Novel histone acetylation-related lncRNA signature for predicting prognosis and tumor microenvironment in esophageal carcinoma.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:38478744", "kind": "science-record", "revision": 2, "content_hash": "sha256:2b51071055ae7f50f58445d9b0a111cdabc4d6ac4623910576f6f20a699b041e", "created_at": "2026-11-01T19:20:25Z", "updated_at": "2026-11-01T21:32:41Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Novel histone acetylation-related lncRNA signature for predicting prognosis and tumor microenvironment in esophageal carcinoma.", "doi": "10.18632/aging.205636", "pmid": "38478744", "authors": ["Batter Han", "Ying Ma", "Pengjie Yang", "Fangchao Zhao", "Haiyong Zhu", "Shujun Li", "Rong Yu", "Subudao Bao"], "journal": "Aging", "year": 2024, "abstract": "Histone acetylation is one of the most common epigenetic modifications and plays a crucial role in tumorigenesis. However, the prognostic significance of histone acetylation-related lncRNAs (HARlncRNAs) in esophageal carcinoma (ESCA) is not well understood. A total of 653 differentially expressed lncRNAs (DElncRNAs) were identified between 162 ESCA tissues and 11 normal tissues in the TCGA database, and 7 of them were correlated with acetylation regulators. We employed univariate Cox regression analysis, combining it with clinical prognosis information, to select 3 prognostic-related HARlncRNAs for further analysis. Subsequently, we used LASSO regression analysis to construct a risk signature for ESCA and identified C21orf62-AS1 and SSTR5.AS1 as potential biomarkers for the prognosis of ESCA patients. Based on the risk score calculated using the risk signature, we categorized patients into high- and low-risk groups. We identified the risk score as an independent risk factor and validated it in the training, test, and GSE53624 datasets. Additionally, patients categorized by their risk scores exhibited distinct immune statuses, tumor mutation burdens, responses to immunotherapy, and drug sensitivities.", "claims": [{"id": "claim-method", "statement": "To prevent overfitting, we also carried out LASSO Cox regression with 10,000 iterations, employing the “glmnet” package.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:38478744", "locator": "sections[19] \"Construction and validation of the prognostic signature\" paragraph 2", "quote": "To prevent overfitting, we also carried out LASSO Cox regression with 10,000 iterations, employing the “glmnet” package."}], "state": "complete"}, {"id": "claim-target-result", "statement": "LASSO regression analysis was used to construct an ESCA risk signature identifying C21orf62-AS1 and SSTR5.AS1 as potential prognostic biomarkers.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:38478744", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "Subsequently, we used LASSO regression analysis to construct a risk signature for ESCA and identified C21orf62-AS1 and SSTR5.AS1 as potential biomarkers for the prognosis of ESCA patients."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "partial", "objective": "LASSO regression analysis was used to construct an ESCA risk signature identifying C21orf62-AS1 and SSTR5.AS1 as potential prognostic biomarkers.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:38478744"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "blocked", "blocked_on": "data:accession_absent", "description": "The GEO series accession resolves and its sample accessions are listed. 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