with decreased overall survival (OS) in AML according to the TCGA data (P = 0.006), which was validated by other four independent cohorts. DNA methylation levels of ALOX5AP were significantly lower in AML patients compared to normal samples (P < 0.05), as confirmed in the Diseasemeth database and the independent cohort GSE63409. ALOX5AP level was positively associated with genes with proleukemic effects such as PAX2, HOX family, SOX11, H19, and microRNAs that act as oncogenes in leukemia, such as miR125b, miR-93, miR-494, miR-193b, while anti-leukemia-related genes and tumor suppressor microRNAs such as miR-582, miR-9 family and miR-205 were negatively correlated.\nCONCLUSION: ALOX5AP overexpression, associated with its hypomethylation, predicts poorer prognosis in AML.", "claims": [{"id": "claim-method", "statement": "The prognostic value of ALOX5AP was identified by the Kaplan–Meier method and log-rank test.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37994961", "locator": "sections[0] \"Abstract\" paragraph 2", "quote": "The prognostic value of ALOX5AP was identified by the Kaplan–Meier method and log-rank test."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets analyzed in this study are available in the following open access repositories: TCGA, http://www.cbioportal.org, http://gdac.broadinstitute.org. 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GEO, https://www.ncbi.nlm.nih.gov/geo/ (GEO accession numbers: GSE24006, GSE10358, GSE37642, GSE106291, GSE146173, GSE63270, and GSE63409). BloodSpot, http://servers.binf.ku.dk/bloodspot/. The in-house methylation data was provided as Additional file 2. Other datasets are available from the corresponding author upon reasonable request.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The datasets analyzed in this study are available in the following open access repositories: TCGA, http://www.cbioportal.org, http://gdac.broadinstitute.org. GEO, https://www.ncbi.nlm.nih.gov/geo/ (GEO accession numbers: GSE24006, GSE10358, GSE37642, GSE106291, GSE146173, GSE63270, and GSE63409). BloodSpot, http://servers.binf.ku.dk/bloodspot/. The in-house methylation data was provided as Additional file 2. Other datasets are available from the corresponding author upon reasonable request.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM2835244", "GSM2835245", "GSM2835246", "GSM2835247", "GSM2835248", "GSM2835249", "GSM2835250", "GSM2835251", "GSM2835252", "GSM2835253", "GSM2835254", "GSM2835255", "GSM2835256", "GSM2835257", "GSM2835258", "GSM2835259", "GSM2835260", "GSM2835261", "GSM2835262", "GSM2835263", "GSM2835264", "GSM2835265", "GSM2835266", "GSM2835267", "GSM2835268", "GSM2835269", "GSM2835270", "GSM2835271", "GSM2835272", "GSM2835273", "GSM2835274", "GSM2835275", "GSM2835276", "GSM2835277", "GSM2835278", "GSM2835279", "GSM2835280", "GSM2835281", "GSM2835282", "GSM2835283", "GSM2835284", "GSM2835285", "GSM2835286", "GSM2835287", "GSM2835288", "GSM2835289", "GSM2835290", "GSM2835291", "GSM2835292", "GSM2835293", "GSM2835294", "GSM2835295", "GSM2835296", "GSM2835297", "GSM2835298", "GSM2835299", "GSM2835300", "GSM2835301", "GSM2835302", "GSM2835303", "GSM2835304", "GSM2835305", "GSM2835306", "GSM2835307", "GSM2835308", "GSM2835309", "GSM2835310", "GSM2835311", "GSM2835312", "GSM2835313", "GSM2835314", "GSM2835315", "GSM2835316", "GSM2835317", "GSM2835318", "GSM2835319", "GSM2835320", "GSM2835321", "GSM2835322", "GSM2835323", "GSM2835324", "GSM2835325", "GSM2835326", "GSM