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pmid:40528762

Hyaluronan accumulation is associated with reduced hyaluronidase expression in renal cell carcinoma, with CD44, HAS1, and HYAL2 emerging as prognostic markers.

The journal of pathology. Clinical research · 2025 doi:10.1002/2056-4538.70035

Paper

partial

Experiment

partial

Data

partial

Analysis

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Execution

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Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
id
pmid:40528762
kind
science-record
content_hash
sha256:f4f356c292a30fd11ca212c7d74d6823a1a849e8bea4bf818296e9c24175a12e
schema
https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json
created_at
2026-11-01T10:25:51Z
updated_at
2026-11-01T14:01:42Z
generator object · 3 fields
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corpus-assay-engine
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sep_to_sci_v1
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urn:bntrg:sep:1.0.0
paper object · 10 fields
state
partial
title
Hyaluronan accumulation is associated with reduced hyaluronidase expression in renal cell carcinoma, with CD44, HAS1, and HYAL2 emerging as prognostic markers.
doi
10.1002/2056-4538.70035
pmid
40528762
authors
null
journal
The journal of pathology. Clinical research
year
2025
abstract
null
claims array · 1 item
[0] object · 6 fields
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claim-1
statement
the headline numerical result the paper states for its main finding
kind
qualitative
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blocked
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value
null
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null
tolerance
null
source
null
evidence array · 0 items
gaps array · 2 items
[0]
abstract
[1]
authors
experiment object · 8 fields
state
partial
objective
the headline numerical result the paper states for its main finding
steps array · 3 items
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read_published_estimate
order
1
name
Read the published estimate and its interval from the source
kind
other
state
complete
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null
description
The number a replication must land on, and the sentence it came from.
parameters object · 0 fields
inputs array · 1 item
[0]
source:pmid:40528762
outputs array · 1 item
[0]
the published estimate, its unit and its interval
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[1] object · 13 fields
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obtain_source_data
order
2
name
Obtain the source data behind the published result
kind
data-preparation
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blocked
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data:not_downloaded
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The published result cannot be recomputed without the data the paper analysed.
parameters object · 0 fields
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outputs array · 1 item
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the source data with its provenance
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run_analysis
order
3
name
Run the analysis programme
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analysis
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blocked
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no owned computational capability is bound to this experiment
description
Re-run the paper's analysis on the source data and produce the registered result. | SEP input not carried into the asset list: materials:the source data behind the published result in pmid:40528762
parameters object · 0 fields
inputs array · 0 items
outputs array · 1 item
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the registered result
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step:obtain_source_data blocked on data:not_downloaded
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step:run_analysis blocked on no owned computational capability is bound to this experiment
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step:run_analysis input 'materials:the source data behind the published result in pmid:40528762' does not resolve to a declared asset
data object · 3 fields
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partial
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id
source:pmid:40528762
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manuscript
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xml
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application/xml
