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pmid:39827436

FHL1 as a prognostic biomarker and therapeutic target in acute promyelocytic leukaemia.

Discover oncology · 2025 doi:10.1007/s12672-025-01738-6

Paper

partial

Experiment

partial

Data

partial

Analysis

absent

Execution

absent

Execution evidence has not yet been added to this .science file. Explore its methods, data and open questions to plan the next step.
Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
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pmid:39827436
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science-record
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https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json
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2026-11-01T10:25:49Z
updated_at
2026-11-01T10:25:49Z
generator object · 3 fields
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corpus-assay-engine
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sep_to_sci_v1
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urn:bntrg:sep:1.0.0
paper object · 10 fields
state
partial
title
FHL1 as a prognostic biomarker and therapeutic target in acute promyelocytic leukaemia.
doi
10.1007/s12672-025-01738-6
pmid
39827436
authors
null
journal
Discover oncology
year
2025
abstract
null
claims array · 1 item
[0] object · 6 fields
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claim-1
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the headline numerical result the paper states for its main finding
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qualitative
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null
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null
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null
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null
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[0]
abstract
[1]
authors
experiment object · 8 fields
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partial
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the headline numerical result the paper states for its main finding
steps array · 3 items
[0] object · 13 fields
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read_published_estimate
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1
name
Read the published estimate and its interval from the source
kind
other
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complete
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null
description
The number a replication must land on, and the sentence it came from.
parameters object · 0 fields
inputs array · 1 item
[0]
source:pmid:39827436
outputs array · 1 item
[0]
the published estimate, its unit and its interval
instruments array · 0 items
reagents array · 0 items
[1] object · 13 fields
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obtain_source_data
order
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data-preparation
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blocked
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The published result cannot be recomputed without the data the paper analysed.
parameters object · 0 fields
inputs array · 0 items
outputs array · 1 item
[0]
the source data with its provenance
instruments array · 0 items
reagents array · 0 items
[2] object · 13 fields
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run_analysis
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Run the analysis programme
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blocked
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no owned computational capability is bound to this experiment
description
Re-run the paper's analysis on the source data and produce the registered result. | SEP input not carried into the asset list: materials:the source data behind the published result in pmid:39827436
parameters object · 0 fields
inputs array · 0 items
outputs array · 1 item
[0]
the registered result
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step:run_analysis input 'materials:the source data behind the published result in pmid:39827436' does not resolve to a declared asset
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partial
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read_published_estimate
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source:pmid:39827436
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corpus_record_absent
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partial
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FHL1 was found to be the most prognostic independent biomarker by GSE12417 screening and GSE37642 validation.
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2026-10-31T15:20:18.255409+00:00
[1] object · 8 fields
