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pmid:40410601

Integration of cuproptosis-related gene signatures in stomach adenocarcinoma: implications for prognostic prediction and therapeutic strategies in cancer drug resistance.

Discover oncology · 2025 doi:10.1007/s12672-025-02740-8

Paper

partial

Experiment

partial

Data

partial

Analysis

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Execution

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Integration of cuproptosis-related gene signatures in stomach adenocarcinoma: implications for prognostic prediction and therapeutic strategies in cancer drug resistance.
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10.1007/s12672-025-02740-8
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40410601
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null
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Discover oncology
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2025
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Clinical and molecular characteristics associated with overall survival in stomach adenocarcinoma patients from univariate and multivariate cox analyses
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Clinical and molecular factors influencing prognosis
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Table 1
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Clinical and molecular characteristics associated with overall survival in stomach adenocarcinoma patients from univariate and multivariate cox analyses
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[0]
Characteristics
[1]
Total(N)
[2]
Univariate analysis
[3]
Multivariate analysis
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[0]
Hazard ratio (95% CI)
[1]
P value
[2]
Hazard ratio (95% CI)
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T stage
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[3]
[4]
[5]
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96
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Reference
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[4]
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266
[2]
1.719 (1.131–2.612)
[3]
0.011
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1.325 (0.706–2.484)
[5]
0.381
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[0]
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352
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[3]
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Reference
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1.650 (1.182–2.302)
[3]
0.003
[4]
1.542 (0.880–2.700)
[5]
0.130
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M stage
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352
[2]
[3]
[4]
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M0
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327
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Reference
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M1
[1]
25
[2]
2.254 (1.295–3.924)
[3]
0.004
[4]
1.349 (0.595–3.058)
[5]
0.474
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Pathologic stage
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347
[2]
[3]
[4]
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Stage I and stage II
[1]
160
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Reference
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Stage III and stage IV
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187
[2]
1.947 (1.358–2.793)
[3]
< 0.001
[4]
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0.782
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[3]
[4]
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Reference
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[3]
< 0.001
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< 0.001
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Reference
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Reference
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142
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Reference
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[1]
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[3]
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[2]
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0.317
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Barretts esophagus
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[3]
[4]
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[3]
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Reference
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[3]
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[4]
[5]
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FDX1
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[3]
[4]
[5]
[51] array · 6 items
[0]
Low
[1]
185
[2]
Reference
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[4]
[5]
[52] array · 6 items
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[1]
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[2]
0.714 (0.513–0.994)
[3]
0.046
[4]
0.825 (0.546–1.246)
[5]
0.360
[53] array · 6 items
[0]
LIAS
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370
[2]
[3]
[4]
[5]
[54] array · 6 items
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[1]
186
[2]
Reference
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[4]
[5]
[55] array · 6 items
[0]
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[1]
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[2]
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[3]
0.295
[4]
[5]
[56] array · 6 items
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LIPT1
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[2]
[3]
[4]
[5]
[57] array · 6 items
[0]
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[1]
185
[2]
Reference
[3]
[4]
[5]
[58] array · 6 items
[0]
High
[1]
185
[2]
1.243 (0.895–1.726)
[3]
0.195
[4]
[5]
[59] array · 6 items
[0]
DLD
[1]
370
[2]
[3]
[4]
[5]
[60] array · 6 items
[0]
Low
[1]
185
[2]
Reference
[3]
[4]
[5]
[61] array · 6 items
[0]
High
[1]
185
[2]
1.035 (0.746–1.435)
[3]
0.838
[4]
[5]
[62] array · 6 items
[0]
DLAT
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[2]
