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pmid:38283752
Impact of ferroptosis-related risk genes on macrophage M1/M2 polarization and prognosis in glioblastoma.
Xin Xu · Yue Zhang · Chenlong Liao · Han Zhou · Yiwei Wu · Wenchuan Zhang
Frontiers in cellular neuroscience · 2023 doi:10.3389/fncel.2023.1294029
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Experiment
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Data
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Analysis
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Execution
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Complete file
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Macrophages were analyzed using the CIBERSORTx deconvolution algorithm. Samples from The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA) and a single-cell RNA sequencing dataset (GSE84465) were included. The expression levels of ferroptosis-related risk genes and molecular markers of M1 and M2 macrophages were detected by qPCR and western blot.\nResults: A total of fourteen ferroptosis-related risk genes were obtained and the patients' risk scores were calculated. Compared with patients in the low-risk group, patients in the high-risk group had worse prognosis. The M1/M2 macrophage ratio and risk score were negatively correlated, indicating that the tumor microenvironment of glioblastoma in the high-risk group contained more M2 than M1 macrophages. In the single-cell RNA sequencing dataset, the risk score of ferroptosis-related genes in tumor cells was positively correlated with the proportion of high M2 macrophages. The expression of eight ferroptosis-related risk genes was increased in glioblastoma cell, which promoted the polarization of M1 macrophages to M2.\nConclusion: We investigated the fourteen ferroptosis-related risk genes in glioblastoma for the first time, and clarified the impact of ferroptosis-related risk genes on M1/M2 macrophage polarization and patient prognosis.", "claims": [{"id": "claim-method", "statement": "The relationship between ferroptosis-related genes and patients’ overall survival (OS) was evaluated by univariate Cox regression analysis using R software. 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"GSM2244070", "GSM2244071", "GSM2244072", "GSM2244073", "GSM2244074", "GSM2244075", "GSM2244076", "GSM2244077", "GSM2244078", "GSM2244079", "GSM2244080", "GSM2244081", "GSM2244082", "GSM2244083", "GSM2244084", "GSM2244085", "GSM2244086", "GSM2244087", "GSM2244088", "GSM2244089", "GSM2244090", "GSM2244091", "GSM2244092", "GSM2244093", "GSM2244094", "GSM2244095", "GSM2244096", "GSM2244097", "GSM2244098", "GSM2244099", "GSM2244100", "GSM2244101", "GSM2244102", "GSM2244103", "GSM2244104", "GSM2244105", "GSM2244106", "GSM2244107", "GSM2244108", "GSM2244109", "GSM2244110", "GSM2244111", "GSM2244112", "GSM2244113", "GSM2244114", "GSM2244115", "GSM2244116", "GSM2244117", "GSM2244118", "GSM2244119", "GSM2244120", "GSM2244121", "GSM2244122", "GSM2244123", "GSM2244124", "GSM2244125", "GSM2244126", "GSM2244127", "GSM2244128", "GSM2244129", "GSM2244130", "GSM2244131", "GSM2244132", "GSM2244133", "GSM2244134", "GSM2244135", "GSM2244136", "GSM2244137", "GSM2244138", "GSM2244139", "GSM2244140", "GSM2244141", "GSM2244142", "GSM2244143", "GSM2244144", "GSM2244145", "GSM