Energy Metabolism Dysregulation in Myocardial Infarction: An Integrative Analysis of Ischemic Cardiomyopathy.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:39069811", "kind": "science-record", "revision": 4, "content_hash": "sha256:6d6e052df17cdc654a52e43f796dcd0e7cf82af081fbfe55dde970ae2f79ab23", "created_at": "2026-11-01T20:29:08Z", "updated_at": "2026-11-01T22:54:46Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Energy Metabolism Dysregulation in Myocardial Infarction: An Integrative Analysis of Ischemic Cardiomyopathy.", "doi": "10.2174/0115701611289159240724114844", "pmid": "39069811", "authors": ["Zongtao Wang", "Zhixin Xie", "Tudi Li", "Rong Chen", "Zhihuan Zeng", "Jun Guo"], "journal": "Current vascular pharmacology", "year": 2025, "abstract": "BACKGROUND: Myocardial metabolism is closely related to functional changes after myocardial infarction (MI).\nOBJECTIVE: This study aimed to present an integrative examination of human ischemic cardiomyopathy.\nMETHODS: We used both GSE121893 single-cell suspension sequencing and GSE19303 transcription microarray data sets from the GEO database, along with a murine MI model for full-spectrum metabolite detection. Through a systematic investigation that involved differential metabolite identification and functional enrichment analysis, we shed light on the pivotal role of energy metabolism dysregulation in the progression of MI.\nRESULTS: Our findings revealed an association between the core regulatory genes CDKN1A, FOS, ITGB4, and MAP2K1 and the underlying pathophysiology of the disease. These genes are identified as critical elements in the complex landscape of myocardial ischemic disorder, highlighting novel insights into therapeutic targets and the intricate biological mechanisms involved.\nCONCLUSION: This analysis provides a framework for future research on the metabolic alterations associated with MI.", "claims": [{"id": "claim-method", "statement": "The differentially expressed genes (DEGs) were identified using standard methods, such as the DESeq2 package or edgeR package in R, based on criteria with B-H adjusted p-value < 0.05 and log2|fold-change| more than 0.25.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:39069811", "locator": "sections[6] \"Clustering and Identification of Marker Genes\" paragraph 2", "quote": "The differentially expressed genes (DEGs) were identified using standard methods, such as the DESeq2 package or edgeR package in R, based on criteria with B-H adjusted p-value < 0.05 and log2|fold-change| more than 0.25."}], "state": "complete"}, {"id": "claim-data-access", "statement": "All the data and supporting information are provided within the article.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:39069811", "locator": "sections[24] \"AVAILABILITY OF DATA AND MATERIALS\" paragraph 2", "quote": "All the data and supporting information are provided within the article."}], "state": "complete"}, {"id": "claim-target-result", "statement": "The study identified CDKN1A, FOS, ITGB4, and MAP2K1 as core regulatory genes associated with energy metabolism dysregulation and the pathophysiology of myocardial infarction.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:39069811", "locator": "sections[0] \"Abstract\" paragraph 4", "quote": "Our findings revealed an association between the core regulatory genes CDKN1A, FOS, ITGB4, and MAP2K1 and the underlying pathophysiology of the disease."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "The study identified CDKN1A, FOS, ITGB4, and MAP2K1 as core regulatory genes associated with energy metabolism dysregulation and the pathophysiology of myocardial infarction.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:39069811"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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