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pmid:40531258

Seven Hypoxia and Immune-Related Features Predict Prognosis in Patients with Hepatocellular Carcinoma.

Digestive diseases and sciences · 2025 doi:10.1007/s10620-025-09152-2

Paper

partial

Experiment

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Data

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Analysis

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Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
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pmid:40531258
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2
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2026-11-01T10:25:51Z
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2026-11-01T14:01:42Z
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paper object · 10 fields
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title
Seven Hypoxia and Immune-Related Features Predict Prognosis in Patients with Hepatocellular Carcinoma.
doi
10.1007/s10620-025-09152-2
pmid
40531258
authors
null
journal
Digestive diseases and sciences
year
2025
abstract
null
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the headline numerical result the paper states for its main finding
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qualitative
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abstract
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authors
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the headline numerical result the paper states for its main finding
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Read the published estimate and its interval from the source
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source:pmid:40531258
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the published estimate, its unit and its interval
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the source data with its provenance
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Run the analysis programme
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no owned computational capability is bound to this experiment
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duration_hours
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parameters object · 0 fields
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the registered result
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https://doi.org/10.1007/s10620-025-09152-2
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sha256:a663337cf88273d05f420a5f0d58c4ea8a8db476a88ea0bbc2a91ec396792d48
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10.1007/s10620-025-09152-2
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Source read by the package builder: full_text.
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Information of 78 HIRDEGs identified in this study
structure object · 5 fields
pmcid
PMC12627134
section_index
4
section_title
Prognostic Modeling of Hypoxia-Immune-Related DEGs in the TCGA Cohort
row_count
157
column_count
9
table object · 8 fields
label
Table 1
caption
Information of 78 HIRDEGs identified in this study
rows array · 157 items
[0] array · 9 items
[0]
Gene
[1]
HR
[2]
95% CI lower
[3]
95% CI upper
[4]
p value
[5]
log2FC
[6]
P.adj
[7]
Gene.type
[8]
Regulated
[1] array · 9 items
[0]
ANKZF1
[1]
1.2
[2]
1
[3]
1.5
[4]
0.026
[5]
1.27
[6]
3.48E−39
[7]
Hypoxia gene
[8]
Up-Regulated
[2] array · 9 items
[0]
EFNA3
[1]
1.2
[2]
1
[3]
1.3
[4]
0.0052
[5]
2.5
[6]
1.42E−35
[7]
Hypoxia gene
[8]
Up-Regulated
[3] array · 9 items
[0]
ANXA2
[1]
1.2
[2]
1.1
[3]
1.4
[4]
0.0032
[5]
1.57
[6]
1.39E−30
[7]
Hypoxia gene
[8]
Up-Regulated
[4] array · 9 items
[0]
ALDOA
[1]
1.3
[2]
1.1
[3]
1.4
[4]
0.00022
[5]
1.49
[6]
2.27E−24
[7]
Hypoxia gene
[8]
Up-Regulated
[5] array · 9 items
[0]
NEDD4L
[1]
1.2
[2]
1
[3]
1.4
[4]
0.033
[5]
1.26
[6]
4.01E−23
[7]
Hypoxia gene
[8]
Up-Regulated
[6] array · 9 items
[0]
DDIT3
[1]
1.2
[2]
1
[3]
1.3
[4]
0.028
[5]
1.26
[6]
7.75E−19
[7]
Hypoxia gene
[8]
Up-Regulated
[7] array · 9 items
[0]
NDRG1
[1]
1.2
[2]
1.1
[3]
1.4
[4]
0.00031
[5]
1.55
[6]
1.44E−15
[7]
Hypoxia gene
[8]
Up-Regulated
[8] array · 9 items
[0]
STC2
[1]
1.1
[2]
1
[3]
1.2
[4]
0.0079
[5]
2.33
[6]
1.29E−25
[7]
Hypoxia gene
[8]
Up-Regulated
[9] array · 9 items
[0]
LOX
[1]
1.1
[2]
1
[3]
1.2
[4]
0.017
[5]
1.99
[6]
2.14E−19
[7]
Hypoxia gene
[8]
Up-Regulated
[10] array · 9 items
[0]
PGF
[1]
1.1
[2]
1
[3]
1.3
[4]
0.0065
[5]
1.36
[6]
1.70E−17
[7]
Hypoxia gene
[8]
Up-Regulated
[11] array · 9 items
[0]
ZFP36
[1]
1.1
[2]
1
[3]
1.3
[4]
0.037
[5]
− 1.81
[6]
3.24E−42
[7]
Hypoxia gene
[8]
Down-Regulated
[12] array · 9 items
[0]
FOS
[1]
1.1
[2]
1
[3]
1.2
[4]
0.044
[5]
− 2.89
[6]
7.33E−36
[7]
Hypoxia gene
[8]
Down-Regulated
[13] array · 9 items
[0]
IGFBP3
[1]
1.2
[2]
1.1
[3]
1.3
[4]
0.00011
[5]
− 1.67
[6]
1.90E−20
[7]
Hypoxia gene
[8]
Down-Regulated
[14] array · 9 items
[0]
PLAC8
[1]
1.1
[2]
1
[3]
1.2
[4]
0.019
[5]
− 2.03
[6]
3.93E−14
[7]
Hypoxia gene
[8]
Down-Regulated
[15] array · 9 items
[0]
PPFIA4
[1]
1.2
[2]
1.1
[3]
1.3
[4]
7.60E−06
[5]
2.89
[6]
2.38E−18
[7]
Hypoxia gene
[8]
Up-Regulated
[16] array · 9 items
[0]
BHLHE40
[1]
1.2
[2]
1
[3]
1.3
[4]
0.033
[5]
− 1
[6]
1.20E−12
[7]
Hypoxia gene
[8]
Down-Regulated
[17] array · 9 items
[0]
PFKP
[1]
1.2
[2]
1.1
[3]
1.3
[4]
2.00E−04
[5]
1.88
[6]
1.72E−13
[7]
Hypoxia gene
[8]
Up-Regulated
[18] array · 9 items
[0]
DPYSL4
[1]
1.1
[2]
1.1
[3]
1.2
[4]
0.00025
[5]
2.26
[6]
1.96E−11
[7]
Hypoxia gene
[8]
Up-Regulated
[19] array · 9 items
[0]
SLC6A6
[1]
1.1
[2]
1
[3]
1.2
[4]
0.017
[5]
1.09
[6]
6.23E−06
[7]
Hypoxia gene
[8]
Up-Regulated
[20] array · 9 items
[0]