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https://doi.org/10.1002/2056-4538.70035
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Source read by the package builder: full_text.
structure object · 1 field
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[1] object · 16 fields
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asset:table:pmid:40528762:1
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read_table
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Clinicopathological variables
structure object · 5 fields
pmcid
PMC12174875
section_index
3
section_title
Patient data and sample collection
row_count
37
column_count
5
table object · 8 fields
label
Table 1
caption
Clinicopathological variables
rows array · 37 items
[0] array · 5 items
[0]
[1]
n = 315
[2]
(%)
[3]
Mean
[4]
SD
[1] array · 1 item
[0]
Sex
[2] array · 5 items
[0]
Male
[1]
169
[2]
(53.7)
[3]
[4]
[3] array · 5 items
[0]
Female
[1]
146
[2]
(46.3)
[3]
[4]
[4] array · 5 items
[0]
Age (years)
[1]
[2]
[3]
65.3
[4]
10.57
[5] array · 1 item
[0]
Histology
[6] array · 5 items
[0]
Clear cell
[1]
284
[2]
(90.2)
[3]
[4]
[7] array · 5 items
[0]
Papillary
[1]
18
[2]
(5.7)
[3]
[4]
[8] array · 5 items
[0]
Chromophobe
[1]
8
[2]
(2.5)
[3]
[4]
[9] array · 5 items
[0]
Other
[1]
5
[2]
(1.6)
[3]
[4]
[10] array · 1 item
[0]
ISUP grade
[11] array · 5 items
[0]
Grade 1
[1]
23
[2]
(7.5)
[3]
[4]
[12] array · 5 items
[0]
Grade 2
[1]
165
[2]
(53.8)
[3]
[4]
[13] array · 5 items
[0]
Grade 3
[1]
61
[2]
(19.9)
[3]
[4]
[14] array · 5 items
[0]
Grade 4
[1]
58
[2]
(18.9)
[3]
[4]
[15] array · 5 items
[0]
Not graded (chromophobe RCCs)
[1]
8
[2]
[3]
[4]
[16] array · 1 item
[0]
Sarcomatoid change
[17] array · 5 items
[0]
Yes
[1]
34
[2]
(10.8)
[3]
[4]
[18] array · 5 items
[0]
No
[1]
281
[2]
(89.2)
[3]
[4]
[19] array · 1 item
[0]
Rhabdoid change
[20] array · 5 items
[0]
Yes
[1]
27
[2]
(8.6)
[3]
[4]
[21] array · 5 items
[0]
No
[1]
288
[2]
(91.4)
[3]
[4]
[22] array · 1 item
[0]
Clinical Stage (UICC)
[23] array · 5 items
[0]
I
[1]
160
[2]
(51.1)
[3]
[4]
[24] array · 5 items
[0]
II
[1]
39
[2]
(12.5)
[3]
[4]
[25] array · 5 items
[0]
III
[1]
62
[2]
(19.8)
[3]
[4]
[26] array · 5 items
[0]
IV
[1]
52
[2]
(16.6)
[3]
[4]
[27] array · 1 item
[0]
Metastasis at diagnosis (M1)
[28] array · 5 items
[0]
Yes
[1]
50
[2]
(15.9)
[3]
[4]
[29] array · 5 items
[0]
No
[1]
265
[2]
(84.1)
[3]
[4]
[30] array · 5 items
[0]
Follow‐up time (months)
[1]
315
[2]
[3]
98.8
[4]
70.3
[31] array · 1 item
[0]
Disease relapse
[32] array · 5 items
[0]
Yes
[1]
68
[2]
(25.3)
[3]
[4]
[33] array · 5 items
[0]
No
[1]
201
[2]
(74.7)
[3]
[4]
[34] array · 1 item
[0]
Disease related death
[35] array · 5 items
[0]
Yes
[1]
95
[2]
(30.2)
[3]
[4]
[36] array · 5 items
[0]
No
[1]
220
[2]
(69.8)
[3]
[4]
locator
section[3]/table-wrap[1]#cjp270035-tbl-0001
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section[5]/table-wrap[1]#cjp270035-tbl-0002
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Primary antibody details
structure object · 5 fields
pmcid
PMC12174875
section_index
5
section_title
Immunohistochemistry and hyaluronan staining
row_count
7
column_count
7
table object · 8 fields
label
Table 2
caption
Primary antibody details
rows array · 7 items
[0] array · 7 items
[0]
Antibody
[1]
Clonality
[2]
Host species
[3]
Company/Vendor
[4]
Concentration
[5]
Catalog number
[6]
LOT number
[1] array · 7 items
[0]
CD44
[1]
Monoclonal
[2]
Mouse
[3]
BioSB
[4]
Recommended dilution 1:250–1:1000
[5]
BSB‐6236
[6]
6238TOA05
[2] array · 7 items
[0]
HYAL1
[1]
Polyclonal
[2]
Rabbit
[3]
Sigma‐Aldrich
[4]
0.2 mg/ml
[5]
HPA002112‐100
[6]
C115919
[3] array · 7 items
[0]
HYAL2
[1]
Polyclonal
[2]
Rabbit
[3]
Abcam
[4]
1 mg/ml
[5]
Ab68608
[6]
GR3267063‐2
[4] array · 7 items
[0]
HAS1
[1]
Monoclonal
[2]
Mouse
[3]
GeneTex
[4]
NA
[5]
GTX82799‐100
[6]
822402988
[5] array · 7 items
[0]
HAS2
[1]
Monoclonal
[2]
Mouse
[3]
GeneTex
[4]
1 mg/ml
[5]
GTX60647‐100
[6]
822402988
[6] array · 7 items
[0]
HAS3
[1]
Monoclonal
[2]
Mouse
[3]
GeneTex
[4]
1 mg/ml
[5]
GTX60588‐100
[6]
822402988
locator
section[5]/table-wrap[1]#cjp270035-tbl-0002
[3] object · 16 fields
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asset:table:pmid:40528762:3
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section[11]/table-wrap[1]#cjp270035-tbl-0003
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null
note
Associations between CD44, HYAL1, and HYAL2 protein expression and clinicopathological variables
structure object · 5 fields
pmcid
PMC12174875
section_index
11
section_title
Association with hyaluronan content
row_count
42
column_count
12
table object · 8 fields
label
Table 3
caption
