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pmid:38017264
Identification and validation of candidate clinical signatures of apolipoprotein L isoforms in hepatocellular carcinoma.
Xiang-Kun Wang · Yu-Xiang Guo · Miao Wang · Xu-Dong Zhang · Zhong-Yuan Liu · Mao-Sen Wang · Kai Luo · Shuai Huang · Ren-Feng Li
Scientific reports · 2023 doi:10.1038/s41598-023-48366-0
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Experiment
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Data
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Analysis
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Execution
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Complete file
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Apolipoprotein (APOL) isoforms have been explored for their associations with HCC.The GSE14520 cohort was used for training data; The Cancer Genome Atlas (TCGA) database was used for validated data. Diagnostic, prognostic significance and mechanisms were explored using these cohorts. Risk score models and nomograms were constructed using prognosis-related isoforms and clinical factors for survival prediction. Oncomine and HCCDB databases were further used for validation of diagnostic, prognostic significance. APOL1, 3, and 6 were differentially expressed in two cohorts (all P ≤ 0.05). APOL1 and APOL6 had diagnostic capacity whereas APOL3 and APOL6 had prognostic capacity in two cohorts (areas under curves [AUCs] > 0.7, P ≤ 0.05). Mechanism studies demonstrated that APOL3 and APOL6 might be involved in humoral chemokine signaling pathways (all P ≤ 0.05). Risk score models and nomograms were constructed and validated for survival prediction of HCC. Moreover, diagnostic values of APOL1 and weak APOL6 were validated in Oncomine database (AUC > 0.700, 0.694); prognostic values of APOL3 and APOL6 were validated in HCCDB database (all P < 0.05). Differentially expressed APOL1 and APOL6 might be diagnostic biomarkers; APOL3 and APOL6 might be prognostic biomarkers of RFS and OS for HCC via chemokine signaling pathways.", "claims": [{"id": "claim-method", "statement": "Calculations of 95% confidence intervals and hazard ratios were by univariate and multivariate Cox regression models. Median survival time and log-rank P value were calculated by the Kaplan–Meier method.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:38017264", "locator": "sections[9] \"Statistical analysis\" paragraph 2", "quote": "Calculations of 95% confidence intervals and hazard ratios were by univariate and multivariate Cox regression models. 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