SLC2A1
[1]
1.3
[2]
1.2
[3]
1.4
[4]
1.70E−07
[5]
1.33
[6]
8.08E−10
[7]
Hypoxia gene
[8]
Up-Regulated
[21] array · 9 items
[0]
ENO2
[1]
1.2
[2]
1.1
[3]
1.3
[4]
0.00093
[5]
1.08
[6]
8.88E−06
[7]
Hypoxia gene
[8]
Up-Regulated
[22] array · 9 items
[0]
KIF5A
[1]
1.1
[2]
1
[3]
1.2
[4]
0.0049
[5]
3.54
[6]
2.35E−18
[7]
Hypoxia gene
[8]
Up-Regulated
[23] array · 9 items
[0]
TES
[1]
1.2
[2]
1
[3]
1.3
[4]
0.018
[5]
1.05
[6]
7.66E−12
[7]
Hypoxia gene
[8]
Up-Regulated
[24] array · 9 items
[0]
ADORA2B
[1]
1.1
[2]
1
[3]
1.2
[4]
0.0053
[5]
1.01
[6]
5.16E−05
[7]
Hypoxia gene
[8]
Up-Regulated
[25] array · 9 items
[0]
HK2
[1]
1.1
[2]
1
[3]
1.2
[4]
0.0013
[5]
1.9
[6]
1.75E−10
[7]
Hypoxia gene
[8]
Up-Regulated
[26] array · 9 items
[0]
JUN
[1]
1.2
[2]
1
[3]
1.3
[4]
0.016
[5]
− 1.17
[6]
2.55E−16
[7]
Hypoxia gene
[8]
Down-Regulated
[27] array · 9 items
[0]
SERPINE1
[1]
1.1
[2]
1.1
[3]
1.2
[4]
0.00074
[5]
− 1.88
[6]
2.63E−16
[7]
Hypoxia gene
[8]
Down-Regulated
[28] array · 9 items
[0]
NFIL3
[1]
1.2
[2]
1
[3]
1.3
[4]
0.048
[5]
− 1.04
[6]
1.20E−15
[7]
Hypoxia gene
[8]
Down-Regulated
[29] array · 9 items
[0]
KDELR3
[1]
1.2
[2]
1
[3]
1.3
[4]
0.0055
[5]
1.36
[6]
8.93E−13
[7]
Hypoxia gene
[8]
Up-Regulated
[30] array · 9 items
[0]
MARCO
[1]
1.1
[2]
1
[3]
1.1
[4]
0.014
[5]
− 4.77
[6]
7.33E−41
[7]
Immune gene
[8]
Down-Regulated
[31] array · 9 items
[0]
SPP1
[1]
1.1
[2]
1.1
[3]
1.2
[4]
1.90E−05
[5]
4.52
[6]
1.60E−33
[7]
Immune gene
[8]
Up-Regulated
[32] array · 9 items
[0]
HSP90AB1
[1]
1.2
[2]
1
[3]
1.4
[4]
0.031
[5]
1.26
[6]
1.91E−33
[7]
Immune gene
[8]
Up-Regulated
[33] array · 9 items
[0]
CACYBP
[1]
1.3
[2]
1.1
[3]
1.5
[4]
0.0094
[5]
1.34
[6]
8.62E−32
[7]
Immune gene
[8]
Up-Regulated
[34] array · 9 items
[0]
SHC1
[1]
1.2
[2]
1
[3]
1.5
[4]
0.02
[5]
1.16
[6]
1.46E−30
[7]
Immune gene
[8]
Up-Regulated
[35] array · 9 items
[0]
PLXNA1
[1]
1.2
[2]
1.1
[3]
1.3
[4]
0.0041
[5]
1.62
[6]
5.05E−28
[7]
Immune gene
[8]
Up-Regulated
[36] array · 9 items
[0]
FABP5
[1]
1.1
[2]
1
[3]
1.3
[4]
0.03
[5]
2
[6]
3.12E−26
[7]
Immune gene
[8]
Up-Regulated
[37] array · 9 items
[0]
MMP12
[1]
1.1
[2]
1
[3]
1.1
[4]
0.014
[5]
4.29
[6]
7.89E−24
[7]
Immune gene
[8]
Up-Regulated
[38] array · 9 items
[0]
FPR2
[1]
1.1
[2]
1
[3]
1.2
[4]
0.01
[5]
− 2.66
[6]
1.02E−22
[7]
Immune gene
[8]
Down-Regulated
[39] array · 9 items
[0]
CKLF
[1]
1.3
[2]
1.1
[3]
1.5
[4]
0.0017
[5]
1.33
[6]
1.04E−22
[7]
Immune gene
[8]
Up-Regulated
[40] array · 9 items
[0]
S100A10
[1]
1.2
[2]
1.1
[3]
1.4
[4]
0.0032
[5]
1.54
[6]
3.53E−22
[7]
Immune gene
[8]
Up-Regulated
[41] array · 9 items
[0]
IRF3
[1]
1.2
[2]
1
[3]
1.5
[4]
0.042
[5]
1.03
[6]
1.44E−21
[7]
Immune gene
[8]
Up-Regulated
[42] array · 9 items
[0]
NR6A1
[1]
1.2
[2]
1
[3]
1.3
[4]
0.024
[5]
1.58
[6]
1.45E−21
[7]
Immune gene
[8]
Up-Regulated
[43] array · 9 items
[0]
PLXNA3
[1]
1.1
[2]
1
[3]
1.2
[4]
0.043
[5]
1.72
[6]
2.10E−21
[7]
Immune gene
[8]
Up-Regulated
[44] array · 9 items
[0]
HRAS
[1]
1.2
[2]
1
[3]
1.4
[4]
0.011
[5]
1.26
[6]
7.14E−20
[7]
Immune gene
[8]
Up-Regulated
[45] array · 9 items
[0]
PTGS2
[1]
1.1
[2]
1
[3]
1.2
[4]
0.039
[5]
− 2.3
[6]
1.80E−19
[7]
Immune gene
[8]
Down-Regulated
[46] array · 9 items
[0]
PTHLH
[1]
1.1
[2]
1
[3]
1.2
[4]
0.01
[5]
2.93
[6]
2.11E−17
[7]
Immune gene
[8]
Up-Regulated
[47] array · 9 items
[0]
CCL26
[1]
1.1
[2]
1
[3]
1.2
[4]
0.048
[5]
3.29
[6]
3.10E−17
[7]
Immune gene
[8]
Up-Regulated
[48] array · 9 items
[0]
NR0B1
[1]
1.1
[2]
1.1
[3]
1.2
[4]
5.60E−07
[5]
6.35
[6]
6.85E−17
[7]
Immune gene
[8]
Up-Regulated
[49] array · 9 items
[0]
IKBKE
[1]
1.1
[2]
1
[3]
1.3
[4]
0.0053
[5]
1.5
[6]
2.89E−16
[7]
Immune gene
[8]
Up-Regulated
[50] array · 9 items
[0]
TMSB10
[1]
1.1
[2]
1
[3]
1.2
[4]
0.011
[5]
1.67
[6]
8.45E−16
[7]
Immune gene
[8]
Up-Regulated
[51] array · 9 items
[0]
SRC
[1]
1.1
[2]
1
[3]
1.2
[4]
0.021
[5]
1.49
[6]
2.32E−15
[7]
Immune gene
[8]
Up-Regulated
[52] array · 9 items
[0]
KITLG
[1]
1.1
[2]
1
[3]
1.3
[4]
0.032
[5]
1.44
[6]
3.11E−15
[7]
Immune gene
[8]
Up-Regulated
[53] array · 9 items
[0]
SEMA3G
[1]
0.89
[2]
0.79
[3]
0.99
[4]
0.028
[5]
1.36
[6]
3.96E−15
[7]
Immune gene
[8]
Up-Regulated
[54] array · 9 items
[0]
CCR1
[1]
1.1
[2]
1
[3]
1.3
[4]
0.042
[5]
− 1.3
[6]
7.63E−15
[7]
Immune gene
[8]
Down-Regulated
[55] array · 9 items
[0]
MMP9
[1]
1.1
[2]
1
[3]
1.1
[4]
0.043
[5]
2.16
[6]
1.84E−14
[7]
Immune gene
[8]
Up-Regulated
[56] array · 9 items
[0]
CD320
[1]
1.3
[2]
1.1
[3]
1.5
[4]
0.0067
[5]
1.09
[6]
3.02E−14
[7]
Immune gene
[8]
Up-Regulated
[57] array · 9 items
[0]
CCL3
[1]
1.1
[2]
1
[3]
1.3
[4]
0.043
[5]
− 1.41
[6]
4.02E−14
[7]
Immune gene
[8]
Down-Regulated
[58] array · 9 items
[0]
IL1B
[1]
1.1
[2]
1
[3]
1.2
[4]
0.016
[5]
− 1.62
[6]
3.99E−13
[7]
Immune gene
[8]
Down-Regulated
[59] array · 9 items
[0]
FABP6
[1]
1.1
[2]
1.1
[3]
1.2
[4]
4.10E−05
[5]
3.84
[6]
4.31E−12
[7]
Immune gene
[8]
Up-Regulated
[60] array · 9 items
[0]
HTR3A
[1]
1.1
[2]
1
[3]
1.2
[4]
0.026
[5]
3.58
[6]
6.46E−12
[7]
Immune gene
[8]
Up-Regulated
[61] array · 9 items
[0]
APOBEC3A
[1]
1.1
[2]
1
[3]
1.3
[4]
0.0064
[5]
− 1.61
[6]
7.24E−12
[7]
Immune gene
[8]
Down-Regulated
[62] array · 9 items
[0]
OXTR
[1]
1.1
[2]
1
[3]
1.2
[4]
0.0069
[5]
1.52
[6]
1.43E−10
[7]
Immune gene
[8]
Up-Regulated
[63] array · 9 items
[0]
AMHR2
[1]
1.1
[2]
1
[3]
1.2
[4]
0.024
[5]
− 2.61
[6]
2.28E−10
[7]
Immune gene
[8]
Down-Regulated
[64] array · 9 items
[0]
TNFSF9
[1]
1.1
[2]
1
[3]
1.2
[4]
0.034
[5]
1.75
[6]
5.24E−10
[7]
Immune gene
[8]
Up-Regulated
[65] array · 9 items
[0]
GLP2R
[1]
1.1
[2]
1
[3]
1.2
[4]
0.0027
[5]
− 2.13
[6]
1.15E−09
[7]
Immune gene
[8]
Down-Regulated
[66] array · 9 items
[0]
SEMA3A
[1]
1.1
[2]
1
[3]
1.2
[4]
0.048
[5]
1.83
[6]
2.50E−09
[7]
Immune gene
[8]
Up-Regulated