Associations between CD44, HYAL1, and HYAL2 protein expression and clinicopathological variables
rows array · 42 items
[0] array · 8 items
[0]
[1]
Total, N (%)
[2]
CD44 H‐score, N (%)
[3]
p
[4]
HYAL1 H‐score, N (%)
[5]
p
[6]
HYAL2 H‐score, N (%)
[7]
p
[1] array · 8 items
[0]
315 (100.0)
[1]
0 (negative)
[2]
1–100 (low)
[3]
≥101 (high)
[4]
0–100 (low)
[5]
≥101 (high)
[6]
0–100 (low)
[7]
≥101 (high)
[2] array · 1 item
[0]
ISUP grade
[3] array · 12 items
[0]
I
[1]
23 (7.5)
[2]
20 (9.6)
[3]
2 (3.6)
[4]
1 (2.4)
[5]
<0.001 *
[6]
17 (10.2)
[7]
6 (4.0)
[8]
0.005 **
[9]
7 (5.3)
[10]
16 (8.7)
[11]
0.022 **
[4] array · 9 items
[0]
II
[1]
165 (53.7)
[2]
139 (66.4)
[3]
29 (51.8)
[4]
2 (4.8)
[5]
93 (56.0)
[6]
77 (51.7)
[7]
62 (47.3)
[8]
108 (58.7)
[5] array · 9 items
[0]
III
[1]
60 (19.5)
[2]
35 (16.8)
[3]
17 (30.4)
[4]
10 (23.8)
[5]
18 (10.8)
[6]
43 (28.9)
[7]
27 (20.6)
[8]
35 (19.0)
[6] array · 9 items
[0]
IV
[1]
59 (19.2)
[2]
23 (10.3)
[3]
18 (32.1)
[4]
18 (42.9)
[5]
38 (22.9)
[6]
23 (15.4)
[7]
35 (26.7)
[8]
25 (13.6)
[7] array · 1 item
[0]
Stage
[8] array · 12 items
[0]
I
[1]
160 (51.1)
[2]
134 (61.8)
[3]
21 (32.8)
[4]
5 (16.1)
[5]
<0.001 **
[6]
79 (47.6)
[7]
81 (55.1)
[8]
0.624**
[9]
51 (38.9)
[10]
109 (59.9)
[11]
0.00267 **
[9] array · 10 items
[0]
II
[1]
39 (12.5)
[2]
23 (10.6)
[3]
11 (17.2)
[4]
5 (16.1)
[5]
25 (15.1)
[6]
14 (9.5)
[7]
15 (11.5)
[8]
24 (13.2)
[9]
[10] array · 9 items
[0]
III
[1]
62 (19.8)
[2]
32 (14.8)
[3]
18 (28.1)
[4]
11 (35.5)
[5]
33 (19.9)
[6]
29 (19.7)
[7]
33 (25.2)
[8]
29 (15.9)
[11] array · 10 items
[0]
IV
[1]
52 (16.6)
[2]
28 (12.9)
[3]
14 (21.9)
[4]
10 (32.3)
[5]
29 (17.5)
[6]
23 (15.6)
[7]
32 (24.4)
[8]
20 (11.0)
[9]
[12] array · 1 item
[0]
Histology
[13] array · 12 items
[0]
ccRCC
[1]
284 (91.6)
[2]
197 (92.5)
[3]
58 (89.2)
[4]
28 (90.3)
[5]
0.593*
[6]
155 (95.7)
[7]
127 (87.0)
[8]
0.041 *
[9]
111 (86.0)
[10]
172 (95.6)
[11]
0.0121 *
[14] array · 10 items
[0]
Papillary
[1]
18 (5.8)
[2]
10 (4.7)
[3]
5 (7.7)
[4]
3 (9.7)
[5]
6 (3.7)
[6]
12 (8.2)
[7]
12 (9.3)
[8]
6 (3.3)
[9]
[15] array · 10 items
[0]
Chromophobe
[1]
8 (2.6)
[2]
6 (2.8)
[3]
2 (3.1)
[4]
0 (0.0)
[5]
1 (0.6)
[6]
7 (4.8)
[7]
6 (4.7)
[8]
2 (1.1)
[9]
[16] array · 1 item
[0]
Sarcomatoid
[17] array · 12 items
[0]
No
[1]
281 (89.2)
[2]
208 (95.9)
[3]
56 (84.9)
[4]
18 (58.1)
[5]
<0.001 *
[6]
146 (88.0)
[7]
136 (91.3)
[8]
0.624**
[9]
107 (81.7)
[10]
174 (94.6)
[11]
0.00267 **
[18] array · 9 items
[0]
Yes
[1]
34 (10.8)
[2]
9 (4.2)
[3]
10 (15.2)
[4]
13 (41.9)
[5]
20 (12.0)
[6]
13 (8.7)
[7]
24 (18.3)
[8]
10 (5.4)
[19] array · 1 item
[0]
Rhabdoid
[20] array · 12 items
[0]
No
[1]
288 (91.4)
[2]
206 (94.9)
[3]
61 (92.4)
[4]
20 (64.5)
[5]
<0.001 *
[6]
150 (90.9)
[7]
137 (91.9)
[8]
0.963**
[9]
117 (89.3)
[10]
171 (92.9)
[11]
0.354**
[21] array · 9 items
[0]
Yes
[1]
27 (8.6)
[2]
11 (5.1)
[3]
5 (7.6)
[4]
11 (35.5)
[5]
15 (9.1)
[6]
12 (8.1)
[7]
14 (10.7)
[8]
13 (7.1)
[22] array · 1 item
[0]
Metastasis at diagnosis
[23] array · 12 items
[0]
M0
[1]
265 (84.1)
[2]
191 (88.0)
[3]
52 (78.8)
[4]
21 (67.7)
[5]
0.0109 *
[6]
139 (83.7)
[7]
126 (84.6)
[8]
0.963**
[9]
101 (77.1)
[10]
164 (89.1)
[11]
<0.0118 **
[24] array · 9 items
[0]
M1
[1]
50 (15.9)
[2]
26 (12.0)
[3]
14 (21.2)
[4]
10 (32.3)
[5]
27 (16.3)
[6]
23 (15.4)
[7]
30 (22.9)
[8]
20 (10.9)
[25] array · 1 item
[0]
Tumor size
[26] array · 12 items
[0]
T1
[1]
170 (54.5)
[2]
142 (65.4)
[3]
22 (34.4)
[4]
6 (20.0)
[5]
<0.001 *
[6]
82 (49.4)
[7]
88 (60.3)
[8]
0.261**
[9]
56 (43.1)
[10]
114 (62.6)
[11]
0.00375 **
[27] array · 9 items
[0]
T2
[1]
44 (14.1)
[2]
29 (13.4)
[3]
10 (15.6)
[4]
5 (16.7)
[5]
30 (18.1)
[6]
14 (9.6)
[7]
18 (13.8)
[8]
26 (14.3)
[28] array · 9 items
[0]
T3
[1]
87 (27.9)
[2]
41 (18.9)
[3]
29 (45.3)
[4]
16 (53.3)
[5]
47 (28.3)
[6]
40 (27.4)
[7]
49 (37.7)
[8]
38 (20.9)
[29] array · 9 items
[0]
T4
[1]
11 (3.5)
[2]
5 (2.3)
[3]
3 (4.7)
[4]
3 (10.0)
[5]
7 (4.2)
[6]
4 (2.7)
[7]
7 (5.4)
[8]
4 (2.2)
[30] array · 1 item
[0]
Hyaluronan
[31] array · 12 items
[0]
Negative
[1]
158 (50.3)
[2]
127 (58.8)
[3]
25 (37.9)
[4]
5 (16.1)
[5]
<0.001 **
[6]
72 (43.4)
[7]
88 (59.1)
[8]
0.00382 **
[9]
41 (31.3)
[10]
117 (63.6)
[11]
<0.001 **
[32] array · 9 items
[0]
Positive
[1]
156 (49.7)
[2]
89 (41.2)
[3]
41 (62.1)
[4]
26 (83.9)
[5]
94 (56.6)
[6]
61 (40.9)
[7]
90 (68.7)
[8]
67 (36.4)
[33] array · 1 item
[0]
TILs
[34] array · 12 items
[0]
None
[1]
191 (61.0)
[2]
141 (65.0)
[3]
37 (56.9)
[4]
12 (40.0)
[5]
0.127*
[6]
97 (58.4)
[7]
94 (63.9)
[8]
0.579**
[9]
65 (50.0)
[10]
126 (68.9)
[11]
0.0118 **
[35] array · 9 items
[0]
Low
[1]
54 (17.3)
[2]
36 (17.0)
[3]
12 (18.5)
[4]
6 (20.0)
[5]
26 (15.7)
[6]
28 (19.0)
[7]
31 (23.8)
[8]
23 (12.6)
[36] array · 9 items
[0]
Moderate
[1]
35 (11.2)
[2]
21 (9.7)
[3]
7 (10.8)
[4]
7 (23.3)
[5]
22 (13.3)