2835327", "GSM2835328", "GSM2835329", "GSM2835330", "GSM2835331", "GSM2835332", "GSM2835333", "GSM2835334", "GSM2835335", "GSM2835336", "GSM2835337", "GSM2835338", "GSM2835339", "GSM2835340", "GSM2835341", "GSM2835342", "GSM2835343", "GSM2835344", "GSM2835345", "GSM2835346", "GSM2835347", "GSM2835348", "GSM2835349", "GSM2835350", "GSM2835351", "GSM2835352", "GSM2835353", "GSM2835354", "GSM2835355", "GSM2835356", "GSM2835357", "GSM2835358", "GSM2835359", "GSM2835360", "GSM2835361", "GSM2835362", "GSM2835363", "GSM2835364", "GSM2835365", "GSM2835366", "GSM2835367", "GSM2835368", "GSM2835369", "GSM2835370", "GSM2835371", "GSM2835372", "GSM2835373", "GSM2835374", "GSM2835375", "GSM2835376", "GSM2835377", "GSM2835378", "GSM2835379", "GSM2835380", "GSM2835381", "GSM2835382", "GSM2835383", "GSM2835384", "GSM2835385", "GSM2835386", "GSM2835387", "GSM2835388", "GSM2835389", "GSM2835390", "GSM2835391", "GSM2835392", "GSM2835393", "GSM2835394", "GSM2835395", "GSM2835396", "GSM2835397", "GSM2835398", "GSM2835399", "GSM2835400", "GSM2835401", "GSM2835402", "GSM2835403", "GSM2835404", "GSM2835405", "GSM2835406", "GSM2835407", "GSM2835408", "GSM2835409", "GSM2835410", "GSM2835411", "GSM2835412", "GSM2835413", "GSM2835414", "GSM2835415", "GSM2835416", "GSM2835417", "GSM2835418", "GSM2835419", "GSM2835420", "GSM2835421", "GSM2835422", "GSM2835423", "GSM2835424", "GSM2835425", "GSM2835426", "GSM2835427", "GSM2835428", "GSM2835429", "GSM2835430", "GSM2835431", "GSM2835432", "GSM2835433", "GSM2835434", "GSM2835435", "GSM2835436", "GSM2835437", "GSM2835438", "GSM2835439", "GSM2835440", "GSM2835441", "GSM2835442", "GSM2835443", "GSM2835444", "GSM2835445", "GSM2835446", "GSM2835447", "GSM2835448", "GSM2835449", "GSM2835450", "GSM2835451", "GSM2835452", "GSM2835453", "GSM2835454", "GSM2835455", "GSM2835456", "GSM2835457", "GSM2835458", "GSM2835459", "GSM2835460", "GSM2835461", "GSM2835462", "GSM2835463", "GSM2835464", "GSM2835465", "GSM2835466", "GSM2835467", "GSM2835468", "GSM2835469", "GSM2835470", "GSM2835471", "GSM2835472", "GSM2835473", "GSM2835474", "GSM2835475", "GSM2835476", "GSM2835477", "GSM2835478", "GSM2835479", "GSM2835480", "GSM2835481", "GSM2835482", "GSM2835483", "GSM2835484", "GSM2835485", "GSM2835486", "GSM2835487", "GSM2835488", "GSM2835489", "GSM2835490", "GSM2835491", "GSM2835492", "GSM2835493"], "sample_count": 250, "group_sizes": null, "group_sizes_basis": null, "platform": "18460", "taxon": "Homo sapiens", "title": "A 29-Gene and Cytogenetic Score for the Prediction of Resistance to Induction Treatment in Acute Myeloid Leukemia", "resolution_checked_at": "2026-11-01T18:06:43Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE146173", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE146173", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE146173", "version": null, "note": "The datasets analyzed in this study are available in the following open access repositories: TCGA, http://www.cbioportal.org, http://gdac.broadinstitute.org. GEO, https://www.ncbi.nlm.nih.gov/geo/ (GEO accession numbers: GSE24006, GSE10358, GSE37642, GSE106291, GSE146173, GSE63270, and GSE63409). BloodSpot, http://servers.binf.ku.dk/bloodspot/. The in-house methylation data was provided as Additional file 2. Other datasets are available from the corresponding author upon reasonable request.