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pmid:40398662

β-catenin is a Potential Prognostic Biomarker in Uterine Sarcoma.

Technology in cancer research & treatment · 2025 doi:10.1177/15330338251345208

Paper

partial

Experiment

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Data

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Analysis

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Execution

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Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
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2026-11-01T10:25:50Z
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β-catenin is a Potential Prognostic Biomarker in Uterine Sarcoma.
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10.1177/15330338251345208
pmid
40398662
authors
null
journal
Technology in cancer research & treatment
year
2025
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null
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the published estimate, its unit and its interval
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Baseline Characteristics of 31 US Patients from the Clinical Cohort.
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9
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Baseline Characteristics
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Table 1.
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Baseline Characteristics of 31 US Patients from the Clinical Cohort.
rows array · 39 items
[0] array · 7 items
[0]
Characteristics
[1]
All Patients
[2]
AS
[3]
LG-ESS
[4]
HG-ESS
[5]
LMS
[6]
P value
[1] array · 5 items
[0]
(n = 31)
[1]
(n = 1)
[2]
(n = 12)
[3]
(n = 2)
[4]
(n = 16)
[2] array · 7 items
[0]
Age at diagnosis (years), n (%)
[1]
[2]
[3]
[4]
[5]
[6]
.389
[3] array · 7 items
[0]
≤50
[1]
16 (51.61)
[2]
1 (6.25)
[3]
6 (37.5)
[4]
0 (0.00)
[5]
9 (56.25)
[6]
[4] array · 7 items
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>50
[1]
15 (48.39)
[2]
0 (0.00)
[3]
6 (40.0)
[4]
2 (13.33)
[5]
7 (46.67)
[6]
[5] array · 7 items
[0]
Menopausal status, n (%)
[1]
[2]
[3]
[4]
[5]
[6]
.872
[6] array · 7 items
[0]
Postmenopausal
[1]
11 (35.48)
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0 (0.00)
[3]
4 (36.36)
[4]
1 (9.09)
[5]
6 (54.55)
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Premenopausal
[1]
20 (64.52)
[2]
1 (5.00)
[3]
8 (40.00)
[4]
1 (5.00)
[5]
10 (50.00)
[6]
[8] array · 7 items
[0]
Symptoms, n (%)
[1]
[2]
[3]
[4]
[5]
[6]
.118
[9] array · 7 items
[0]
Colporrhagia
[1]
9 (29.03)
[2]
0 (0.00)
[3]
4 (44.44)
[4]
2 (22.22)
[5]
3 (33.33)
[6]
[10] array · 7 items
[0]
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[1]
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[2]
0 (0.00)
[3]
2 (28.57)
[4]
0 (0.00)
[5]
5 (71.43)
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[11] array · 7 items
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Abdominal mass
[1]
10 (32.26)
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0 (0.00)
[3]
4 (40.00)
[4]
0 (0.00)
[5]
6 (60.00)
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[12] array · 7 items
[0]
Asymptomatic
[1]
5 (16.13)
[2]
1 (20.00)
[3]
2 (40.00)
[4]
0 (0.00)
[5]
2 (40.00)
[6]
[13] array · 7 items
[0]
Tumor size (cm), n (%)
[1]
[2]
[3]
[4]
[5]
[6]
.072
[14] array · 7 items
[0]
≤5
[1]
10 (32.26)
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1 (10.00)
[3]
6 (60.00)
[4]
1 (10.00)
[5]
2 (20.00)
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[15] array · 7 items
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[1]
21 (67.74)
[2]
0 (0.00)
[3]
6 (28.57)
[4]
1 (4.76)
[5]
14 (66.67)
[6]
[16] array · 7 items
[0]
CA125 (U/ml), n (%)
[1]
[2]
[3]
[4]
[5]
[6]
.541
[17] array · 7 items
[0]
<35
[1]
14 (45.16)
[2]
1 (7.14)
[3]
5 (35.71)
[4]
1 (7.14)
[5]
7 (50.00)
[6]
[18] array · 7 items
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>35
[1]
8 (25.81)
[2]
0 (0.00)
[3]
2 (25.00)
[4]
1 (12.50)
[5]
5 (62.50)
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[1]
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0 (0.00)
[3]
5 (55.56)
[4]
0 (0.00)
[5]
4 (44.44)
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[20] array · 7 items
