Identification CCL2,CXCR2,S100A9 of the immune-related gene markers and immune infiltration characteristics of inflammatory bowel disease and heart failure via bioinformatics analysis and machine learning.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:38034382", "kind": "science-record", "revision": 3, "content_hash": "sha256:321fa8e6c47431917332d55827ec498e93c58ec5d50c0f48afe49ff9b4d5c645", "created_at": "2026-11-01T19:02:58Z", "updated_at": "2026-11-01T22:10:47Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Identification CCL2,CXCR2,S100A9 of the immune-related gene markers and immune infiltration characteristics of inflammatory bowel disease and heart failure via bioinformatics analysis and machine learning.", "doi": "10.3389/fcvm.2023.1268675", "pmid": "38034382", "authors": ["Xu Luo", "Rui Wang", "Xin Zhang", "Xin Wen", "Siwei Deng", "Wen Xie"], "journal": "Frontiers in cardiovascular medicine", "year": 2023, "abstract": "Background: Recently, heart failure (HF) and inflammatory bowel disease (IBD) have been considered to be related diseases with increasing incidence rates; both diseases are related to immunity. This study aims to analyze and identify immune-related gene (IRG) markers of HF and IBD through bioinformatics and machine learning (ML) methods and to explore their immune infiltration characteristics.\nMethods: This study used gene expressiondata (GSE120895, GSE21610, GSE4183) from the Gene Expression Omnibus (GEO) database to screen differentially expressed genes (DEGs) and compare them with IRGs from the ImmPort database to obtain differentially expressed immune-related genes (DIRGs). Functional enrichment analysis of IRGs was performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, three machine models and protein-protein interactions (PPIs) were established to identify diagnostic biomarkers. The receiver operating characteristic (ROC) curves were applied to evaluate the diagnostic value of the candidate biomarkersin the validation set (GSE1145, GSE36807) and obtain their correlations with immune cells through the Spearman algorithm. Finally, the CIBERSORT algorithm was used to evaluate the immune cell infiltration of the two diseases.\nResults: Thirty-four DIRGs were screened and GO and KEGG analysis results showed that these genes are mainly related to inflammatory and immune responses. CCL2, CXCR2 and S100A9 were identified as biomarkers.The immune correlation results indicated in both diseases that CCL2 is positively correlated with mast cell activation, CXCR2 is positively correlated with neutrophils and S100A9 is positively correlated with neutrophils and mast cell activation. Analysis of immune characteristics showed that macrophages M2, macrophages M0 and neutrophils were present in both diseases.\nConclusions: CCL2, CXCR2 and S100A9 are promising biomarkers that will become potential immunogenetic biomarkers for diagnosing comorbidities of HF and IBD. macrophages M2, macrophages M0, neutrophil-mediated inflammation and immune regulation play important roles in the development of HF and IBD and may become diagnostic and therapeutic targets.", "claims": [{"id": "claim-method", "statement": "The diagnostic validity of the selected characteristic genes was evaluated with the ROCR package of R and MedCalc software using receiver operating characteristic(ROC) curves.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:38034382", "locator": "sections[6] \"Verification of diagnostic markers\" paragraph 2", "quote": "The diagnostic validity of the selected characteristic genes was evaluated with the ROCR package of R and MedCalc software using receiver operating characteristic(ROC) curves."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:38034382", "locator": "sections[18] \"Data availability statement\" paragraph 2", "quote": "The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author."}], "state": "complete"}, {"id": "claim-target-result", "statement": "CCL2, CXCR2 and S100A9 were identified as biomarkers.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:38034382", "locator": "sections[0] \"Abstract\" paragraph 3", "quote": "CCL2, CXCR2 and S100A9 were identified as biomarkers."