Unveiling the role of YARS1 in bladder cancer: A prognostic biomarker and therapeutic target.

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We analysed variations in YARS1 expression and survival in bladder cancer using multiple data sets, including TCGA-BLCA, GSE13507 and bladder cancer-specific tissue microarrays. Furthermore, we explored the biological functions of YARS1 using transcriptome data. Our findings revealed a noteworthy correlation between YARS1 and immune infiltration in bladder cancer, as determined using the XCELL algorithm and single-cell analysis. In addition, we employed the TIDE algorithm to evaluate the responsiveness of different cohorts to immune checkpoint therapy. We investigated the regulatory associations between YARS1 and various aspects of bladder cancer, including senescence, ferroptosis and stemness. Finally, we established a ceRNA network that is directly linked to the overall prognosis, YARS1 can serve as a prognostic biomarker for bladder cancer; its interaction with MYC has implications for bladder cancer cell senescence, ferroptosis and stemness. Moreover, the identified ceRNA network has potential as a therapeutic target in bladder cancer.", "claims": [{"id": "claim-method", "statement": "YARS1 expression in bladder cancer and normal bladder tissues was determined by the Wilcoxon rank‐sum test. Prognostic analysis was performed using the log‐rank test. Statistical significance was defined as p < 0.05.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:38506098", "locator": "sections[10] \"Statistical analysis\" paragraph 2", "quote": "YARS1 expression in bladder cancer and normal bladder tissues was determined by the Wilcoxon rank‐sum test. Prognostic analysis was performed using the log‐rank test. Statistical significance was defined as p < 0.05."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The data sets obtained from TCGA database (https://portal.gdc.cancer.gov/) and UALCAN database (http://ualcan.path.uab.edu/analysis.html), GEO database (https://www.ncbi.nlm.nih.gov/geo/), partial analysis by Cbioportal for Cancer Genomics website (http://www.cbioportal.org), TISCH (http://tisch.comp‐genomics.org/home/) database and SMART database (http://www.bioinfo‐zs.com/smartapp/).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:38506098", "locator": "sections[28] \"DATA AVAILABILITY STATEMENT\" paragraph 2", "quote": "The data sets obtained from TCGA database (https://portal.gdc.cancer.gov/) and UALCAN database (http://ualcan.path.uab.edu/analysis.html), GEO database (https://www.ncbi.nlm.nih.gov/geo/), partial analysis by Cbioportal for Cancer Genomics website (http://www.cbioportal.org), TISCH (http://tisch.comp‐genomics.org/home/) database and SMART database (http://www.bioinfo‐zs.com/smartapp/)."}], "state": "complete"}, {"id": "claim-target-result", "statement": "YARS1 was elevated in bladder carcinoma and was associated with an unfavourable prognosis.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:38506098", "locator": "sections[13] \"YARS1 can be used as a prognostic marker for bladder cancer\" paragraph 2", "quote": "In conclusion, our investigation substantiates the elevated expression of YARS1 in bladder carcinoma and the unfavourable prognosis associated with this elevated expression."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "partial", "objective": "YARS1 was elevated in bladder carcinoma and was associated with an unfavourable prognosis.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:38506098"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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