[0]
FIGO stage, n (%)
[1]
[2]
[3]
[4]
[5]
[6]
.328
[21] array · 7 items
[0]
I
[1]
22 (70.97)
[2]
1 (4.55)
[3]
10 (45.45)
[4]
0 (0.00)
[5]
11 (50.00)
[6]
[22] array · 7 items
[0]
II
[1]
3 (9.68)
[2]
0 (0.00)
[3]
1 (33.33)
[4]
1 (33.33)
[5]
1 (33.33)
[6]
[23] array · 7 items
[0]
III
[1]
2 (6.45)
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0 (0.00)
[3]
1 (50.00)
[4]
1 (50.00)
[5]
0 (0.00)
[6]
[24] array · 7 items
[0]
IV
[1]
4 (12.90)
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0 (0.00)
[3]
0 (0.00)
[4]
0 (0.00)
[5]
4 (100.00)
[6]
[25] array · 7 items
[0]
Surgical approach, n (%)
[1]
[2]
[3]
[4]
[5]
[6]
.363
[26] array · 7 items
[0]
TH + BSO
[1]
16 (51.61)
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0 (0.00)
[3]
8 (50.00)
[4]
0 (0.00)
[5]
8 (50.00)
[6]
[27] array · 7 items
[0]
TH + BSO + PLA
[1]
7 (22.58)
[2]
1 (14.29)
[3]
3 (42.86)
[4]
2 (28.57)
[5]
1 (14.29)
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[28] array · 7 items
[0]
TH + BSO + PLA + omentectomy
[1]
5 (16.13)
[2]
0 (0.00)
[3]
1 (20.00)
[4]
0 (0.00)
[5]
4 (80.00)
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[0]
TH + BSO + PLA + omentectomy + appendectomy
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[2]
0 (0.00)
[3]
0 (0.00)
[4]
0 (0.00)
[5]
3 (100.00)
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[30] array · 7 items
[0]
Lymphadenectomy, n (%)
[1]
[2]
[3]
[4]
[5]
[6]
.250
[31] array · 7 items
[0]
Yes
[1]
15 (48.39)
[2]
1 (6.67)
[3]
4 (26.67)
[4]
2 (13.33)
[5]
8 (53.33)
[6]
[32] array · 7 items
[0]
No
[1]
16 (51.61)
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0 (0.00)
[3]
8 (50.00)
[4]
0 (0.00)
[5]
8 (50.00)
[6]
[33] array · 7 items
[0]
Chemotherapy, n (%)
[1]
[2]
[3]
[4]
[5]
[6]
.869
[34] array · 7 items
[0]
Yes
[1]
13 (41.94)
[2]
0 (0.00)
[3]
5 (38.46)
[4]
1 (7.69)
[5]
7 (53.85)
[6]
[35] array · 7 items
[0]
No
[1]
18 (58.06)
[2]
1 (5.56)
[3]
7 (38.88)
[4]
1 (5.56)
[5]
9 (50.00)
[6]
[36] array · 7 items
[0]
Radiotherapy, n (%)
[1]
[2]
[3]
[4]
[5]
[6]
.802
[37] array · 7 items
[0]
Yes
[1]
6 (19.35)
[2]
0 (0.00)
[3]
2 (33.33)
[4]
0 (0.00)
[5]
4 (66.67)
[6]
[38] array · 7 items
[0]
No
[1]
25 (80.65)
[2]
1 (4.00)
[3]
10 (40.00)
[4]
2 (8.00)
[5]
12 (48.00)
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Univariate cox Analysis of OS in US Patients from the Sweden Microarray Cohort.
structure object · 5 fields
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PMC12099139
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12
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Univariate and Multivariate cox Regression Analysis
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Table 2.
caption
Univariate cox Analysis of OS in US Patients from the Sweden Microarray Cohort.
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[0]
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[1]
Univariate analysis
[1] array · 3 items
[0]
HR
[1]
95% CI
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P value
[2] array · 4 items
[0]
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0.96
[2]
0.51–1.80
[3]
.891
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1.05–3.96
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[2]
0.09–0.48
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2.33
[2]
1.21–4.50
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[6] array · 4 items
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1.96
[2]
1.01–3.80
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.046
[7] array · 4 items
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RNA group (Developmental vs Others)
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0.70
[2]
0.37–1.32
[3]
.270
[8] array · 4 items
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1.75
[2]
0.82–3.72
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.148
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Univariate cox Analysis of PFS in US Patients from the Clinical Cohort.
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section_index
12
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Univariate and Multivariate cox Regression Analysis