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "CCL2, CXCR2 and S100A9 were identified as biomarkers.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:38034382"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE1145"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE1145"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:38034382", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.3389/fcvm.2023.1268675", "sha256": "sha256:24bc80f254d81f7d4c6481ac78c971c4189623d0cdf9d0bdd8afc8b60eefbba3", "bytes": 34896, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.3389/fcvm.2023.1268675", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC10687362", "source": "europe_pmc_fulltext", "coverage": "whole_body_without_references", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE1145", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE1145", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE1145", "version": null, "note": "The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM18422", "GSM18423", "GSM18424", "GSM18425", "GSM18426", "GSM18427", "GSM18428", "GSM18429", "GSM18430", "GSM18431", "GSM18432", "GSM18433", "GSM18434", "GSM18435", "GSM18436", "GSM18442", "GSM18443", "GSM18444", "GSM18445", "GSM18446", "GSM18447", "GSM18448", "GSM18449", "GSM18450", "GSM18451", "GSM18452", "GSM18477", "GSM18478", "GSM18479", "GSM18480", "GSM18481", "GSM18482", "GSM18483", "GSM18484", "GSM18485", "GSM18486", "GSM18487", "GSM25784", "GSM25785", "GSM25786", "GSM25787", "GSM25788", "GSM25789", "GSM25790", "GSM25791", "GSM25792", "GSM25793", "GSM25794", "GSM25795", "GSM25796", "GSM25797", "GSM25798", "GSM25799", "GSM25800", "GSM25801", "GSM25802", "GSM25803", "GSM25804", "GSM25805", "GSM25806", "GSM25807", "GSM25808", "GSM25809", "GSM25810", "GSM25811", "GSM25812", "GSM25813", "GSM25814", "GSM25815", "GSM25816", "GSM25817", "GSM25818", "GSM25819", "GSM25820", "GSM25821", "GSM25822", "GSM25823", "GSM25825", "GSM25826", "GSM25827", "GSM25828", "GSM25829", "GSM25830", "GSM25831", "GSM25832", "GSM25833", "GSM25834", "GSM25835", "GSM25836", "GSM25837", "GSM25838", "GSM25839", "GSM25840", "GSM25841", "GSM25842", "GSM25843", "GSM25844", "GSM25845", "GSM25846", "GSM25847", "GSM25848", "GSM25849", "GSM25850", "GSM25851", "GSM25852", "GSM25853", "GSM25854"], "sample_count": 107, "group_sizes": null, "group_sizes_basis": null, "platform": "8300;570", "taxon": "Homo sapiens", "title": "changes in cardiac transcription profiles brought about by heart failure", "resolution_checked_at": "2026-11-01T18:06:43Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE120895", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE120895", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE120895", "version": null, "note": "The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM3417936", "GSM3417937", "GSM3417938", "GSM3417939", "GSM3417940", "GSM3417941", "GSM3417942", "GSM3417943", "GSM3417944", "GSM3417945", "GSM3417946", "GSM3417947", "GSM3417948", "GSM3417949", "GSM3417950", "GSM3417951", "GSM3417952", "GSM3417953", "GSM3417954", "GSM3417955", "GSM3417956", "GSM3417957", "GSM3417958", "GSM3417959", "GSM3417960", "GSM3417961", "GSM3417962", "GSM3417963", "GSM3417964", "GSM3417965", "GSM3417966", "GSM3417967", "GSM3417968", "GSM3417969", "GSM3417970", "GSM3417971", "GSM3417972", "GSM3417973", "GSM3417974", "GSM3417975", "GSM3417976", "GSM3417977", "GSM3417978", "GSM3417979", "GSM3417980", "GSM3417981", "GSM3417982", "GSM3417983", "GSM3417984", "GSM3417985", "GSM3417986", "GSM3417987", "GSM3417988", "GSM3417989", "GSM3417990"], "sample_count": 55, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Correlation of clinical parameters of heart failure with myocardial gene expression in dilated