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The datasets analyzed in this study are available in the following open access repositories: TCGA, http://www.cbioportal.org, http://gdac.broadinstitute.org. GEO, https://www.ncbi.nlm.nih.gov/geo/ (GEO accession numbers: GSE24006, GSE10358, GSE37642, GSE106291, GSE146173, GSE63270, and GSE63409). BloodSpot, http://servers.binf.ku.dk/bloodspot/. The in-house methylation data was provided as Additional file 2. Other datasets are available from the corresponding author upon reasonable request.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM4367507", "GSM4367508", "GSM4367509", "GSM4367510", "GSM4367511", "GSM4367512", "GSM4367513", "GSM4367514", "GSM4367515", "GSM4367516", "GSM4367517", "GSM4367518", "GSM4367519", "GSM4367520", "GSM4367521", "GSM4367522", "GSM4367523", "GSM4367524", "GSM4367525", "GSM4367526", "GSM4367527", "GSM4367528", "GSM4367529", "GSM4367530", "GSM4367531", "GSM4367532", "GSM4367533", "GSM4367534", "GSM4367535", "GSM4367536", "GSM4367537", "GSM4367538", "GSM4367539", "GSM4367540", "GSM4367541", "GSM4367542", "GSM4367543", "GSM4367544", "GSM4367545", "GSM4367546", "GSM4367547", "GSM4367548", "GSM4367549", "GSM4367550", "GSM4367551", "GSM4367552", "GSM4367553", "GSM4367554", "GSM4367555", "GSM4367556", "GSM4367557", "GSM4367558", "GSM4367559", "GSM4367560", "GSM4367561", "GSM4367562", "GSM4367563", "GSM4367564", "GSM4367565", "GSM4367566", "GSM4367567", "GSM4367568", "GSM4367569", "GSM4367570", "GSM4367571", "GSM4367572", "GSM4367573", "GSM4367574", "GSM4367575", "GSM4367576", "GSM4367577", "GSM4367578", "GSM4367579", "GSM4367580", "GSM4367581", "GSM4367582", "GSM4367583", "GSM4367584", "GSM4367585", "GSM4367586", "GSM4367587", "GSM4367588", "GSM4367589", "GSM4367590", "GSM4367591", "GSM4367592", "GSM4367593", "GSM4367594", "GSM4367595", "GSM4367596", "GSM4367597", "GSM4367598", "GSM4367599", "GSM4367600", "GSM4367601", "GSM4367602", "GSM4367603", "GSM4367604", "GSM4367605", "GSM4367606", "GSM4367607", "GSM4367608", "GSM4367609", "GSM4367610", "GSM4367611", "GSM4367612", "GSM4367613", "GSM4367614", "GSM4367615", "GSM4367616", "GSM4367617", "GSM4367618", "GSM4367619", "GSM4367620", "GSM4367621", "GSM4367622", "GSM4367623", "GSM4367624", "GSM4367625", "GSM4367626", "GSM4367627", "GSM4367628", "GSM4367629", "GSM4367630", "GSM4367631", "GSM4367632", "GSM4367633", "GSM4367634", "GSM4367635", "GSM4367636", "GSM4367637", "GSM4367638", "GSM4367639", "GSM4367640", "GSM4367641", "GSM4367642", "GSM4367643", "GSM4367644", "GSM4367645", "GSM4367646", "GSM4367647", "GSM4367648", "GSM4367649", "GSM4367650", "GSM4367651", "GSM4367652", "GSM4367653", "GSM4367654", "GSM4367655", "GSM4367656", "GSM4367657", "GSM4367658", "GSM4367659", "GSM4367660", "GSM4367661", "GSM4367662", "GSM4367663", "GSM4367664", "GSM4367665", "GSM4367666", "GSM4367667", "GSM4367668", "GSM4367669", "GSM4367670", "GSM4367671", "GSM4367672", "GSM4367673", "GSM4367674", "GSM4367675", "GSM4367676", "GSM4367677", "GSM4367678", "GSM4367679", "GSM4367680", "GSM4367681", "GSM4367682", "GSM4367683", "GSM4367684", "GSM4367685", "GSM4367686", "GSM4367687", "GSM4367688", "GSM4367689", "GSM4367690", "GSM4367691", "GSM4367692", "GSM4367693", "GSM4367694", "GSM4367695", "GSM4367696", "GSM4367697", "GSM4367698", "GSM4367699", "GSM4367700", "GSM4367701", "GSM4367702", "GSM4367703", "GSM4367704", "GSM4367705", "GSM4367706", "GSM4367707", "GSM4367708", "GSM4367709", "GSM4367710", "GSM4367711", "GSM4367712", "GSM4367713", "GSM4367714", "GSM4367715", "GSM4367716", "GSM4367717", "GSM4367718", "GSM4367719", "GSM4367720", "GSM4367721", "GSM4367722", "GSM4367723", "GSM4367724", "GSM4367725", "GSM4367726", "GSM4367727", "GSM4367728", "GSM4367729", "GSM4367730", "GSM4367731", "GSM4367732", "GSM4367733", "GSM4367734", "GSM4367735", "GSM4367736", "GSM4367737", "GSM4367738", "GSM4367739", "GSM4367740", "GSM4367741", "GSM4367742", "GSM4367743", "GSM4367744", "GSM4367745", "GSM4367746", "GSM4367747", "GSM4367748", "GSM4367749", "GSM4367750", "GSM4367751", "GSM4367752"], "sample_count": 