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Table 3.
caption
Univariate cox Analysis of PFS in US Patients from the Clinical Cohort.
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[0]
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[1]
Univariate analysis
[1] array · 3 items
[0]
HR
[1]
95% CI
[2]
P value
[2] array · 4 items
[0]
Age (years) (≤50 vs > 50)
[1]
2.29
[2]
0.67–7.87
[3]
.187
[3] array · 4 items
[0]
Tumor stage (I/II vs III/IV)
[1]
5.95
[2]
1.68–21.11
[3]
.006
[4] array · 4 items
[0]
Menopausal status (Postmenopausal vs Premenopausal)
[1]
0.99
[2]
0.29–3.38
[3]
.984
[5] array · 4 items
[0]
Tumor size (cm) (≤5 vs > 5)
[1]
1.65
[2]
0.44–6.25
[3]
.458
[6] array · 4 items
[0]
CA125 (U/ml) (<35 vs > 35)
[1]
2.27
[2]
0.95–5.46
[3]
.066
[7] array · 4 items
[0]
Tumor type (AS + LG-ESS vs LMS + HG-ESS)
[1]
9.89
[2]
1.26–77.92
[3]
.030
[8] array · 4 items
[0]
Lymphadenectomy (Yes vs No)
[1]
3.34
[2]
0.88–12.60
[3]
.076
[9] array · 4 items
[0]
Family history of malignancy (Yes vs No)
[1]
9.22
[2]
0.96–88.69
[3]
.055
[10] array · 4 items
[0]
Tumor recurrence (Yes vs No)
[1]
16.89
[2]
4.30–66.32
[3]
<.001
[11] array · 4 items
[0]
Adjuvant chemotherapy (Yes vs No)
[1]
1.84
[2]
0.56–6.05
[3]
.316
[12] array · 4 items
[0]
Adjuvant radiotherapy (Yes vs No)
[1]
0.86
[2]
0.18–3.98
[3]
.844
[13] array · 4 items
[0]
β-catenin expression (High vs Low)
[1]
1.72
[2]
0.46–6.52
[3]
.423
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Univariate cox Analysis of OS in US Patients from the Clinical Cohort.
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pmcid
PMC12099139
section_index
12
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Univariate and Multivariate cox Regression Analysis
row_count
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column_count
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table object · 8 fields
label
Table 4.
caption
Univariate cox Analysis of OS in US Patients from the Clinical Cohort.
rows array · 14 items
[0] array · 2 items
[0]
Clinicopathological features
[1]
Univariate analysis
[1] array · 3 items
[0]
HR
[1]
95% CI
[2]
P value
[2] array · 4 items
[0]
Age (years) (≤50 vs > 50)
[1]
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[2]
0.79–11.80
[3]
.107
[3] array · 4 items
[0]
Tumor stage (I/II vs III/IV)
[1]
3.52
[2]
0.99–12.54
[3]
.052
[4] array · 4 items
[0]
Menopausal status (Postmenopausal vs Premenopausal)
[1]
1.18
[2]
0.33–4.20
[3]
.798
[5] array · 4 items
[0]
Tumor size (cm) (≤5 vs > 5)
[1]
1.42
[2]
0.37–5.53
[3]
.610
[6] array · 4 items
[0]
CA125 (U/ml) (<35 vs > 35)
[1]
2.31
[2]
0.94–5.70
[3]
.068
[7] array · 4 items
[0]
Tumor type (AS + LG-ESS vs LMS + HG-ESS)
[1]
8.94
[2]
1.12–71.02
[3]
.038
[8] array · 4 items
[0]
Lymphadenectomy (Yes vs No)
[1]
4.97
[2]
1.05–23.45
[3]
.043
[9] array · 4 items
[0]
Family history of malignancy (Yes vs No)
[1]
14.13
[2]
1.28–156.01
[3]
.031
[10] array · 4 items
[0]
Tumor recurrence (Yes vs No)
[1]
12.46
[2]
3.09–50.27
[3]
<.001
[11] array · 4 items
[0]
Adjuvant chemotherapy (Yes vs No)
[1]
1.61
[2]
0.46–5.57
[3]
.453
[12] array · 4 items
[0]
Adjuvant radiotherapy (Yes vs No)
[1]
0.47
[2]
0.06–3.75
[3]
.480
[13] array · 4 items
[0]
β-catenin expression (High vs Low)
[1]
1.53
[2]
0.40–5.93
[3]
.538
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asset:table:pmid:40398662:3
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asset:table:pmid:40398662:4
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source:pmid:40398662
gaps array · 1 item
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corpus_record_absent
review object · 5 fields
state
partial
machine_critique object · 7 fields
status
blocked
providers array · 0 items
target_providers array · 0 items
agreement
false
disagreements array · 0 items
agreement_basis object · 2 fields
policy
decisive_fields
decisive_fields array · 4 items
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work_type
[1]
number_stated
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parent_value
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unit
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human_critique object · 5 fields