[67] array · 9 items
[0]
FCGR2B
[1]
1.1
[2]
1
[3]
1.2
[4]
0.021
[5]
− 1.68
[6]
5.53E−09
[7]
Immune gene
[8]
Down-Regulated
[68] array · 9 items
[0]
S100A11
[1]
1.2
[2]
1.1
[3]
1.3
[4]
0.00022
[5]
1.21
[6]
5.92E−09
[7]
Immune gene
[8]
Up-Regulated
[69] array · 9 items
[0]
ADM
[1]
1.2
[2]
1.1
[3]
1.4
[4]
0.00013
[5]
− 1.06
[6]
1.13E−08
[7]
Immune gene
[8]
Down-Regulated
[70] array · 9 items
[0]
S100A6
[1]
1.1
[2]
1
[3]
1.2
[4]
0.0041
[5]
1.41
[6]
1.46E−08
[7]
Immune gene
[8]
Up-Regulated
[71] array · 9 items
[0]
CCL20
[1]
1.1
[2]
1
[3]
1.1
[4]
0.012
[5]
1.64
[6]
7.31E−07
[7]
Immune gene
[8]
Up-Regulated
[72] array · 9 items
[0]
TNFRSF11A
[1]
1.1
[2]
1
[3]
1.3
[4]
0.0048
[5]
1.03
[6]
2.13E−06
[7]
Immune gene
[8]
Up-Regulated
[73] array · 9 items
[0]
IL11
[1]
1.1
[2]
1
[3]
1.2
[4]
0.037
[5]
1.47
[6]
4.94E−06
[7]
Immune gene
[8]
Up-Regulated
[74] array · 9 items
[0]
ZC3HAV1L
[1]
1.1
[2]
1
[3]
1.2
[4]
0.034
[5]
1.22
[6]
7.84E−06
[7]
Immune gene
[8]
Up-Regulated
[75] array · 9 items
[0]
S100A8
[1]
1.1
[2]
1.1
[3]
1.2
[4]
0.001
[5]
− 1.26
[6]
2.04E−05
[7]
Immune gene
[8]
Down-Regulated
[76] array · 9 items
[0]
S100A2
[1]
1.1
[2]
1.1
[3]
1.2
[4]
0.00042
[5]
1.26
[6]
0.000157
[7]
Immune gene
[8]
Up-Regulated
[77] array · 9 items
[0]
IGLV7-46
[1]
1.1
[2]
1
[3]
1.1
[4]
0.023
[5]
− 1.24
[6]
0.004049
[7]
Immune gene
[8]
Down-Regulated
[78] array · 9 items
[0]
IGKV6-21
[1]
1.1
[2]
1
[3]
1.2
[4]
0.035
[5]
− 1.36
[6]
0.006348
[7]
Immune gene
[8]
Down-Regulated
[79] array · 9 items
[0]
ANKZF1
[1]
1.2
[2]
1
[3]
1.5
[4]
0.026
[5]
1.272077
[6]
3.48E−39
[7]
Hypoxia gene
[8]
Up-Regulated
[80] array · 9 items
[0]
EFNA3
[1]
1.2
[2]
1
[3]
1.3
[4]
0.0052
[5]
2.504656
[6]
1.42E−35
[7]
Hypoxia gene
[8]
Up-Regulated
[81] array · 9 items
[0]
ANXA2
[1]
1.2
[2]
1.1
[3]
1.4
[4]
0.0032
[5]
1.568519
[6]
1.39E−30
[7]
Hypoxia gene
[8]
Up-Regulated
[82] array · 9 items
[0]
ALDOA
[1]
1.3
[2]
1.1
[3]
1.4
[4]
0.00022
[5]
1.494684
[6]
2.27E−24
[7]
Hypoxia gene
[8]
Up-Regulated
[83] array · 9 items
[0]
NEDD4L
[1]
1.2
[2]
1
[3]
1.4
[4]
0.033
[5]
1.257916
[6]
4.01E−23
[7]
Hypoxia gene
[8]
Up-Regulated
[84] array · 9 items
[0]
DDIT3
[1]
1.2
[2]
1
[3]
1.3
[4]
0.028
[5]
1.261629
[6]
7.75E−19
[7]
Hypoxia gene
[8]
Up-Regulated
[85] array · 9 items
[0]
NDRG1
[1]
1.2
[2]
1.1
[3]
1.4
[4]
0.00031
[5]
1.547209
[6]
1.44E−15
[7]
Hypoxia gene
[8]
Up-Regulated
[86] array · 9 items
[0]
STC2
[1]
1.1
[2]
1
[3]
1.2
[4]
0.0079
[5]
2.332275
[6]
1.29E−25
[7]
Hypoxia gene
[8]
Up-Regulated
[87] array · 9 items
[0]
LOX
[1]
1.1
[2]
1
[3]
1.2
[4]
0.017
[5]
1.988764
[6]
2.14E−19
[7]
Hypoxia gene
[8]
Up-Regulated
[88] array · 9 items
[0]
PGF
[1]
1.1
[2]
1
[3]
1.3
[4]
0.0065
[5]
1.35752
[6]
1.70E−17
[7]
Hypoxia gene
[8]
Up-Regulated
[89] array · 9 items
[0]
ZFP36
[1]
1.1
[2]
1
[3]
1.3
[4]
0.037
[5]
− 1.81281
[6]
3.24E−42
[7]
Hypoxia gene
[8]
Down-Regulated
[90] array · 9 items
[0]
FOS
[1]
1.1
[2]
1
[3]
1.2
[4]
0.044
[5]
− 2.89205
[6]
7.33E−36
[7]
Hypoxia gene
[8]
Down-Regulated
[91] array · 9 items
[0]
IGFBP3
[1]
1.2
[2]
1.1
[3]
1.3
[4]
0.00011
[5]
− 1.6726
[6]
1.90E−20
[7]
Hypoxia gene
[8]
Down-Regulated
[92] array · 9 items
[0]
PLAC8
[1]
1.1
[2]
1
[3]
1.2
[4]
0.019
[5]
− 2.02516
[6]
3.93E−14
[7]
Hypoxia gene
[8]
Down-Regulated
[93] array · 9 items
[0]
PPFIA4
[1]
1.2
[2]
1.1
[3]
1.3
[4]
7.60E−06
[5]
2.888876
[6]
2.38E−18
[7]
Hypoxia gene
[8]
Up-Regulated
[94] array · 9 items
[0]
BHLHE40
[1]
1.2
[2]
1
[3]
1.3
[4]
0.033
[5]
− 1.00309
[6]
1.20E−12
[7]
Hypoxia gene
[8]
Down-Regulated
[95] array · 9 items
[0]
PFKP
[1]
1.2
[2]
1.1
[3]
1.3
[4]
2.00E−04
[5]
1.883723
[6]
1.72E−13
[7]
Hypoxia gene
[8]
Up-Regulated
[96] array · 9 items
[0]
DPYSL4
[1]
1.1
[2]
1.1
[3]
1.2
[4]
0.00025
[5]
2.255871
[6]
1.96E−11
[7]
Hypoxia gene
[8]
Up-Regulated
[97] array · 9 items
[0]
SLC6A6
[1]
1.1
[2]
1
[3]
1.2
[4]
0.017
[5]
1.087187
[6]
6.23E−06
[7]
Hypoxia gene
[8]
Up-Regulated
[98] array · 9 items
[0]
SLC2A1
[1]
1.3
[2]
1.2
[3]
1.4
[4]
1.70E−07
[5]
1.329015
[6]
8.08E−10
[7]
Hypoxia gene
[8]
Up-Regulated
[99] array · 9 items
[0]
ENO2
[1]
1.2
[2]
1.1
[3]
1.3
[4]
0.00093
[5]
1.084453
[6]
8.88E−06
[7]
Hypoxia gene
[8]
Up-Regulated
[100] array · 9 items
[0]
KIF5A
[1]
1.1
[2]
1
[3]
1.2
[4]
0.0049
[5]
3.535681
[6]
2.35E−18
[7]
Hypoxia gene
[8]
Up-Regulated
[101] array · 9 items
[0]
TES
[1]
1.2
[2]
1
[3]
1.3
[4]
0.018
[5]
1.052133
[6]
7.66E−12
[7]
Hypoxia gene
[8]
Up-Regulated
[102] array · 9 items
[0]
ADORA2B
[1]
1.1
[2]
1
[3]
1.2
[4]
0.0053
[5]
1.007072
[6]
5.16E−05
[7]
Hypoxia gene
[8]
Up-Regulated
[103] array · 9 items
[0]
HK2
[1]
1.1
[2]
1
[3]
1.2
[4]
0.0013
[5]
1.899485
[6]
1.75E−10
[7]
Hypoxia gene
[8]
Up-Regulated
[104] array · 9 items
[0]
JUN
[1]
1.2
[2]
1
[3]
1.3
[4]
0.016
[5]
− 1.17213
[6]
2.55E−16
[7]
Hypoxia gene
[8]
Down-Regulated
[105] array · 9 items
[0]
SERPINE1
[1]
1.1
[2]
1.1
[3]
1.2
[4]
0.00074
[5]
− 1.88064
[6]
2.63E−16
[7]
Hypoxia gene
[8]
Down-Regulated
[106] array · 9 items
[0]
NFIL3
[1]
1.2
[2]
1
[3]
1.3
[4]
0.048
[5]
− 1.03917
[6]
1.20E−15
[7]
Hypoxia gene
[8]
Down-Regulated
[107] array · 9 items
[0]
KDELR3
[1]
1.2
[2]
1
[3]
1.3
[4]
0.0055
[5]
1.355106
[6]
8.93E−13
[7]
Hypoxia gene
[8]
Up-Regulated
[108] array · 9 items
[0]
MARCO
[1]
1.1
[2]
1
[3]
1.1
[4]
0.014
[5]
− 4.77417
[6]
7.33E−41
[7]
Immune gene
[8]
Down-Regulated
[109] array · 9 items
[0]
SPP1
[1]
1.1
[2]
1.1
[3]
1.2
[4]
1.90E−05
[5]
4.516552
[6]
1.60E−33
[7]
Immune gene
[8]
Up-Regulated
[110] array · 9 items
[0]
HSP90AB1
[1]
1.2
[2]
1
[3]
1.4
[4]
0.031
[5]
1.25676
[6]
1.91E−33
[7]
Immune gene
[8]
Up-Regulated
[111] array · 9 items
[0]
CACYBP
[1]
1.3
[2]
1.1
[3]
1.5
[4]
0.0094
[5]
1.344684
[6]
8.62E−32
[7]
Immune gene
[8]
Up-Regulated