246, "group_sizes": null, "group_sizes_basis": null, "platform": "18460", "taxon": "Homo sapiens", "title": "Clinical presentation and differential splicing of SRSF2, U2AF1 and SF3B1 mutations in patients with Acute Myeloid Leukemia", "resolution_checked_at": "2026-11-01T18:46:34Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE24006", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE24006", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE24006", "version": null, "note": "The datasets analyzed in this study are available in the following open access repositories: TCGA, http://www.cbioportal.org, http://gdac.broadinstitute.org. GEO, https://www.ncbi.nlm.nih.gov/geo/ (GEO accession numbers: GSE24006, GSE10358, GSE37642, GSE106291, GSE146173, GSE63270, and GSE63409). BloodSpot, http://servers.binf.ku.dk/bloodspot/. The in-house methylation data was provided as Additional file 2. Other datasets are available from the corresponding author upon reasonable request.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The datasets analyzed in this study are available in the following open access repositories: TCGA, http://www.cbioportal.org, http://gdac.broadinstitute.org. GEO, https://www.ncbi.nlm.nih.gov/geo/ (GEO accession numbers: GSE24006, GSE10358, GSE37642, GSE106291, GSE146173, GSE63270, and GSE63409). BloodSpot, http://servers.binf.ku.dk/bloodspot/. The in-house methylation data was provided as Additional file 2. Other datasets are available from the corresponding author upon reasonable request.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM591201", "GSM591202", "GSM591203", "GSM591204", "GSM591205", "GSM591206", "GSM591207", "GSM591208", "GSM591209", "GSM591210", "GSM591211", "GSM591212", "GSM591213", "GSM591214", "GSM591215", "GSM591216", "GSM591217", "GSM591218", "GSM591219", "GSM591220", "GSM591221", "GSM591222", "GSM591223", "GSM591224", "GSM591225", "GSM591226", "GSM591227", "GSM591228", "GSM591229", "GSM591230", "GSM591231", "GSM591232", "GSM591233", "GSM591234", "GSM591235", "GSM591236", "GSM591237", "GSM591238", "GSM591239", "GSM591240", "GSM591241", "GSM591242", "GSM591243", "GSM591244", "GSM591245", "GSM591246", "GSM591247", "GSM591248", "GSM591249", "GSM591250", "GSM591251", "GSM591252", "GSM591253", "GSM591254"], "sample_count": 54, "group_sizes": null, "group_sizes_basis": null, "platform": "10881", "taxon": "Homo sapiens", "title": "A Leukemic Stem Cell Expression Signature is Associated with Clinical Outcomes in Acute Myeloid Leukemia", "resolution_checked_at": "2026-11-01T18:06:43Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE37642", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE37642", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE37642", "version": null, "note": "The datasets analyzed in this study are available in the following open access repositories: TCGA, http://www.cbioportal.org, http://gdac.broadinstitute.org. GEO, https://www.ncbi.nlm.nih.gov/geo/ (GEO accession numbers: GSE24006, GSE10358, GSE37642, GSE106291, GSE146173, GSE63270, and GSE63409). BloodSpot, http://servers.binf.ku.dk/bloodspot/. The in-house methylation data was provided as Additional file 2. Other datasets are available from the corresponding author upon reasonable request.