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pmid:39051702

SpatialQC: automated quality control for spatial transcriptome data.

Guangyao Mao · Yi Yang · Zhuojuan Luo · Chengqi Lin · Peng Xie

Bioinformatics (Oxford, England) · 2024 doi:10.1093/bioinformatics/btae458

Paper

complete

Experiment

partial

Data

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Analysis

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Execution

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title
SpatialQC: automated quality control for spatial transcriptome data.
doi
10.1093/bioinformatics/btae458
pmid
39051702
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Guangyao Mao
[1]
Yi Yang
[2]
Zhuojuan Luo
[3]
Chengqi Lin
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Peng Xie
journal
Bioinformatics (Oxford, England)
year
2024
abstract
SUMMARY: The advent of spatial transcriptomics has revolutionized our understanding of the spatial heterogeneity in tissues, providing unprecedented insights into the cellular and molecular mechanisms underlying biological processes. Although quality control (QC) critical for downstream data analyses, there is currently a lack of specialized tools for one-stop spatial transcriptome QC. Here, we introduce SpatialQC, a one-stop QC pipeline, which generates comprehensive QC reports and produces clean data in an interactive fashion. SpatialQC is widely applicable to spatial transcriptomic techniques. AVAILABILITY AND IMPLEMENTATION: source code and user manuals are available via https://github.com/mgy520/spatialQC, and deposited on Zenodo (https://doi.org/10.5281/zenodo.12634669).
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The stereo-seq data for Drosophila embryonic stages E14-E16h were obtained from StomicsDB, with the dataset identifier STDS0000060. Drosophila embryonic stages E14-E16h scRNA-seq data is available via https://shendure-web.gs.washington.edu/content/members/DEAP_website/public/.
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