cardiomyopathy", "resolution_checked_at": "2026-11-01T18:06:43Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE21610", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE21610", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE21610", "version": null, "note": "The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM545657", "GSM545658", "GSM545659", "GSM545660", "GSM545661", "GSM545662", "GSM545663", "GSM545664", "GSM545665", "GSM545666", "GSM545667", "GSM545668", "GSM545669", "GSM545670", "GSM545671", "GSM545672", "GSM545673", "GSM545674", "GSM545675", "GSM545676", "GSM545677", "GSM545678", "GSM545679", "GSM545680", "GSM545681", "GSM545682", "GSM545683", "GSM545684", "GSM545685", "GSM545686", "GSM545687", "GSM545688", "GSM545689", "GSM545690", "GSM545691", "GSM545692", "GSM545693", "GSM545694", "GSM545695", "GSM545696", "GSM545697", "GSM545698", "GSM545699", "GSM545700", "GSM545701", "GSM545702", "GSM545703", "GSM545704", "GSM545705", "GSM545706", "GSM545707", "GSM545708", "GSM545709", "GSM545710", "GSM545711", "GSM545712", "GSM545713", "GSM545714", "GSM545715", "GSM545716", "GSM545717", "GSM545718", "GSM545719", "GSM545720", "GSM545721", "GSM545722", "GSM545723", "GSM545724"], "sample_count": 68, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Gene expression analysis in non-failing and failing myocardium pre and post pulsatile and non-pulsatile VAD support", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE36807", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE36807", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE36807", "version": null, "note": "The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM901319", "GSM901320", "GSM901321", "GSM901322", "GSM901323", "GSM901324", "GSM901325", "GSM901326", "GSM901327", "GSM901328", "GSM901329", "GSM901330", "GSM901331", "GSM901332", "GSM901333", "GSM901334", "GSM901335", "GSM901336", "GSM901337", "GSM901338", "GSM901339", "GSM901340", "GSM901341", "GSM901342", "GSM901343", "GSM901344", "GSM901345", "GSM901346", "GSM901347", "GSM901348", "GSM901349", "GSM901350", "GSM901351", "GSM901352", "GSM901353"], "sample_count": 35, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Genome-wide analysis of Crohn's disease and ulcerative colitis biopsy samples.", "resolution_checked_at": "2026-11-01T17:30:42Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE4183", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE4183", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE4183", "version": null, "note": "The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM95473", "GSM95474", "GSM95475", "GSM95476", "GSM95477", "GSM95478", "GSM95479", "GSM95480", "GSM95481", "GSM95482", "GSM95483", "GSM95484", "GSM95485", "GSM95486", "GSM95487", "GSM95488", "GSM95489", "GSM95490", "GSM95491", "GSM95492", "GSM95493", "GSM95494", "GSM95495", "GSM95496", "GSM95497", "GSM95498", "GSM95499", "GSM95500", "GSM95501", "GSM95502", "GSM95503", "GSM95504", "GSM95505", "GSM95506", "GSM95507", "GSM95508", "GSM95509", "GSM95510", "GSM95511", "GSM95512", "GSM95513", "GSM95514", "GSM95515", "GSM95516", "GSM95517", "GSM95518", "GSM95519", "GSM95520", "GSM95521", "GSM95522", "GSM95523", "GSM95524", "GSM95525"], "sample_count": 53, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Inflammation, adenoma and cancer: objective classification of colon biopsy specimens with gene expression signature", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}], "gaps": ["asset:data:geo:GSE1145 not downloaded", "asset:data:geo:GSE1145 licence not read", "asset:data:geo:GSE120895 not downloaded", "asset:data:geo:GSE120895 licence not read", "asset:data:geo:GSE21610 not downloaded", "asset:data:geo:GSE21610 licence not read", "asset:data:geo:GSE36807 not downloaded", "asset:data:geo:GSE36807 licence not read", "asset:data:geo:GSE4183 not downloaded", "asset:data:geo:GSE4183 licence not read"]}, "analysis": {"state": "partial", "methods": [{"id": "method-1", "family": "network_analysis", "specific": "ppi_network", "label": "Network / pathway analysis", "dsl_operations": ["build_graph", "centrality_scores", "pathway_enrich"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["edge_list"], "evidence": {"score": 0.7, "band": "medium", "quote": "PPI"}}, {"id": "method-2", "family": null, "specific": null, "label": "receiver operating characteristic (ROC) curves", "dsl_operations": [], "missing_operations": [], "expressible": null, "parameters": {}, "data_shapes": [], "evidence": {"score": 1.0, "band": "verbatim", "quote": "The diagnostic validity of the selected characteristic genes was evaluated with the ROCR package of R and MedCalc software using receiver operating characteristic(ROC) curves."