[3]
[4]
[5]
[63] array · 6 items
[0]
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[1]
184
[2]
Reference
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[4]
[5]
[64] array · 6 items
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High
[1]
186
[2]
1.031 (0.742–1.432)
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0.855
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PDHA1
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[3]
[4]
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Reference
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[67] array · 6 items
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[1]
184
[2]
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[3]
0.844
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PDHB
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[3]
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Reference
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[1]
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[2]
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[3]
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185
[2]
Reference
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[1]
185
[2]
0.814 (0.587–1.130)
[3]
0.219
[4]
[5]
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GLS
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[3]
[4]
[5]
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[1]
185
[2]
Reference
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[4]
[5]
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High
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185
[2]
1.139 (0.821–1.580)
[3]
0.437
[4]
[5]
[77] array · 6 items
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CDKN2A
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370
[2]
[3]
[4]
[5]
[78] array · 6 items
[0]
Low
[1]
184
[2]
Reference
[3]
[4]
[5]
[79] array · 6 items
[0]
High
[1]
186
[2]
0.873 (0.629–1.211)
[3]
0.415
[4]
[5]
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Clinical and molecular characteristics associated with disease specific survival in stomach adenocarcinoma patients from univariate and multivariate cox analyses
structure object · 5 fields
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PMC12102457
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18
section_title
Clinical and molecular factors influencing prognosis
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Table 2
caption
Clinical and molecular characteristics associated with disease specific survival in stomach adenocarcinoma patients from univariate and multivariate cox analyses
rows array · 80 items
[0] array · 4 items
[0]
Characteristics
[1]
Total(N)
[2]
Univariate analysis
[3]
Multivariate analysis
[1] array · 4 items
[0]
Hazard ratio (95% CI)
[1]
P value
[2]
Hazard ratio (95% CI)
[3]
P value
[2] array · 6 items
[0]
T stage
[1]
345
[2]
[3]
[4]
[5]
[3] array · 6 items
[0]
T1 and T2
[1]
90
[2]
Reference
[3]
[4]
[5]
[4] array · 6 items
[0]
T3 and T4
[1]
255
[2]
2.089 (1.192–3.660)
[3]
0.010
[4]
1.302 (0.645–2.628)
[5]
0.462
[5] array · 6 items
[0]
N stage
[1]
334
[2]
[3]
[4]
[5]
[6] array · 6 items
[0]
N0 and N1
[1]
192
[2]
Reference
[3]
[4]
[5]
[7] array · 6 items
[0]
N2 and N3
[1]
142
[2]
2.110 (1.378–3.231)
[3]
< 0.001
[4]
2.264 (1.071–4.785)
[5]
0.032
[8] array · 6 items
[0]
M stage
[1]
333
[2]
[3]
[4]
[5]
[9] array · 6 items
[0]
M0
[1]
311
[2]
Reference
[3]
[4]
[5]
[10] array · 6 items
[0]
M1
[1]
22
[2]
2.438 (1.221–4.870)
[3]
0.012
[4]
1.098 (0.432–2.791)
[5]
0.844
[11] array · 6 items
[0]
Pathologic stage
[1]
331
[2]
[3]
[4]
[5]
[12] array · 6 items
[0]
Stage I and stage II
[1]
154
[2]
Reference
[3]
[4]
[5]
[13] array · 6 items
[0]
Stage III and stage IV
[1]
177
[2]
2.146 (1.352–3.404)
[3]
0.001
[4]
0.752 (0.312–1.809)
[5]
0.524
[14] array · 6 items
[0]
Primary therapy outcome
[1]
310
[2]
[3]
[4]
[5]
[15] array · 6 items
[0]
PD and SD
[1]
78
[2]
Reference
[3]
[4]
[5]
[16] array · 6 items
[0]
PR and CR
[1]
232
[2]
0.125 (0.079–0.197)
[3]
< 0.001
[4]
0.130 (0.076–0.224)
[5]
< 0.001
[17] array · 6 items
[0]
Gender
[1]
349
[2]
[3]
[4]
[5]
[18] array · 6 items
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Female
[1]
125
[2]
Reference
[3]
[4]
[5]
[19] array · 6 items
[0]
Male
[1]
224
[2]
1.573 (0.985–2.514)
[3]
0.058
[4]
1.335 (0.751–2.376)
[5]
0.325
[20] array · 6 items
[0]
Age
[1]
346
[2]
[3]
[4]
[5]
[21] array · 6 items
[0]
< = 65
[1]
160
[2]
Reference
[3]
[4]
[5]
[22] array · 6 items
[0]
> 65
[1]
186
[2]
1.211 (0.797–1.840)
[3]
0.371
[4]
[5]
[23] array · 6 items
[0]
Residual tumor
[1]
314
[2]
[3]
[4]
[5]
[24] array · 6 items
[0]
R0
[1]
287
[2]
Reference
[3]
[4]
[5]
[25] array · 6 items
[0]
R1 and R2
[1]
27
[2]
5.142 (3.014–8.771)
[3]
< 0.001
[4]
2.748 (1.432–5.275)
[5]
0.002
[26] array · 6 items
[0]
Histologic grade
[1]
340
[2]
[3]
[4]
[5]
[27] array · 6 items
[0]
G1
[1]
9
[2]
Reference
[3]
[4]
[5]
[28] array · 6 items
[0]
G2 and G3
[1]
331
[2]
2.014 (0.280–14.475)
[3]
0.486
[4]
[5]
[29] array · 6 items
[0]
Reflux history
[1]
208
[2]
[3]
[4]
[5]
[30] array · 6 items
[0]
No
[1]
169
[2]
Reference
[3]
[4]
[5]
[31] array · 6 items
[0]
Yes
[1]
39
[2]
0.598 (0.272–1.313)
[3]
0.200
[4]
[5]
[32] array · 6 items
[0]
Antireflux treatment
[1]
167
[2]
[3]
[4]
[5]
[33] array · 6 items
[0]
No
[1]
131
[2]
Reference
[3]
[4]
[5]
[34] array · 6 items
[0]
Yes
[1]
36
[2]
0.758 (0.380–1.511)
[3]
0.431
[4]
[5]
[35] array · 6 items
[0]
H. pylori infection
[1]
157
[2]
[3]
[4]
[5]
[36] array · 6 items
[0]
No
[1]
139
[2]
Reference
[3]
[4]
[5]
[37] array · 6 items
[0]
Yes
[1]
18
[2]
0.558 (0.200–1.554)
[3]
0.264
[4]
[5]
[38] array · 6 items
[0]
Barretts esophagus
[1]
201
[2]
[3]
[4]
[5]
[39] array · 6 items
[0]
No
[1]
187
[2]
Reference
[3]
[4]
[5]
[40] array · 6 items
[0]
Yes
[1]
14
[2]
0.974 (0.304–3.118)
[3]
0.964
[4]
[5]
[41] array · 6 items
[0]
Race
[1]
305
[2]
[3]
[4]
[5]
[42] array · 6 items
[0]
Asian
[1]
71
[2]
Reference
[3]
[4]
[5]
[43] array · 6 items
[0]
Black or African American and White
[1]
234
[2]
1.050 (0.593–1.857)
[3]
0.867
[4]
[5]
[44] array · 6 items
[0]
Histological type
[1]
348
[2]
[3]
[4]
[5]
[45] array · 6 items
[0]
Not otherwise specified
[1]
184
[2]
