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pmid:40488804

Targeting NLRC4 for potential therapeutic strategies in lung adenocarcinoma.

Discover oncology · 2025 doi:10.1007/s12672-025-02839-y

Paper

partial

Experiment

partial

Data

partial

Analysis

absent

Execution

absent

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Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator

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title

Targeting NLRC4 for potential therapeutic strategies in lung adenocarcinoma.

doi

10.1007/s12672-025-02839-y

pmid

40488804

authors

null

journal

Discover oncology

year

2025

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Primer sequences for qRT-PCR analysis of 7 ARGs

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PMC12149082

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section_title

Construction and verification of the risk prediction model for DEARGs

row_count

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Table 1

caption

Primer sequences for qRT-PCR analysis of 7 ARGs

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Primer sequence (5ʹ → 3ʹ)

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ATIC-F

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AGTGTGTCCGTGTGGATAAGG

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GTGGTGTCAATCTGGGTCTCC

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CTGACATTGGAGAGGGAATGGA

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CAGACAAGCAGCAGGAGACTA

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Univariate Cox analysis of 13 DEARGs

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section_title

Expression and correlation of DEARGs and consensus clustering analysis in LUAD

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Table 2

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Univariate Cox analysis of 13 DEARGs

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1.000424955

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1.01673896

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Univariate and multivariate Cox regression analysis of autophagy-related gene prognostic signature (ARGPS)

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Expression and correlation of DEARGs and consensus clustering analysis in LUAD

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Table 3

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Univariate and multivariate Cox regression analysis of autophagy-related gene prognostic signature (ARGPS)

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[7]

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[8]

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[7]

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[8]

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Seven autophage-related genes differential expression across 18 cancer types

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DEARGs expression in pan-cancer

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Table 4

caption

Seven autophage-related genes differential expression across 18 cancer types

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[0] array · 8 items

[0]

Cancer

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ITGB4

[2]

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[3]

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[4]

ATIC

[5]

DAPK2

[6]

DLC1

[7]

DRAM1

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[1]

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[2]

9.14E−09

[3]

0.461482

[4]

4.49E−05

[5]

0.053169

[6]

1.27E−07

[7]

0.832511598

[2] array · 8 items

[0]

BRCA

[1]

3.21E−14

[2]

1.22E−57

[3]

0.494234

[4]

1.16E−47

[5]

7.32E−33

[6]

6.13E−46

[7]

1.37E−06

[3] array · 8 items

[0]

CHOL

[1]

2.26E−09

[2]

2.26E−09

[3]

0.017317

[4]

2.26E−09

[5]

0.000332

[6]

0.038115

[7]

6.77E−08

[4] array · 8 items

[0]

COAD

[1]

0.000487

[2]

6.71E−21

[3]

1.86E−05

[4]

6.54E−23

[5]

4.77E−05

[6]

1.82E−06

[7]

1.00E−11

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[0]

ESCA

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[2]

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[3]

0.060705

[4]

0.000169

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0.186179

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0.113364

[7]

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[6]

0.460228

[7]

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HNSC

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[2]

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[3]

3.73E−07

[4]

4.89E−18

[5]

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[6]

0.296516

[7]

1.52E−09

[8] array · 8 items

[0]

KICH

[1]

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[2]

5.90E−05

[3]

0.026817

[4]

1.36E−09

[5]

0.563391

[6]

2.48E−10

[7]

3.38E−05

[9] array · 8 items

[0]

KIRC

[1]

0.002579

[2]

9.07E−34

[3]

9.22E−32

[4]

0.001142

[5]

0.282792

[6]

0.607538

[7]

9.36E−20

[10] array · 8 items

[0]

KIRP

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[2]

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[3]

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[4]

1.67E−09

[5]

3.01E−09

[6]

3.98E−16

[7]

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[11] array · 8 items

[0]

LIHC

[1]

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[2]

2.35E−28

[3]

0.052874

[4]

1.56E−23

[5]

1.19E−20

[6]

1.55E−10

[7]

1.11E−11

[12] array · 8 items

[0]

LUAD

[1]

9.76E−12

[2]

2.68E−32

[3]

1.32E−32

[4]

8.51E−34

[5]

5.82E−30

[6]

1.76E−30

[7]

4.75E−19

[13] array · 8 items

[0]

LUSC

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4.50E−26

[2]

1.26E−30

[3]

7.77E−30

[4]

8.41E−27

[5]

5.16E−28

[6]

1.08E−30

[7]