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<think>We need answer JSON only. Need inspect source. Registered target headline numerical result paper states for main finding. Source appears abstract snippets no numerical result except dataset IDs, thresholds, versions, 1000 permutations, p values, DOI. It says FHL1 most prognostic independent biomarker, highly expressed, knockdown increases sensitivity. No headline numeric result for main finding. Therefore number_stated false, parent_value 0, unit "", evidence "". target_result what text states instead. Need likely concise exact statement, maybe "FHL1 was found to be the most prognostic independent biomarker by GSE12417 screening and GSE37642 validation. FHL1 is highly expressed in AML, and knockdown of FHL1 can increase the sensitivity of AML cells to cytarabine and daunorubicin." Could mention no numerical result. Need valid JSON. Ensure target_result perhaps textual findings. They demand "say in target_result what the text does state instead." Could say "The text states that FHL1 was found to be the most prognostic independent biomarker..." This is not evidence requirement because false. Exact quote perhaps beneficial, but target result can paraphrase? They say say what text does state instead. Could quote exactly. Headline number only if exists, but doesn't. Need be cautious: Could "GSE12417" be numerical, but not result. No. "P &lt; 0.1" methodological cutoff. "1000" permutations. "3.6.1", "8". Main finding qualitative. So false. JSON: { "parent_value": 0, "unit": "", "evidence": "", "target_result": "The text states that FHL1 was found to be the most prognostic independent biomarker by GSE12417 screening and GSE37642 validation; it also states that FHL1 is highly expressed in AML and that knockdown of FHL1 can increase AML-cell sensitivity to cytarabine and daunorubicin. It does not state a headline numerical result for the main finding.", "number_stated": false } Could exact quote perhaps target_result exact: “FHL1 was found ...” The instruction evidence must exact quotation only if number stated? "The evidence must be an exact..." but false means evidence empty. target_result should state what text does. Could use exact quotation, preserving. Need JSON escaping en dash not issue. Let's provide.</think> {"parent_value":0,"unit":"","evidence":"","target_result":"The text states: \"FHL1 was found to be the most prognostic independent biomarker by GSE12417 screening and GSE37642 validation. FHL1 is highly expressed in AML, and knockdown of FHL1 can increase the sensitivity of AML cells to cytarabine and daunorubicin.\" No headline numerical result for the main finding is stated.","number_stated":false}
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parent_value
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The text states: "FHL1 was found to be the most prognostic independent biomarker by GSE12417 screening and GSE37642 validation. FHL1 is highly expressed in AML, and knockdown of FHL1 can increase the sensitivity of AML cells to cytarabine and daunorubicin." No headline numerical result for the main finding is stated.
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[2]
gene set enrichment analysis (GSEA)
[3]
Wilcoxon rank-sum test
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Kruskal–Wallis test
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Wilcoxon rank-sum test
[5]
Kruskal–Wallis test
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step:run_analysis input 'materials:the source data behind the published result in pmid:39827436' does not resolve to a declared asset
[12]
targets
Complete file
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"6baf8802069d33d83374f82d5f0f6ae09f0f027f1e2c5288e4614048a657b2e8", "raw_response": "<think>We need answer JSON only. Need inspect source. Registered target headline numerical result paper states for main finding. Source appears abstract snippets no numerical result except dataset IDs, thresholds, versions, 1000 permutations, p values, DOI. It says FHL1 most prognostic independent biomarker, highly expressed, knockdown increases sensitivity. No headline numeric result for main finding. Therefore number_stated false, parent_value 0, unit \"\", evidence \"\". target_result what text states instead. Need likely concise exact statement, maybe \"FHL1 was found to be the most prognostic independent biomarker by GSE12417 screening and GSE37642 validation. FHL1 is highly expressed in AML, and knockdown of FHL1 can increase the sensitivity of AML cells to cytarabine and daunorubicin.\" Could mention no numerical result. Need valid JSON. Ensure target_result perhaps textual findings. They demand \"say in target_result what the text does state instead.\" Could say \"The text states that FHL1 was found to be the most prognostic independent biomarker...\" This is not evidence requirement because false. Exact quote perhaps beneficial, but target result can paraphrase? They say say what text does state instead. Could quote exactly. Headline number only if exists, but doesn't.