Reference
[3]
[4]
[5]
[46] array · 6 items
[0]
Diffuse type and mucinous type and papillary type and signet ring type and tubular type
[1]
164
[2]
1.204 (0.792–1.831)
[3]
0.386
[4]
[5]
[47] array · 6 items
[0]
Anatomic neoplasm subdivision
[1]
341
[2]
[3]
[4]
[5]
[48] array · 6 items
[0]
Other
[1]
4
[2]
Reference
[3]
[4]
[5]
[49] array · 6 items
[0]
Antrum/Distal and Cardia/Proximal and Fundus/Body and Gastroesophageal junction
[1]
337
[2]
9,382,799.777 (0.000-Inf)
[3]
0.994
[4]
[5]
[50] array · 6 items
[0]
FDX1
[1]
349
[2]
[3]
[4]
[5]
[51] array · 6 items
[0]
Low
[1]
175
[2]
Reference
[3]
[4]
[5]
[52] array · 6 items
[0]
High
[1]
174
[2]
0.677 (0.444–1.033)
[3]
0.070
[4]
0.917 (0.555–1.513)
[5]
0.733
[53] array · 6 items
[0]
LIAS
[1]
349
[2]
[3]
[4]
[5]
[54] array · 6 items
[0]
Low
[1]
178
[2]
Reference
[3]
[4]
[5]
[55] array · 6 items
[0]
High
[1]
171
[2]
0.743 (0.488–1.131)
[3]
0.166
[4]
[5]
[56] array · 6 items
[0]
LIPT1
[1]
349
[2]
[3]
[4]
[5]
[57] array · 6 items
[0]
Low
[1]
179
[2]
Reference
[3]
[4]
[5]
[58] array · 6 items
[0]
High
[1]
170
[2]
1.231 (0.811–1.869)
[3]
0.329
[4]
[5]
[59] array · 6 items
[0]
DLD
[1]
349
[2]
[3]
[4]
[5]
[60] array · 6 items
[0]
Low
[1]
181
[2]
Reference
[3]
[4]
[5]
[61] array · 6 items
[0]
High
[1]
168
[2]
0.890 (0.586–1.353)
[3]
0.587
[4]
[5]
[62] array · 6 items
[0]
DLAT
[1]
349
[2]
[3]
[4]
[5]
[63] array · 6 items
[0]
Low
[1]
179
[2]
Reference
[3]
[4]
[5]
[64] array · 6 items
[0]
High
[1]
170
[2]
0.881 (0.580–1.337)
[3]
0.551
[4]
[5]
[65] array · 6 items
[0]
PDHA1
[1]
349
[2]
[3]
[4]
[5]
[66] array · 6 items
[0]
Low
[1]
180
[2]
Reference
[3]
[4]
[5]
[67] array · 6 items
[0]
High
[1]
169
[2]
0.816 (0.537–1.238)
[3]
0.339
[4]
[5]
[68] array · 6 items
[0]
PDHB
[1]
349
[2]
[3]
[4]
[5]
[69] array · 6 items
[0]
Low
[1]
179
[2]
Reference
[3]
[4]
[5]
[70] array · 6 items
[0]
High
[1]
170
[2]
1.184 (0.781–1.794)
[3]
0.427
[4]
[5]
[71] array · 6 items
[0]
MTF1
[1]
349
[2]
[3]
[4]
[5]
[72] array · 6 items
[0]
Low
[1]
176
[2]
Reference
[3]
[4]
[5]
[73] array · 6 items
[0]
High
[1]
173
[2]
0.822 (0.542–1.247)
[3]
0.356
[4]
[5]
[74] array · 6 items
[0]
GLS
[1]
349
[2]
[3]
[4]
[5]
[75] array · 6 items
[0]
Low
[1]
177
[2]
Reference
[3]
[4]
[5]
[76] array · 6 items
[0]
High
[1]
172
[2]
1.191 (0.785–1.807)
[3]
0.411
[4]
[5]
[77] array · 6 items
[0]
CDKN2A
[1]
349
[2]
[3]
[4]
[5]
[78] array · 6 items
[0]
Low
[1]
168
[2]
Reference
[3]
[4]
[5]
[79] array · 6 items
[0]
High
[1]
181
[2]
0.997 (0.657–1.511)
[3]
0.987
[4]
[5]
row_count
80
column_count
6
numeric_cells
150
header_rows
2
locator
section[18]/table-wrap[2]#Tab2
[3] object · 16 fields
id
asset:table:pmid:40410601:3
role
table
format
jats-table
media_type
application/vnd.jats.table+json
uri
null
sha256
sha256:478c8250f45afdd333db3571bb3d43c1648bf66af8427ec3d61df5f8a52c15ab
bytes
4178
access
open
state
verified
reader
read_table
reader_status
available
identifier
section[18]/table-wrap[3]#Tab3
version
null
note
Clinical and molecular characteristics associated with progression free interval in stomach adenocarcinoma patients from univariate and multivariate cox analyses
structure object · 5 fields
pmcid
PMC12102457
section_index
18
section_title
Clinical and molecular factors influencing prognosis
row_count
80
column_count
6
table object · 8 fields
label
Table 3
caption
Clinical and molecular characteristics associated with progression free interval in stomach adenocarcinoma patients from univariate and multivariate cox analyses
rows array · 80 items
[0] array · 4 items
[0]
Characteristics
[1]
Total(N)
[2]
Univariate analysis
[3]
Multivariate analysis
[1] array · 4 items
[0]
Hazard ratio (95% CI)
[1]
P value
[2]
Hazard ratio (95% CI)
[3]
P value
[2] array · 6 items
[0]
T stage
[1]
364
[2]
[3]
[4]
[5]
[3] array · 6 items
[0]
T1 and T2
[1]
97
[2]
Reference
[3]
[4]
[5]
[4] array · 6 items
[0]
T3 and T4
[1]
267
[2]
1.705 (1.095–2.654)
[3]
0.018
[4]
0.643 (0.250–1.656)
[5]
0.361
[5] array · 6 items
[0]
N stage
[1]
354
[2]
[3]
[4]
[5]
[6] array · 6 items
[0]
N0 and N1
[1]
205
[2]
Reference
[3]
[4]
[5]
[7] array · 6 items
[0]
N2 and N3
[1]
149
[2]
1.892 (1.325–2.703)
[3]
< 0.001
[4]
1.429 (0.662–3.083)
[5]
0.364
[8] array · 6 items
[0]
M stage
[1]
353
[2]
[3]
[4]
[5]
[9] array · 6 items
[0]
M0
[1]
328
[2]
Reference
[3]
[4]
[5]
[10] array · 6 items
[0]
M1
[1]
25
[2]
2.224 (1.194–4.144)
[3]
0.012
[4]
0.997 (0.314–3.164)
[5]
0.996
[11] array · 6 items
[0]
Pathologic stage
[1]
349
[2]
[3]
[4]
[5]
[12] array · 6 items
[0]
Stage I and stage II
[1]
161
[2]
Reference
[3]
[4]
[5]
[13] array · 6 items
[0]
Stage III and stage IV
[1]
188
[2]
1.676 (1.154–2.435)
[3]
0.007
[4]
1.406 (0.507–3.901)
[5]
0.513
[14] array · 6 items
[0]
Primary therapy outcome
[1]
315
[2]
[3]
[4]
[5]
[15] array · 6 items
[0]
PD and SD
[1]
82
[2]
Reference
[3]
[4]
[5]
[16] array · 6 items
[0]
PR and CR
[1]
233
[2]
0.128 (0.087–0.188)
[3]
< 0.001
[4]
0.111 (0.051–0.245)
[5]
< 0.001
[17] array · 6 items
[0]
Gender
[1]
372
[2]
[3]
[4]
[5]
[18] array · 6 items
[0]
Female
[1]
133
[2]
Reference
[3]
[4]
[5]
[19] array · 6 items
[0]
Male
[1]
239
[2]
1.638 (1.099–2.440)
[3]
0.015
[4]
1.591 (0.721–3.509)
[5]
0.250
[20] array · 6 items
[0]
Age
[1]
369
[2]
[3]
[4]
[5]
[21] array · 6 items
[0]
< = 65
[1]
164
[2]
Reference
[3]
[4]
[5]
[22] array · 6 items
[0]
> 65
[1]
205
[2]
0.858 (0.603–1.221)
[3]
0.395
[4]
[5]
[23] array · 6 items
[0]
Residual tumor
[1]
326
[2]
[3]
[4]
[5]
[24] array · 6 items
[0]
R0
[1]
295
[2]
Reference
[3]
[4]
[5]
[25] array · 6 items
[0]
R1 and R2
[1]
31
[2]
3.469 (2.127–5.656)
[3]
< 0.001
[4]
1.571 (0.757–3.260)
[5]
0.225
[26] array · 6 items
[0]
Histologic grade
[1]
363
[2]
[3]
[4]
[5]
[27] array · 6 items
[0]
G1
[1]
10
[2]
Reference
[3]
[4]
[5]
[28] array · 6 items
[0]
G2 and G3
[1]
353
[2]
1.555 (0.384–6.294)
[3]
0.536
[4]
[5]
[29] array · 6 items
[0]
Reflux history
[1]
214
[2]
[3]
[4]
[5]
[30] array · 6 items
[0]
No
[1]
175
[2]
Reference
[3]
[4]
[5]
[31] array · 6 items
[0]
Yes
[1]
39
[2]
0.482 (0.232–1.000)
[3]
0.050
[4]
1.534 (0.417–5.647)
[5]
0.520
[32] array · 6 items
[0]
Antireflux treatment
[1]
179
[2]
[3]
[4]
[5]
[33] array · 6 items
[0]
No
[1]
142
[2]
Reference
[3]
[4]
[5]
[34] array · 6 items
[0]
Yes
[1]
37
[2]
0.584 (0.298–1.146)