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The datasets analyzed in this study are available in the following open access repositories: TCGA, http://www.cbioportal.org, http://gdac.broadinstitute.org. GEO, https://www.ncbi.nlm.nih.gov/geo/ (GEO accession numbers: GSE24006, GSE10358, GSE37642, GSE106291, GSE146173, GSE63270, and GSE63409). BloodSpot, http://servers.binf.ku.dk/bloodspot/. The in-house methylation data was provided as Additional file 2. Other datasets are available from the corresponding author upon reasonable request.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM923596", "GSM923597", "GSM923598", "GSM923599", "GSM923600", "GSM923601", "GSM923602", "GSM923603", "GSM923604", "GSM923605", "GSM923606", "GSM923607", "GSM923608", "GSM923609", "GSM923610", "GSM923611", "GSM923612", "GSM923613", "GSM923614", "GSM923615", "GSM923616", "GSM923617", "GSM923618", "GSM923619", "GSM923620", "GSM923621", "GSM923622", "GSM923623", "GSM923624", "GSM923625", "GSM923626", "GSM923627", "GSM923628", "GSM923629", "GSM923630", "GSM923631", "GSM923632", "GSM923633", "GSM923634", "GSM923635", "GSM923636", "GSM923637", "GSM923638", "GSM923639", "GSM923640", "GSM923641", "GSM923642", "GSM923643", "GSM923644", "GSM923645", "GSM923646", "GSM923647", "GSM923648", "GSM923649", "GSM923650", "GSM923651", "GSM923652", "GSM923653", "GSM923654", "GSM923655", "GSM923656", "GSM923657", "GSM923658", "GSM923659", 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"group_sizes_basis": null, "platform": "570;96;97", "taxon": "Homo sapiens", "title": "Prognostic gene signature for AML", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE63270", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE63270", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE63270", "version": null, "note": "The datasets analyzed in this study are available in the following open access repositories: TCGA, http://www.cbioportal.org, http://gdac.broadinstitute.org. GEO, https://www.ncbi.nlm.nih.gov/geo/ (GEO accession numbers: GSE24006, GSE10358, GSE37642, GSE106291, GSE146173, GSE63270, and GSE63409). BloodSpot, http://servers.binf.ku.dk/bloodspot/. The in-house methylation data was provided as Additional file 2. Other datasets are available from the corresponding author upon reasonable request.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The datasets analyzed in this study are available in the following open access repositories: TCGA, http://www.cbioportal.org, http://gdac.broadinstitute.org. GEO, https://www.ncbi.nlm.nih.gov/geo/ (GEO accession numbers: GSE24006, GSE10358, GSE37642, GSE106291, GSE146173, GSE63270, and GSE63409). BloodSpot, http://servers.binf.ku.dk/bloodspot/. The in-house methylation data was provided as Additional file 2. Other datasets are available from the corresponding author upon reasonable request.