}}], "targets": [], "gaps": ["method.reader_named_unmapped"]}, "capability": {"state": "complete", "requirements": [{"capability_id": "capability:computational_analysis", "label": "Computational analysis platform", "assay_families": ["meta_analysis", "machine_learning", "survival_analysis", "statistical_regression", "pca", "molecular_docking", "network_analysis", "differential_expression", "gwas"], "availability_state": "owned", "tier_unlocked": "R1", "candidate": "Automated Assays Laravel application and simulated adapters"}], "gaps": []}, "readiness": {"state": "complete", "tier": "R1", "blocking_axis": "none", "blocked_on": "nothing:replicable_now", "axes": {"method": {"tier": "R1", "expressible": true, "required_operations": ["build_graph", "centrality_scores", "pathway_enrich"], "missing_operations": [], "basis": "The paper names the method it used and the corpus's method extractor maps it onto the DSL catalogue: ppi_network."}, "capability": {"tier": "R1", "capability_id": "capability:computational_analysis", "availability_state": "owned", "basis": "The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE120895", "GSE21610", "GSE4183", "GSE1145", "GSE36807"], "resolved_accessions": ["GSE120895", "GSE21610", "GSE4183", "GSE1145", "GSE36807"], "statements": ["The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author."], "basis": "The paper names GSE120895, GSE21610, GSE4183, GSE1145, GSE36807 in Gene Expression Omnibus (GEO) and the accession resolves in the repository. No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": ["build_graph", "centrality_scores", "pathway_enrich"], "assets": ["source:pmid:38034382", "data:geo:GSE1145"], "steps": ["run_analysis"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:GSE1145"]}, "gaps": []}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": "2026-11-01T19:01:10Z", "independence": "single_reader"}, "evidence_check": {"method": "verbatim", "availability": "verbatim"}, "calls": 5, "usage": {"prompt_tokens": 9541, "completion_tokens": 2096, "cached_tokens": 256}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:38034382", "type": "paper", "label": "pmid:38034382"}, {"id": "source:pmid:38034382", "type": "manuscript", "label": "PMID 38034382 full text"}, {"id": "data:geo:GSE1145", "type": "dataset", "label": "GEO GSE1145"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:38034382", "type": "paper", "label": "pmid:38034382"}, {"id": "source:pmid:38034382", "type": "manuscript", "label": "PMID 38034382 full text"}, {"id": "data:geo:GSE1145", "type": "dataset", "label": "GEO GSE1145"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-38034382", "type": "extraction", "used": ["source:pmid:38034382"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-GSE1145", "type": "accession_resolution", "used": ["data:geo:GSE1145"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:38034382", "parent_hash": "sha256:e60ffe1d5f717b702af90ed5f64e58afa945f781302ec78b45dc32ed72d0748b", "fork_of": null, "generation": 2}, "gaps": ["asset:data:geo:GSE1145 licence not read", "asset:data:geo:GSE1145 not downloaded", "asset:data:geo:GSE120895 licence not read", "asset:data:geo:GSE120895 not downloaded", "asset:data:geo:GSE21610 licence not read", "asset:data:geo:GSE21610 not downloaded", "asset:data:geo:GSE36807 licence not read", "asset:data:geo:GSE36807 not downloaded", "asset:data:geo:GSE4183 licence not read", "asset:data:geo:GSE4183 not downloaded", "execution.not_run", "method.reader_named_unmapped", "review.human_critique", "review.independent_reader", "review.machine_critique"], "assays": [{"role": "analysis", "definition_id": "network_analysis", "definition_version": "f2132e96ae6c7a4e", "definition_digest": null, "required_operations": ["build_graph", "centrality_scores", "pathway_enrich"], "support_state": "supported", "source_hashes": {"dsl_catalogue": "f2132e96ae6c7a4e"}, "confidence": 0.7, "evidence": ["PPI"], "order_basis": "analysis_only", "id": "assay:1"}]}