[6]
13 (8.8)
[7]
17 (13.1)
[8]
18 (9.8)
[37] array · 9 items
[0]
High
[1]
33 (10.5)
[2]
19 (8.8)
[3]
9 (13.9)
[4]
5 (16.7)
[5]
21 (12.7)
[6]
12 (8.2)
[7]
17 (13.1)
[8]
16 (8.7)
[38] array · 1 item
[0]
Type
[39] array · 12 items
[0]
Primary
[1]
315 (83.1)
[2]
190 (86.8)
[3]
79 (79.8)
[4]
46 (76.7)
[5]
0.176*
[6]
166 (85.1)
[7]
149 (81.4)
[8]
0.782**
[9]
131 (82.4)
[10]
184 (84.0)
[11]
0.132**
[40] array · 11 items
[0]
LVI
[1]
42 (11.1)
[2]
20 (9.1)
[3]
11 (11.1)
[4]
10 (16.7)
[5]
[6]
19 (9.7)
[7]
22 (12.0)
[8]
22 (13.8)
[9]
19 (8.7)
[10]
[41] array · 11 items
[0]
Metastasis
[1]
22 (5.8)
[2]
9 (4.1)
[3]
9 (9.1)
[4]
4 (6.7)
[5]
[6]
10 (5.1)
[7]
12 (6.6)
[8]
6 (3.8)
[9]
16 (7.3)
[10]
locator
section[11]/table-wrap[1]#cjp270035-tbl-0003
[4] object · 16 fields
id
asset:table:pmid:40528762:4
role
table
format
jats-table
media_type
application/vnd.jats.table+json
uri
null
sha256
sha256:9d147cf79765010770b84d1496a0ca0e798bbedf5bfd341ddeba58f76e31f425
bytes
4007
access
open
state
verified
reader
read_table
reader_status
available
identifier
section[11]/table-wrap[2]#cjp270035-tbl-0004
version
null
note
Associations between HAS1‐3 protein expression and clinicopathological variables
structure object · 5 fields
pmcid
PMC12174875
section_index
11
section_title
Association with hyaluronan content
row_count
42
column_count
12
table object · 8 fields
label
Table 4
caption
Associations between HAS1‐3 protein expression and clinicopathological variables
rows array · 42 items
[0] array · 8 items
[0]
[1]
Total, N (%)
[2]
HAS1 H‐score, N (%)
[3]
p
[4]
HAS2 H‐score, N (%)
[5]
p
[6]
HAS3 H‐score, N (%)
[7]
p
[1] array · 8 items
[0]
315 (100.0)
[1]
0–100 (low)
[2]
≥101 (high)
[3]
0 (negative)
[4]
1–100 (low)
[5]
≥101 (high)
[6]
0–100 (low)
[7]
≥101 (high)
[2] array · 1 item
[0]
ISUP grade
[3] array · 12 items
[0]
I
[1]
23 (7.5)
[2]
3 (8.8)
[3]
20 (7.1)
[4]
0.0422 *
[5]
5 (26.3)
[6]
15 (10.9)
[7]
3 (1.9)
[8]
<0.001 *
[9]
18 (8.4)
[10]
4 (4.0)
[11]
0.690**
[4] array · 9 items
[0]
II
[1]
165 (53.7)
[2]
16 (47.1)
[3]
153 (54.6)
[4]
11 (57.9)
[5]
87 (63.0)
[6]
70 (45.2)
[7]
116 (54.0)
[8]
54 (54.5)
[5] array · 9 items
[0]
III
[1]
60 (19.5)
[2]
2 (5.9)
[3]
59 (21.1)
[4]
2 (10.5)
[5]
18 (13.0)
[6]
41 (26.5)
[7]
40 (18.6)
[8]
21 (21.2)
[6] array · 9 items
[0]
IV
[1]
59 (19.2)
[2]
13 (38.2)
[3]
48 (17.1)
[4]
1 (5.3)
[5]
18 (13.0)
[6]
41 (26.5)
[7]
41 (19.1)
[8]
20 (20.2)
[7] array · 1 item
[0]
Stage
[8] array · 12 items
[0]
I
[1]
160 (51.1)
[2]
12 (35.3)
[3]
147 (52.9)
[4]
0.1593*
[5]
10 (52.6)
[6]
78 (56.5)
[7]
71 (46.1)
[8]
0.293*
[9]
108 (50.5)
[10]
51 (52.0)
[11]
0.497**
[9] array · 9 items
[0]
II
[1]
39 (12.5)
[2]
3 (8.8)
[3]
36 (12.9)
[4]
2 (10.5)
[5]
21 (15.2)
[6]
16 (10.4)
[7]
29 (13.6)
[8]
10 (10.2)
[10] array · 9 items
[0]
III
[1]
62 (19.8)
[2]
10 (29.4)
[3]
52 (18.7)
[4]
4 (21.1)
[5]
24 (17.4)
[6]
33 (21.4)
[7]
47 (22.0)
[8]
15 (15.3)
[11] array · 9 items
[0]
IV
[1]
52 (16.6)
[2]
9 (26.5)
[3]
43 (15.5)
[4]
3 (15.8)
[5]
15 (10.9)
[6]
34 (22.1)
[7]
30 (14.0)
[8]
22 (22.4)
[12] array · 1 item
[0]
Histology
[13] array · 12 items
[0]
ccRCC
[1]
284 (91.6)
[2]
29 (87.9)
[3]
253 (92.0)
[4]
0.347*
[5]
17 (94.4)
[6]
128 (94.8)
[7]
136 (91.3)
[8]
0.413*
[9]
196 (92.9)
[10]
86 (88.7)
[11]
0.497*
[14] array · 10 items
[0]
Papillary
[1]
18 (5.8)
[2]
2 (6.1)
[3]
16 (5.8)
[4]
0 (0.0)
[5]
6 (4.4)
[6]
7 (4.7)
[7]
11 (5.2)
[8]
7 (7.2)
[9]
[15] array · 10 items
[0]
Chromophobe
[1]
8 (2.6)
[2]
2 (6.1)
[3]
6 (2.2)
[4]
1 (5.6)
[5]
1 (0.7)
[6]
6 (4.0)
[7]
4 (1.9)
[8]
4 (4.1)
[9]
[16] array · 1 item
[0]
Sarcomatoid
[17] array · 12 items
[0]
No
[1]
281 (89.2)
[2]
26 (76.5)
[3]
256 (91.4)
[4]
0.0422 *
[5]
19 (100.0)
[6]
129 (92.8)
[7]
133 (85.8)
[8]
0.120*
[9]
192 (89.3)
[10]
89 (89.9)
[11]
1.000**
[18] array · 9 items
[0]
Yes
[1]
34 (10.8)
[2]
8 (23.5)
[3]
24 (8.6)
[4]
0 (0.0)
[5]
10 (7.2)
[6]
22 (14.2)
[7]
23 (10.7)
[8]
10 (10.1)
[19] array · 1 item
[0]
Rhabdoid
[20] array · 12 items
[0]
No
[1]
288 (91.4)
[2]
27 (79.4)
[3]
260 (92.9)
[4]
0.0422 *
[5]
19 (100.0)
[6]
130 (93.5)
[7]
138 (89.0)
[8]
0.305*
[9]
197 (91.6)
[10]
91 (91.9)
[11]
1.000**
[21] array · 9 items
[0]
Yes
[1]
27 (8.6)
[2]
7 (20.6)
[3]
20 (7.1)
[4]
0 (0.0)
[5]
9 (6.5)
[6]
17 (11.0)
[7]
18 (8.4)
[8]
8 (8.1)
[22] array · 1 item
[0]
Metastasis at diagnosis
[23] array · 12 items
[0]
M0
[1]
265 (84.1)
[2]
26 (76.5)
[3]
238 (85.0)
[4]
0.334**
[5]
16 (84.2)
[6]
124 (89.2)
[7]
122 (78.7)
[8]
0.120*
[9]
185 (86.0)
[10]
79 (79.8)
[11]
0.497**
[24] array · 9 items
[0]
M1
[1]
50 (15.9)
[2]
8 (23.5)
[3]
42 (15.0)
[4]
3 (15.8)
[5]
15 (10.8)
[6]
33 (21.3)
[7]
30 (14.0)
[8]
20 (20.2)
[25] array · 1 item
[0]
Tumor size
[26] array · 12 items
[0]
T1
[1]
170 (54.5)
[2]
14 (41.2)