[3]
0.118
[4]
[5]
[35] array · 6 items
[0]
H. pylori infection
[1]
163
[2]
[3]
[4]
[5]
[36] array · 6 items
[0]
No
[1]
145
[2]
Reference
[3]
[4]
[5]
[37] array · 6 items
[0]
Yes
[1]
18
[2]
0.321 (0.100–1.024)
[3]
0.055
[4]
0.947 (0.251–3.579)
[5]
0.936
[38] array · 6 items
[0]
Barretts esophagus
[1]
208
[2]
[3]
[4]
[5]
[39] array · 6 items
[0]
No
[1]
193
[2]
Reference
[3]
[4]
[5]
[40] array · 6 items
[0]
Yes
[1]
15
[2]
0.953 (0.348–2.612)
[3]
0.926
[4]
[5]
[41] array · 6 items
[0]
Race
[1]
322
[2]
[3]
[4]
[5]
[42] array · 6 items
[0]
Asian
[1]
74
[2]
Reference
[3]
[4]
[5]
[43] array · 6 items
[0]
Black or African American and White
[1]
248
[2]
0.992 (0.624–1.578)
[3]
0.973
[4]
[5]
[44] array · 6 items
[0]
Histological type
[1]
371
[2]
[3]
[4]
[5]
[45] array · 6 items
[0]
Not otherwise specified
[1]
204
[2]
Reference
[3]
[4]
[5]
[46] array · 6 items
[0]
Diffuse type and mucinous type and papillary type and signet ring type and tubular type
[1]
167
[2]
1.080 (0.759–1.536)
[3]
0.671
[4]
[5]
[47] array · 6 items
[0]
Anatomic neoplasm subdivision
[1]
358
[2]
[3]
[4]
[5]
[48] array · 6 items
[0]
Other
[1]
4
[2]
Reference
[3]
[4]
[5]
[49] array · 6 items
[0]
Antrum/distal and Cardia/proximal and Fundus/body and gastroesophageal Junction
[1]
354
[2]
9,479,916.218 (0.000-Inf)
[3]
0.993
[4]
[5]
[50] array · 6 items
[0]
FDX1
[1]
372
[2]
[3]
[4]
[5]
[51] array · 6 items
[0]
Low
[1]
186
[2]
Reference
[3]
[4]
[5]
[52] array · 6 items
[0]
High
[1]
186
[2]
0.758 (0.532–1.080)
[3]
0.126
[4]
[5]
[53] array · 6 items
[0]
LIAS
[1]
372
[2]
[3]
[4]
[5]
[54] array · 6 items
[0]
Low
[1]
186
[2]
Reference
[3]
[4]
[5]
[55] array · 6 items
[0]
High
[1]
186
[2]
0.567 (0.395–0.816)
[3]
0.002
[4]
0.996 (0.531–1.868)
[5]
0.990
[56] array · 6 items
[0]
LIPT1
[1]
372
[2]
[3]
[4]
[5]
[57] array · 6 items
[0]
Low
[1]
185
[2]
Reference
[3]
[4]
[5]
[58] array · 6 items
[0]
High
[1]
187
[2]
0.969 (0.680–1.381)
[3]
0.861
[4]
[5]
[59] array · 6 items
[0]
DLD
[1]
372
[2]
[3]
[4]
[5]
[60] array · 6 items
[0]
Low
[1]
187
[2]
Reference
[3]
[4]
[5]
[61] array · 6 items
[0]
High
[1]
185
[2]
0.875 (0.614–1.247)
[3]
0.460
[4]
[5]
[62] array · 6 items
[0]
DLAT
[1]
372
[2]
[3]
[4]
[5]
[63] array · 6 items
[0]
Low
[1]
186
[2]
Reference
[3]
[4]
[5]
[64] array · 6 items
[0]
High
[1]
186
[2]
0.816 (0.573–1.162)
[3]
0.260
[4]
[5]
[65] array · 6 items
[0]
PDHA1
[1]
372
[2]
[3]
[4]
[5]
[66] array · 6 items
[0]
Low
[1]
186
[2]
Reference
[3]
[4]
[5]
[67] array · 6 items
[0]
High
[1]
186
[2]
0.668 (0.468–0.953)
[3]
0.026
[4]
0.896 (0.484–1.659)
[5]
0.727
[68] array · 6 items
[0]
PDHB
[1]
372
[2]
[3]
[4]
[5]
[69] array · 6 items
[0]
Low
[1]
184
[2]
Reference
[3]
[4]
[5]
[70] array · 6 items
[0]
High
[1]
188
[2]
0.891 (0.626–1.267)
[3]
0.520
[4]
[5]
[71] array · 6 items
[0]
MTF1
[1]
372
[2]
[3]
[4]
[5]
[72] array · 6 items
[0]
Low
[1]
187
[2]
Reference
[3]
[4]
[5]
[73] array · 6 items
[0]
High
[1]
185
[2]
0.836 (0.588–1.190)
[3]
0.321
[4]
[5]
[74] array · 6 items
[0]
GLS
[1]
372
[2]
[3]
[4]
[5]
[75] array · 6 items
[0]
Low
[1]
187
[2]
Reference
[3]
[4]
[5]
[76] array · 6 items
[0]
High
[1]
185
[2]
0.995 (0.699–1.418)
[3]
0.979
[4]
[5]
[77] array · 6 items
[0]
CDKN2A
[1]
372
[2]
[3]
[4]
[5]
[78] array · 6 items
[0]
Low
[1]
185
[2]
Reference
[3]
[4]
[5]
[79] array · 6 items
[0]
High
[1]
187
[2]
0.855 (0.601–1.218)
[3]
0.386
[4]
[5]
row_count
80
column_count
6
numeric_cells
156
header_rows
2
locator
section[18]/table-wrap[3]#Tab3
[4] object · 16 fields
id
asset:table:pmid:40410601:4
role
table
format
jats-table
media_type
application/vnd.jats.table+json
uri
null
sha256
sha256:3578352c6326f3f91b886ff9a4c27d800cfea232c0b8a270fee033c926480a62
bytes
3265
access
open
state
verified
reader
read_table
reader_status
available
identifier
section[19]/table-wrap[1]#Tab4
version
null
note
Clinical and demographic characteristics of stomach adenocarcinoma patients with low and high expression of FDX1
structure object · 5 fields
pmcid
PMC12102457
section_index
19
section_title
Association of FDX1 expression with clinical features
row_count
77
column_count
4
table object · 8 fields
label
Table 4
caption
Clinical and demographic characteristics of stomach adenocarcinoma patients with low and high expression of FDX1
rows array · 77 items
[0] array · 4 items
[0]
Characteristic
[1]
Low expression of FDX1
[2]
High expression of FDX1
[3]
p
[1] array · 4 items
[0]
n
[1]
187
[2]
188
[3]
[2] array · 4 items
[0]
T stage, n (%)
[1]
[2]
[3]
0.498
[3] array · 4 items
[0]
T1
[1]
8 (2.2%)
[2]
11 (3%)
[3]
[4] array · 4 items
[0]
T2
[1]
41 (11.2%)
[2]
39 (10.6%)
[3]
[5] array · 4 items
[0]
T3
[1]
90 (24.5%)
[2]
78 (21.3%)
[3]
[6] array · 4 items
[0]
T4
[1]
45 (12.3%)
[2]
55 (15%)
[3]
[7] array · 4 items
[0]
N stage, n (%)
[1]
[2]
[3]
0.137
[8] array · 4 items
[0]
N0
[1]
58 (16.2%)
[2]
53 (14.8%)
[3]
[9] array · 4 items
[0]
N1
[1]
41 (11.5%)
[2]
56 (15.7%)
[3]
[10] array · 4 items
[0]
N2
[1]
35 (9.8%)
[2]
40 (11.2%)
[3]
[11] array · 4 items
[0]
N3
[1]
44 (12.3%)
[2]
30 (8.4%)
[3]
[12] array · 4 items
[0]
M stage, n (%)
[1]
[2]
[3]
0.188
[13] array · 4 items
[0]
M0
[1]
159 (44.8%)
[2]
171 (48.2%)
[3]
[14] array · 4 items
[0]
M1
[1]
16 (4.5%)
[2]
9 (2.5%)
[3]
[15] array · 4 items
[0]
Pathologic stage, n (%)
[1]
[2]
[3]
0.466
[16] array · 4 items
[0]
Stage I
[1]
26 (7.4%)
[2]
27 (7.7%)
[3]
[17] array · 4 items
[0]
Stage II
[1]
49 (13.9%)
[2]
62 (17.6%)
[3]
[18] array · 4 items
[0]
Stage III
[1]
77 (21.9%)
[2]
73 (20.7%)
[3]
[19] array · 4 items
[0]
Stage IV
[1]
22 (6.2%)
[2]
16 (4.5%)
[3]
[20] array · 4 items
[0]
Primary therapy outcome, n (%)
[1]
[2]
[3]
0.123
[21] array · 4 items
[0]
PD
[1]
41 (12.9%)
[2]
24 (7.6%)
[3]
[22] array · 4 items
[0]
SD
[1]
8 (2.5%)
[2]
9 (2.8%)
[3]
[23] array · 4 items
[0]
PR
[1]
2 (0.6%)
[2]
2 (0.6%)
[3]
[24] array · 4 items
[0]
CR
[1]
108 (34.1%)
[2]
123 (38.8%)
[3]
[25] array · 4 items
[0]
Gender, n (%)
[1]
[2]
[3]
0.173
[26] array · 4 items
[0]
Female
[1]
60 (16%)
[2]
74 (19.7%)
[3]
[27] array · 4 items
[0]
Male
[1]
127 (33.9%)
[2]
114 (30.4%)
[3]
[28] array · 4 items
[0]
Race, n (%)
[1]
[2]
[3]
0.028
[29] array · 4 items
[0]
Asian
[1]
32 (9.9%)
[2]
42 (13%)
[3]
[30] array · 4 items
[0]
Black or African American
[1]
2 (0.6%)
[2]
