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pmid:40177272

Development and validation of a 14-CpG DNA methylation signature and drug targets for prognostic prediction in breast cancer.

Frontiers in medicine · 2025 doi:10.3389/fmed.2025.1548726

Paper

partial

Experiment

partial

Data

partial

Analysis

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Execution

absent

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Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
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pmid:40177272
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science-record
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title
Development and validation of a 14-CpG DNA methylation signature and drug targets for prognostic prediction in breast cancer.
doi
10.3389/fmed.2025.1548726
pmid
40177272
authors
null
journal
Frontiers in medicine
year
2025
abstract
null
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the headline numerical result the paper states for its main finding
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Read the published estimate and its interval from the source
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other
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The number a replication must land on, and the sentence it came from.
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the published estimate, its unit and its interval
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the source data with its provenance
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Run the analysis programme
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no owned computational capability is bound to this experiment
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Re-run the paper's analysis on the source data and produce the registered result. | SEP input not carried into the asset list: materials:the source data behind the published result in pmid:40177272
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ROC curve for various cut-off levels of the risk score.
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11
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Construction of risk model based on prognosis-related CpGs
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Table 1
caption
ROC curve for various cut-off levels of the risk score.
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[0] array · 4 items
[0]
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Sensitivity
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Specificity
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DOC
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Demographic and clinical, pathologic characteristics of the patient with BC.
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12
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Demographic and clinical, pathologic characteristics
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Table 2
caption
Demographic and clinical, pathologic characteristics of the patient with BC.
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[0]
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Total
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Group
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c 2
[4]
p-value
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[0]
Low risk
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High risk
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[0]
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[1]
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[2]
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[0]
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[1]
95
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63
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32
[4]
4.600
[5]
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191
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205
[4]
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86
[3]
44
[4]
79.974
[5]
<0.001
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338
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143
[4]
[5]
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[0]
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92
[4]
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[0]
HER2
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29
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41
[4]
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63
[3]
108
[4]
[5]
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T1
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179
[3]
83
[4]
14.271
[5]
0.001
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333
[3]
270
[4]
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[2]
89
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[4]
[5]
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[2]
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[3]
208
[4]
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[5]
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[2]
97
[3]
88
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[1]
1,013
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595
[3]
418
[4]
2.924
[5]
0.087
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[0]
M1
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16
[2]
6
[3]
10
[4]
[5]
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Univariate and multivariate Cox proportional hazard models of PFI in BC.
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pmcid
PMC11961922
section_index
13
section_title
A 14 CpGs signature associated with prognosis of patients with BC
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20
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Table 3
caption
Univariate and multivariate Cox proportional hazard models of PFI in BC.
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[0]
Variables
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Univariate
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Multivariate
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95% CI
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p-value
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p-value
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[0]
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Molecular subtype
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0.420–1.106
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0.120
[4]
[5]
[6]
[7] array · 7 items
[0]
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0.371–1.306
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[5]
[6]
[8] array · 7 items
[0]
HER2
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[5]
[6]
[9] array · 7 items
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Basal-like
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0.703–2.054
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[5]
[6]
[10] array · 1 item
[0]
Tumor size status
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T2
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1.137–3.024
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[4]
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[5]
0.829–2.273
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0.218
[12] array · 7 items
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T3–T4
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2.099–6.133
[3]
<0.001
[4]
1.956
[5]
1.089–3.511
[6]
0.025
[13] array · 1 item
[0]
Lymph node status
[14] array · 7 items
[0]
N1
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1.646
[2]
1.090–2.486
[3]
0.018
[4]
1.412
[5]
0.921–2.387
[6]
0.113
[15] array · 7 items
[0]
N2–N3
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3.181
[2]
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[3]
<0.001
[4]
2.040
[5]
1.232–3.377
[6]
0.006
[16] array · 1 item
[0]
Metastasis status
[17] array · 7 items
[0]
M1
[1]
7.841
[2]
4.407–13.942
[3]
<0.001
[4]
3.632
[5]
1.898–6.951
[6]
<0.001
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[0]
Risk group
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[0]
High risk
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2.717
[2]
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[3]
<0.001
[4]
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[5]
1.730–3.607
[6]
<0.001
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[0]
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read_published_estimate
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xml
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source:pmid:40177272
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corpus_record_absent
review object · 5 fields
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minimax
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[1] object · 7 fields
provider
minimax_alt
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minimax
A 14-CpG DNA methylation prognostic model significantly associated with progression-free interval (PFI), disease-specific survival (DSS), and overall survival (OS) in breast cancer patients.
minimax_alt
A 14-CpG DNA methylation model significantly associated with progression-free interval (PFI), disease-specific survival (DSS), and overall survival (OS) in BC patients.
decisive
false
analysis_methods object · 3 fields
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[0]
univariate Cox proportional hazard regression
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LASSO Cox regression
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Kaplan–Meier survival analysis with log-rank test
[3]
receiver operating characteristic analysis
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nomogram validation
minimax_alt array · 7 items
[0]
Wilcoxon test for differential analysis of methylated CpGs
[1]
Univariate Cox regression
[2]
LASSO Cox regression
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Kaplan–Meier analysis with the log-rank test
[4]
Receiver operating characteristic (ROC) curve analysis
[5]
Nomogram validation
[6]
Chi-square test
decisive
false
statistical_method object · 3 fields
minimax
univariate Cox proportional hazard regression and LASSO Cox regression
minimax_alt
Univariate Cox regression followed by LASSO Cox regression
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true
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decisive_fields
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[0]
work_type
[1]
number_stated
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parent_value
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null
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null
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target_materials
status
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null
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null
[1] object · 4 fields
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independent_readings
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minimax
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HTTP Error 429: Too Many Requests
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provider
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HTTP Error 429: Too Many Requests
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source_resolution
status
pending
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protocol_reconstruction
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review.human_critique
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sep_package
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agent:minimax
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minimax
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agent:minimax_alt
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minimax_alt
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agent:corpus-assay-engine
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lineage object · 4 fields
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step:run_analysis input 'materials:the source data behind the published result in pmid:40177272' does not resolve to a declared asset
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targets
Complete file
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