[3]
155 (56.0)
[4]
0.0494 *
[5]
11 (57.9)
[6]
81 (58.7)
[7]
77 (50.3)
[8]
0.430*
[9]
114 (53.3)
[10]
55 (56.7)
[11]
0.456*
[27] array · 9 items
[0]
T2
[1]
44 (14.1)
[2]
3 (8.8)
[3]
41 (14.8)
[4]
2 (10.5)
[5]
23 (16.7)
[6]
19 (12.4)
[7]
32 (15.0)
[8]
12 (12.4)
[28] array · 9 items
[0]
T3
[1]
87 (27.9)
[2]
13 (38.2)
[3]
74 (26.7)
[4]
5 (26.3)
[5]
31 (22.5)
[6]
50 (32.7)
[7]
64 (29.9)
[8]
23 (23.7)
[29] array · 9 items
[0]
T4
[1]
11 (3.5)
[2]
4 (11.8)
[3]
7 (2.5)
[4]
1 (5.3)
[5]
3 (2.2)
[6]
7 (4.6)
[7]
4 (1.9)
[8]
7 (7.2)
[30] array · 1 item
[0]
Hyaluronan
[31] array · 12 items
[0]
Negative
[1]
158 (50.3)
[2]
13 (38.2)
[3]
146 (52.1)
[4]
0.253**
[5]
11 (57.9)
[6]
74 (53.2)
[7]
75 (48.4)
[8]
0.588**
[9]
95 (44.2)
[10]
65 (65.7)
[11]
0.00639 **
[32] array · 9 items
[0]
Positive
[1]
156 (49.7)
[2]
21 (61.8)
[3]
134 (47.9)
[4]
8 (42.1)
[5]
65 (46.8)
[6]
80 (51.6)
[7]
120 (55.8)
[8]
34 (34.3)
[33] array · 1 item
[0]
TILs
[34] array · 12 items
[0]
None
[1]
191 (61.0)
[2]
17 (50.0)
[3]
173 (62.2)
[4]
0.332**
[5]
13 (68.4)
[6]
99 (71.7)
[7]
77 (50.5)
[8]
0.024 *
[9]
130 (60.7)
[10]
60 (61.2)
[11]
0.515**
[35] array · 9 items
[0]
Low
[1]
54 (17.3)
[2]
10 (29.4)
[3]
44 (15.8)
[4]
4 (21.1)
[5]
21 (15.2)
[6]
29 (18.8)
[7]
41 (19.2)
[8]
13 (13.3)
[36] array · 9 items
[0]
Moderate
[1]
35 (11.2)
[2]
4 (11.8)
[3]
31 (11.2)
[4]
1 (5.3)
[5]
10 (7.2)
[6]
24 (15.6)
[7]
24 (11.2)
[8]
11 (11.2)
[37] array · 9 items
[0]
High
[1]
33 (10.5)
[2]
3 (8.8)
[3]
30 (10.8)
[4]
1 (5.3)
[5]
8 (5.8)
[6]
24 (15.6)
[7]
19 (8.9)
[8]
14 (14.3)
[38] array · 1 item
[0]
Type
[39] array · 12 items
[0]
Primary
[1]
315 (83.1)
[2]
34 (63.0)
[3]
280 (87.5)
[4]
<0.001 *
[5]
19 (95.0)
[6]
139 (85.8)
[7]
155 (81.2)
[8]
0.453*
[9]
215 (85.7)
[10]
99 (80.5)
[11]
0.497**
[40] array · 9 items
[0]
LVI
[1]
42 (11.1)
[2]
14 (25.9)
[3]
24 (7.5)
[4]
0 (0.0)
[5]
14 (8.6)
[6]
24 (12.6)
[7]
21 (8.4)
[8]
17 (13.8)
[41] array · 9 items
[0]
Metastasis
[1]
22 (5.8)
[2]
6 (11.1)
[3]
16 (5.0)
[4]
1 (5.0)
[5]
9 (5.6)
[6]
12 (6.3)
[7]
15 (6.0)
[8]
7 (5.7)
locator
section[11]/table-wrap[2]#cjp270035-tbl-0004
[5] object · 16 fields
id
asset:table:pmid:40528762:5
role
table
format
jats-table
media_type
application/vnd.jats.table+json
uri
null
sha256
sha256:32bd2418e9efb8cd5c04b436b97993c1477b4ec37aaceaa0bf9b4dff62f09345
bytes
1527
access
open
state
verified
reader
read_table
reader_status
available
identifier
section[13]/table-wrap[1]#cjp270035-tbl-0005
version
null
note
Univariate and multivariate analysis of disease‐specific survival (DSS) in RCC patients
structure object · 5 fields
pmcid
PMC12174875
section_index
13
section_title
Prognostic significance
row_count
22
column_count
4
table object · 8 fields
label
Table 5
caption
Univariate and multivariate analysis of disease‐specific survival (DSS) in RCC patients
rows array · 22 items
[0] array · 4 items
[0]
Variables
[1]
Categories
[2]
HR (95% CI)
[3]
p
[1] array · 1 item
[0]
Univariate analysis
[2] array · 4 items
[0]
Age
[1]
≥65/<65
[2]
0.94 (0.63–1.41)
[3]
0.76
[3] array · 4 items
[0]
Sex
[1]
Male/Female
[2]
1.68 (1.11–2.54)
[3]
0.015
[4] array · 4 items
[0]
WHO/ISUP grade
[1]
3–4/1–2
[2]
3.86 (2.55–5.85)
[3]
1.94 × 10 −10
[5] array · 4 items
[0]
Stage
[1]
3–4/1–2
[2]
5.7884 (3.75–8.94)
[3]
2.25 × 10 −15
[6] array · 4 items
[0]
HYAL2 protein expression
[1]
High/Low
[2]
0.45 (0.30–0.67)
[3]
0.00011
[7] array · 4 items
[0]
CD44 protein expression
[1]
Positive/Negative
[2]
2.79 (1.85–4.21)
[3]
9.51 × 10 −7
[8] array · 4 items
[0]
HAS1 protein expression
[1]
High/Low
[2]
0.54 (0.32–0.93)
[3]
0.025
[9] array · 4 items
[0]
Hyaluronan staining
[1]
Positive/Negative
[2]
3.89 (2.45–6.19)
[3]
9.18 × 10 −9
[10] array · 1 item
[0]
Multivariate analysis
[11] array · 4 items
[0]
Age
[1]
≥65/<65
[2]
1.01 (0.85–2.03)
[3]
0.49
[12] array · 4 items
[0]
Sex
[1]
Male/Female
[2]
1.31 (1.21–2.03)
[3]
0.22
[13] array · 4 items
[0]
WHO/ISUP grade
[1]
3–4/1–2
[2]
2.51 (1.62–3.88)
[3]
3.48 × 10 −5
[14] array · 4 items
[0]
Stage
[1]
3–4/1–2
[2]
4.06 (2.57–6.41)
[3]
1.75 × 10 −9
[15] array · 4 items
[0]
HYAL2 protein expression
[1]
High/Low
[2]
0.64 0.42–0.97)
[3]
0.037
[16] array · 1 item
[0]
Multivariate analysis
[17] array · 4 items
[0]
Age
[1]
≥65/<65
[2]
1.08 (0.72–1.64)
[3]
0.70
[18] array · 4 items
[0]
Sex
[1]
Male/Female
[2]
1.08 (0.69–1.69)
[3]
0.73
[19] array · 4 items
[0]
WHO/ISUP grade
[1]
3–4/1–2
[2]
2.35 (1.51–3.64)
[3]
0.00013
[20] array · 4 items
[0]
Stage
[1]
3–4/1–2
[2]
4.12 (2.639–6.46)
[3]
7.13 × 10 −10
[21] array · 4 items
[0]
CD44 protein expression
[1]
Positive/Negative
[2]
1.73 (1.12–2.66)
[3]
0.012
locator
section[13]/table-wrap[1]#cjp270035-tbl-0005
gaps array · 1 item
[0]
asset:source:pmid:40528762 not verified