2244146", "GSM2244147", "GSM2244148", "GSM2244149", "GSM2244150", "GSM2244151", "GSM2244152", "GSM2244153", "GSM2244154", "GSM2244155", "GSM2244156", "GSM2244157", "GSM2244158", "GSM2244159", "GSM2244160", "GSM2244161", "GSM2244162", "GSM2244163", "GSM2244164", "GSM2244165", "GSM2244166", "GSM2244167", "GSM2244168", "GSM2244169", "GSM2244170", "GSM2244171", "GSM2244172", "GSM2244173", "GSM2244174", "GSM2244175", "GSM2244176", "GSM2244177", "GSM2244178", "GSM2244179", "GSM2244180", "GSM2244181", "GSM2244182", "GSM2244183", "GSM2244184", "GSM2244185", "GSM2244186", "GSM2244187", "GSM2244188", "GSM2244189", "GSM2244190", "GSM2244191", "GSM2244192", "GSM2244193", "GSM2244194", "GSM2244195", "GSM2244196", "GSM2244197", "GSM2244198", "GSM2244199", "GSM2244200", "GSM2244201", "GSM2244202", "GSM2244203", "GSM2244204", "GSM2244205", "GSM2244206", "GSM2244207", "GSM2244208", "GSM2244209", "GSM2244210", "GSM2244211", "GSM2244212", "GSM2244213", "GSM2244214", "GSM2244215", "GSM2244216", "GSM2244217", "GSM2244218", "GSM2244219", "GSM2244220", "GSM2244221", "GSM2244222", "GSM2244223", "GSM2244224", "GSM2244225", "GSM2244226", "GSM2244227", "GSM2244228", "GSM2244229", "GSM2244230", "GSM2244231", "GSM2244232", "GSM2244233", "GSM2244234", "GSM2244235", "GSM2244236", "GSM2244237", "GSM2244238", "GSM2244239", "GSM2244240", "GSM2244241", "GSM2244242", "GSM2244243", "GSM2244244", "GSM2244245", "GSM2244246", "GSM2244247", "GSM2244248", "GSM2244249", "GSM2244250", "GSM2244251", "GSM2244252", "GSM2244253", "GSM2244254", "GSM2244255", "GSM2244256", "GSM2244257", "GSM2244258", "GSM2244259", "GSM2244260", "GSM2244261", "GSM2244262", "GSM2244263", "GSM2244264", "GSM2244265", "GSM2244266", "GSM2244267", "GSM2244268", "GSM2244269", "GSM2244270", "GSM2244271", "GSM2244272", "GSM2244273", "GSM2244274", "GSM2244275", "GSM2244276", "GSM2244277", "GSM2244278", "GSM2244279", "GSM2244280", "GSM2244281", "GSM2244282", "GSM2244283", "GSM2244284", "GSM2244285", "GSM2244286", "GSM2244287", "GSM2244288", "GSM2244289", "GSM2244290", "GSM2244291", "GSM2244292", "GSM2244293", "GSM2244294", "GSM2244295", "GSM2244296", "GSM2244297", "GSM2244298", "GSM2244299", "GSM2244300", "GSM2244301", "GSM2244302", "GSM2244303", "GSM2244304", "GSM2244305", "GSM2244306", "GSM2244307", "GSM2244308", "GSM2244309", "GSM2244310", "GSM2244311", "GSM2244312", "GSM2244313", "GSM2244314", "GSM2244315", "GSM2244316", "GSM2244317", "GSM2244318", "GSM2244319", "GSM2244320", "GSM2244321", "GSM2244322", "GSM2244323", "GSM2244324", "GSM2244325", "GSM2244326", "GSM2244327", "GSM2244328", "GSM2244329", "GSM2244330", "GSM2244331", "GSM2244332", "GSM2244333", "GSM2244334", "GSM2244335", "GSM2244336", "GSM2244337", "GSM2244338", "GSM2244339", "GSM2244340", "GSM2244341", "GSM2244342", "GSM2244343", "GSM2244344", "GSM2244345", "GSM2244346", "GSM2244347", "GSM2244348", "GSM2244349", "GSM2244350", "GSM2244351", "GSM2244352", "GSM2244353", "GSM2244354", "GSM2244355", "GSM2244356", "GSM2244357", "GSM2244358", "GSM2244359", "GSM2244360", "GSM2244361", "GSM2244362", "GSM2244363", "GSM2244364", "GSM2244365", "GSM2244366", "GSM2244367", "GSM2244368", "GSM2244369", "GSM2244370", "GSM2244371", "GSM2244372", "GSM2244373", "GSM2244374", "GSM2244375", "GSM2244376", "GSM2244377", "GSM2244378", "GSM2244379", "GSM2244380", "GSM2244381", "GSM2244382", "GSM2244383