The Co-pathogenic Target Gene CNTN1 Involved in Coronary Artery Disease and Pulmonary Arterial Hypertension Has Potential for Diagnosis of Coronary Artery Disease.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:39087405", "kind": "science-record", "revision": 3, "content_hash": "sha256:e36e68ba55d8b02a1803e821a3d892c945de02bcc90d9b0ab1423da0931efbb7", "created_at": "2026-11-01T20:29:10Z", "updated_at": "2026-11-01T22:12:21Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "The Co-pathogenic Target Gene CNTN1 Involved in Coronary Artery Disease and Pulmonary Arterial Hypertension Has Potential for Diagnosis of Coronary Artery Disease.", "doi": "10.14744/AnatolJCardiol.2024.4331", "pmid": "39087405", "authors": ["Kun Cheng", "Qixuan Zhai", "Jieqiong Song", "Bing Liu"], "journal": "Anatolian journal of cardiology", "year": 2024, "abstract": "BACKGROUND: We aimed to find a gene for coronary artery disease (CAD) early diagnosis by detecting co-pathogenic target gene involved in CAD and pulmonary arterial hypertension (PAH).
 
 Methods: Datasets were obtained from the Gene Expression Omnibus (GEO) database, including GSE113079, GSE113439, and GSE12288, to investigate gene expression patterns in cardiovascular diseases. Weighted Gene Co-expression Network Analysis (WGCNA) was performed to identify gene modules associated with clinical traits. Differential gene expression analysis and functional enrichment analysis were carried out. Protein-protein interaction (PPI) networks were constructed. JASPAR database and FIMO tool were utilized to predict transcription factor (TF) binding sites.
 
 Results: Fifteen key genes were identified in CAD and PAH, with CNTN1 being prioritized for further investigation due to its high connectivity degree. Upstream regulation analysis identified potential TFs (DRGX, HOXD3, and RAX) and 7 miRNAs targeting CNTN1. The expression profile of CNTN1 was significantly upregulated in CAD samples, and ROC analysis indicated potential diagnostic value for CAD. CMap database analysis predicted potential targeted drugs for CAD.
 
 Conclusion: CNTN1 was detected as a co-pathogenetic gene for CAD and PAH. It is highly expressed in CAD patients and has potential value for CAD diagnosis. CNTN1 is potentially regulated by 3 TFs and 7 miRNAs.", "claims": [{"id": "claim-method", "statement": "Weighted Gene Co-expression Network Analysis (WGCNA) was performed to identify gene modules associated with clinical traits.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:39087405", "locator": "sections[0] \"Abstract\" paragraph 2", "quote": "Weighted Gene Co-expression Network Analysis (WGCNA) was performed to identify gene modules associated with clinical traits."}], "state": "complete"}, {"id": "claim-data-access", "statement": "Availability of Data and Materials: The data that support the findings of this study are available in the Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo/), STRING (https://string-db.org/, version 11.0), the JASPAR database (https://jaspar.genereg.net/), and the CMap database (https://clue.io).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:39087405", "locator": "sections[23] \"Footnotes\" paragraph 2", "quote": "Availability of Data and Materials: The data that support the findings of this study are available in the Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo/), STRING (https://string-db.org/, version 11.0), the JASPAR database (https://jaspar.genereg.net/), and the CMap database (https://clue.io)."}], "state": "complete"}, {"id": "claim-target-result", "statement": "CNTN1 was detected as a co-pathogenetic gene for CAD and PAH. It is highly expressed in CAD patients and has potential value for CAD diagnosis. CNTN1 is potentially regulated by 3 TFs and 7 miRNAs.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:39087405", "locator": "sections[0] \"Abstract\" paragraph 4", "quote": "CNTN1 was detected as a co-pathogenetic gene for CAD and PAH. It is highly expressed in CAD patients and has potential value for CAD diagnosis. CNTN1 is potentially regulated by 3 TFs and 7 miRNAs."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "partial", "objective": "CNTN1 was detected as a co-pathogenetic gene for CAD and PAH. It is highly expressed in CAD patients and has potential value for CAD diagnosis. CNTN1 is potentially regulated by 3 TFs and 7 miRNAs.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:39087405"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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