analysis object · 4 fields
state
absent
methods array · 0 items
targets array · 0 items
gaps array · 2 items
[0]
method
[1]
targets
capability object · 3 fields
state
absent
requirements array · 0 items
gaps array · 1 item
[0]
capability
readiness object · 8 fields
state
partial
tier
null
blocked_on
null
axes object · 0 fields
can_run object · 3 fields
dsl_operations array · 0 items
assets array · 6 items
[0]
source:pmid:40528762
[1]
asset:table:pmid:40528762:1
[2]
asset:table:pmid:40528762:2
[3]
asset:table:pmid:40528762:3
[4]
asset:table:pmid:40528762:4
[5]
asset:table:pmid:40528762:5
steps array · 1 item
[0]
read_published_estimate
must_build object · 5 fields
dsl_operations array · 0 items
converters array · 0 items
readers array · 1 item
[0]
xml
capabilities array · 0 items
data_gaps array · 1 item
[0]
source:pmid:40528762
gaps array · 1 item
[0]
corpus_record_absent
review object · 5 fields
state
partial
machine_critique object · 7 fields
status
blocked
providers array · 0 items
target_providers array · 0 items
agreement
false
disagreements array · 0 items
agreement_basis object · 2 fields
policy
decisive_fields
decisive_fields array · 4 items
[0]
work_type
[1]
number_stated
[2]
parent_value
[3]
unit
blinded
true
human_critique object · 5 fields
status
not_run
reviewer
null
signed_at
null
conflict_checked
false
commentary
null
stages array · 7 items
[0] object · 4 fields
key
target_materials
status
pending
reason
null
evidence
null
[1] object · 4 fields
key
independent_readings
status
blocked
reason
The independent readings are incomplete or disagree; the source evidence must resolve the difference.
evidence object · 1 field
provider_errors array · 4 items
[0] object · 4 fields
provider
minimax
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[1] object · 4 fields
provider
minimax_alt
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[2] object · 4 fields
provider
minimax
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[3] object · 4 fields
provider
minimax_alt
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[2] object · 4 fields
key
source_resolution
status
pending
reason
null
evidence
null
[3] object · 4 fields
key
protocol_reconstruction
status
pending
reason
null
evidence
null
[4] object · 4 fields
key
control_execution
status
pending
reason
null
evidence
null
[5] object · 4 fields
key
control_comparison
status
pending
reason
null
evidence
null
[6] object · 4 fields
key
publication
status
pending
reason
null
evidence
null
gaps array · 3 items
[0]
review.human_critique
[1]
review.machine_critique.blocked
[2]
review.machine_critique.providers
execution object · 5 fields
state
absent
status
not_run
mode
null
runs array · 0 items
gaps array · 1 item
[0]
execution.not_run
provenance object · 7 fields
entities array · 1 item
[0] object · 3 fields
id
package:bfaf641d3f268529aa9d7221233bae0d46a29f7c84091235453bd55b2c60c72e
type
sep_package
label
SEP v1 package for pmid:40528762
activities array · 1 item
[0] object · 4 fields
id
activity:conversion:pmid:40528762
type
conversion
used array · 1 item
[0]
package:bfaf641d3f268529aa9d7221233bae0d46a29f7c84091235453bd55b2c60c72e
agent
agent:corpus-assay-engine
agents array · 1 item
[0] object · 3 fields
id
agent:corpus-assay-engine
type
software
label
Corpus assay engine
source_run_id
run-20261023T122449232913
dsl_catalogue_fingerprint
343fb30756ba6ec3
capability_table_fingerprint
2cb3e42f047d2ecf
snapshot_id
ba34b49490d9bfaf
lineage object · 4 fields
parent_id
pmid:40528762
parent_hash
sha256:f5a6b37d014d98f6d52961abfe6654691cd851771a1fa7d5410b8b70bb3cbca7
fork_of
null
gaps array · 14 items
[0]
abstract
[1]
asset:source:pmid:40528762 not verified
[2]
authors
[3]
capability
[4]
corpus_record_absent
[5]
execution.not_run
[6]
method
[7]
review.human_critique
[8]
review.machine_critique.blocked
[9]
review.machine_critique.providers
[10]
step:obtain_source_data blocked on data:not_downloaded
[11]
step:run_analysis blocked on no owned computational capability is bound to this experiment
[12]
step:run_analysis input 'materials:the source data behind the published result in pmid:40528762' does not resolve to a declared asset
[13]
targets
Complete file