", "GSM2244384", "GSM2244385", "GSM2244386", "GSM2244387", "GSM2244388", "GSM2244389", "GSM2244390", "GSM2244391", "GSM2244392", "GSM2244393", "GSM2244394", "GSM2244395", "GSM2244396", "GSM2244397", "GSM2244398", "GSM2244399", "GSM2244400", "GSM2244401", "GSM2244402", "GSM2244403", "GSM2244404", "GSM2244405", "GSM2244406", "GSM2244407", "GSM2244408", "GSM2244409", "GSM2244410", "GSM2244411", "GSM2244412", "GSM2244413", "GSM2244414", "GSM2244415", "GSM2244416", "GSM2244417", "GSM2244418", "GSM2244419", "GSM2244420", "GSM2244421", "GSM2244422", "GSM2244423", "GSM2244424", "GSM2244425", "GSM2244426", "GSM2244427", "GSM2244428", "GSM2244429", "GSM2244430", "GSM2244431", "GSM2244432", "GSM2244433", "GSM2244434", "GSM2244435", "GSM2244436", "GSM2244437", "GSM2244438", "GSM2244439", "GSM2244440", "GSM2244441", "GSM2244442", "GSM2244443", "GSM2244444", "GSM2244445", "GSM2244446", "GSM2244447", "GSM2244448", "GSM2244449", "GSM2244450", "GSM2244451", "GSM2244452", "GSM2244453", "GSM2244454", "GSM2244455", "GSM2244456", "GSM2244457", "GSM2244458", "GSM2244459", "GSM2244460", "GSM2244461", "GSM2244462", "GSM2244463", "GSM2244464", "GSM2244465", "GSM2244466", "GSM2244467", "GSM2244468", "GSM2244469", "GSM2244470", "GSM2244471", "GSM2244472", "GSM2244473", "GSM2244474", "GSM2244475", "GSM2244476", "GSM2244477", "GSM2244478", "GSM2244479", "GSM2244480", "GSM2244481", "GSM2244482", "GSM2244483", "GSM2244484", "GSM2244485", "GSM2244486", "GSM2244487", "GSM2244488", "GSM2244489", "GSM2244490", "GSM2244491", "GSM2244492", "GSM2244493", "GSM2244494", "GSM2244495", "GSM2244496", "GSM2244497", "GSM2244498", "GSM2244499", "GSM2244500", "GSM2244501", "GSM2244502", "GSM2244503", "GSM2244504", "GSM2244505", "GSM2244506", "GSM2244507", "GSM2244508", "GSM2244509", "GSM2244510", "GSM2244511", "GSM2244512", "GSM2244513", "GSM2244514", "GSM2244515", "GSM2244516", "GSM2244517", "GSM2244518", "GSM2244519", "GSM2244520", "GSM2244521", "GSM2244522", "GSM2244523", "GSM2244524", "GSM2244525", "GSM2244526", "GSM2244527", "GSM2244528", "GSM2244529", "GSM2244530", "GSM2244531", "GSM2244532", "GSM2244533", "GSM2244534", "GSM2244535", "GSM2244536", "GSM2244537", "GSM2244538", "GSM2244539", "GSM2244540", "GSM2244541", "GSM2244542", "GSM2244543", "GSM2244544", "GSM2244545", "GSM2244546", "GSM2244547", "GSM2244548", "GSM2244549", "GSM2244550", "GSM2244551", "GSM2244552", "GSM2244553", "GSM2244554", "GSM2244555", "GSM2244556", "GSM2244557", "GSM2244558", "GSM2244559", "GSM2244560", "GSM2244561", "GSM2244562", "GSM2244563", "GSM2244564", "GSM2244565", "GSM2244566", "GSM2244567", "GSM2244568", "GSM2244569", "GSM2244570", "GSM2244571", "GSM2244572", "GSM2244573", "GSM2244574", "GSM2244575", "GSM2244576", "GSM2244577", "GSM2244578", "GSM2244579", "GSM2244580", "GSM2244581", "GSM2244582", "GSM2244583", "GSM2244584", "GSM2244585", "GSM2244586", "GSM2244587", "GSM2244588", "GSM2244589", "GSM2244590", "GSM2244591", "GSM2244592", "GSM2244593", "GSM2244594", "GSM2244595", "GSM2244596", "GSM2244597", "GSM2244598", "GSM2244599", "GSM2244600", "GSM2244601", "GSM2244602", "GSM2244603", "GSM2244604", "GSM2244605", "GSM2244606", "GSM2244607", "GSM2244608", "GSM2244609", "GSM2244610", "GSM2244611", "GSM2244612", "GSM2244613", "GSM2244614", "GSM2244615", "GSM2244616", "GSM2244617", "GSM2244618", "GSM2244619", "GSM2244620", "GSM2244621", "GSM2244622", "GSM2244623", "GSM2244624", "GSM2244625", "GSM2244626", "GSM2244627", "GSM2244628", "GSM2244629", "GSM2244630", "GSM2244631", "GSM2244632", "GSM2244633", "GSM2244634", "GSM2244635", "GSM2244636", "GSM2244637", "GSM2244638", "GSM2244639", "GSM2244640", "GSM2244641", "GSM2244642", "GSM2244643", "GSM2244644", "GSM2244645", "GSM2244646", "GSM2244647", "GSM2244648", "GSM2244649", "GSM2244650", "GSM2244651", "GSM2244652", "GSM2244653", "GSM2244654", "GSM2244655", "GSM2244656", "GSM2244657", "GSM2244658", "GSM2244659", "GSM2244660", "GSM2244661", "GSM2244662", "GSM2244663", "GSM2244664", "GSM2244665", "GSM2244666", "GSM2244667", "GSM2244668", "GSM2244669", "GSM2244670", "GSM2244671", "GSM2244672", "GSM2244673", "GSM2244674", "GSM2244675", "GSM2244676", "GSM2244677", "GSM2244678", "GSM2244679", "GSM2244680", "GSM2244681", "GSM2244682", "GSM2244683", "GSM2244684", "GSM2244685", "GSM2244686", "GSM2244687", "GSM2244688", "GSM2244689", "GSM2244690", "GSM2244691", "GSM2244692", "GSM2244693", "GSM2244694", "GSM2244695", "GSM2244696", "GSM2244697", "GSM2244698", "GSM2244699", "GSM2244700", "GSM2244701", "GSM2244702", "GSM2244703", "GSM2244704", "GSM2244705", "GSM2244706", "GSM2244707", "GSM2244708", "GSM2244709", "GSM2244710", "GSM2244711", "GSM2244712", "GSM2244713", "GSM2244714", "GSM2244715", "GSM2244716", "GSM2244717", "GSM2244718", "GSM2244719", "GSM2244720", "GSM2244721", "GSM2244722", "GSM2244723", "GSM2244724", "GSM2244725", "GSM2244726", "GSM2244727", "GSM2244728", "GSM2244729", "GSM2244730", "GSM2244731", "GSM2244732", "GSM2244733", "GSM2244734", "GSM2244735", "GSM2244736", "GSM2244737", "GSM2244738", "GSM2244739", "GSM2244740", "GSM2244741", "GSM2244742", "GSM2244743", "GSM2244744", "GSM2244745", "GSM2244746", "GSM2244747", "GSM2244748", "GSM2244749", "GSM2244750", "GSM2244751", "GSM2244752", "GSM2244753", "GSM2244754", "GSM2244755", "GSM2244756", "GSM2244757", "GSM2244758", "GSM2244759", "GSM2244760", "GSM2244761", "GSM2244762", "GSM2244763", "GSM2244764", "GSM2244765", "GSM2244766", "GSM2244767", "GSM2244768", "GSM2244769", "GSM2244770", "GSM2244771", "GSM2244772", "GSM2244773", "GSM2244774", "GSM2244775", "GSM2244776", "GSM2244777", "GSM2244778", "GSM2244779", "GSM2244780", "GSM2244781", "GSM2244782", "GSM2244783", "GSM2244784", "GSM2244785", "GSM2244786", "GSM2244787", "GSM2244788", "GSM2244789", "GSM2244790", "GSM2244791", "GSM2244792", "GSM2244793", "GSM2244794", "GSM2244795", "GSM2244796", "GSM2244797", "GSM2244798", "GSM2244799", "GSM2244800", "GSM2244801", "GSM2244802", "GSM2244803", "GSM2244804", "GSM2244805", "GSM2244806", "GSM2244807", "GSM2244808", "GSM2244809", "GSM2244810", "GSM2244811", "GSM2244812", "GSM2244813", "GSM2244814", "GSM2244815", "GSM2244816", "GSM2244817", "GSM2244818", "GSM2244819", "GSM2244820", "GSM2244821", "GSM2244822", "GSM2244823", "GSM2244824", "GSM2244825", "GSM2244826", "GSM2244827", "GSM2244828", "GSM2244829", "GSM2244830", "GSM2244831", "GSM2244832", "GSM2244833", "GSM2244834", "GSM2244835", "GSM2244836", "GSM2244837", "GSM2244838", "GSM2244839", "GSM2244840", "GSM2244841", "GSM2244842", "GSM2244843", "GSM2244844", "GSM2244845", "GSM2244846", "GSM2244847", "GSM2244848", "GSM2244849", "GSM2244850", "GSM2244851", "GSM2244852", "GSM2244853", "GSM2244854", "GSM2244855", "GSM2244856", "GSM2244857", "GSM2244