[112] array · 9 items
[0]
SHC1
[1]
1.2
[2]
1
[3]
1.5
[4]
0.02
[5]
1.1605
[6]
1.46E−30
[7]
Immune gene
[8]
Up-Regulated
[113] array · 9 items
[0]
PLXNA1
[1]
1.2
[2]
1.1
[3]
1.3
[4]
0.0041
[5]
1.616181
[6]
5.05E−28
[7]
Immune gene
[8]
Up-Regulated
[114] array · 9 items
[0]
FABP5
[1]
1.1
[2]
1
[3]
1.3
[4]
0.03
[5]
1.995793
[6]
3.12E−26
[7]
Immune gene
[8]
Up-Regulated
[115] array · 9 items
[0]
MMP12
[1]
1.1
[2]
1
[3]
1.1
[4]
0.014
[5]
4.293032
[6]
7.89E−24
[7]
Immune gene
[8]
Up-Regulated
[116] array · 9 items
[0]
FPR2
[1]
1.1
[2]
1
[3]
1.2
[4]
0.01
[5]
− 2.661
[6]
1.02E−22
[7]
Immune gene
[8]
Down-Regulated
[117] array · 9 items
[0]
CKLF
[1]
1.3
[2]
1.1
[3]
1.5
[4]
0.0017
[5]
1.333721
[6]
1.04E−22
[7]
Immune gene
[8]
Up-Regulated
[118] array · 9 items
[0]
S100A10
[1]
1.2
[2]
1.1
[3]
1.4
[4]
0.0032
[5]
1.539881
[6]
3.53E−22
[7]
Immune gene
[8]
Up-Regulated
[119] array · 9 items
[0]
IRF3
[1]
1.2
[2]
1
[3]
1.5
[4]
0.042
[5]
1.028591
[6]
1.44E−21
[7]
Immune gene
[8]
Up-Regulated
[120] array · 9 items
[0]
NR6A1
[1]
1.2
[2]
1
[3]
1.3
[4]
0.024
[5]
1.578946
[6]
1.45E−21
[7]
Immune gene
[8]
Up-Regulated
[121] array · 9 items
[0]
PLXNA3
[1]
1.1
[2]
1
[3]
1.2
[4]
0.043
[5]
1.721173
[6]
2.10E−21
[7]
Immune gene
[8]
Up-Regulated
[122] array · 9 items
[0]
HRAS
[1]
1.2
[2]
1
[3]
1.4
[4]
0.011
[5]
1.255789
[6]
7.14E−20
[7]
Immune gene
[8]
Up-Regulated
[123] array · 9 items
[0]
PTGS2
[1]
1.1
[2]
1
[3]
1.2
[4]
0.039
[5]
− 2.30408
[6]
1.80E−19
[7]
Immune gene
[8]
Down-Regulated
[124] array · 9 items
[0]
PTHLH
[1]
1.1
[2]
1
[3]
1.2
[4]
0.01
[5]
2.929178
[6]
2.11E−17
[7]
Immune gene
[8]
Up-Regulated
[125] array · 9 items
[0]
CCL26
[1]
1.1
[2]
1
[3]
1.2
[4]
0.048
[5]
3.288943
[6]
3.10E−17
[7]
Immune gene
[8]
Up-Regulated
[126] array · 9 items
[0]
NR0B1
[1]
1.1
[2]
1.1
[3]
1.2
[4]
5.60E−07
[5]
6.346336
[6]
6.85E−17
[7]
Immune gene
[8]
Up-Regulated
[127] array · 9 items
[0]
IKBKE
[1]
1.1
[2]
1
[3]
1.3
[4]
0.0053
[5]
1.495667
[6]
2.89E−16
[7]
Immune gene
[8]
Up-Regulated
[128] array · 9 items
[0]
TMSB10
[1]
1.1
[2]
1
[3]
1.2
[4]
0.011
[5]
1.674014
[6]
8.45E−16
[7]
Immune gene
[8]
Up-Regulated
[129] array · 9 items
[0]
SRC
[1]
1.1
[2]
1
[3]
1.2
[4]
0.021
[5]
1.488588
[6]
2.32E−15
[7]
Immune gene
[8]
Up-Regulated
[130] array · 9 items
[0]
KITLG
[1]
1.1
[2]
1
[3]
1.3
[4]
0.032
[5]
1.440809
[6]
3.11E−15
[7]
Immune gene
[8]
Up-Regulated
[131] array · 9 items
[0]
SEMA3G
[1]
0.89
[2]
0.79
[3]
0.99
[4]
0.028
[5]
1.357656
[6]
3.96E−15
[7]
Immune gene
[8]
Up-Regulated
[132] array · 9 items
[0]
CCR1
[1]
1.1
[2]
1
[3]
1.3
[4]
0.042
[5]
− 1.30151
[6]
7.63E−15
[7]
Immune gene
[8]
Down-Regulated
[133] array · 9 items
[0]
MMP9
[1]
1.1
[2]
1
[3]
1.1
[4]
0.043
[5]
2.158964
[6]
1.84E−14
[7]
Immune gene
[8]
Up-Regulated
[134] array · 9 items
[0]
CD320
[1]
1.3
[2]
1.1
[3]
1.5
[4]
0.0067
[5]
1.090493
[6]
3.02E−14
[7]
Immune gene
[8]
Up-Regulated
[135] array · 9 items
[0]
CCL3
[1]
1.1
[2]
1
[3]
1.3
[4]
0.043
[5]
− 1.41379
[6]
4.02E−14
[7]
Immune gene
[8]
Down-Regulated
[136] array · 9 items
[0]
IL1B
[1]
1.1
[2]
1
[3]
1.2
[4]
0.016
[5]
− 1.61712
[6]
3.99E−13
[7]
Immune gene
[8]
Down-Regulated
[137] array · 9 items
[0]
FABP6
[1]
1.1
[2]
1.1
[3]
1.2
[4]
4.10E−05
[5]
3.83992
[6]
4.31E−12
[7]
Immune gene
[8]
Up-Regulated
[138] array · 9 items
[0]
HTR3A
[1]
1.1
[2]
1
[3]
1.2
[4]
0.026
[5]
3.583696
[6]
6.46E−12
[7]
Immune gene
[8]
Up-Regulated
[139] array · 9 items
[0]
APOBEC3A
[1]
1.1
[2]
1
[3]
1.3
[4]
0.0064
[5]
− 1.60742
[6]
7.24E−12
[7]
Immune gene
[8]
Down-Regulated
[140] array · 9 items
[0]
OXTR
[1]
1.1
[2]
1
[3]
1.2
[4]
0.0069
[5]
1.524812
[6]
1.43E−10
[7]
Immune gene
[8]
Up-Regulated
[141] array · 9 items
[0]
AMHR2
[1]
1.1
[2]
1
[3]
1.2
[4]
0.024
[5]
− 2.60958
[6]
2.28E−10
[7]
Immune gene
[8]
Down-Regulated
[142] array · 9 items
[0]
TNFSF9
[1]
1.1
[2]
1
[3]
1.2
[4]
0.034
[5]
1.753932
[6]
5.24E−10
[7]
Immune gene
[8]
Up-Regulated
[143] array · 9 items
[0]
GLP2R
[1]
1.1
[2]
1
[3]
1.2
[4]
0.0027
[5]
− 2.12716
[6]
1.15E−09
[7]
Immune gene
[8]
Down-Regulated
[144] array · 9 items
[0]
SEMA3A
[1]
1.1
[2]
1
[3]
1.2
[4]
0.048
[5]
1.826776
[6]
2.50E−09
[7]
Immune gene
[8]
Up-Regulated
[145] array · 9 items
[0]
FCGR2B
[1]
1.1
[2]
1
[3]
1.2
[4]
0.021
[5]
− 1.68376
[6]
5.53E−09
[7]
Immune gene
[8]
Down-Regulated
[146] array · 9 items
[0]
S100A11
[1]
1.2
[2]
1.1
[3]
1.3
[4]
0.00022
[5]
1.213205
[6]
5.92E−09
[7]
Immune gene
[8]
Up-Regulated
[147] array · 9 items
[0]
ADM
[1]
1.2
[2]
1.1
[3]
1.4
[4]
0.00013
[5]
− 1.06415
[6]
1.13E−08
[7]
Immune gene
[8]
Down-Regulated
[148] array · 9 items
[0]
S100A6
[1]
1.1
[2]
1
[3]
1.2
[4]
0.0041
[5]
1.40655
[6]
1.46E−08
[7]
Immune gene
[8]
Up-Regulated
[149] array · 9 items
[0]
CCL20
[1]
1.1
[2]
1
[3]
1.1
[4]
0.012
[5]
1.636874
[6]
7.31E−07
[7]
Immune gene
[8]
Up-Regulated
[150] array · 9 items
[0]
TNFRSF11A
[1]
1.1
[2]
1
[3]
1.3
[4]
0.0048
[5]
1.033954
[6]
2.13E−06
[7]
Immune gene
[8]
Up-Regulated
[151] array · 9 items
[0]
IL11
[1]
1.1
[2]
1
[3]
1.2
[4]
0.037
[5]
1.4665
[6]
4.94E−06
[7]
Immune gene
[8]
Up-Regulated
[152] array · 9 items
[0]
ZC3HAV1L
[1]
1.1
[2]
1
[3]
1.2
[4]
0.034
[5]
1.218699
[6]
7.84E−06
[7]
Immune gene
[8]
Up-Regulated
[153] array · 9 items
[0]
S100A8
[1]
1.1
[2]
1.1
[3]
1.2
[4]
0.001
[5]
− 1.25586
[6]
2.04E−05
[7]
Immune gene
[8]
Down-Regulated
[154] array · 9 items
[0]
S100A2
[1]
1.1
[2]
1.1
[3]
1.2
[4]
0.00042
[5]
1.255099
[6]
0.000157
[7]
Immune gene
[8]
Up-Regulated
[155] array · 9 items
[0]
IGLV7-46
[1]
1.1
[2]
1
[3]
1.1
[4]
0.023
[5]
− 1.2377
[6]
0.004049
[7]
Immune gene
[8]
Down-Regulated
[156] array · 9 items
[0]
IGKV6-21
[1]
1.1
[2]
1
[3]
1.2
[4]
0.035
[5]
− 1.36368
[6]
0.006348
[7]
Immune gene
[8]
Down-Regulated