2.81E−30

[14] array · 8 items

[0]

PRAD

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[2]

2.54E−20

[3]

0.384298

[4]

3.49E−05

[5]

0.447155

[6]

0.009781

[7]

4.23E−05

[15] array · 8 items

[0]

READ

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0.053814

[4]

2.70E−07

[5]

0.165055

[6]

0.001607

[7]

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[0]

STAD

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3.13E−05

[2]

5.16E−13

[3]

5.44E−08

[4]

1.25E−16

[5]

0.715863

[6]

0.327452

[7]

3.17E−08

[17] array · 8 items

[0]

THCA

[1]

4.40E−18

[2]

5.86E−07

[3]

0.000155

[4]

3.51E−22

[5]

1.34E−16

[6]

9.59E−08

[7]

6.76E−18

[18] array · 8 items

[0]

UCEC

[1]

0.308201

[2]

1.90E−21

[3]

0.79143

[4]

9.83E−17

[5]

6.12E−05

[6]

2.98E−17

[7]

0.354524369

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column_count

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The top 26 compounds selected from YaTCM as potential drugs targeting NLRC4

structure object · 5 fields

pmcid

PMC12149082

section_index

section_title

Virtual screening for potential drugs targeting NLRC4

row_count

column_count

table object · 8 fields

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Table 5

caption

The top 26 compounds selected from YaTCM as potential drugs targeting NLRC4

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[0] array · 3 items

[0]

Hits

[1]

Name

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Docking score

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[0]

[1]

Paleatin B

[2]

− 12.171

[2] array · 3 items

[0]

[1]

Magnolignan C

[2]

− 11.508

[3] array · 3 items

[0]

[1]

(±)−3ʹ,3ʹʹ-Bisdemethylpinoresinol

[2]

− 11.313

[4] array · 3 items

[0]

[1]

Muricarpone B

[2]

− 11.088

[5] array · 3 items

[0]

[1]

5-O-Ethyl-hirsutanonol

[2]

− 11.081

[6] array · 3 items

[0]

[1]

(2R-trans)−2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)−3-(hydroxymethyl)−7-methoxy-5-benzofuran-propanol

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− 10.727

[7] array · 3 items

[0]

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3-(-alpha,4-Dihydroxy-3-methoxybenzyl)−4-(hydroxy-3-methoxybenzyl)tetrahydrofuran

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[0]

[1]

5-O-Methylhirsutanonol

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[9] array · 3 items

[0]

[1]

Princepin

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[0]

[1]

3-(alpha,4-Dihydroxy-3-methoxybenzyl)−4-(hydroxy-3-methoxybenzyl) tetrahydrofuran

[2]

− 10.426

[11] array · 3 items

[0]

[1]

Licarin A

[2]

− 10.319

[12] array · 3 items

[0]

[1]

Citrusin A_qt

[2]

− 10.187

[13] array · 3 items

[0]

[1]

Isoamericanol A

[2]

− 10.116

[14] array · 3 items

[0]

[1]

5-(3-hydroxy-4-isoacetoxybutyn-1)-bithiophene

[2]

− 10.107

[15] array · 3 items

[0]

[1]

Polyhalogenated homosesquiterpenic fatty acid D

[2]

− 10.048

[16] array · 3 items

[0]

[1]

Nordihydroguaiaretic acid

[2]

− 9.936

[17] array · 3 items

[0]

[1]

(2R-trans) 2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)−3-(hydroxymethyl)−7-methoxy-5-benzofuranpropanol acetate

[2]

− 9.86

[18] array · 3 items

[0]

[1]

5-(3,4-dihydroxybutyn-1)-bithiophene

[2]

− 9.374

[19] array · 3 items

[0]

[1]

(s)-tryptophan-betaxanthin

[2]

− 9.197

[20] array · 3 items

[0]

[1]

Isoamericanol A

[2]

− 9.197

[21] array · 3 items

[0]

[1]

(SC2RC7)-gamma-Glutamyl-S-benzylcysteine

[2]

− 8.538

[22] array · 3 items

[0]

[1]

(–)-Thujaplicatin trimethyl ether

[2]

− 8.23

[23] array · 3 items

[0]

[1]

5alpha,6beta,7beta-Trihydroxy-8alpha-methoxy-2-(2-phenylethyl) chromone

[2]

− 8.07

[24] array · 3 items

[0]

