Identification of core gene in chronic rhinosinusitis with nasal polyps and correlations with inflammation-related genes.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:38490010", "kind": "science-record", "revision": 4, "content_hash": "sha256:1aa9717f610f32bd6cc601970021c1abe73f43f0e4d26fed6d7c8132b57fc7b8", "created_at": "2026-11-01T19:20:26Z", "updated_at": "2026-11-01T22:53:53Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Identification of core gene in chronic rhinosinusitis with nasal polyps and correlations with inflammation-related genes.", "doi": "10.1016/j.bjorl.2024.101410", "pmid": "38490010", "authors": ["Jingpu Yang", "Chang Liu", "Jinzhang Cheng", "Yunmeng Wang", "Zonggui Wang", "Wei Zhong"], "journal": "Brazilian journal of otorhinolaryngology", "year": 2024, "abstract": "OBJECTIVE: Our aim in this study is to identify the core genes of chronic rhinosinusitis with nasal polyps and analyze the correlations between it and inflammation-related genes.\nMETHODS: GSE72713 dataset containing gene expression data of ECRSwNP, nonECRSwNP and healthy samples was obtained from Gene Expression Omnibus (GEO) and filtered by limma to identify DEGs among three groups, then the functions and correlated pathways of DEGs were analyzed using GO and KEGG. The core DEGs were selected by the intersection of DEGs and the PPI network was constructed via STRING. The correlations between the expression levels of CRSwNP core gene and inflammation-related genes were analyzed via the Mann-Whitney U test.\nRESULTS: The DEGs among ECRSwNP, nonECRSwNP, and CTRL were filtered respectively, and enrichment analysis showed they were associated with olfaction and/or immune responses. The PPI network was constructed by 7 core DEGs obtained via the intersection among three groups, and ALOX15 was confirmed as the core gene in the network. Subsequently, the correlations between the expression levels of ALOX15 and inflammation-related genes were illustrated.\nCONCLUSION: In this study, the core gene ALOX15 was selected from the DEGs among ECRSwNP, nonECRSwNP, and CTRL. IL5, IL1RL1, and IL1RAP were found to exhibit a significant positive correlation with ALOX15.\nLEVEL OF EVIDENCE: Level 3.", "claims": [{"id": "claim-method", "statement": "The limma (version 1.34.0)15 was employed to perform differential analysis on the expression matrix of sequencing data in all chips to identify Differentially Expressed Genes (DEGs) among ECRSwNP, nonECRSwNP, and CTRL.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:38490010", "locator": "sections[4] \"Differentially expressed genes analysis\" paragraph 2", "quote": "The limma (version 1.34.0)15 was employed to perform differential analysis on the expression matrix of sequencing data in all chips to identify Differentially Expressed Genes (DEGs) among ECRSwNP, nonECRSwNP, and CTRL."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:38490010", "locator": "sections[19] \"Data availability statement\" paragraph 2", "quote": "The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request."}], "state": "complete"}, {"id": "claim-target-result", "statement": "In this study, the core gene ALOX15 was selected from the DEGs among ECRSwNP, nonECRSwNP, and CTRL.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:38490010", "locator": "sections[0] \"Abstract\" paragraph 8", "quote": "In this study, the core gene ALOX15 was selected from the DEGs among ECRSwNP, nonECRSwNP, and CTRL."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "In this study, the core gene ALOX15 was selected from the DEGs among ECRSwNP, nonECRSwNP, and CTRL.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:38490010"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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