row_count
157
column_count
9
numeric_cells
972
header_rows
1
locator
section[4]/table-wrap[1]#Tab1
gaps array · 1 item
[0]
asset:source:pmid:40531258 not verified
analysis object · 4 fields
state
absent
methods array · 0 items
targets array · 0 items
gaps array · 2 items
[0]
method
[1]
targets
capability object · 3 fields
state
absent
requirements array · 0 items
gaps array · 1 item
[0]
capability
readiness object · 8 fields
state
partial
tier
null
blocking_axis
null
blocked_on
null
axes object · 0 fields
can_run object · 3 fields
dsl_operations array · 0 items
assets array · 2 items
[0]
source:pmid:40531258
[1]
asset:table:pmid:40531258:1
steps array · 1 item
[0]
read_published_estimate
must_build object · 5 fields
dsl_operations array · 0 items
converters array · 0 items
readers array · 1 item
[0]
xml
capabilities array · 0 items
data_gaps array · 1 item
[0]
source:pmid:40531258
gaps array · 1 item
[0]
corpus_record_absent
review object · 5 fields
state
partial
machine_critique object · 7 fields
status
blocked
providers array · 0 items
target_providers array · 0 items
agreement
false
disagreements array · 0 items
agreement_basis object · 2 fields
policy
decisive_fields
decisive_fields array · 4 items
[0]
work_type
[1]
number_stated
[2]
parent_value
[3]
unit
blinded
true
human_critique object · 5 fields
status
not_run
reviewer
null
signed_at
null
conflict_checked
false
commentary
null
stages array · 7 items
[0] object · 4 fields
key
target_materials
status
pending
reason
null
evidence
null
[1] object · 4 fields
key
independent_readings
status
blocked
reason
The independent readings are incomplete or disagree; the source evidence must resolve the difference.
evidence object · 1 field
provider_errors array · 4 items
[0] object · 4 fields
provider
minimax
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[1] object · 4 fields
provider
minimax_alt
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[2] object · 4 fields
provider
minimax
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[3] object · 4 fields
provider
minimax_alt
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[2] object · 4 fields
key
source_resolution
status
pending
reason
null
evidence
null
[3] object · 4 fields
key
protocol_reconstruction
status
pending
reason
null
evidence
null
[4] object · 4 fields
key
control_execution
status
pending
reason
null
evidence
null
[5] object · 4 fields
key
control_comparison
status
pending
reason
null
evidence
null
[6] object · 4 fields
key
publication
status
pending
reason
null
evidence
null
gaps array · 3 items
[0]
review.human_critique
[1]
review.machine_critique.blocked
[2]
review.machine_critique.providers
execution object · 5 fields
state
absent
status
not_run
mode
null
runs array · 0 items
gaps array · 1 item
[0]
execution.not_run
provenance object · 7 fields
entities array · 1 item
[0] object · 3 fields
id
package:97ba8e4248e362502f52d783656d8f3b472a5b9d20901deaa02cab659a44a4bc
type
sep_package
label
SEP v1 package for pmid:40531258
activities array · 1 item
[0] object · 4 fields
id
activity:conversion:pmid:40531258
type
conversion
used array · 1 item
[0]
package:97ba8e4248e362502f52d783656d8f3b472a5b9d20901deaa02cab659a44a4bc
agent
agent:corpus-assay-engine
agents array · 1 item
[0] object · 3 fields
id
agent:corpus-assay-engine
type
software
label
Corpus assay engine
source_run_id
run-20261023T122449232913
dsl_catalogue_fingerprint
343fb30756ba6ec3
capability_table_fingerprint
2cb3e42f047d2ecf
snapshot_id
ba34b49490d9bfaf
lineage object · 4 fields
parent_id
pmid:40531258
parent_hash
sha256:a3ae988e95bf338711d807d643c18fe53b1bd64edea3b101a1f63a4bfe83e6cd
fork_of
null
generation
2
gaps array · 14 items
[0]
abstract
[1]
asset:source:pmid:40531258 not verified
[2]
authors
[3]
capability
[4]
corpus_record_absent
[5]
execution.not_run
[6]
method
[7]
review.human_critique
[8]
review.machine_critique.blocked
[9]
review.machine_critique.providers
[10]
step:obtain_source_data blocked on data:not_downloaded
[11]
step:run_analysis blocked on no owned computational capability is bound to this experiment
[12]
step:run_analysis input 'materials:the source data behind the published result in pmid:40531258' does not resolve to a declared asset
[13]
targets
Complete file 
{"sci_version": "1.0", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:40531258", "kind": "science-record", "revision": 2, "content_hash": "sha256:28fec146310a3502ed52fd79b4918a1351437d63799796906b021f33c589728b", "created_at": "2026-11-01T10:25:51Z", "updated_at": "2026-11-01T14:01:42Z", "generator": {"name": "corpus-assay-engine", "converter": "sep_to_sci_v1", "source_package_schema": "urn:bntrg:sep:1.0.0"}, "paper": {"state": "partial", "title": "Seven Hypoxia and Immune-Related Features Predict Prognosis in Patients with Hepatocellular Carcinoma.", "doi": "10.1007/s10620-025-09152-2", "pmid": "40531258", "authors": null, "journal": "Digestive diseases and sciences", "year": 2025, "abstract": null, "claims": [{"id": "claim-1", "statement": "the headline numerical result the paper states for its main finding", "kind": "qualitative", "state": "blocked", "target": {"value": null, "unit": null, "tolerance": null, "source": null}, "evidence": []}], "gaps": ["abstract", "authors"]}, "experiment": {"state": "partial", "objective": "the headline numerical result the paper states for its main finding", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate and its interval from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The number a replication must land on, and the sentence it came from.