Immunological profile of lactate metabolism-related genes in Psoriasis a comprehensive analysis based on bulk and single-cell RNA sequencing data.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:40011693", "kind": "science-record", "revision": 3, "content_hash": "sha256:bef28bd4ba5f2f48647fc9bbd8454a9bb0af91b08c931fd3c6b05d9fbf4c4cbb", "created_at": "2026-11-01T20:30:14Z", "updated_at": "2026-11-01T22:13:41Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Immunological profile of lactate metabolism-related genes in Psoriasis a comprehensive analysis based on bulk and single-cell RNA sequencing data.", "doi": "10.1038/s41598-025-91237-z", "pmid": "40011693", "authors": ["Si-Yu Liu", "Juan Lv", "Fangqing Li", "Yi-Xuan Zhang"], "journal": "Scientific reports", "year": 2025, "abstract": "Psoriasis (Pso) is a chronic erythema squamous disease often accompanied by metabolic abnormalities. Disturbances in lactate metabolism have been observed in the skin of patients with Pso, but the role of lactate metabolism in the pathogenesis of Pso remains unclear. To identify core genes associated with lactate metabolism in Pso, we downloaded and merged two Pso-related datasets (GSE13355, GSE109248) from the GEO database. Through comprehensive analysis, we analyzed the functions associated with these hub genes and the correlation between their expression levels and immune infiltration. Additionally, we explored lactate metabolism-related hub genes in different immune cells using single-cell sequencing data. We identified four lactate metabolism-related hub genes that are highly associated with Pso. Further analysis revealed that these four hub genes were significantly correlated with the levels of immune cell infiltration. To further elucidate the impact of lactate metabolism on immune cells, we analyzed single-cell sequencing data from healthy controls and Pso patients. The expression of lactate metabolism-related hub genes was primarily observed in moDCs and T cells. These results suggest that lactate metabolism-related genes and their functions are closely associated with changes in inflammatory cells in Pso patients. This study provides new insights into the role of lactate metabolism in the pathogenesis of Pso and highlights potential therapeutic targets for the disease.", "claims": [{"id": "claim-method", "statement": "The R-based ‘glmnet’ package was utilized to execute the LASSO regression analysis.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:40011693", "locator": "sections[6] \"Least absolute shrinkage and selection operator (LASSO)\" paragraph 2", "quote": "The R-based ‘glmnet’ package was utilized to execute the LASSO regression analysis."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The original contributions presented in the study are publicly available. 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This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE109248"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE109248"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:40011693", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.1038/s41598-025-91237-z", "sha256": "sha256:e96c052b776483136f07cbd5af33bc5c273db195ab81c8cf980491097151cc70", "bytes": 30811, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.1038/s41598-025-91237-z", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC11865271", "source": "europe_pmc_fulltext", "coverage": "whole_body_without_references", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE109248", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE109248", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE109248", "version": null, "note": "The original contributions presented in the study are publicly available. 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