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pmid:40495644

Impact of SPP1 and HMOX1 Genes in Glioma: Correlations With Oncolytic Virus Infection, Adverse Prognosis and Increased Cell Proliferation.

Journal of cellular and molecular medicine · 2025 doi:10.1111/jcmm.70651

Paper

partial

Experiment

partial

Data

partial

Analysis

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Execution

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Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
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1.0
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pmid:40495644
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2026-11-01T10:25:51Z
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paper object · 10 fields
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title
Impact of SPP1 and HMOX1 Genes in Glioma: Correlations With Oncolytic Virus Infection, Adverse Prognosis and Increased Cell Proliferation.
doi
10.1111/jcmm.70651
pmid
40495644
authors
null
journal
Journal of cellular and molecular medicine
year
2025
abstract
null
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abstract
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authors
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the headline numerical result the paper states for its main finding
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Read the published estimate and its interval from the source
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The number a replication must land on, and the sentence it came from.
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the published estimate, its unit and its interval
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parameters object · 0 fields
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the source data with its provenance
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Run the analysis programme
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Re-run the paper's analysis on the source data and produce the registered result. | SEP input not carried into the asset list: materials:the source data behind the published result in pmid:40495644
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parameters object · 0 fields
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the registered result
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Baseline clinical characteristics data of glioma patients.
structure object · 5 fields
pmcid
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section_index
16
section_title
Clinicopathological Characteristics of Glioma Patients and Correlation With SPP1/HMOX1 Expression
row_count
29
column_count
7
table object · 8 fields
label
TABLE 1
caption
Baseline clinical characteristics data of glioma patients.
rows array · 29 items
[0] array · 3 items
[0]
Characteristics
[1]
SPP1
[2]
HMOX1
[1] array · 6 items
[0]
Low expression
[1]
High expression
[2]
p
[3]
Low expression
[4]
High expression
[5]
p
[2] array · 7 items
[0]
n
[1]
349
[2]
350
[3]
[4]
349
[5]
350
[6]
[3] array · 1 item
[0]
Gender, n (%)
[4] array · 7 items
[0]
Female
[1]
152 (21.7%)
[2]
146 (20.9%)
[3]
0.62
[4]
165 (23.6%)
[5]
133 (19%)
[6]
0.01
[5] array · 6 items
[0]
Male
[1]
197 (28.2%)
[2]
204 (29.2%)
[3]
[4]
184 (26.3%)
[5]
217 (31%)
[6] array · 1 item
[0]
Age, n (%)
[7] array · 7 items
[0]
< = 60
[1]
307 (43.9%)
[2]
249 (35.6%)
[3]
3.53E‐08
[4]
307 (43.9%)
[5]
249 (35.6%)
[6]
3.5E‐08
[8] array · 6 items
[0]
> 60
[1]
42 (6%)
[2]
101 (14.4%)
[3]
[4]
42 (6%)
[5]
101 (14.4%)
[9] array · 1 item
[0]
WHO grade, n (%)
[10] array · 7 items
[0]
G2
[1]
155 (24.3%)
[2]
69 (10.8%)
[3]
6.04E‐34
[4]
158 (24.8%)
[5]
66 (10.4%)
[6]
1.49E‐38
[11] array · 6 items
[0]
G3
[1]
138 (21.7%)
[2]
107 (16.8%)
[3]
[4]
137 (21.5%)
[5]
108 (17%)
[12] array · 6 items
[0]
G4
[1]
14 (2.2%)
[2]
154 (24.2%)
[3]
[4]
9 (1.4%)
[5]
159 (25%)
[13] array · 1 item
[0]
Histological type, n (%)
[14] array · 7 items
[0]
Astrocytoma
[1]
96 (13.7%)
[2]
100 (14.3%)
[3]
3.33E‐40
[4]
98 (14%)
[5]
98 (14%)
[6]
4.17E‐45