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null
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null
conflict_checked
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null
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target_materials
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null
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null
[1] object · 4 fields
key
independent_readings
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blocked
reason
The independent readings are incomplete or disagree; the source evidence must resolve the difference.
evidence object · 1 field
provider_errors array · 4 items
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provider
minimax
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null
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HTTP Error 429: Too Many Requests
raw_response
null
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provider
minimax_alt
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null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[2] object · 4 fields
provider
minimax
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null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[3] object · 4 fields
provider
minimax_alt
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null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[2] object · 4 fields
key
source_resolution
status
pending
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null
evidence
null
[3] object · 4 fields
key
protocol_reconstruction
status
pending
reason
null
evidence
null
[4] object · 4 fields
key
control_execution
status
pending
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null
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null
[5] object · 4 fields
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pending
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null
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null
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key
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pending
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null
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null
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review.human_critique
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review.machine_critique.blocked
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execution object · 5 fields
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not_run
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null
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provenance object · 7 fields
entities array · 1 item
[0] object · 3 fields
id
package:4302602bd3e00146944cabc3bf8371d5da0eea03a4ca484c93b2e13785fe2894
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sep_package
label
SEP v1 package for pmid:40398662
activities array · 1 item
[0] object · 4 fields
id
activity:conversion:pmid:40398662
type
conversion
used array · 1 item
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package:4302602bd3e00146944cabc3bf8371d5da0eea03a4ca484c93b2e13785fe2894
agent
agent:corpus-assay-engine
agents array · 1 item
[0] object · 3 fields
id
agent:corpus-assay-engine
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software
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source_run_id
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dsl_catalogue_fingerprint
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capability_table_fingerprint
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snapshot_id
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lineage object · 4 fields
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[1]
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[10]
step:obtain_source_data blocked on data:not_downloaded
[11]
step:run_analysis blocked on no owned computational capability is bound to this experiment
[12]
step:run_analysis input 'materials:the source data behind the published result in pmid:40398662' does not resolve to a declared asset
[13]
targets
Complete file 
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