Human serum proteomics reveals a molecular signature after one night of sleep deprivation.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:39131770", "kind": "science-record", "revision": 2, "content_hash": "sha256:1e34b916d0ac9236eee3bc02abffc0cbad8bd12df68263d2a8a0543bfb8fa24d", "created_at": "2026-11-01T20:29:13Z", "updated_at": "2026-11-01T21:33:40Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Human serum proteomics reveals a molecular signature after one night of sleep deprivation.", "doi": "10.1093/sleepadvances/zpae042", "pmid": "39131770", "authors": ["Alvhild Alette Bjørkum", "Leandra Griebel", "Even Birkeland"], "journal": "Sleep advances : a journal of the Sleep Research Society", "year": 2024, "abstract": "Study Objectives: Sleep deprivation is highly prevalent and caused by conditions such as night shift work or illnesses like obstructive sleep apnea. Compromised sleep affects cardiovascular-, immune-, and neuronal systems. Recently, we published human serum proteome changes after a simulated night shift. This pilot proteomic study aimed to further explore changes in human blood serum after 6 hours of sleep deprivation at night.\nMethods: Human blood serum samples from eight self-declared healthy females were analyzed using Orbitrap Eclipse mass spectrometry (MS-MS) and high-pressure liquid chromatography. We used a within-participant design, in which the samples were taken after 6 hours of sleep at night and after 6 hours of sleep deprivation the following night. Systems biological databases and bioinformatic software were used to analyze the data and comparative analysis were done with other published sleep-related proteomic datasets.\nResults: Out of 494 proteins, 66 were found to be differentially expressed proteins (DEPs) after 6 hours of sleep deprivation. Functional enrichment analysis revealed the associations of these DEPs with several biological functions related to the altered regulation of cellular processes such as platelet degranulation and blood coagulation, as well as associations with different curated gene sets.\nConclusions: This study presents serum proteomic changes after 6 hours of sleep deprivation, supports previous findings showing that short sleep deprivation affects several biological processes, and reveals a molecular signature of proteins related to pathological conditions such as altered coagulation and platelet function, impaired lipid and immune function, and cell proliferation. Data are available via ProteomeXchange with identifier PXD045729. This paper is part of the Genetic and other molecular underpinnings of sleep, sleep disorders, and circadian rhythms including translational approaches Collection.", "claims": [{"id": "claim-method", "statement": "A paired two-tailed t-test for the 494 proteins was performed using the t.test function in the statistical computing software R [18] version 4.2.2 in order to identify the proteins with significant differential expression (p-values ≤ .05 were considered statistically significant) after 6 hours of sleep deprivation.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:39131770", "locator": "sections[11] \"Data analysis and statistics\" paragraph 2", "quote": "A paired two-tailed t-test for the 494 proteins was performed using the t.test function in the statistical computing software R [18] version 4.2.2 in order to identify the proteins with significant differential expression (p-values ≤ .05 were considered statistically significant) after 6 hours of sleep deprivation."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The data underlying this article are available at PRIDE with the unique identifier PDX045729.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:39131770", "locator": "sections[31] \"Data Availability\" paragraph 2", "quote": "The data underlying this article are available at PRIDE with the unique identifier PDX045729."}], "state": "complete"}, {"id": "claim-target-result", "statement": "After filtering criteria and adjustments, as described in the materials and methods section, out of 494 proteins identified and considered for further analysis, 66 proteins were found to be significantly differentiated by the paired t-test in R after 6 hours of sleep deprivation at night (uncorrected p-value ≤ .05; Table 1).", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:39131770", "locator": "sections[16] \"DEPs (66) after one night of sleep deprivation\" paragraph 2", "quote": "After filtering criteria and adjustments, as described in the materials and methods section, out of 494 proteins identified and considered for further analysis, 66 proteins were found to be significantly differentiated by the paired t-test in R after 6 hours of sleep deprivation at night (uncorrected p-value ≤ .05; Table 1)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "After filtering criteria and adjustments, as described in the materials and methods section, out of 494 proteins identified and considered for further analysis, 66 proteins were found to be significantly differentiated by the paired t-test in R after 6 hours of sleep deprivation at night (uncorrected p-value ≤ .05; Table 1).", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:39131770"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": [], "assets": ["source:pmid:39131770", "data:geo:GSE98582"], "steps": ["run_analysis"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:GSE98582"]}, "gaps": ["method:not_determinable"]}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": "2026-11-01T19:27:34Z", "independence": "single_reader"}, "evidence_check": {"method": "verbatim", "availability": "verbatim"}, "calls": 5, "usage": {"prompt_tokens": 13126, "completion_tokens": 2189, "cached_tokens": 264}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:39131770", "type": "paper", "label": "pmid:39131770"}, {"id": "source:pmid:39131770", "type": "manuscript", "label": "PMID 39131770 full text"}, {"id": "data:geo:GSE98582", "type": "dataset", "label": "GEO GSE98582"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:39131770", "type": "paper", "label": "pmid:39131770"}, {"id": "source:pmid:39131770", "type": "manuscript", "label": "PMID 39131770 full text"}, {"id": "data:geo:GSE98582", "type": "dataset", "label": "GEO GSE98582"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-39131770", "type": "extraction", "used": ["source:pmid:39131770"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-GSE98582", "type": "accession_resolution", "used": ["data:geo:GSE98582"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:39131770", "parent_hash": "sha256:9a5814a67356230e06d70c8fde773ec6133d9e42f93dc120639c500165589384", "fork_of": null, "generation": 1}, "gaps": ["asset:data:geo:GSE98582 licence not read", "asset:data:geo:GSE98582 not downloaded", "asset:data:geo:PXD032734 licence not read", "asset:data:geo:PXD032734 not downloaded", "asset:data:geo:PXD045729 licence not read", "asset:data:geo:PXD045729 not downloaded", "execution.not_run", "method.reader_named_unmapped", "review.human_critique", "review.independent_reader", "review.machine_critique"], "assays": [{"role": "data_generation", "definition_id": "mass_spectrometry", "definition_version": "99e1195c7d6f", "definition_digest": null, "required_operations": [], "support_state": "partial", "source_hashes": {"assay_lexicon": "99e1195c7d6f"}, "confidence": 0.99, "evidence": ["Human serum proteomics reveals a molecular signature after one nigh", "es after a simulated night shift. This pilot proteomic study aimed to further explore changes in hu", "were done with other published sleep-related proteomic datasets. Results: Out of 494 proteins, 66 w", "sets. Conclusions: This study presents serum proteomic changes after 6 hours of sleep deprivation,"], "order_basis": "paper_text_order:0", "id": "assay:1"}]}