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:40531258"], "outputs": ["the published estimate, its unit and its interval"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data behind the published result", "kind": "data-preparation", "state": "blocked", "blocked_on": "data:not_downloaded", "description": "The published result cannot be recomputed without the data the paper analysed.", "duration_hours": null, "parameters": {}, "inputs": [], "outputs": ["the source data with its provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the analysis programme", "kind": "analysis", "state": "blocked", "blocked_on": "no owned computational capability is bound to this experiment", "description": "Re-run the paper's analysis on the source data and produce the registered result. | SEP input not carried into the asset list: materials:the source data behind the published result in pmid:40531258", "duration_hours": null, "parameters": {}, "inputs": [], "outputs": ["the registered result"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": ["step:obtain_source_data blocked on data:not_downloaded", "step:run_analysis blocked on no owned computational capability is bound to this experiment", "step:run_analysis input 'materials:the source data behind the published result in pmid:40531258' does not resolve to a declared asset"]}, "data": {"state": "partial", "assets": [{"id": "source:pmid:40531258", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.1007/s10620-025-09152-2", "sha256": "sha256:a663337cf88273d05f420a5f0d58c4ea8a8db476a88ea0bbc2a91ec396792d48", "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.1007/s10620-025-09152-2", "version": null, "note": "Source read by the package builder: full_text.", "structure": {"access_state": "full_text"}}, {"id": "asset:table:pmid:40531258:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:91cda7ffe4113aa35752a9af9a68910b59fe1477c53fd8d9fc361bb95d01be90", "bytes": 14082, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[4]/table-wrap[1]#Tab1", "version": null, "note": "Information of 78 HIRDEGs identified in this study", "structure": {"pmcid": "PMC12627134", "section_index": 4, "section_title": "Prognostic Modeling of Hypoxia-Immune-Related DEGs in the TCGA Cohort", "row_count": 157, "column_count": 9}, "table": {"label": "Table 1", "caption": "Information of 78 HIRDEGs identified in this study", "rows": [["Gene", "HR", "95% CI lower", "95% CI upper", "p value", "log2FC", "P.adj", "Gene.type", "Regulated"], ["ANKZF1", "1.2", "1", "1.5", "0.026", "1.27", "3.48E−39", "Hypoxia gene", "Up-Regulated"], ["EFNA3", "1.2", "1", "1.3", "0.0052", "2.5", "1.42E−35", "Hypoxia gene", "Up-Regulated"], ["ANXA2", "1.2", "1.1", "1.4", "0.0032", "1.57", "1.39E−30", "Hypoxia gene", "Up-Regulated"], ["ALDOA", "1.3", "1.1", "1.4", "0.00022", "1.49", "2.27E−24", "Hypoxia gene", "Up-Regulated"], ["NEDD4L", "1.2", "1", "1.4", "0.033", "1.26", "4.01E−23", "Hypoxia gene", "Up-Regulated"], ["DDIT3", "1.2", "1", "1.3", "0.028", "1.26", "7.75E−19", "Hypoxia gene", "Up-Regulated"], ["NDRG1", "1.2", "1.1", "1.4", "0.00031", "1.55", "1.44E−15", "Hypoxia gene", "Up-Regulated"], ["STC2", "1.1", "1", "1.2", "0.0079", "2.33", "1.29E−25", "Hypoxia gene", "Up-Regulated"], ["LOX", "1.1", "1", "1.2", "0.017", "1.99", "2.14E−19", "Hypoxia gene", "Up-Regulated"], ["PGF", "1.1", "1", "1.3", "0.0065", "1.36", "1.70E−17", "Hypoxia gene", "Up-Regulated"], ["ZFP36", "1.1", "1", "1.3", "0.037", "− 1.81", "3.24E−42", "Hypoxia gene", "Down-Regulated"], ["FOS", "1.1", "1", "1.2", "0.044", "− 2.89", "7.33E−36", "Hypoxia gene", "Down-Regulated"], ["IGFBP3", "1.2", "1.1", "1.3", "0.00011", "− 1.67", "1.90E−20", "Hypoxia gene", "Down-Regulated"], ["PLAC8", "1.1", "1", "1.2", "0.019", "− 2.03", "3.93E−14", "Hypoxia gene", "Down-Regulated"], ["PPFIA4", "1.2", "1.1", "1.3", "7.60E−06", "2.89", "2.38E−18", "Hypoxia gene", "Up-Regulated"], ["BHLHE40", "1.2", "1", "1.3", "0.033", "− 1", "1.20E−12", "Hypoxia gene", "Down-Regulated"], ["PFKP", "1.2", "1.1", "1.3", "2.00E−04", "1.88", "1.72E−13", "Hypoxia gene", "Up-Regulated"], ["DPYSL4", "1.1", "1.1", "1.2", "0.00025", "2.26", "1.96E−11", "Hypoxia gene", "Up-Regulated"], ["SLC6A6", "1.1", "1", "1.2", "0.017", "1.09", "6.23E−06", "Hypoxia gene", "Up-Regulated"], ["SLC2A1", "1.3", "1.2", "1.4", "1.70E−07", "1.33", "8.08E−10", "Hypoxia gene", "Up-Regulated"], ["ENO2", "1.2", "1.1", "1.3", "0.00093", "1.08", "8.88E−06", "Hypoxia gene", "Up-Regulated"], ["KIF5A", "1.1", "1", "1.2", "0.0049", "3.54", "2.35E−18", "Hypoxia gene", "Up-Regulated"], ["TES", "1.2", "1", "1.3", "0.018", "1.05", "7.66E−12", "Hypoxia gene", "Up-Regulated"], ["ADORA2B", "1.1", "1", "1.2", "0.0053", "1.01", "5.16E−05", "Hypoxia gene", "Up-Regulated"], ["HK2", "1.1", "1", "1.2", "0.0013", "1.9", "1.75E−10", "Hypoxia gene", "Up-Regulated"], ["JUN", "1.2", "1", "1.3", "0.016", "− 1.17", "2.55E−16", "Hypoxia gene", "Down-Regulated"], ["SERPINE1", "1.1", "1.1", "1.2", "0.00074", "− 1.88", "2.63E−16", "Hypoxia gene", "Down-Regulated"], ["NFIL3", "1.2", "1", "1.3", "0.048", "− 1.04", "1.20E−15", "Hypoxia gene", "Down-Regulated"], ["KDELR3", "1.2", "1", "1.3", "0.0055", "1.36", "8.93E−13", "Hypoxia gene", "Up-Regulated"], ["MARCO", "1.1", "1", "1.1", "0.014", "− 4.77", "7.33E−41", "Immune gene", "Down-Regulated"], ["SPP1", "1.1", "1.1", "1.2", "1.90E−05", "4.52", "1.60E−33", "Immune gene", "Up-Regulated"], ["HSP90AB1", "1.2", "1", "1.4", "0.031", "1.26", "1.91E−33", "Immune gene", "Up-Regulated"], ["CACYBP", "1.3", "1.1", "1.5", "0.0094", "1.34", "8.62E−32", "Immune gene", "Up-Regulated"], ["SHC1", "1.2", "1", "1.5", "0.02", "1.16", "1.46E−30", "Immune