[1]

threo-2,2ʹ-Dimethoxy-4-(3-hydroxy-1-propenyl)−4ʹ-(1,2,3-tri-hydroxypropyl) diphenyl ether

[2]

− 7.969

[25] array · 3 items

[0]

[1]

Citric acid

[2]

− 7.785

[26] array · 3 items

[0]

[1]

S-Methylglutathione

[2]

− 7.583

row_count

column_count

numeric_cells

header_rows

locator

section[20]/table-wrap[1]#Tab5

gaps array · 1 item

[0]

asset:source:pmid:40488804 not verified

analysis object · 4 fields

state

absent

methods array · 0 items

targets array · 0 items

gaps array · 2 items

[0]

method

[1]

targets

capability object · 3 fields

state

absent

requirements array · 0 items

gaps array · 1 item

[0]

capability

readiness object · 8 fields

state

partial

tier

null

blocking_axis

null

blocked_on

null

axes object · 0 fields

can_run object · 3 fields

dsl_operations array · 0 items

assets array · 6 items

[0]

source:pmid:40488804

[1]

asset:table:pmid:40488804:1

[2]

asset:table:pmid:40488804:2

[3]

asset:table:pmid:40488804:3

[4]

asset:table:pmid:40488804:4

[5]

asset:table:pmid:40488804:5

steps array · 1 item

[0]

read_published_estimate

must_build object · 5 fields

dsl_operations array · 0 items

converters array · 0 items

readers array · 1 item

[0]

xml

capabilities array · 0 items

data_gaps array · 1 item

[0]

source:pmid:40488804

gaps array · 1 item

[0]

corpus_record_absent

review object · 5 fields

state

partial

machine_critique object · 7 fields

status

blocked

providers array · 0 items

target_providers array · 0 items

agreement

false

disagreements array · 0 items

agreement_basis object · 2 fields

policy

decisive_fields

decisive_fields array · 4 items

[0]

work_type

[1]

number_stated

[2]

parent_value

[3]

unit

blinded

true

human_critique object · 5 fields

status

not_run

reviewer

null

signed_at

null

conflict_checked

false

commentary

null

stages array · 7 items

[0] object · 4 fields

key

target_materials

status

pending

reason

null

evidence

null

[1] object · 4 fields

key

independent_readings

status

blocked

reason

The independent readings are incomplete or disagree; the source evidence must resolve the difference.

evidence object · 1 field

provider_errors array · 4 items

[0] object · 4 fields

provider

minimax

model

null

reason

HTTP Error 429: Too Many Requests

raw_response

null

[1] object · 4 fields

provider

minimax_alt

model

null

reason

HTTP Error 429: Too Many Requests

raw_response

null

[2] object · 4 fields

provider

minimax

model

null

reason

HTTP Error 429: Too Many Requests

raw_response

null

[3] object · 4 fields

provider

minimax_alt

model

null

reason

HTTP Error 429: Too Many Requests

raw_response

null

[2] object · 4 fields

key

source_resolution

status

pending

reason

null

evidence

null

[3] object · 4 fields

key

protocol_reconstruction

status

pending

reason

null

evidence

null

[4] object · 4 fields

key

control_execution

status

pending

reason

null

evidence

null

[5] object · 4 fields

key

control_comparison

status

pending

reason

null

evidence

null

[6] object · 4 fields

key

publication

status

pending

reason

null

evidence

null

gaps array · 3 items

[0]

review.human_critique

[1]

review.machine_critique.blocked

[2]

review.machine_critique.providers

execution object · 5 fields

state

absent

status

not_run

mode

null

runs array · 0 items

gaps array · 1 item

[0]

execution.not_run

provenance object · 7 fields

entities array · 1 item

[0] object · 3 fields

package:d9a245af9bea3eabe194421d242e6361104d3d2c2c6414ea614d93c9accd5400

type

sep_package

label

SEP v1 package for pmid:40488804

activities array · 1 item

[0] object · 4 fields

activity:conversion:pmid:40488804

type

conversion

used array · 1 item

[0]

package:d9a245af9bea3eabe194421d242e6361104d3d2c2c6414ea614d93c9accd5400

agent

agent:corpus-assay-engine

agents array · 1 item

[0] object · 3 fields

agent:corpus-assay-engine

type

software

label

Corpus assay engine

source_run_id

run-20261023T122449232913

dsl_catalogue_fingerprint

343fb30756ba6ec3

capability_table_fingerprint

2cb3e42f047d2ecf

snapshot_id

ba34b49490d9bfaf

lineage object · 4 fields

parent_id

pmid:40488804

parent_hash

sha256:3d32e45130032548cceaba15a80baafeba2c391b46a88fee87720db40464ad35

fork_of

null

generation

gaps array · 14 items

[0]

abstract

[1]

asset:source:pmid:40488804 not verified

[2]

authors

[3]

capability

[4]

corpus_record_absent

[5]

execution.not_run

[6]

method

[7]

review.human_critique

[8]

review.machine_critique.blocked

[9]

review.machine_critique.providers

[10]

step:obtain_source_data blocked on data:not_downloaded

[11]

step:run_analysis blocked on no owned computational capability is bound to this experiment