\n\nNeed be cautious: Could \"GSE12417\" be numerical, but not result. No. \"P &lt; 0.1\" methodological cutoff. \"1000\" permutations. \"3.6.1\", \"8\". Main finding qualitative. So false.\n\nJSON:\n{\n \"parent_value\": 0,\n \"unit\": \"\",\n \"evidence\": \"\",\n \"target_result\": \"The text states that FHL1 was found to be the most prognostic independent biomarker by GSE12417 screening and GSE37642 validation; it also states that FHL1 is highly expressed in AML and that knockdown of FHL1 can increase AML-cell sensitivity to cytarabine and daunorubicin. It does not state a headline numerical result for the main finding.\",\n \"number_stated\": false\n}\nCould exact quote perhaps target_result exact: “FHL1 was found ...” The instruction evidence must exact quotation only if number stated? \"The evidence must be an exact...\" but false means evidence empty. target_result should state what text does. Could use exact quotation, preserving. Need JSON escaping en dash not issue. Let's provide.</think>\n\n{\"parent_value\":0,\"unit\":\"\",\"evidence\":\"\",\"target_result\":\"The text states: \\\"FHL1 was found to be the most prognostic independent biomarker by GSE12417 screening and GSE37642 validation. FHL1 is highly expressed in AML, and knockdown of FHL1 can increase the sensitivity of AML cells to cytarabine and daunorubicin.\\\" No headline numerical result for the main finding is stated.\",\"number_stated\":false}", "reading": {"parent_value": 0, "unit": "", "evidence": "", "target_result": "The text states: \"FHL1 was found to be the most prognostic independent biomarker by GSE12417 screening and GSE37642 validation. FHL1 is highly expressed in AML, and knockdown of FHL1 can increase the sensitivity of AML cells to cytarabine and daunorubicin.\" No headline numerical result for the main finding is stated.", "number_stated": false, "source_locator": null}, "recorded_at": "2026-10-31T15:20:21.511072+00:00"}], "agreement": true, "disagreements": {"target_result": {"minimax": "unclear", "minimax_alt": "unknown", "decisive": false}, "analysis_methods": {"minimax": ["Kaplan–Meier survival analysis", "univariate Cox regression analysis", "gene set enrichment analysis (GSEA)", "Wilcoxon rank-sum test", "Kruskal–Wallis test"], "minimax_alt": ["Gene Expression Omnibus data analysis", "Kaplan–Meier survival analysis", "univariate Cox regression analysis", "gene set enrichment analysis (GSEA)", "Wilcoxon rank-sum test", "Kruskal–Wallis test"], "decisive": false}}, "agreement_basis": {"policy": "decisive_fields", "decisive_fields": ["work_type", "number_stated", "parent_value", "unit"]}, "blinded": true}, "human_critique": {"status": "not_run", "reviewer": null, "signed_at": null, "conflict_checked": false, "commentary": null}, "stages": [{"key": "target_materials", "status": "pending", "reason": null, "evidence": null}, {"key": "independent_readings", "status": "passed", "reason": "The independent readings are incomplete or disagree; the source evidence must resolve the difference.", "evidence": {"provider_errors": []}}, {"key": "source_resolution", "status": "pending", "reason": null, "evidence": null}, {"key": "protocol_reconstruction", "status": "pending", "reason": null, "evidence": null}, {"key": "control_execution", "status": "pending", "reason": null, "evidence": null}, {"key": "control_comparison", "status": "pending", "reason": null, "evidence": null}, {"key": "publication", "status": "pending", "reason": null, "evidence": null}], "gaps": ["review.human_critique", "review.machine_critique.passed"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "package:3e6712188bc903dea96e97a7f0ade2fe935dac8a774d1167c245170114bf0d6f", "type": "sep_package", "label": "SEP v1 package for pmid:39827436"}], "activities": [{"id": "activity:conversion:pmid:39827436", "type": "conversion", "used": ["package:3e6712188bc903dea96e97a7f0ade2fe935dac8a774d1167c245170114bf0d6f"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:minimax", "type": "model", "label": "minimax"}, {"id": "agent:minimax_alt", "type": "model", "label": "minimax_alt"}, {"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}], "source_run_id": "run-20261023T122449232913", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "11d6255a-f6f8-4f82-b14e-0dfb982ec0a8", "parent_hash": "3e6712188bc903dea96e97a7f0ade2fe935dac8a774d1167c245170114bf0d6f", "fork_of": null, "generation": 1}, "gaps": ["abstract", "asset:source:pmid:39827436 not verified", "authors", "capability", "corpus_record_absent", "execution.not_run", "method", "review.human_critique", "review.machine_critique.passed", "step:obtain_source_data blocked on data:not_downloaded", "step:run_analysis blocked on no owned computational capability is bound to this experiment", "step:run_analysis input 'materials:the source data behind the published result in pmid:39827436' does not resolve to a declared asset", "targets"]}