9 (2.8%)
[3]
[31] array · 4 items
[0]
White
[1]
128 (39.6%)
[2]
110 (34.1%)
[3]
[32] array · 4 items
[0]
Age, n (%)
[1]
[2]
[3]
0.270
[33] array · 4 items
[0]
< = 65
[1]
88 (23.7%)
[2]
76 (20.5%)
[3]
[34] array · 4 items
[0]
> 65
[1]
98 (26.4%)
[2]
109 (29.4%)
[3]
[35] array · 4 items
[0]
Histological type, n (%)
[1]
[2]
[3]
0.050
[36] array · 4 items
[0]
Diffuse type
[1]
42 (11.2%)
[2]
21 (5.6%)
[3]
[37] array · 4 items
[0]
Mucinous type
[1]
11 (2.9%)
[2]
8 (2.1%)
[3]
[38] array · 4 items
[0]
Not otherwise specified
[1]
95 (25.4%)
[2]
112 (29.9%)
[3]
[39] array · 4 items
[0]
Papillary type
[1]
2 (0.5%)
[2]
3 (0.8%)
[3]
[40] array · 4 items
[0]
Signet ring type
[1]
7 (1.9%)
[2]
4 (1.1%)
[3]
[41] array · 4 items
[0]
Tubular type
[1]
30 (8%)
[2]
39 (10.4%)
[3]
[42] array · 4 items
[0]
Residual tumor, n (%)
[1]
[2]
[3]
0.014
[43] array · 4 items
[0]
R0
[1]
143 (43.5%)
[2]
155 (47.1%)
[3]
[44] array · 4 items
[0]
R1
[1]
13 (4%)
[2]
2 (0.6%)
[3]
[45] array · 4 items
[0]
R2
[1]
8 (2.4%)
[2]
8 (2.4%)
[3]
[46] array · 4 items
[0]
Histologic grade, n (%)
[1]
[2]
[3]
0.936
[47] array · 4 items
[0]
G1
[1]
5 (1.4%)
[2]
5 (1.4%)
[3]
[48] array · 4 items
[0]
G2
[1]
66 (18%)
[2]
71 (19.4%)
[3]
[49] array · 4 items
[0]
G3
[1]
110 (30.1%)
[2]
109 (29.8%)
[3]
[50] array · 4 items
[0]
Anatomic neoplasm subdivision, n (%)
[1]
[2]
[3]
0.286
[51] array · 4 items
[0]
Antrum/distal
[1]
65 (18%)
[2]
73 (20.2%)
[3]
[52] array · 4 items
[0]
Cardia/proximal
[1]
29 (8%)
[2]
19 (5.3%)
[3]
[53] array · 4 items
[0]
Fundus/body
[1]
62 (17.2%)
[2]
68 (18.8%)
[3]
[54] array · 4 items
[0]
Gastroesophageal junction
[1]
24 (6.6%)
[2]
17 (4.7%)
[3]
[55] array · 4 items
[0]
Other
[1]
1 (0.3%)
[2]
3 (0.8%)
[3]
[56] array · 4 items
[0]
Reflux history, n (%)
[1]
[2]
[3]
0.723
[57] array · 4 items
[0]
No
[1]
86 (40.2%)
[2]
89 (41.6%)
[3]
[58] array · 4 items
[0]
Yes
[1]
21 (9.8%)
[2]
18 (8.4%)
[3]
[59] array · 4 items
[0]
Antireflux treatment, n (%)
[1]
[2]
[3]
0.036
[60] array · 4 items
[0]
No
[1]
66 (36.9%)
[2]
76 (42.5%)
[3]
[61] array · 4 items
[0]
Yes
[1]
25 (14%)
[2]
12 (6.7%)
[3]
[62] array · 4 items
[0]
H. pylori infection, n (%)
[1]
[2]
[3]
0.781
[63] array · 4 items
[0]
No
[1]
71 (43.6%)
[2]
74 (45.4%)
[3]
[64] array · 4 items
[0]
Yes
[1]
10 (6.1%)
[2]
8 (4.9%)
[3]
[65] array · 4 items
[0]
Barretts esophagus, n (%)
[1]
[2]
[3]
0.301
[66] array · 4 items
[0]
No
[1]
95 (45.7%)
[2]
98 (47.1%)
[3]
[67] array · 4 items
[0]
Yes
[1]
10 (4.8%)
[2]
5 (2.4%)
[3]
[68] array · 4 items
[0]
OS event, n (%)
[1]
[2]
[3]
0.031
[69] array · 4 items
[0]
Alive
[1]
103 (27.5%)
[2]
125 (33.3%)
[3]
[70] array · 4 items
[0]
Dead
[1]
84 (22.4%)
[2]
63 (16.8%)
[3]
[71] array · 4 items
[0]
DSS event, n (%)
[1]
[2]
[3]
0.089
[72] array · 4 items
[0]
Alive
[1]
124 (35%)
[2]
139 (39.3%)
[3]
[73] array · 4 items
[0]
Dead
[1]
53 (15%)
[2]
38 (10.7%)
[3]
[74] array · 4 items
[0]
PFI event, n (%)
[1]
[2]
[3]
0.143
[75] array · 4 items
[0]
Alive
[1]
118 (31.5%)
[2]
133 (35.5%)
[3]
[76] array · 4 items
[0]
Dead
[1]
69 (18.4%)
[2]
55 (14.7%)
[3]
row_count
77
column_count
4
numeric_cells
135
header_rows
1
locator
section[19]/table-wrap[1]#Tab4
[5] object · 16 fields
id
asset:table:pmid:40410601:5
role
table
format
jats-table
media_type
application/vnd.jats.table+json
uri
null
sha256
sha256:4c9e11afe1fd948327da26049caf0c31fd745fbcb19237883e6b033e7fd9f295
bytes
618
access
open
state
verified
reader
read_table
reader_status
available
identifier
section[20]/table-wrap[1]#Tab5
version
null
note
Association of FDX1 expression with drug sensitivity in STAD cell lines
structure object · 5 fields
pmcid
PMC12102457
section_index
20
section_title
Diagnostic and prognostic significance of FDX1
row_count
6
column_count
4
table object · 8 fields
label
Table 5
caption
Association of FDX1 expression with drug sensitivity in STAD cell lines
rows array · 6 items
[0] array · 4 items
[0]
Drug
[1]
Low expression of FDX1
[2]
High expression of FDX1
[3]
p value
[1] array · 4 items
[0]
Cisplatin IC50 (µM)
[1]
8.24 ± 2.71
[2]
5.13 ± 1.89
[3]
0.012
[2] array · 4 items
[0]
5-Fluorouracil IC50 (µM)
[1]
15.63 ± 4.28
[2]
10.82 ± 3.45
[3]
0.034
[3] array · 4 items
[0]
Paclitaxel IC50 (nM)
[1]
6.72 ± 2.14
[2]
5.89 ± 1.97
[3]
0.267
[4] array · 4 items
[0]
Doxorubicin IC50 (µM)
[1]
1.83 ± 0.62
[2]
1.51 ± 0.54
[3]
0.114
[5] array · 4 items
[0]
Oxaliplatin IC50 (µM)
[1]
12.47 ± 3.21
[2]
9.18 ± 2.86
[3]
0.041
row_count
6
column_count
4
numeric_cells
20
header_rows
1
locator
section[20]/table-wrap[1]#Tab5
gaps array · 1 item
[0]
asset:source:pmid:40410601 not verified
analysis object · 4 fields
state
absent
methods array · 0 items
targets array · 0 items
gaps array · 2 items
[0]
method
[1]
targets
capability object · 3 fields
state
absent
requirements array · 0 items
gaps array · 1 item
[0]
capability
readiness object · 8 fields
state
partial
tier
null
blocking_axis
null
blocked_on
null
axes object · 0 fields
can_run object · 3 fields
dsl_operations array · 0 items
assets array · 6 items
[0]
source:pmid:40410601
[1]
asset:table:pmid:40410601:1
[2]
asset:table:pmid:40410601:2
[3]
asset:table:pmid:40410601:3
[4]
asset:table:pmid:40410601:4
[5]
asset:table:pmid:40410601:5
steps array · 1 item
[0]
read_published_estimate
must_build object · 5 fields
dsl_operations array · 0 items
converters array · 0 items
readers array · 1 item
[0]
xml
capabilities array · 0 items
data_gaps array · 1 item
[0]
source:pmid:40410601
gaps array · 1 item
[0]
corpus_record_absent
review object · 5 fields
state
partial
machine_critique object · 7 fields
status
blocked
providers array · 0 items
target_providers array · 0 items
agreement
false
disagreements array · 0 items
agreement_basis object · 2 fields
policy
decisive_fields
decisive_fields array · 4 items
[0]
work_type
[1]
number_stated
[2]
parent_value
[3]
unit
blinded
true
human_critique object · 5 fields
status
not_run
reviewer
null
signed_at
null
conflict_checked
false
commentary
null
stages array · 7 items
[0] object · 4 fields
key
target_materials
status
pending
reason
null
evidence
null
[1] object · 4 fields
key
independent_readings
status
blocked
reason
The independent readings are incomplete or disagree; the source evidence must resolve the difference.
