Development and validation of a prognostic model based on disulfidptosis-related ferroptosis genes: DRD4 and SLC2A3 as biomarkers for predicting prognosis in colon cancer.

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"MiniMax-M3", "prompt_version": "full-text-reading-v1", "prompt_hash": "339e516fd5d83b7c956135d68b13e66c69a273f56ef34df5872985280b6746fb", "source_hash": "a8033752f0000a738ac0710a28206c9c47c6552a48761fb446c77674b85531cd", "raw_response_sha256": "sha256:01b2bdeeb4d25a83c832f2d4e16afe33ac57ba14504556b9e19625b31977d37d", "raw_response_chars": 31660}], "target_providers": [{"provider": "minimax", "model": "MiniMax-M3.1-Flash", "prompt_version": "replication-target-v2", "prompt_hash": "986a8e192dac50f08e1605aeebde3598e42c23e020d0c6348c155ac962ff62d0", "source_hash": "a8033752f0000a738ac0710a28206c9c47c6552a48761fb446c77674b85531cd", "raw_response": "{\"parent_value\":0.75,\"unit\":\"C-index\",\"evidence\":\"with a C-index of 0.75 indicating strong predictive accuracy\",\"target_result\":\"The final prognostic model has a C-index of 0.75.\",\"number_stated\":true}", "reading": {"parent_value": 0.75, "unit": "C-index", "evidence": "with a C-index of 0.75 indicating strong predictive accuracy", "target_result": "The final prognostic model has a C-index of 0.75.", "number_stated": true, "source_locator": "chars 2095-2155 of source sha256 a8033752f0000a738ac0710a28206c9c47c6552a48761fb446c77674b85531cd"}, "recorded_at": "2026-10-31T15:24:27.341592+00:00"}, {"provider": "minimax_alt", "model": "MiniMax-M3", "prompt_version": "replication-target-v2", "prompt_hash": "bd77c2b0a9e943633ed726aec6c17d886608b3e136ef62e2df1e4284b283970e", "source_hash": "a8033752f0000a738ac0710a28206c9c47c6552a48761fb446c77674b85531cd", "raw_response": "<think>We need answer JSON only. Need identify single numerical result headline main finding. Registered target: headline numerical result paper states for main finding. Likely C-index 0.75. Need unit as printed. Evidence exact contiguous quote containing number and attribution, whole clause. \"High expression levels ... poor prognosis, with a C-index of 0.75 indicating strong predictive accuracy.\" Parent_value 0.75. Unit perhaps \"C-index\" (unit the paper prints). Could unit empty? They ask unit must be unit paper prints. C-index is dimensionless metric, but paper says \"a C-index of 0.75\". Use unit \"C-index\". Evidence exact contiguous quote. target_result concise maybe \"C-index of 0.75\". number_stated true.\n\nNeed be careful: headline numerical result could be HR? Main finding stated in abstract is C-index 0.75. They explicitly headline number. The prompt likely from task where registered target generic \"headline numerical result ... main finding\", and source supplies a summary. Yes C-index.\n\nExact quote should contain number and attribution. Could use sentence exactly: \"High expression levels of DRD4 and SLC2A3 correlated with advanced clinicopathological stages and poor prognosis, with a C-index of 0.75 indicating strong predictive accuracy.\" This is contiguous exact. unit perhaps \"C-index\". JSON valid.</think>\n\n{\"parent_value\":0.75,\"unit\":\"C-index\",\"evidence\":\"High expression levels of DRD4 and SLC2A3 correlated with advanced clinicopathological stages and poor prognosis, with a C-index of 0.75 indicating strong predictive accuracy.\",\"target_result\":\"The prognostic model achieved a C-index of 0.75.\",\"number_stated\":true}", "reading": {"parent_value": 0.75, "unit": "C-index", "evidence": "High expression levels of DRD4 and SLC2A3 correlated with advanced clinicopathological stages and poor prognosis, with a C-index of 0.75 indicating strong predictive accuracy.", "target_result": "The prognostic model achieved a C-index of 0.75.", "number_stated": true, "source_locator": "chars 1981-2156 of source sha256 a8033752f0000a738ac0710a28206c9c47c6552a48761fb446c77674b85531cd"}, "recorded_at": "2026-10-31T15:24:31.095926+00:00"}], "agreement": true, "disagreements": {"target_result": {"minimax": "C-index of 0.75 indicating strong predictive accuracy", "minimax_alt": "The final DRD4/SLC2A3 prognostic model achieved a C-index of 0.75, indicating strong predictive accuracy.", "decisive": false}, "analysis_methods": {"minimax": ["Pearson correlation analysis", "least absolute shrinkage and selection operator (LASSO)", "Cox regression analysis", "C-index"], "minimax_alt": ["Pearson correlation analysis", "least absolute shrinkage and selection operator (LASSO)", "Cox regression analysis", "univariate and multivariate Cox regression analyses", "C-index", "random allocation into training and validation cohorts", "external cohort validation", "nomogram", "paired t-test"], "decisive": false}}, "agreement_basis": {"policy": "decisive_fields", "decisive_fields": ["work_type", "number_stated", "parent_value", "unit"]}, "blinded": true}, "human_critique": {"status": "not_run", "reviewer": null, "signed_at": null, "conflict_checked": false, "commentary": null}, "stages": [{"key": "target_materials", "status": "pending", "reason": null, "evidence": null}, {"key": "independent_readings", "status": "passed", "reason": "The independent readings are incomplete or disagree; the source evidence must resolve the difference.", "evidence": {"provider_errors": []}}, {"key": "source_resolution", "status": "pending", "reason": null, "evidence": null}, {"key": "protocol_reconstruction", "status": "pending", "reason": null, "evidence": null}, {"key": "control_execution", "status": "pending", "reason": null, "evidence": null}, {"key": "control_comparison", "status": "pending", "reason": null, "evidence": null}, {"key": "publication", "status": "pending", "reason": null, "evidence": null}], "gaps": ["review.human_critique", "review.machine_critique.passed"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "package:2847d77ac8d78aed3ae7ad897e4e98fc4a2b22c8af7bb48d24d24606f4b7d716", "type": "sep_package", "label": "SEP v1 package for pmid:39974379"}], "activities": [{"id": "activity:conversion:pmid:39974379", "type": "conversion", "used": ["package:2847d77ac8d78aed3ae7ad897e4e98fc4a2b22c8af7bb48d24d24606f4b7d716"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:minimax", "type": "model", "label": "minimax"}, {"id": "agent:minimax_alt", "type": "model", "label": "minimax_alt"}, {"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}], "source_run_id": "run-20261023T122449232913", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "2e77ea47-c2e8-48f6-8e32-389c78e79ac0", "parent_hash": "2847d77ac8d78aed3ae7ad897e4e98fc4a2b22c8af7bb48d24d24606f4b7d716", "fork_of": null, "generation": 1}, "gaps": ["abstract", "asset:source:pmid:39974379 not verified", "authors", "capability", "corpus_record_absent", "execution.not_run", "method", "review.human_critique", "review.machine_critique.passed", "step:obtain_source_data blocked on data:not_downloaded", "step:run_analysis blocked on no owned computational capability is bound to this experiment", "step:run_analysis input 'materials:the source data behind the published result in pmid:39974379' does not resolve to a declared asset", "targets"]}