[12]

step:run_analysis input 'materials:the source data behind the published result in pmid:40488804' does not resolve to a declared asset

[13]

targets

Complete file

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"0.789", "0.887", "0.642", "1.225", "0.466"], ["Stage", "1.667", "1.438", "1.931", "1.12E−11", "1.474", "1.184", "1.834", "0.001"], ["T", "1.526", "1.251", "1.861", "3.12E−05", "1.157", "0.929", "1.441", "0.194"], ["M", "0.923", "0.769", "1.107", "0.386", "0.987", "0.811", "1.200", "0.894"], ["N", "1.725", "1.445", "2.060", "1.82E−09", "1.207", "0.945", "1.540", "0.131"], ["Riskscore", "2.313", "1.755", "3.049", "2.64E−09", "2.331", "1.735", "3.130", "1.89E-08"]], "row_count": 9, "column_count": 9, "numeric_cells": 60, "header_rows": 2, "locator": "section[13]/table-wrap[2]#Tab3"}}, {"id": "asset:table:pmid:40488804:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:7662037895139bb69f32e3dff95e7ac400bfe702e67cfee1f861a4de6264d889", "bytes": 2012, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[16]/table-wrap[1]#Tab4", "version": null, "note": 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["HNSC", "3.69E−18", "2.54E−24", "3.73E−07", "4.89E−18", "0.006703", "0.296516", "1.52E−09"], ["KICH", "4.50E−10", "5.90E−05", "0.026817", "1.36E−09", "0.563391", "2.48E−10", "3.38E−05"], ["KIRC", "0.002579", "9.07E−34", "9.22E−32", "0.001142", "0.282792", "0.607538", "9.36E−20"], ["KIRP", "7.00E−07", "3.85E−16", "2.31E−05", "1.67E−09", "3.01E−09", "3.98E−16", "1.18E−11"], ["LIHC", "1.85E−10", "2.35E−28", "0.052874", "1.56E−23", "1.19E−20", "1.55E−10", "1.11E−11"], ["LUAD", "9.76E−12", "2.68E−32", "1.32E−32", "8.51E−34", "5.82E−30", "1.76E−30", "4.75E−19"], ["LUSC", "4.50E−26", "1.26E−30", "7.77E−30", "8.41E−27", "5.16E−28", "1.08E−30", "2.81E−30"], ["PRAD", "3.76E−14", "2.54E−20", "0.384298", "3.49E−05", "0.447155", "0.009781", "4.23E−05"], ["READ", "0.001995", "0.000185", "0.053814", "2.70E−07", "0.165055", "0.001607", "0.001678706"], ["STAD", "3.13E−05", "5.16E−13", "5.44E−08", "1.25E−16", "0.715863", "0.327452", "3.17E−08"], ["THCA", "4.40E−18", "5.86E−07", "0.000155", "3.51E−22", "1.34E−16", "9.59E−08", "6.76E−18"], ["UCEC", "0.308201", "1.90E−21", "0.79143", "9.83E−17", "6.12E−05", "2.98E−17", "0.354524369"]], "row_count": 19, "column_count": 8, "numeric_cells": 126, "header_rows": 1, "locator": "section[16]/table-wrap[1]#Tab4"}}, {"id": "asset:table:pmid:40488804:5", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:59f84c58de7759e3ba429fa9e219b7257f59fa2004b1a94c67d9f7824d5f13d8", "bytes": 1848, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[20]/table-wrap[1]#Tab5", "version": null, "note": "The top 26 compounds selected from YaTCM as potential drugs targeting NLRC4", "structure": {"pmcid": "PMC12149082", "section_index": 20, "section_title": "Virtual screening for potential drugs targeting NLRC4", "row_count": 27, "column_count": 3}, "table": {"label": "Table 5", "caption": "The top 26 compounds selected from YaTCM as 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