evidence object · 1 field
provider_errors array · 4 items
[0] object · 4 fields
provider
minimax
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[1] object · 4 fields
provider
minimax_alt
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[2] object · 4 fields
provider
minimax
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[3] object · 4 fields
provider
minimax_alt
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[2] object · 4 fields
key
source_resolution
status
pending
reason
null
evidence
null
[3] object · 4 fields
key
protocol_reconstruction
status
pending
reason
null
evidence
null
[4] object · 4 fields
key
control_execution
status
pending
reason
null
evidence
null
[5] object · 4 fields
key
control_comparison
status
pending
reason
null
evidence
null
[6] object · 4 fields
key
publication
status
pending
reason
null
evidence
null
gaps array · 3 items
[0]
review.human_critique
[1]
review.machine_critique.blocked
[2]
review.machine_critique.providers
execution object · 5 fields
state
absent
status
not_run
mode
null
runs array · 0 items
gaps array · 1 item
[0]
execution.not_run
provenance object · 7 fields
entities array · 1 item
[0] object · 3 fields
id
package:2b320ae852278b6e66ebc4364946f383ddd409a103b552f3d1c445dc2ae15cf1
type
sep_package
label
SEP v1 package for pmid:40410601
activities array · 1 item
[0] object · 4 fields
id
activity:conversion:pmid:40410601
type
conversion
used array · 1 item
[0]
package:2b320ae852278b6e66ebc4364946f383ddd409a103b552f3d1c445dc2ae15cf1
agent
agent:corpus-assay-engine
agents array · 1 item
[0] object · 3 fields
id
agent:corpus-assay-engine
type
software
label
Corpus assay engine
source_run_id
run-20261023T122449232913
dsl_catalogue_fingerprint
343fb30756ba6ec3
capability_table_fingerprint
2cb3e42f047d2ecf
snapshot_id
ba34b49490d9bfaf
lineage object · 4 fields
parent_id
pmid:40410601
parent_hash
sha256:8e9c3b87bef21e2f69f6cdd70d6f3210a1de5db540d9057eb36f57a4f941d029
fork_of
null
generation
2
gaps array · 14 items
[0]
abstract
[1]
asset:source:pmid:40410601 not verified
[2]
authors
[3]
capability
[4]
corpus_record_absent
[5]
execution.not_run
[6]
method
[7]
review.human_critique
[8]
review.machine_critique.blocked
[9]
review.machine_critique.providers
[10]
step:obtain_source_data blocked on data:not_downloaded
[11]
step:run_analysis blocked on no owned computational capability is bound to this experiment
[12]
step:run_analysis input 'materials:the source data behind the published result in pmid:40410601' does not resolve to a declared asset
[13]
targets
Complete file 
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"data": {"state": "partial", "assets": [{"id": "source:pmid:40410601", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.1007/s12672-025-02740-8", "sha256": "sha256:31f742b4bdf8966371d06a07e60fba017b68b244459e5e2fc6b4c23da07f6bcd", "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.1007/s12672-025-02740-8", "version": null, "note": "Source read by the package builder: full_text.", "structure": {"access_state": "full_text"}}, {"id": "asset:table:pmid:40410601:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:974fd439c45e90bb96a35a26da8dd9d68c6408c6da816e501c4d9a12d7c7cf3e", "bytes": 4091, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[18]/table-wrap[1]#Tab1", "version": null, "note": "Clinical and molecular characteristics associated with overall survival in stomach adenocarcinoma patients from univariate and multivariate cox analyses", "structure": {"pmcid": "PMC12102457", "section_index": 18, "section_title": "Clinical and molecular factors influencing prognosis", "row_count": 80, "column_count": 6}, "table": {"label": "Table 1", "caption": "Clinical and molecular characteristics associated with overall survival in stomach adenocarcinoma patients from univariate and multivariate cox analyses", "rows": [["Characteristics", "Total(N)", "Univariate analysis", "Multivariate analysis"], ["Hazard ratio (95% CI)", "P value", "Hazard ratio (95% CI)", "P value"], ["T stage", "362", "", "", "", ""], ["T1 and T2", "96", "Reference", "", "", ""], ["T3 and T4", "266", "1.719 (1.131–2.612)", "0.011", "1.325 (0.706–2.484)", "0.381"], ["N stage", "352", "", "", "", ""], ["N0 and N1", "204", "Reference", "", "", ""], ["N2 and N3", "148", "1.650 (1.182–2.302)", "0.003", "1.542 (0.880–2.700)", "0.130"], ["M stage", "352", "", "", "", ""], ["M0", "327", "Reference", "", "", ""], ["M1", "25", "2.254 (1.295–3.924)", "0.004", "1.349 (0.595–3.058)", "0.474"], ["Pathologic stage", "347", "", "", "", ""], ["Stage I and stage II", "160", "Reference", "", "", ""], ["Stage III and stage IV", "187", "1.947 (1.358–2.793)", "< 0.001", "1.101 (0.559–2.166)", "0.782"], ["Primary therapy outcome", "313", "", "", "", ""], ["PD and SD", "80", "Reference", "", "", ""], ["PR and CR", "233", "0.244 (0.168–0.354)", "< 0.001", "0.269 (0.176–0.410)", "< 0.001"], ["Gender", "370", "", "", "", ""], ["Female", "133", "Reference", "", "", ""], ["Male", "237", "1.267 (0.891–1.804)", "0.188", "", ""], ["Age", "367", "", "", "", ""], ["< = 65", "163", "Reference", "", "", ""], ["> 65", "204", "1.620 (1.154–2.276)", "0.005", "1.510 (0.992–2.300)", "0.055"], ["Residual tumor", "325", "", "", "", ""], ["R0", "294", "Reference", "", "", ""], ["R1 and R2", "31", "3.445 (2.160–5.494)", "< 0.001", "1.717 (0.929–3.174)", "0.084"], ["Histologic grade", "361", "", "", "", ""], ["G1", "10", "Reference", "", "", ""], ["G2 and G3", "351", "1.957 (0.484–7.910)", "0.346", "", ""], ["Reflux history", "213", "", "", "", ""], ["No", "174", "Reference", "", "", ""], ["Yes", "39", "0.582 (0.291–1.162)", "0.125", "", ""], ["Antireflux treatment", "179", "", "", "", ""], ["No", "142", "Reference", "", "", ""], ["Yes", "37", "0.756 (0.422–1.353)", "0.346", "", ""], ["H. pylori infection", "162", "", "", "", ""], ["No", "144", "Reference", "", "", ""], ["Yes", "18", "0.650 (0.279–1.513)", "0.317", "", ""], ["Barretts esophagus", "207", "", "", "", ""], ["No", "192", "Reference", "", "", ""], ["Yes", "15", "0.892 (0.326–2.441)", "0.824", "", ""], ["Race", "320", "", "", "", ""], ["Asian", "73", "Reference", "", "", ""], ["Black or African American and White", "247", "1.473 (0.890–2.439)", "0.132", "", ""], ["Histological type", "369", "", "", "", ""], ["Not otherwise specified", "202", "Reference", "", "", ""], ["Diffuse type and mucinous type and papillary type and signet ring type and tubular type", "167", "0.815 (0.586–1.132)", "0.222", "", ""], ["Anatomic neoplasm subdivision", "357", "", "", "", ""], ["Other", "4", "Reference", "", "", ""], ["Antrum/distal and cardia/proximal and fundus/body and gastroesophageal junction", "353", "9,411,274.129 (0.000-Inf)", "0.993", "", ""], ["FDX1", "370", "", "", "", ""], ["Low", "185", "Reference", "", "", ""], ["High", "185", "0.714 (0.513–0.994)", "0.046", "0.825 (0.546–1.246)", "0.360"], ["LIAS", "370", "", "", "", ""], ["Low", "186", "Reference", "", "", ""], ["High", "184", "0.839 (0.604–1.165)", "0.295", "", ""], ["LIPT1", "370", "", "", "", ""], ["Low", "185", "Reference", "", "", ""], ["High", "185", "1.243 (0.895–1.726)", "0.195", "", ""], ["DLD", "370", "", "", "", ""], ["Low", "185", "Reference", "", "", ""], ["High", "185", "1.035 (0.746–1.435)", "0.838", "", ""], ["DLAT", "370", "", "", "", ""], ["Low", "184", "Reference", "", "", ""], ["High", "186", "1.031 (0.742–1.432)", "0.855", "", ""], ["PDHA1", "370", "", "", "", ""], ["Low", "186", "Reference", "", "", ""], ["High", "184", "1.033 (0.745–1.434)", "0.844", "", ""], ["PDHB", "370", "", "", "", ""], ["Low", "183", "Reference", "", "", ""], ["High", "187", "1.151 (0.830–1.597)", "0.399", "", ""], ["MTF1", "370", "", "", "", ""], ["Low", "185", "Reference", "", "", ""], ["High", "185", "0.814 (0.587–1.130)", "0.219", "", ""], ["GLS", "370", "", "", "", ""], ["Low", "185", "Reference", "", "", ""], ["High", "185", "1.139 (0.821–1.580)", "0.437", "", ""], ["CDKN2A", "370", "", "", "", ""], ["Low", "184", "Reference", "", "", ""], ["High", "186", "0.873 (0.629–1.211)", "0.415", "", ""]], "row_count": 80, "column_count": 6, "numeric_cells": 150, "header_rows": 2, "locator": "section[18]/table-wrap[1]#Tab1"}}, {"id": "asset:table:pmid:40410601:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:910ddd025b78926f7dae90705b9ead82c8bb307b12af6984ffed70787809a0c2", "bytes": 4100, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[18]/table-wrap[2]#Tab2", "version": null, "note": "Clinical and molecular characteristics associated with disease specific survival in stomach adenocarcinoma patients from univariate and multivariate cox analyses", "structure": {"pmcid": "PMC12102457", "section_index": 18, "section_title": "Clinical and molecular factors influencing prognosis", "row_count": 80, "column_count": 6}, "table": {"label": "Table 2", "caption": "Clinical and molecular characteristics associated with disease specific survival in stomach adenocarcinoma patients from univariate and multivariate cox analyses", "rows": [["Characteristics", "Total(N)", "Univariate analysis", "Multivariate analysis"], ["Hazard ratio (95% CI)", "P value", "Hazard ratio (95% CI)", "P value"], ["T stage", "345", "", "", "", ""], ["T1 and T2", "90", "Reference", "", "", ""], ["T3 and T4", "255", "2.089 (1.192–3.660)", "0.010", "1.302 (0.645–2.628)", "0.462"], ["N stage", "334", "", "", "", ""], ["N0 and N1", "192", "Reference", "", "", ""], ["N2 and N3", "142", "2.110 (1.378–3.231)", "< 0.001", "2.264 (1.071–4.785)", "0.032"], ["M stage", "333", "", "", "", ""], ["M0", "311", "Reference", "", "", ""], ["M1", "22", "2.438 (1.221–4.870)", "0.012", "1.098 (0.432–2.791)", "0.844"], ["Pathologic stage", "331", "", "", "", ""], ["Stage I and stage II", "154", "Reference", "", "", ""], ["Stage III and stage IV", "177", "2.146 (1.352–3.404)", "0.001", "0.752 (0.312–1.809)", "0.524"], ["Primary therapy outcome", "310", "", "", "", ""], ["PD and SD", "78", "Reference", "", "", ""], ["PR and CR", "232", "0.125 (0.079–0.197)", "< 0.001", "0.130 (0.076–0.224)", "< 0.001"], ["Gender", "349", "", "", "", ""], ["Female", "125", "Reference", "", "", ""], ["Male", "224", "1.573 (0.985–2.514)", "0.058", "1.335 (0.751–2.376)", "0.325"], ["Age", "346", "", "", "", ""], ["< = 65", "160", "Reference", "", "", ""], ["> 65", "186", "1.211 (0.797–1.840)", "0.371", "", ""], ["Residual tumor", "314", "", "", "", ""], ["R0", "287", "Reference", "", "", ""], ["R1 and R2", "27", "5.142 (3.014–8.771)", "< 0.001", "2.748 (1.432–5.275)", "0.002"], ["Histologic grade", "340", "", "", "", ""], ["G1", "9", "Reference", "", "", ""], ["G2 and G3", "331", "2.014 (0.280–14.475)", "0.486", "", ""], ["Reflux history", "208", "", "", "", ""], ["No", "169", "Reference", "", "", ""], ["Yes", "39", "0.598 (0.272–1.313)", "0.200", "", ""], ["Antireflux treatment", "167", "", "", "", ""], ["No", "131", "Reference", "", "", ""], ["Yes", "36", "0.758 (0.380–1.511)", "0.431", "", ""], ["H. pylori infection", "157", "", "", "", ""], ["No", "139", "Reference", "", "", ""], ["Yes", "18", "0.558 (0.200–1.554)", "0.264", "", ""], ["Barretts esophagus", "201", "", "", "", ""], ["No", "187", "Reference", "", "", ""], ["Yes", "14", "0.974 (0.304–3.118)", "0.964", "", ""], ["Race", "305", "", "", "", ""], ["Asian", "71", "Reference", "", "", ""], ["Black or African American and White", "234", "1.050 (0.593–1.857)", "0.867", "", ""], ["Histological type", "348", "", "", "", ""], ["Not otherwise specified", "184", "Reference", "", "", ""], ["Diffuse type and mucinous type and papillary type and signet ring type and tubular type", "164", "1.204 (0.792–1.831)", "0.386", "", ""], ["Anatomic neoplasm subdivision", "341", "", "", "", ""], ["Other", "4", "Reference", "", "", ""], ["Antrum/Distal and Cardia/Proximal and Fundus/Body and Gastroesophageal junction", "337", "9,382,799.777 (0.000-Inf)", "0.994", "", ""], ["FDX1", "349", "", "", "", ""], ["Low", "175", "Reference", "", "", ""], ["High", "174", "0.677 (0.444–1.033)", "0.070", "0.917 (0.555–1.513)", "0.733"], ["LIAS", "349", "", "", "", ""], ["Low", "178", "Reference", "", "", ""], ["High", "171", "0.743 (0.488–1.131)", "0.166", "", ""], ["LIPT1", "349", "", "", "", ""], ["Low", "179", "Reference", "", "", ""], ["High", "170", "1.231 (0.811–1.869)", "0.329", "", ""], ["DLD", "349", "", "", "", ""], ["Low", "181", "Reference", "", "", ""], ["High", "168", "0.890 (0.586–1.353)", "0.587", "", ""], ["DLAT", "349", "", "", "", ""], ["Low", "179", "Reference", "", "", ""], ["High", "170", "0.881 (0.580–1.337)", "0.551", "", ""], ["PDHA1", "349", "", "", "", ""], ["Low", "180", "Reference", "", "", ""], ["High", "169", "0.816 (0.537–1.238)", "0.339", "", ""], ["PDHB", "349", "", "", "", ""], ["Low", "179", "Reference", "", "", ""], ["High", "170", "1.184 (0.781–1.794)", "0.427", "", ""], ["MTF1", "349", "", "", "", ""], ["Low", "176", "Reference", "", "", ""], ["High", "173", "0.822 (0.542–1.247)", "0.356", "", ""], ["GLS", "349", "", "", "", ""], ["Low", "177", "Reference", "", "", ""], ["High", "172", "1.191 (0.785–1.807)", "0.411", "", ""], ["CDKN2A", "349", "", "", "", ""], ["Low", "168", "Reference", "", "", ""], ["High", "181", "0.997 (0.657–1.511)", "0.987", "", ""]], "row_count": 80, "column_count": 6, "numeric_cells": 150, "header_rows": 2, "locator": "section[18]/table-wrap[2]#Tab2"}}, {"id": "asset:table:pmid:40410601:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:478c8250f45afdd333db3571bb3d43c1648bf66af8427ec3d61df5f8a52c15ab", "bytes": 4178, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[18]/table-wrap[3]#Tab3", "version": null, "note": "Clinical and molecular characteristics associated with progression free interval in stomach adenocarcinoma patients from univariate and multivariate cox analyses", "structure": {"pmcid": "PMC12102457", "section_index": 18, "section_title": "Clinical and molecular factors influencing prognosis", "row_count": 80, "column_count": 6}, "table": {"label": "Table 3", "caption": "Clinical and molecular characteristics associated with progression free interval in stomach adenocarcinoma patients from univariate and multivariate cox analyses", "rows": [["Characteristics", "Total(N)", "Univariate analysis", "Multivariate analysis"], ["Hazard ratio (95% CI)", "P value", "Hazard ratio (95% CI)", "P value"], ["T stage", "364", "", "", "", ""], ["T1 and T2", "97", "Reference", "", "", ""], ["T3 and T4", "267", "1.705 (1.095–2.654)", "0.018", "0.643 (0.250–1.656)", "0.361"], ["N stage", "354", "", "", "", ""], ["N0 and N1", "205", "Reference", "", "", ""], ["N2 and N3", "149", "1.892 (1.325–2.703)", "< 0.001", "1.429 (0.662–3.083)", "0.364"], ["M