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pmid:40219635

Transcriptomic miRNA and mRNA signatures in primary prostate cancer that are associated with lymph-node invasion.

Clinical and translational medicine · 2025 doi:10.1002/ctm2.70288

Paper

partial

Experiment

partial

Data

partial

Analysis

absent

Execution

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Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
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pmid:40219635
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science-record
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2026-11-01T10:25:50Z
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title
Transcriptomic miRNA and mRNA signatures in primary prostate cancer that are associated with lymph-node invasion.
doi
10.1002/ctm2.70288
pmid
40219635
authors
null
journal
Clinical and translational medicine
year
2025
abstract
null
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the published estimate, its unit and its interval
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Clinical and pathological variables of prostate cancer (PCa) patients included in the human transcriptome panel (HTP) dataset.
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Study design
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TABLE 1
caption
Clinical and pathological variables of prostate cancer (PCa) patients included in the human transcriptome panel (HTP) dataset.
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pN1 group (n = 44)
[2]
pN0 group (n = 44)
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p‐value
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[0]
Age at surgery, median (range)
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65 (52–80)
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68 (51–78)
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.375
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Clinical and pathological variables of prostate cancer (PCa) patients of the TCGA‐PRAD dataset.
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Transcriptomic patterns found in primary PCa of patients with confirmed LNM
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TABLE 2
caption
Clinical and pathological variables of prostate cancer (PCa) patients of the TCGA‐PRAD dataset.
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p‐value
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Common differentially expressed genes (DEGs) in tissue samples from pathologically diagnosed as N1 (pN1) versus pathologically diagnosed as N0 (pN0) prostate cancer (PCa) patients using the human transcriptome panel (HTP) or TCGA‐PRAD datasets.
structure object · 5 fields
pmcid
PMC11992358
section_index
8
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Transcriptomic patterns found in primary PCa of patients with confirmed LNM
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12
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TABLE 3
caption
Common differentially expressed genes (DEGs) in tissue samples from pathologically diagnosed as N1 (pN1) versus pathologically diagnosed as N0 (pN0) prostate cancer (PCa) patients using the human transcriptome panel (HTP) or TCGA‐PRAD datasets.
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DEGs associated with RFS (HTP)
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DEGs associated with increased number of pN1 cases (HTP)
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[0]
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[4]
Yes
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[0]
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Yes
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[0]
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[0]
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[4]
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[4]
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[5]
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[11] array · 6 items
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[4]
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[5]
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Clinical and pathological variables of the prostate cancer (PCa) patients obtained from the GSE220095 dataset.
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PMC11992358
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9
section_title
Validation of the mRNA signature in PCa primary tumours
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TABLE 4
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Clinical and pathological variables of the prostate cancer (PCa) patients obtained from the GSE220095 dataset.
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[0]
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p‐value
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[2]
[3]
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[0]
pT2
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107 (77.5%)
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<.0001
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pT3a
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22 (16%)
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[0]
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[0]
GG, n (%)
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[3]
[8] array · 4 items
[0]
GG2
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100 (72.5%)
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GG3
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28 (20%)
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Upregulated miRs in primary tumour tissues from pathologically diagnosed as N1 (pN1) versus pathologically diagnosed as N0 (pN0) patients using the whole‐transcriptome assay (WTA) dataset.
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PMC11992358
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12
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The miR and mRNA levels were negatively correlated in primary PCa tumours of patients who develop LNM
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TABLE 5
caption
Upregulated miRs in primary tumour tissues from pathologically diagnosed as N1 (pN1) versus pathologically diagnosed as N0 (pN0) patients using the whole‐transcriptome assay (WTA) dataset.
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Upregulated miRs associated with increased number of pN1 cases (WTA)
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[3]
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No
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[3]
Yes
[4]
No
[6] array · 5 items
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[2]
No
[3]
Yes
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No
[7] array · 5 items
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miR‐3687
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[3]
Yes
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[0]
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[3]
Yes
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review.machine_critique.blocked
[9]
review.machine_critique.providers
[10]
step:obtain_source_data blocked on data:not_downloaded
[11]
step:run_analysis blocked on no owned computational capability is bound to this experiment
[12]
step:run_analysis input 'materials:the source data behind the published result in pmid:40219635' does not resolve to a declared asset
[13]
targets
Complete file
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