gene", "Up-Regulated"], ["PLXNA1", "1.2", "1.1", "1.3", "0.0041", "1.62", "5.05E−28", "Immune gene", "Up-Regulated"], ["FABP5", "1.1", "1", "1.3", "0.03", "2", "3.12E−26", "Immune gene", "Up-Regulated"], ["MMP12", "1.1", "1", "1.1", "0.014", "4.29", "7.89E−24", "Immune gene", "Up-Regulated"], ["FPR2", "1.1", "1", "1.2", "0.01", "− 2.66", "1.02E−22", "Immune gene", "Down-Regulated"], ["CKLF", "1.3", "1.1", "1.5", "0.0017", "1.33", "1.04E−22", "Immune gene", "Up-Regulated"], ["S100A10", "1.2", "1.1", "1.4", "0.0032", "1.54", "3.53E−22", "Immune gene", "Up-Regulated"], ["IRF3", "1.2", "1", "1.5", "0.042", "1.03", "1.44E−21", "Immune gene", "Up-Regulated"], ["NR6A1", "1.2", "1", "1.3", "0.024", "1.58", "1.45E−21", "Immune gene", "Up-Regulated"], ["PLXNA3", "1.1", "1", "1.2", "0.043", "1.72", "2.10E−21", "Immune gene", "Up-Regulated"], ["HRAS", "1.2", "1", "1.4", "0.011", "1.26", "7.14E−20", "Immune gene", "Up-Regulated"], ["PTGS2", "1.1", "1", "1.2", "0.039", "− 2.3", "1.80E−19", "Immune gene", "Down-Regulated"], ["PTHLH", "1.1", "1", "1.2", "0.01", "2.93", "2.11E−17", "Immune gene", "Up-Regulated"], ["CCL26", "1.1", "1", "1.2", "0.048", "3.29", "3.10E−17", "Immune gene", "Up-Regulated"], ["NR0B1", "1.1", "1.1", "1.2", "5.60E−07", "6.35", "6.85E−17", "Immune gene", "Up-Regulated"], ["IKBKE", "1.1", "1", "1.3", "0.0053", "1.5", "2.89E−16", "Immune gene", "Up-Regulated"], ["TMSB10", "1.1", "1", "1.2", "0.011", "1.67", "8.45E−16", "Immune gene", "Up-Regulated"], ["SRC", "1.1", "1", "1.2", "0.021", "1.49", "2.32E−15", "Immune gene", "Up-Regulated"], ["KITLG", "1.1", "1", "1.3", "0.032", "1.44", "3.11E−15", "Immune gene", "Up-Regulated"], ["SEMA3G", "0.89", "0.79", "0.99", "0.028", "1.36", "3.96E−15", "Immune gene", "Up-Regulated"], ["CCR1", "1.1", "1", "1.3", "0.042", "− 1.3", "7.63E−15", "Immune gene", "Down-Regulated"], ["MMP9", "1.1", "1", "1.1", "0.043", "2.16", "1.84E−14", "Immune gene", "Up-Regulated"], ["CD320", "1.3", "1.1", "1.5", "0.0067", "1.09", "3.02E−14", "Immune gene", "Up-Regulated"], ["CCL3", "1.1", "1", "1.3", "0.043", "− 1.41", "4.02E−14", "Immune gene", "Down-Regulated"], ["IL1B", "1.1", "1", "1.2", "0.016", "− 1.62", "3.99E−13", "Immune gene", "Down-Regulated"], ["FABP6", "1.1", "1.1", "1.2", "4.10E−05", "3.84", "4.31E−12", "Immune gene", "Up-Regulated"], ["HTR3A", "1.1", "1", "1.2", "0.026", "3.58", "6.46E−12", "Immune gene", "Up-Regulated"], ["APOBEC3A", "1.1", "1", "1.3", "0.0064", "− 1.61", "7.24E−12", "Immune gene", "Down-Regulated"], ["OXTR", "1.1", "1", "1.2", "0.0069", "1.52", "1.43E−10", "Immune gene", "Up-Regulated"], ["AMHR2", "1.1", "1", "1.2", "0.024", "− 2.61", "2.28E−10", "Immune gene", "Down-Regulated"], ["TNFSF9", "1.1", "1", "1.2", "0.034", "1.75", "5.24E−10", "Immune gene", "Up-Regulated"], ["GLP2R", "1.1", "1", "1.2", "0.0027", "− 2.13", "1.15E−09", "Immune gene", "Down-Regulated"], ["SEMA3A", "1.1", "1", "1.2", "0.048", "1.83", "2.50E−09", "Immune gene", "Up-Regulated"], ["FCGR2B", "1.1", "1", "1.2", "0.021", "− 1.68", "5.53E−09", "Immune gene", "Down-Regulated"], ["S100A11", "1.2", "1.1", "1.3", "0.00022", "1.21", "5.92E−09", "Immune gene", "Up-Regulated"], ["ADM", "1.2", "1.1", "1.4", "0.00013", "− 1.06", "1.13E−08", "Immune gene", "Down-Regulated"], ["S100A6", "1.1", "1", "1.2", "0.0041", "1.41", "1.46E−08", "Immune gene", "Up-Regulated"], ["CCL20", "1.1", "1", "1.1", "0.012", "1.64", "7.31E−07", "Immune gene", "Up-Regulated"], ["TNFRSF11A", "1.1", "1", "1.3", "0.0048", "1.03", "2.13E−06", "Immune gene", "Up-Regulated"], ["IL11", "1.1", "1", "1.2", "0.037", "1.47", "4.94E−06", "Immune gene", "Up-Regulated"], ["ZC3HAV1L", "1.1", "1", "1.2", "0.034", "1.22", "7.84E−06", "Immune gene", "Up-Regulated"], ["S100A8", "1.1", "1.1", "1.2", "0.001", "− 1.26", "2.04E−05", "Immune gene", "Down-Regulated"], ["S100A2", "1.1", "1.1", "1.2", "0.00042", "1.26", "0.000157", "Immune gene", "Up-Regulated"], ["IGLV7-46", "1.1", "1", "1.1", "0.023", "− 1.24", "0.004049", "Immune gene", "Down-Regulated"], ["IGKV6-21", "1.1", "1", "1.2", "0.035", "− 1.36", "0.006348", "Immune gene", "Down-Regulated"], ["ANKZF1", "1.2", "1", "1.5", "0.026", "1.272077", "3.48E−39", "Hypoxia gene", "Up-Regulated"], ["EFNA3", "1.2", "1", "1.3", "0.0052", "2.504656", "1.42E−35", "Hypoxia gene", "Up-Regulated"], ["ANXA2", "1.2", "1.1", "1.4", "0.0032", "1.568519", "1.39E−30", "Hypoxia gene", "Up-Regulated"], ["ALDOA", "1.3", "1.1", "1.4", "0.00022", "1.494684", "2.27E−24", "Hypoxia gene", "Up-Regulated"], ["NEDD4L", "1.2", "1", "1.4", "0.033", "1.257916", "4.01E−23", "Hypoxia gene", "Up-Regulated"], ["DDIT3", "1.2", "1", "1.3", "0.028", "1.261629", "7.75E−19", "Hypoxia gene", "Up-Regulated"], ["NDRG1", "1.2", "1.1", "1.4", "0.00031", "1.547209", "1.44E−15", "Hypoxia gene", "Up-Regulated"], ["STC2", "1.1", "1", "1.2", "0.0079", "2.332275", "1.29E−25", "Hypoxia gene", "Up-Regulated"], ["LOX", "1.1", "1", "1.2", "0.017", "1.988764", "2.14E−19", "Hypoxia gene", "Up-Regulated"], ["PGF", "1.1", "1", "1.3", "0.0065", "1.35752", "1.70E−17", "Hypoxia gene", "Up-Regulated"], ["ZFP36", "1.1", "1", "1.3", "0.037", "− 1.81281", "3.24E−42", "Hypoxia gene", "Down-Regulated"], ["FOS", "1.1", "1", "1.2", "0.044", "− 2.89205", "7.33E−36", "Hypoxia gene", "Down-Regulated"], ["IGFBP3", "1.2", "1.1", "1.3", "0.00011", "− 1.6726", "1.90E−20", "Hypoxia gene", "Down-Regulated"], ["PLAC8", "1.1", "1", "1.2", "0.019", "− 2.02516", "3.93E−14", "Hypoxia gene", "Down-Regulated"], ["PPFIA4", "1.2", "1.1", "1.3", "7.60E−06", "2.888876", "2.38E−18", "Hypoxia gene", "Up-Regulated"], ["BHLHE40", "1.2", "1", "1.3", "0.033", "− 1.00309", "1.20E−12", "Hypoxia