[15] array · 6 items
[0]
Oligodendroglioma
[1]
156 (22.3%)
[2]
44 (6.3%)
[3]
[4]
158 (22.6%)
[5]
42 (6%)
[16] array · 6 items
[0]
Oligoastrocytoma
[1]
83 (11.9%)
[2]
52 (7.4%)
[3]
[4]
84 (12%)
[5]
51 (7.3%)
[17] array · 6 items
[0]
Glioblastoma
[1]
14 (2%)
[2]
154 (22%)
[3]
[4]
9 (1.3%)
[5]
159 (22.7%)
[18] array · 1 item
[0]
IDH status, n (%)
[19] array · 7 items
[0]
WT
[1]
42 (6.1%)
[2]
204 (29.6%)
[3]
1.89E‐38
[4]
53 (7.7%)
[5]
193 (28%)
[6]
1.76E‐29
[20] array · 6 items
[0]
Mut
[1]
304 (44.1%)
[2]
139 (20.2%)
[3]
[4]
294 (42.7%)
[5]
149 (21.6%)
[21] array · 1 item
[0]
1p/19q codeletion, n (%)
[22] array · 7 items
[0]
Non‐codel
[1]
207 (29.9%)
[2]
313 (45.2%)
[3]
2.45E‐22
[4]
202 (29.2%)
[5]
318 (46%)
[6]
2.96E‐26
[23] array · 6 items
[0]
Codel
[1]
142 (20.5%)
[2]
30 (4.3%)
[3]
[4]
147 (21.2%)
[5]
25 (3.6%)
[24] array · 1 item
[0]
Primary therapy outcome, n (%)
[25] array · 7 items
[0]
PD
[1]
56 (12%)
[2]
56 (12%)
[3]
0.01
[4]
62 (13.3%)
[5]
50 (10.8%)
[6]
0.13
[26] array · 6 items
[0]
SD
[1]
99 (21.3%)
[2]
49 (10.5%)
[3]
[4]
96 (20.6%)
[5]
52 (11.2%)
[27] array · 6 items
[0]
PR
[1]
46 (9.9%)
[2]
19 (4.1%)
[3]
[4]
46 (9.9%)
[5]
19 (4.1%)
[28] array · 6 items
[0]
CR
[1]
96 (20.6%)
[2]
44 (9.5%)
[3]
[4]
94 (20.2%)
[5]
46 (9.9%)
row_count
29
column_count
7
numeric_cells
97
header_rows
2
locator
section[16]/table-wrap[1]#jcmm70651-tbl-0001
[2] object · 16 fields
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Univariate and multivariate cox regression analysis.
structure object · 5 fields
pmcid
PMC12152367
section_index
17
section_title
High SPP1 and HMOX1 Expression Are Correlated With a Worse Prognosis in Glioma
row_count
29
column_count
6
table object · 8 fields
label
TABLE 2
caption
Univariate and multivariate cox regression analysis.
rows array · 29 items
[0] array · 4 items
[0]
Characteristics
[1]
Total (N)
[2]
Univariate analysis
[3]
Multivariate analysis
[1] array · 4 items
[0]
HR(95% CI)
[1]
p
[2]
HR(95% CI)
[3]
p
[2] array · 1 item
[0]
SPP1
[3] array · 6 items
[0]
Low
[1]
348
[2]
[3]
[4]
[5]
0.184
[4] array · 5 items
[0]
High
[1]
350
[2]
4.049 (3.094–5.299)
[3]
< 0.001
[4]
1.333 (0.872–2.037)
[5] array · 1 item
[0]
HMOX1
[6] array · 6 items
[0]
Low
[1]
348
[2]
[3]
[4]
[5]
0.289
[7] array · 5 items
[0]
High
[1]
350
[2]
3.330 (2.557–4.338)
[3]
< 0.001
[4]
1.248 (0.829–1.879)
[8] array · 1 item
[0]
Age
[9] array · 6 items
[0]
< = 60
[1]
555
[2]
[3]
[4]
[5]
< 0.001
[10] array · 5 items
[0]
> 60
[1]
143
[2]
4.696 (3.620–6.093)
[3]
< 0.001
[4]
4.144 (2.512–6.835)
[11] array · 1 item
[0]
Gender
[12] array · 6 items
[0]
Female
[1]
297
[2]
[3]
[4]
[5]
0.009
[13] array · 5 items
[0]
Male
[1]
401
[2]
1.250 (0.979–1.595)
[3]
0.073
[4]
1.819 (1.165–2.841)
[14] array · 1 item
[0]
WHO grade
[15] array · 6 items
[0]
G2
[1]
223
[2]
[3]
[4]
[5]
[16] array · 6 items
[0]
G3
[1]
245
[2]
2.967 (1.986–4.433)
[3]
< 0.001
[4]
1.970 (1.249–3.109)
[5]
0.004
[17] array · 6 items
[0]
G4
[1]
168
[2]
18.600 (12.448–27.794)
[3]
< 0.001
[4]
6.194 (1.972–19.453)
[5]
0.002
[18] array · 1 item
[0]
IDH status
[19] array · 6 items
[0]
WT
[1]
246
[2]
[3]
[4]
[5]
0.027
[20] array · 5 items
[0]
Mut
[1]
442
[2]
0.116 (0.089–0.151)
[3]
< 0.001
[4]
0.549 (0.323–0.933)
[21] array · 1 item
[0]
1p/19q codeletion
[22] array · 6 items
[0]
Non‐codel
[1]
520
[2]
[3]
[4]
[5]
0.187
[23] array · 5 items
[0]
Codel
[1]
171
[2]
0.225 (0.147–0.346)
[3]
< 0.001
[4]
0.689 (0.396–1.199)
[24] array · 1 item
[0]
Primary therapy outcome
[25] array · 6 items
[0]
PD
[1]
112
[2]
[3]
[4]
[5]
[26] array · 6 items
[0]
SD
[1]
148
[2]
0.440 (0.294–0.658)
[3]
< 0.001
[4]
0.374 (0.225–0.621)
[5]
< 0.001
[27] array · 6 items
[0]
PR
[1]
65
[2]
0.167 (0.073–0.385)
[3]
< 0.001
[4]
0.199 (0.071–0.557)
[5]
0.002
[28] array · 6 items
[0]
CR
[1]
139
[2]
0.131 (0.063–0.273)
[3]
< 0.001
[4]
0.166 (0.077–0.358)
[5]
< 0.001
row_count
29
column_count
6
numeric_cells
68
header_rows
2
locator
section[17]/table-wrap[1]#jcmm70651-tbl-0002
gaps array · 1 item
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Complete file 
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