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pmid:40386276

High-frequency KRAS mutations in pancreatic adenocarcinoma: prognostic significance and potential co-targeting therapies.

Translational cancer research · 2025 doi:10.21037/tcr-24-1832

Paper

partial

Experiment

partial

Data

partial

Analysis

absent

Execution

absent

Execution evidence has not yet been added to this .science file. Explore its methods, data and open questions to plan the next step.
Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
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pmid:40386276
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High-frequency KRAS mutations in pancreatic adenocarcinoma: prognostic significance and potential co-targeting therapies.
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10.21037/tcr-24-1832
pmid
40386276
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null
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Translational cancer research
year
2025
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the published estimate, its unit and its interval
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Univariate and multivariate analysis of overall survival by clinicopathologic characteristics (patients with KRASG12C, G12D, G12V mutation)
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KRAS mutations as independent prognostic risk factors in PAAD
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Table 1
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Univariate and multivariate analysis of overall survival by clinicopathologic characteristics (patients with KRASG12C, G12D, G12V mutation)
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[1]
Univariate
[2]
[3]
Multivariate
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[1]
P value
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[3]
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[0]
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[1]
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[2]
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[3]
[4]
1.02 (0.99–1.05)
[5]
0.12
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[0]
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[2]
[3]
[4]
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[0]
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[5]
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[0]
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[3]
[4]
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[3]
[4]
1.00 (reference)
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[3]
[4]
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[5]
0.28
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[0]
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0.41
[3]
[4]
[5]
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[0]
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[1]
2.91 (0.68–12.45)
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0.15
[3]
[4]
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[2]
[3]
[4]
[5]
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[3]
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1.00 (reference)
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[4]
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0.06
[32] array · 6 items
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0.01
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0.02
[33] array · 6 items
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0.65
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[4]
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[34] array · 6 items
[0]
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[4]
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1.00 (reference)
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[3]
[4]
1.00 (reference)
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Distant metastasis
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1.30 (0.80–2.13)
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0.29
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[4]
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[0]
Locoregional recurrence
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2.34 (1.25–4.38)
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0.008
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[4]
2.49 (1.08–5.75)
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0.03
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[0]
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[39] array · 6 items
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1.00 (reference)
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[3]
[4]
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[40] array · 6 items
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0.38
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Family history of cancer
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[2]
[3]
[4]
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[1]
1.00 (reference)
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1.03 (0.57–1.85)
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0.93
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[4]
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[0]
History of chronic pancreatitis
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[2]
[3]
[4]
[5]
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No
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1.00 (reference)
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[4]
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Yes
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2.15 (0.92–5.03)
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History of diabetes
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1.00 (reference)
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1.10 (0.60–1.99)
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0.76
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[3]
[4]
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1.00 (reference)
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1.00 (reference)
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0.36 (0.16–0.79)
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0.01
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0.29 (0.12–0.71)
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0.006
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1.00 (reference)
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0.68 (0.43–1.07)
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