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pmid:40081214
O-GlcNAc-modified HOXA9 suppresses ferroptosis via promoting UBR5-mediated SIRT6 degradation in nasopharyngeal carcinoma.
Neoplasia (New York, N.Y.) · 2025 doi:10.1016/j.neo.2025.101142
Paper
partial
Experiment
partial
Data
partial
Analysis
absent
Execution
absent
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Complete file
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Need inspect source. Target headline numerical result paper states for main finding. Source abstract/results qualitative, methods numerical reagent amounts and stats, GEO accession, p thresholds, perhaps no headline numerical result. Need determine registered target: \"the headline numerical result the paper states for its main finding\". They ask single numerical result replication target reproduce. No numerical quantitative result in supplied text for main finding. We must number_stated false parent 0 unit/evidence empty target_result say what text states instead. Need formulate target_result perhaps qualitative main finding. Must exact quote evidence empty. Need not invent. JSON valid.\n\nNeed perhaps main finding has no number, but source includes \"2 µg\", \"2 hours\", p values, dataset. Yet target is headline numerical result. No headline numeric result. Thus false. target_result wording can state: \"The text reports that O-GlcNAc-modified HOXA9 inhibits ferroptosis by enhancing UBR5 expression and ubiquitination and degradation of SIRT6 in NPC cells, thus accelerating NPC progression, but gives no numerical result for this main finding.\" Is that okay? \"say in target_result what text does state instead.\" Could quote exact conclusion. Need perhaps avoid claiming exact if target_result need no quote requirement. Use textual statement. Unit and evidence empty. parent 0. Ensure JSON only.</think>\n\n{\"parent_value\":0,\"unit\":\"\",\"evidence\":\"\",\"target_result\":\"The text states that O-GlcNAc-modified HOXA9 inhibits ferroptosis by enhancing UBR5 expression and ubiquitination and degradation of SIRT6 in NPC cells, thus accelerating NPC progression, but it gives no numerical result for this main finding.\",\"number_stated\":false}", "reading": {"parent_value": 0, "unit": "", "evidence": "", "target_result": "The text states that O-GlcNAc-modified HOXA9 inhibits ferroptosis by enhancing UBR5 expression and ubiquitination and degradation of SIRT6 in NPC cells, thus accelerating NPC progression, but it gives no numerical result for this main finding.", "number_stated": false, "source_locator": null}, "recorded_at": "2026-10-31T15:33:34.060580+00:00"}], "agreement": true, "disagreements": {"target_result": {"minimax": "O-GlcNAc-modified HOXA9 inhibits ferroptosis by enhancing UBR5 expression and ubiquitination and degradation of SIRT6 in NPC cells, thus accelerating NPC progression.", "minimax_alt": "unclear — no headline numerical result is stated in the supplied text. 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