858", "GSM2244859", "GSM2244860", "GSM2244861", "GSM2244862", "GSM2244863", "GSM2244864", "GSM2244865", "GSM2244866", "GSM2244867", "GSM2244868", "GSM2244869", "GSM2244870", "GSM2244871", "GSM2244872", "GSM2244873", "GSM2244874", "GSM2244875", "GSM2244876", "GSM2244877", "GSM2244878", "GSM2244879", "GSM2244880", "GSM2244881", "GSM2244882", "GSM2244883", "GSM2244884", "GSM2244885", "GSM2244886", "GSM2244887", "GSM2244888", "GSM2244889", "GSM2244890", "GSM2244891", "GSM2244892", "GSM2244893", "GSM2244894", "GSM2244895", "GSM2244896", "GSM2244897", "GSM2244898", "GSM2244899", "GSM2244900", "GSM2244901", "GSM2244902", "GSM2244903", "GSM2244904", "GSM2244905", "GSM2244906", "GSM2244907", "GSM2244908", "GSM2244909", "GSM2244910", "GSM2244911", "GSM2244912", "GSM2244913", "GSM2244914", "GSM2244915", "GSM2244916", "GSM2244917", "GSM2244918", "GSM2244919", "GSM2244920", "GSM2244921", "GSM2244922", "GSM2244923", "GSM2244924", "GSM2244925", "GSM2244926", "GSM2244927", "GSM2244928", "GSM2244929", "GSM2244930", "GSM2244931", "GSM2244932", "GSM2244933", "GSM2244934", "GSM2244935", "GSM2244936", "GSM2244937", "GSM2244938", "GSM2244939", "GSM2244940", "GSM2244941", "GSM2244942", "GSM2244943", "GSM2244944", "GSM2244945", "GSM2244946", "GSM2244947", "GSM2244948", "GSM2244949", "GSM2244950", "GSM2244951", "GSM2244952", "GSM2244953", "GSM2244954", "GSM2244955", "GSM2244956", "GSM2244957", "GSM2244958", "GSM2244959", "GSM2244960", "GSM2244961", "GSM2244962", "GSM2244963", "GSM2244964", "GSM2244965", "GSM2244966", "GSM2244967", "GSM2244968", "GSM2244969", "GSM2244970", "GSM2244971", "GSM2244972", "GSM2244973", "GSM2244974", "GSM2244975", "GSM2244976", "GSM2244977", "GSM2244978", "GSM2244979", "GSM2244980", "GSM2244981", "GSM2244982", "GSM2244983", "GSM2244984", "GSM2244985", "GSM2244986", "GSM2244987", "GSM2244988", "GSM2244989", "GSM2244990", "GSM2244991", "GSM2244992", 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"GSM2245561", "GSM2245562", "GSM2245563", "GSM2245564", "GSM2245565", "GSM2245566", "GSM2245567", "GSM2245568", "GSM2245569", "GSM2245570", "GSM2245571", "GSM2245572", "GSM2245573", "GSM2245574", "GSM2245575", "GSM2245576", "GSM2245577", "GSM2245578", "GSM2245579", "GSM2245580", "GSM2245581", "GSM2245582", "GSM2245583", "GSM2245584", "GSM2245585", "GSM2245586", "GSM2245587", "GSM2245588", "GSM2245589", "GSM2245590", "GSM2245591", "GSM2245592", "GSM2245593", "GSM2245594", "GSM2245595", "GSM2245596", "GSM2245597", "GSM2245598", "GSM2245599", "GSM2245600", "GSM2245601", "GSM2245602", "GSM2245603", "GSM2245604", "GSM2245605", "GSM2245606", "GSM2245607", "GSM2245608", "GSM2245609", "GSM2245610", "GSM2245611", "GSM2245612", "GSM2245613", "GSM2245614", "GSM2245615", "GSM2245616", "GSM2245617", "GSM2245618", "GSM2245619", "GSM2245620", "GSM2245621", "GSM2245622", "GSM2245623", "GSM2245624", "GSM2245625", "GSM2245626", "GSM2245627", "GSM2245628", "GSM2245629", "GSM2245630", "GSM2245631", "GSM2245632", "GSM2245633", "GSM2245634", "GSM2245635", "GSM2245636", "GSM2245637", "GSM2245638", "GSM2245639", "GSM2245640", "GSM2245641", "GSM2245642", "GSM2245643", "GSM2245644", "GSM2245645", "GSM2245646", "GSM2245647", "GSM2245648", "GSM2245649", "GSM2245650", "GSM2245651", "GSM2245652", "GSM2245653", "GSM2245654", "GSM2245655", "GSM2245656", "GSM2245657", "GSM2245658", "GSM2245659", "