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"sha256:fe6527f0b27759fbfdfe839b13be482ccebb7a34972a1d9916e85046cbc7fe37", "bytes": 1257, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[3]/table-wrap[1]#cjp270035-tbl-0001", "version": null, "note": "Clinicopathological variables", "structure": {"pmcid": "PMC12174875", "section_index": 3, "section_title": "Patient data and sample collection", "row_count": 37, "column_count": 5}, "table": {"label": "Table 1", "caption": "Clinicopathological variables", "rows": [["", "n = 315", "(%)", "Mean", "SD"], ["Sex"], ["Male", "169", "(53.7)", "", ""], ["Female", "146", "(46.3)", "", ""], ["Age (years)", "", "", "65.3", "10.57"], ["Histology"], ["Clear cell", "284", "(90.2)", "", ""], ["Papillary", "18", "(5.7)", "", ""], ["Chromophobe", "8", "(2.5)", "", ""], ["Other", "5", "(1.6)", "", ""], ["ISUP grade"], ["Grade 1", "23", "(7.5)", "", ""], ["Grade 2", "165", "(53.8)", "", ""], ["Grade 3", "61", "(19.9)", "", ""], ["Grade 4", 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"Monoclonal", "Mouse", "GeneTex", "NA", "GTX82799‐100", "822402988"], ["HAS2", "Monoclonal", "Mouse", "GeneTex", "1 mg/ml", "GTX60647‐100", "822402988"], ["HAS3", "Monoclonal", "Mouse", "GeneTex", "1 mg/ml", "GTX60588‐100", "822402988"]], "row_count": 7, "column_count": 7, "numeric_cells": 18, "header_rows": 1, "locator": "section[5]/table-wrap[1]#cjp270035-tbl-0002"}}, {"id": "asset:table:pmid:40528762:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:0c1f8aee706427d193fdd45aca1bd38bca3ff4960f520d85aec3e9292b3234c1", "bytes": 4087, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[11]/table-wrap[1]#cjp270035-tbl-0003", "version": null, "note": "Associations between CD44, HYAL1, and HYAL2 protein expression and clinicopathological variables", "structure": {"pmcid": "PMC12174875", "section_index": 11, "section_title": "Association with hyaluronan content", "row_count": 42, "column_count": 12}, "table": {"label": "Table 3", "caption": "Associations between CD44, HYAL1, and HYAL2 protein expression and clinicopathological variables", "rows": [["", "Total, N (%)", "CD44 H‐score, N (%)", "p", "HYAL1 H‐score, N (%)", "p", "HYAL2 H‐score, N (%)", "p"], ["315 (100.0)", "0 (negative)", "1–100 (low)", "≥101 (high)", "0–100 (low)", "≥101 (high)", "0–100 (low)", "≥101 (high)"], ["ISUP grade"], ["I", "23 (7.5)", "20 (9.6)", "2 (3.6)", "1 (2.4)", "<0.001 *", "17 (10.2)", "6 (4.0)", "0.005 **", "7 (5.3)", "16 (8.7)", "0.022 **"], ["II", "165 (53.7)", "139 (66.4)", "29 (51.8)", "2 (4.8)", "93 (56.0)", "77 (51.7)", "62 (47.3)", "108 (58.7)"], ["III", "60 (19.5)", "35 (16.8)", "17 (30.4)", "10 (23.8)", "18 (10.8)", "43 (28.9)", "27 (20.6)", "35 (19.0)"], ["IV", "59 (19.2)", "23 (10.3)", "18 (32.1)", "18 (42.9)", "38 (22.9)", "23 (15.4)", "35 (26.7)", "25 (13.6)"], ["Stage"], ["I", "160 (51.1)", "134 (61.8)", "21 (32.8)", "5 (16.1)", "<0.001 **", "79 (47.6)", "81 (55.1)", "0.624**", "51 (38.9)", "109 (59.9)", "0.00267 **"], ["II", "39 (12.5)", "23 (10.6)", "11 (17.2)", "5 (16.1)", "25 (15.1)", "14 (9.5)", "15 (11.5)", "24 (13.2)", ""], ["III", "62 (19.8)", "32 (14.8)", "18 (28.1)", "11 (35.5)", "33 (19.9)", "29 (19.7)", "33 (25.2)", "29 (15.9)"], ["IV", "52 (16.6)", "28 (12.9)", "14 (21.9)", "10 (32.3)", "29 (17.5)", "23 (15.6)", "32 (24.4)", "20 (11.0)", ""], ["Histology"], ["ccRCC", "284 (91.6)", "197 (92.5)", "58 (89.2)", "28 (90.3)", "0.593*", "155 (95.7)", "127 (87.0)", "0.041 *", "111 (86.0)", "172 (95.6)", "0.0121 *"], ["Papillary", "18 (5.8)", "10 (4.7)", "5 (7.7)", "3 (9.7)", "6 (3.7)", "12 (8.2)", "12 (9.3)", "6 (3.3)", ""], ["Chromophobe", "8 (2.6)", "6 (2.8)", "2 (3.1)", "0 (0.0)", "1 (0.6)", "7 (4.8)", "6 (4.7)", "2 (1.1)", ""], ["Sarcomatoid"], ["No", "281 (89.2)", "208 (95.9)", "56 (84.9)", "18 (58.1)", "<0.001 *", "146 (88.0)", "136 (91.3)", "0.624**", "107 (81.7)", "174 (94.6)", "0.00267 **"], ["Yes", "34 (10.8)", "9 (4.2)", "10 (15.2)", "13 (41.9)", "20 (12.0)", "13 (8.7)", "24 (18.3)", "10 (5.4)"], ["Rhabdoid"], ["No", "288 (91.4)", "206 (94.9)", "61 (92.4)", "20 (64.5)", "<0.001 *", "150 (90.9)", "137 (91.9)", "0.963**", "117 (89.3)", "171 (92.9)", "0.354**"], ["Yes", "27 (8.6)", "11 (5.1)", "5 (7.6)", "11 (35.5)", "15 (9.1)", "12 (8.1)", "14 (10.7)", "13 (7.1)"], ["Metastasis at diagnosis"], ["M0", "265 (84.1)", "191 (88.0)", "52 (78.8)", "21 (67.7)", "0.0109 *", "139 (83.7)", "126 (84.6)", "0.963**", "101 (77.1)", "164 (89.1)", "<0.0118 **"], ["M1", "50 (15.9)", "26 (12.0)", "14 (21.2)", "10 (32.3)", "27 (16.3)", "23 (15.4)", "30 (22.9)", "20 (10.9)"], ["Tumor size"], ["T1", "170 (54.5)", "142 (65.4)", "22 (34.4)", "6 (20.0)", "<0.001 *", "82 (49.4)", "88 (60.3)", "0.261**", "56 (43.1)", "114 (62.6)", "0.00375 **"], ["T2", "44 (14.1)", "29 (13.4)", "10 (15.6)", "5 (16.7)", "30 (18.1)", "14 (9.6)", "18 (13.8)", "26 (14.3)"], ["T3", "87 (27.9)", "41 (18.9)", "29 (45.3)", "16 (53.3)", "47 (28.3)", "40 (27.4)", "49 (37.7)", "38 (20.9)"], ["T4", "11 (3.5)", "5 (2.3)", "3 (4.7)", "3 (10.0)", "7 (4.2)", "4 (2.7)", "7 (5.4)", "4 (2.2)"], ["Hyaluronan"], ["Negative", "158 (50.3)", "127 (58.8)", "25 (37.9)", "5 (16.1)", "<0.001 **", "72 (43.4)", "88 (59.1)", "0.00382 **", "41 (31.3)", "117 (63.6)", "<0.001 **"], ["Positive", "156 (49.7)", "89 (41.2)", "41 (62.1)", "26 (83.9)", "94 (56.6)", "61 (40.9)", "90 (68.7)", "67 (36.4)"], ["TILs"], ["None", "191 (61.0)", "141 (65.0)", "37 (56.9)", "12 (40.0)", "0.127*", "97 (58.4)", "94 (63.9)", "0.579**", "65 (50.0)", "126 (68.9)", "0.0118 **"], ["Low", "54 (17.3)", "36 (17.0)", "12 (18.5)", "6 (20.0)", "26 (15.7)", "28 (19.0)", "31 (23.8)", "23 (12.6)"], ["Moderate", "35 (11.2)", "21 (9.7)", "7 (10.8)", "7 (23.3)", "22 (13.3)", "13 (8.8)", "17 (13.1)", "18 (9.8)"], ["High", "33 (10.5)", "19 (8.8)", "9 (13.9)", "5 (16.7)", "21 (12.7)", "12 (8.2)", "17 (13.1)", "16 (8.7)"], ["Type"], ["Primary", "315 (83.1)", "190 (86.8)", "79 (79.8)", "46 (76.7)", "0.176*", "166 (85.1)", "149 (81.4)", "0.782**", "131 (82.4)", "184 (84.0)", "0.132**"], ["LVI", "42 (11.1)", "20 (9.1)", "11 (11.1)", "10 (16.7)", "", "19 (9.7)", "22 (12.0)", "22 (13.8)", "19 (8.7)", ""], ["Metastasis", "22 (5.8)", "9 (4.1)", "9 (9.1)", "4 (6.7)", "", "10 (5.1)", "12 (6.6)", "6 (3.8)", "16 (7.3)", ""]], "row_count": 42, "column_count": 12, "numeric_cells": 279, "header_rows": 2, "locator": "section[11]/table-wrap[1]#cjp270035-tbl-0003"}}, {"id": "asset:table:pmid:40528762:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:9d147cf79765010770b84d1496a0ca0e798bbedf5bfd341ddeba58f76e31f425", "bytes": 4007, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[11]/table-wrap[2]#cjp270035-tbl-0004", "version": null, "note": "Associations between HAS1‐3 protein expression and clinicopathological variables", "structure": {"pmcid": "PMC12174875", "section_index": 11, "section_title": "Association with hyaluronan content", "row_count": 42, "column_count": 12}, "table": {"label": "Table 4", "caption": "Associations between HAS1‐3 protein expression and clinicopathological variables", "rows": [["", "Total, N (%)", "HAS1 H‐score, N (%)", "p", "HAS2 H‐score, N (%)", "p", "HAS3 H‐score, N (%)", "p"], ["315 (100.0)", "0–100 (low)", "≥101 (high)", "0 (negative)", "1–100 (low)", "≥101 (high)", "0–100 (low)", "≥101 (high)"], ["ISUP grade"], ["I", "23 (7.5)", "3 (8.8)", "20 (7.1)", "0.0422 *", "5 (26.3)", "15 (10.9)", "3 (1.9)", "<0.001 *", "18 (8.4)", "4 (4.0)", "0.690**"], ["II", "165 (53.7)", "16 (47.1)", "153 (54.6)", "11 (57.9)", "87 (63.0)", "70 (45.2)", "116 (54.0)", "54 (54.5)"], ["III", "60 (19.5)", "2 (5.9)", "59 (21.1)", "2 (10.5)", "18 (13.0)", "41 (26.5)", "40 (18.6)", "21 (21.2)"], ["IV", "59 (19.2)", "13 (38.2)", "48 (17.1)", "1 (5.3)", "18 (13.0)", "41 (26.5)", "41 (19.1)", "20 (20.2)"], ["Stage"], ["I", "160 (51.1)", "12 (35.3)", "147 (52.9)", "0.1593*", "10 (52.6)", "78 (56.5)", "71 (46.1)", "0.293*", "108 (50.5)", "51 (52.0)", "0.497**"], ["II", "39 (12.5)", "3 (8.8)", "36 (12.9)", "2 (10.5)", "21 (15.2)", "16 (10.4)", "29 (13.6)", "10 (10.2)"], ["III", "62 (19.8)", "10 (29.4)", "52 (18.7)", "4 (21.1)", "24 (17.4)", "33 (21.4)", "47 (22.0)", "15 (15.3)"], ["IV", "52 (16.6)", "9 (26.5)", "43 (15.5)", "3 (15.8)", "15 (10.9)", "34 (22.1)", "30 (14.0)", "22 (22.4)"], ["Histology"], ["ccRCC", "284 (91.6)", "29 (87.9)", "253 (92.0)", "0.347*", "17 (94.4)", "128 (94.8)", "136 (91.3)", "0.413*", "196 (92.9)", "86 (88.7)", "0.497*"], ["Papillary", "18 (5.8)", "2 (6.1)", "16 (5.8)", "0 (0.0)", "6 (4.4)", "7 (4.7)", "11 (5.2)", "7 (7.2)", ""], ["Chromophobe", "8 (2.6)", "2 (6.1)", "6 (2.2)", "1 (5.6)", "1 (0.7)", "6 (4.0)", "4 (1.9)", "4 (4.1)", ""], ["Sarcomatoid"], ["No", "281 (89.2)", "26 (76.5)", "256 (91.4)", "0.0422 *", "19 (100.0)", "129 (92.8)", "133 (85.8)", "0.120*", "192 (89.3)", "89 (89.9)", "1.000**"], ["Yes", "34 (10.8)", "8 (23.5)", "24 (8.6)", "0 (0.0)", "10 (7.2)", "22 (14.2)", "23 (10.7)", "10 (10.1)"], ["Rhabdoid"], ["No", "288 (91.4)", "27 (79.4)", "260 (92.9)", "0.0422 *", "19 (100.0)", "130 (93.5)", "138 (89.0)", "0.305*", "197 (91.6)", "91 (91.9)", "1.000**"], ["Yes", "27 (8.6)", "7 (20.6)", "20 (7.1)", "0 (0.0)", "9 (6.5)", "17 (11.0)", "18 (8.4)", "8 (8.1)"], ["Metastasis at diagnosis"], ["M0", "265 (84.1)", "26 (76.5)", "238 (85.0)", "0.334**", "16 (84.2)", "124 (89.2)", "122 (78.7)", "0.120*", "185 (86.0)", "79 (79.8)", "0.497**"], ["M1", "50 (15.9)", "8 (23.5)", "42 (15.0)", "3 (15.8)", "15 (10.8)", "33 (21.3)", "30 (14.0)", "20 (20.2)"], ["Tumor size"], ["T1", "170 (54.5)", "14 (41.2)", "155 (56.0)", "0.0494 *", "11 (57.9)", "81 (58.7)", "77 (50.3)", "0.430*", "114 (53.3)", "55 (56.7)", "0.456*"], ["T2", "44 (14.1)", "3 (8.8)", "41 (14.8)", "2 (10.5)", "23 (16.7)", "19 (12.4)", "32 (15.0)", "12 (12.4)"], ["T3", "87 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