stage", "353", "", "", "", ""], ["M0", "328", "Reference", "", "", ""], ["M1", "25", "2.224 (1.194–4.144)", "0.012", "0.997 (0.314–3.164)", "0.996"], ["Pathologic stage", "349", "", "", "", ""], ["Stage I and stage II", "161", "Reference", "", "", ""], ["Stage III and stage IV", "188", "1.676 (1.154–2.435)", "0.007", "1.406 (0.507–3.901)", "0.513"], ["Primary therapy outcome", "315", "", "", "", ""], ["PD and SD", "82", "Reference", "", "", ""], ["PR and CR", "233", "0.128 (0.087–0.188)", "< 0.001", "0.111 (0.051–0.245)", "< 0.001"], ["Gender", "372", "", "", "", ""], ["Female", "133", "Reference", "", "", ""], ["Male", "239", "1.638 (1.099–2.440)", "0.015", "1.591 (0.721–3.509)", "0.250"], ["Age", "369", "", "", "", ""], ["< = 65", "164", "Reference", "", "", ""], ["> 65", "205", "0.858 (0.603–1.221)", "0.395", "", ""], ["Residual tumor", "326", "", "", "", ""], ["R0", "295", "Reference", "", "", ""], ["R1 and R2", "31", "3.469 (2.127–5.656)", "< 0.001", "1.571 (0.757–3.260)", "0.225"], ["Histologic grade", "363", "", "", "", ""], ["G1", "10", "Reference", "", "", ""], ["G2 and G3", "353", "1.555 (0.384–6.294)", "0.536", "", ""], ["Reflux history", "214", "", "", "", ""], ["No", "175", "Reference", "", "", ""], ["Yes", "39", "0.482 (0.232–1.000)", "0.050", "1.534 (0.417–5.647)", "0.520"], ["Antireflux treatment", "179", "", "", "", ""], ["No", "142", "Reference", "", "", ""], ["Yes", "37", "0.584 (0.298–1.146)", "0.118", "", ""], ["H. pylori infection", "163", "", "", "", ""], ["No", "145", "Reference", "", "", ""], ["Yes", "18", "0.321 (0.100–1.024)", "0.055", "0.947 (0.251–3.579)", "0.936"], ["Barretts esophagus", "208", "", "", "", ""], ["No", "193", "Reference", "", "", ""], ["Yes", "15", "0.953 (0.348–2.612)", "0.926", "", ""], ["Race", "322", "", "", "", ""], ["Asian", "74", "Reference", "", "", ""], ["Black or African American and White", "248", "0.992 (0.624–1.578)", "0.973", "", ""], ["Histological type", "371", "", "", "", ""], ["Not otherwise specified", "204", "Reference", "", "", ""], ["Diffuse type and mucinous type and papillary type and signet ring type and tubular type", "167", "1.080 (0.759–1.536)", "0.671", "", ""], ["Anatomic neoplasm subdivision", "358", "", "", "", ""], ["Other", "4", "Reference", "", "", ""], ["Antrum/distal and Cardia/proximal and Fundus/body and gastroesophageal Junction", "354", "9,479,916.218 (0.000-Inf)", "0.993", "", ""], ["FDX1", "372", "", "", "", ""], ["Low", "186", "Reference", "", "", ""], ["High", "186", "0.758 (0.532–1.080)", "0.126", "", ""], ["LIAS", "372", "", "", "", ""], ["Low", "186", "Reference", "", "", ""], ["High", "186", "0.567 (0.395–0.816)", "0.002", "0.996 (0.531–1.868)", "0.990"], ["LIPT1", "372", "", "", "", ""], ["Low", "185", "Reference", "", "", ""], ["High", "187", "0.969 (0.680–1.381)", "0.861", "", ""], ["DLD", "372", "", "", "", ""], ["Low", "187", "Reference", "", "", ""], ["High", "185", "0.875 (0.614–1.247)", "0.460", "", ""], ["DLAT", "372", "", "", "", ""], ["Low", "186", "Reference", "", "", ""], ["High", "186", "0.816 (0.573–1.162)", "0.260", "", ""], ["PDHA1", "372", "", "", "", ""], ["Low", "186", "Reference", "", "", ""], ["High", "186", "0.668 (0.468–0.953)", "0.026", "0.896 (0.484–1.659)", "0.727"], ["PDHB", "372", "", "", "", ""], ["Low", "184", "Reference", "", "", ""], ["High", "188", "0.891 (0.626–1.267)", "0.520", "", ""], ["MTF1", "372", "", "", "", ""], ["Low", "187", "Reference", "", "", ""], ["High", "185", "0.836 (0.588–1.190)", "0.321", "", ""], ["GLS", "372", "", "", "", ""], ["Low", "187", "Reference", "", "", ""], ["High", "185", "0.995 (0.699–1.418)", "0.979", "", ""], ["CDKN2A", "372", "", "", "", ""], ["Low", "185", "Reference", "", "", ""], ["High", "187", "0.855 (0.601–1.218)", "0.386", "", ""]], "row_count": 80, "column_count": 6, "numeric_cells": 156, "header_rows": 2, "locator": "section[18]/table-wrap[3]#Tab3"}}, {"id": "asset:table:pmid:40410601:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:3578352c6326f3f91b886ff9a4c27d800cfea232c0b8a270fee033c926480a62", "bytes": 3265, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[19]/table-wrap[1]#Tab4", "version": null, "note": "Clinical and demographic characteristics of stomach adenocarcinoma patients with low and high expression of FDX1", "structure": {"pmcid": "PMC12102457", "section_index": 19, "section_title": "Association of FDX1 expression with clinical features", "row_count": 77, "column_count": 4}, "table": {"label": "Table 4", "caption": "Clinical and demographic characteristics of stomach adenocarcinoma patients with low and high expression of FDX1", "rows": [["Characteristic", "Low expression of FDX1", "High expression of FDX1", "p"], ["n", "187", "188", ""], ["T stage, n (%)", "", "", "0.498"], ["T1", "8 (2.2%)", "11 (3%)", ""], ["T2", "41 (11.2%)", "39 (10.6%)", ""], ["T3", "90 (24.5%)", "78 (21.3%)", ""], ["T4", "45 (12.3%)", "55 (15%)", ""], ["N stage, n (%)", "", "", "0.137"], ["N0", "58 (16.2%)", "53 (14.8%)", ""], ["N1", "41 (11.5%)", "56 (15.7%)", ""], ["N2", "35 (9.8%)", "40 (11.2%)", ""], ["N3", "44 (12.3%)", "30 (8.4%)", ""], ["M stage, n (%)", "", "", "0.188"], ["M0", "159 (44.8%)", "171 (48.2%)", ""], ["M1", "16 (4.5%)", "9 (2.5%)", ""], ["Pathologic stage, n (%)", "", "", "0.466"], ["Stage I", "26 (7.4%)", "27 (7.7%)", ""], ["Stage II", "49 (13.9%)", "62 (17.6%)", ""], ["Stage III", "77 (21.9%)", "73 (20.7%)", ""], ["Stage IV", "22 (6.2%)", "16 (4.5%)", ""], ["Primary therapy outcome, n (%)", "", "", "0.123"], ["PD", "41 (12.9%)", "24 (7.6%)", ""], ["SD", "8 (2.5%)", "9 (2.8%)", ""], ["PR", "2 (0.6%)", "2 (0.6%)", ""], ["CR", "108 (34.1%)", "123 (38.8%)", ""], ["Gender, n (%)", "", "", "0.173"], ["Female", "60 (16%)", "74 (19.7%)", ""], ["Male", "127 (33.9%)", "114 (30.4%)", ""], ["Race, n (%)", "", "", "0.028"], ["Asian", "32 (9.9%)", "42 (13%)", ""], ["Black or African American", "2 (0.6%)", "9 (2.8%)", ""], ["White", "128 (39.6%)", "110 (34.1%)", ""], ["Age, n (%)", "", "", "0.270"], ["< = 65", "88 (23.7%)", "76 (20.5%)", ""], ["> 65", "98 (26.4%)", "109 (29.4%)", ""], ["Histological type, n (%)", "", "", "0.050"], ["Diffuse type", "42 (11.2%)", "21 (5.6%)", ""], ["Mucinous type", "11 (2.9%)", "8 (2.1%)", ""], ["Not otherwise specified", "95 (25.4%)", "112 (29.9%)", ""], ["Papillary type", "2 (0.5%)", "3 (0.8%)", ""], ["Signet ring type", "7 (1.9%)", "4 (1.1%)", ""], ["Tubular type", "30 (8%)", "39 (10.4%)", ""], ["Residual tumor, n (%)", "", "", "0.014"], ["R0", "143 (43.5%)", "155 (47.1%)", ""], ["R1", "13 (4%)", "2 (0.6%)", ""], ["R2", "8 (2.4%)", "8 (2.4%)", ""], ["Histologic grade, n (%)", "", "", "0.936"], ["G1", "5 (1.4%)", "5 (1.4%)", ""], ["G2", "66 (18%)", "71 (19.4%)", ""], ["G3", "110 (30.1%)", "109 (29.8%)", ""], ["Anatomic neoplasm subdivision, n (%)", "", "", "0.286"], ["Antrum/distal", "65 (18%)", "73 (20.2%)", ""], ["Cardia/proximal", "29 (8%)", "19 (5.3%)", ""], ["Fundus/body", "62 (17.2%)", "68 (18.8%)", ""], ["Gastroesophageal junction", "24 (6.6%)", "17 (4.7%)", ""], ["Other", "1 (0.3%)", "3 (0.8%)", ""], ["Reflux history, n (%)", "", "", "0.723"], ["No", "86 (40.2%)", "89 (41.6%)", ""], ["Yes", "21 (9.8%)", "18 (8.4%)", ""], ["Antireflux treatment, n (%)", "", "", "0.036"], ["No", "66 (36.9%)", "76 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