GSM2245660", "GSM2245661", "GSM2245662", "GSM2245663", "GSM2245664", "GSM2245665", "GSM2245666", "GSM2245667", "GSM2245668", "GSM2245669", "GSM2245670", "GSM2245671", "GSM2245672", "GSM2245673", "GSM2245674", "GSM2245675", "GSM2245676", "GSM2245677", "GSM2245678", "GSM2245679", "GSM2245680", "GSM2245681", "GSM2245682", "GSM2245683", "GSM2245684", "GSM2245685", "GSM2245686", "GSM2245687", "GSM2245688", "GSM2245689", "GSM2245690", "GSM2245691", "GSM2245692", "GSM2245693", "GSM2245694", "GSM2245695", "GSM2245696", "GSM2245697", "GSM2245698", "GSM2245699", "GSM2245700", "GSM2245701", "GSM2245702", "GSM2245703", "GSM2245704", "GSM2245705", "GSM2245706", "GSM2245707", "GSM2245708", "GSM2245709", "GSM2245710", "GSM2245711", "GSM2245712", "GSM2245713", "GSM2245714", "GSM2245715", "GSM2245716", "GSM2245717", "GSM2245718", "GSM2245719", "GSM2245720", "GSM2245721", "GSM2245722", "GSM2245723", "GSM2245724", "GSM2245725", "GSM2245726", "GSM2245727", "GSM2245728", "GSM2245729", "GSM2245730", "GSM2245731", "GSM2245732", "GSM2245733", "GSM2245734", "GSM2245735", "GSM2245736", "GSM2245737", "GSM2245738", "GSM2245739", "GSM2245740", "GSM2245741", "GSM2245742", "GSM2245743", "GSM2245744", "GSM2245745", "GSM2245746", "GSM2245747", "GSM2245748", "GSM2245749", "GSM2245750", "GSM2245751", "GSM2245752", "GSM2245753", "GSM2245754", "GSM2245755", "GSM2245756", "GSM2245757", "GSM2245758", "GSM2245759", "GSM2245760", "GSM2245761", "GSM2245762", "GSM2245763", "GSM2245764", "GSM2245765", "GSM2245766", "GSM2245767", "GSM2245768", "GSM2245769", "GSM2245770", "GSM2245771", "GSM2245772", "GSM2245773", 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"GSM2247025", "GSM2247026", "GSM2247027", "GSM2247028", "GSM2247029", "GSM2247030", "GSM2247031", "GSM2247032", "GSM2247033", "GSM2247034", "GSM2247035", "GSM2247036", "GSM2247037", "GSM2247038", "GSM2247039", "GSM2247040", "GSM2247041", "GSM2247042", "GSM2247043", "GSM2247044", "GSM2247045", "GSM2247046", "GSM2247047", "GSM2247048", "GSM2247049", "GSM2247050", "GSM2247051", "GSM2247052", "GSM2247053", "GSM2247054", "GSM2247055", "GSM2247056", "GSM2247057", "GSM2247058", "GSM2247059", "GSM2247060", "GSM2247061", "GSM2247062", "GSM2247063", "GSM2247064", "GSM2247065", "GSM2247066", "GSM2247067", "GSM2247068", "GSM2247069", "GSM2247070", "GSM2247071", "GSM2247072", "GSM2247073", "GSM2247074", "GSM2247075", "GSM2247076", "GSM2247077"], "sample_count": 3589, "group_sizes": null, "group_sizes_basis": null, "platform": "18573", "taxon": "Homo sapiens", "title": "Single-Cell RNAseq analysis of diffuse neoplastic infiltrating cells at the migrating front of human glioblastoma", "resolution_checked_at": "2026-11-01T15:39:55Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}], "gaps": ["asset:data:geo:GSE84465 not downloaded", "asset:data:geo:GSE84465 licence not read"]}, "analysis": {"state": "partial", "methods": [{"id": "method-1", "family": "survival_analysis", "specific": "cox_proportional_hazards", "label": "Survival analysis", "dsl_operations": ["cox_ph"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 1.0, "band": "verbatim", "quote": "The relationship between ferroptosis-related genes and patients’ overall survival (OS) was evaluated by univariate Cox regression analysis using R software. 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