Exploration and identification of diabetes targets in nursing: CDH1 and DVL1.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:39495995", "kind": "science-record", "revision": 4, "content_hash": "sha256:5b812794af2c0179658d62e524b652b6c16b441dabd037dacb8f9c71de58391c", "created_at": "2026-11-01T20:29:45Z", "updated_at": "2026-11-01T22:55:32Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Exploration and identification of diabetes targets in nursing: CDH1 and DVL1.", "doi": "10.1097/MD.0000000000040002", "pmid": "39495995", "authors": ["Fei Cheng", "Lixia Li", "Yanting Zhang"], "journal": "Medicine", "year": 2024, "abstract": "Diabetes is a chronic disease caused by absolute or relative insufficiency of insulin secretion and impaired insulin utilization. CDH1 and DVL1 role in diabetes and its nursing care is unclear. The diabetes dataset GSE21321 and GSE19790 profiles were downloaded from the gene expression omnibus (GEO) database. Perform differentially expressed genes (DEGs) screening, weighted gene co-expression network analysis (WGCNA), protein-protein interaction (PPI) network construction and analysis, functional enrichment analysis, gene set enrichment analysis (GSEA), immune infiltration analysis, and Comparative Toxicogenomics Database (CTD) analysis. Gene expression heat map was drawn. TargetScan was used to screen the miRNA that regulates central DEGs. 1983 DEGs were obtained. According to Gene Ontology (GO) analysis, they were mainly enriched in signal regulation, catenin complexes, and signal receptor binding. In Kyoto Encyclopedia of Gene and Genome (KEGG) analysis, they were mainly concentrated in the Rap1 signaling pathway, cAMP signaling pathway, and Hippo signaling pathway. The DEGs are mainly enriched in cell signaling, Wnt signaling vesicles, growth factor activity, and the interaction between neural active ligands and receptors. In the enrichment project of Metascape, BMP signaling pathways and cell population proliferation can be seen in the GO enrichment project. The soft threshold power in WGCNA is set to 5. A total of 15 modules were generated. Core gene expression heatmap showed that core genes (CTNNB1, CDH1, DVL1) were highly expressed in diabetes samples. CTD analysis showed thatCTNNB1, CDH1, DVL1were associated with weight gain, inflammation, and necrosis. CDH1 and DVL1 are highly expressed in diabetes and may become molecular targets for diabetes and its care.", "claims": [{"id": "claim-method", "statement": "The R package “limma” is used for probe aggregation and background correction of the merging matrix of GSE21321 and GSE19790.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:39495995", "locator": "sections[5] \"2.3. Screening of DEGs\" paragraph 2", "quote": "The R package “limma” is used for probe aggregation and background correction of the merging matrix of GSE21321 and GSE19790."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:39495995", "locator": "sections[29] \"fn-group\" paragraph 1", "quote": "The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request."}], "state": "complete"}, {"id": "claim-target-result", "statement": "CDH1 and DVL1 are highly expressed in diabetes and may become molecular targets for diabetes and its care.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:39495995", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "CDH1 and DVL1 are highly expressed in diabetes and may become molecular targets for diabetes and its care."}, {"asset": "source:pmid:39495995", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "1983 DEGs were obtained."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "CDH1 and DVL1 are highly expressed in diabetes and may become molecular targets for diabetes and its care.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:39495995"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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