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM1544800", "GSM1544801", "GSM1544802", "GSM1544803", "GSM1544804", "GSM1544805", "GSM1544806", "GSM1544807", "GSM1544808", "GSM1544809", "GSM1544810", "GSM1544811", "GSM1544812", "GSM1544813", "GSM1544814", "GSM1544815", "GSM1544816", "GSM1544817", "GSM1544818", "GSM1544819", "GSM1544820", "GSM1544821", "GSM1544822", "GSM1544823", "GSM1544824", "GSM1544825", "GSM1544826", "GSM1544827", "GSM1544828", "GSM1544829", "GSM1544830", "GSM1544831", "GSM1544832", "GSM1544833", "GSM1544834", "GSM1544835", "GSM1544836", "GSM1544837", "GSM1544838", "GSM1544839", "GSM1544840", "GSM1544841", "GSM1544842", "GSM1544843", "GSM1544844", "GSM1544845", "GSM1544846", "GSM1544847", "GSM1544848", "GSM1544849", "GSM1544850", "GSM1544851", "GSM1544852", "GSM1544853", "GSM1544854", "GSM1544855", "GSM1544856", "GSM1544857", "GSM1544858", "GSM1544859", "GSM1544860", "GSM1544861", "GSM1544862", "GSM1544863", "GSM1544864", "GSM1544865", "GSM1544866", "GSM1544867", "GSM1544868", "GSM1544869", "GSM1544870", "GSM1544871", "GSM1544872", "GSM1544873", "GSM1544874", "GSM1544875", "GSM1544876", "GSM1544877", "GSM1544878", "GSM1544879", "GSM1544880", "GSM1544881", "GSM1544882", "GSM1544883", "GSM1544884", "GSM1544885", "GSM1544886", "GSM1544887", "GSM1544888", "GSM1544889", "GSM1544890", "GSM1544891", "GSM1544892", "GSM1544893", "GSM1544894", "GSM1544895", "GSM1544896", "GSM1544897", "GSM1544898", "GSM1544899", "GSM1544900", "GSM1544901", "GSM1544902", "GSM1544903"], "sample_count": 104, "group_sizes": null, "group_sizes_basis": null, "platform": "17810", "taxon": "Homo sapiens", "title": "Expression profiles of normal hematopoietic stem and progenitor cells and acute myeloid leukemia sub-populations", "resolution_checked_at": "2026-11-01T15:39:55Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE63409", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE63409", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE63409", "version": null, "note": "The datasets analyzed in this study are available in the following open access repositories: TCGA, http://www.cbioportal.org, http://gdac.broadinstitute.org. GEO, https://www.ncbi.nlm.nih.gov/geo/ (GEO accession numbers: GSE24006, GSE10358, GSE37642, GSE106291, GSE146173, GSE63270, and GSE63409). BloodSpot, http://servers.binf.ku.dk/bloodspot/. The in-house methylation data was provided as Additional file 2. Other datasets are available from the corresponding author upon reasonable request.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The datasets analyzed in this study are available in the following open access repositories: TCGA, http://www.cbioportal.org, http://gdac.broadinstitute.org. GEO, https://www.ncbi.nlm.nih.gov/geo/ (GEO accession numbers: GSE24006, GSE10358, GSE37642, GSE106291, GSE146173, GSE63270, and GSE63409). BloodSpot, http://servers.binf.ku.dk/bloodspot/. The in-house methylation data was provided as Additional file 2. Other datasets are available from the corresponding author upon reasonable request.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM1548150", "GSM1548151", "GSM1548152", "GSM1548153", "GSM1548154", "GSM1548155", "GSM1548156", "GSM1548157", "GSM1548158", "GSM1548159", "GSM1548160", "GSM1548161", "GSM1548162", "GSM1548163", "GSM1548164", "GSM1548165", "GSM1548166", "GSM1548167", "GSM1548168", "GSM1548169", "GSM1548170", "GSM1548171", "GSM1548172", "GSM1548173", "GSM1548174", "GSM1548175", "GSM1548176", "GSM1548177", "GSM1548178", "GSM1548179", "GSM1548180", "GSM1548181", "GSM1548182", "GSM1548183", "GSM1548184", "GSM1548185", "GSM1548186", "GSM1548187", "GSM1548188", "GSM1548189", "GSM1548190", "GSM1548191", "GSM1548192", "GSM1548193", "GSM1548194", "GSM1548195", "GSM1548196", "GSM1548197", "GSM1548198", "GSM1548199", "GSM1548200", "GSM1548201", "GSM1548202", "GSM1548203", "GSM1548204", "GSM1548205", "GSM1548206", "GSM1548207", "GSM1548208", 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