gene", "Down-Regulated"], ["PFKP", "1.2", "1.1", "1.3", "2.00E−04", "1.883723", "1.72E−13", "Hypoxia gene", "Up-Regulated"], ["DPYSL4", "1.1", "1.1", "1.2", "0.00025", "2.255871", "1.96E−11", "Hypoxia gene", "Up-Regulated"], ["SLC6A6", "1.1", "1", "1.2", "0.017", "1.087187", "6.23E−06", "Hypoxia gene", "Up-Regulated"], ["SLC2A1", "1.3", "1.2", "1.4", "1.70E−07", "1.329015", "8.08E−10", "Hypoxia gene", "Up-Regulated"], ["ENO2", "1.2", "1.1", "1.3", "0.00093", "1.084453", "8.88E−06", "Hypoxia gene", "Up-Regulated"], ["KIF5A", "1.1", "1", "1.2", "0.0049", "3.535681", "2.35E−18", "Hypoxia gene", "Up-Regulated"], ["TES", "1.2", "1", "1.3", "0.018", "1.052133", "7.66E−12", "Hypoxia gene", "Up-Regulated"], ["ADORA2B", "1.1", "1", "1.2", "0.0053", "1.007072", "5.16E−05", "Hypoxia gene", "Up-Regulated"], ["HK2", "1.1", "1", "1.2", "0.0013", "1.899485", "1.75E−10", "Hypoxia gene", "Up-Regulated"], ["JUN", "1.2", "1", "1.3", "0.016", "− 1.17213", "2.55E−16", "Hypoxia gene", "Down-Regulated"], ["SERPINE1", "1.1", "1.1", "1.2", "0.00074", "− 1.88064", "2.63E−16", "Hypoxia gene", "Down-Regulated"], ["NFIL3", "1.2", "1", "1.3", "0.048", "− 1.03917", "1.20E−15", "Hypoxia gene", "Down-Regulated"], ["KDELR3", "1.2", "1", "1.3", "0.0055", "1.355106", "8.93E−13", "Hypoxia gene", "Up-Regulated"], ["MARCO", "1.1", "1", "1.1", "0.014", "− 4.77417", "7.33E−41", "Immune gene", "Down-Regulated"], ["SPP1", "1.1", "1.1", "1.2", "1.90E−05", "4.516552", "1.60E−33", "Immune gene", "Up-Regulated"], ["HSP90AB1", "1.2", "1", "1.4", "0.031", "1.25676", "1.91E−33", "Immune gene", "Up-Regulated"], ["CACYBP", "1.3", "1.1", "1.5", "0.0094", "1.344684", "8.62E−32", "Immune gene", "Up-Regulated"], ["SHC1", "1.2", "1", "1.5", "0.02", "1.1605", "1.46E−30", "Immune gene", "Up-Regulated"], ["PLXNA1", "1.2", "1.1", "1.3", "0.0041", "1.616181", "5.05E−28", "Immune gene", "Up-Regulated"], ["FABP5", "1.1", "1", "1.3", "0.03", "1.995793", "3.12E−26", "Immune gene", "Up-Regulated"], ["MMP12", "1.1", "1", "1.1", "0.014", "4.293032", "7.89E−24", "Immune gene", "Up-Regulated"], ["FPR2", "1.1", "1", "1.2", "0.01", "− 2.661", "1.02E−22", "Immune gene", "Down-Regulated"], ["CKLF", "1.3", "1.1", "1.5", "0.0017", "1.333721", "1.04E−22", "Immune gene", "Up-Regulated"], ["S100A10", "1.2", "1.1", "1.4", "0.0032", "1.539881", "3.53E−22", "Immune gene", "Up-Regulated"], ["IRF3", "1.2", "1", "1.5", "0.042", "1.028591", "1.44E−21", "Immune gene", "Up-Regulated"], ["NR6A1", "1.2", "1", "1.3", "0.024", "1.578946", "1.45E−21", "Immune gene", "Up-Regulated"], ["PLXNA3", "1.1", "1", "1.2", "0.043", "1.721173", "2.10E−21", "Immune gene", "Up-Regulated"], ["HRAS", "1.2", "1", "1.4", "0.011", "1.255789", "7.14E−20", "Immune gene", "Up-Regulated"], ["PTGS2", "1.1", "1", "1.2", "0.039", "− 2.30408", "1.80E−19", "Immune gene", "Down-Regulated"], ["PTHLH", "1.1", "1", "1.2", "0.01", "2.929178", "2.11E−17", "Immune gene", "Up-Regulated"], ["CCL26", "1.1", "1", "1.2", "0.048", "3.288943", "3.10E−17", "Immune gene", "Up-Regulated"], ["NR0B1", "1.1", "1.1", "1.2", "5.60E−07", "6.346336", "6.85E−17", "Immune gene", "Up-Regulated"], ["IKBKE", "1.1", "1", "1.3", "0.0053", "1.495667", "2.89E−16", "Immune gene", "Up-Regulated"], ["TMSB10", "1.1", "1", "1.2", "0.011", "1.674014", "8.45E−16", "Immune gene", "Up-Regulated"], ["SRC", "1.1", "1", "1.2", "0.021", "1.488588", "2.32E−15", "Immune gene", "Up-Regulated"], ["KITLG", "1.1", "1", "1.3", "0.032", "1.440809", "3.11E−15", "Immune gene", "Up-Regulated"], ["SEMA3G", "0.89", "0.79", "0.99", "0.028", "1.357656", "3.96E−15", "Immune gene", "Up-Regulated"], ["CCR1", "1.1", "1", "1.3", "0.042", "− 1.30151", "7.63E−15", "Immune gene", "Down-Regulated"], ["MMP9", "1.1", "1", "1.1", "0.043", "2.158964", "1.84E−14", "Immune gene", "Up-Regulated"], ["CD320", "1.3", "1.1", "1.5", "0.0067", "1.090493", "3.02E−14", "Immune gene", "Up-Regulated"], ["CCL3", "1.1", "1", "1.3", "0.043", "− 1.41379", "4.02E−14", "Immune gene", "Down-Regulated"], ["IL1B", "1.1", "1", "1.2", "0.016", "− 1.61712", "3.99E−13", "Immune gene", "Down-Regulated"], ["FABP6", "1.1", "1.1", "1.2", "4.10E−05", "3.83992", "4.31E−12", "Immune gene", "Up-Regulated"], ["HTR3A", "1.1", "1", "1.2", "0.026", "3.583696", "6.46E−12", "Immune gene", "Up-Regulated"], ["APOBEC3A", "1.1", "1", "1.3", "0.0064", "− 1.60742", "7.24E−12", "Immune gene", "Down-Regulated"], ["OXTR", "1.1", "1", "1.2", "0.0069", "1.524812", "1.43E−10", "Immune gene", "Up-Regulated"], ["AMHR2", "1.1", "1", "1.2", "0.024", "− 2.60958", "2.28E−10", "Immune gene", "Down-Regulated"], ["TNFSF9", "1.1", "1", "1.2", "0.034", "1.753932", "5.24E−10", "Immune gene", "Up-Regulated"], ["GLP2R", "1.1", "1", "1.2", "0.0027", "− 2.12716", "1.15E−09", "Immune gene", "Down-Regulated"], ["SEMA3A", "1.1", "1", "1.2", "0.048", "1.826776", "2.50E−09", "Immune gene", "Up-Regulated"], ["FCGR2B", "1.1", "1", "1.2", "0.021", "− 1.68376", "5.53E−09", "Immune gene", "Down-Regulated"], ["S100A11", "1.2", "1.1", "1.3", "0.00022", "1.213205", "5.92E−09", "Immune gene", "Up-Regulated"], ["ADM", "1.2", "1.1", "1.4", "0.00013", "− 1.06415", "1.13E−08", "Immune gene", "Down-Regulated"], ["S100A6", "1.1", "1", "1.2", "0.0041", "1.40655", "1.46E−08", "Immune gene", "Up-Regulated"], ["CCL20", "1.1", "1", "1.1", "0.012", "1.636874", "7.31E−07", "Immune gene", "Up-Regulated"], ["TNFRSF11A", "1.1", "1", "1.3", "0.0048", "1.033954", "2.13E−06", "Immune gene", "Up-Regulated"], ["IL11", "1.1", "1", "1.2", "0.037", "1.4665", "4.94E−06", "Immune gene", "Up-Regulated"], ["ZC3HAV1L", "1.1", "1", "1.2", "0.034", "1.218699", "7.84E−06", "Immune gene", "Up-Regulated"], ["S100A8", "1.1", "1.1", "1.2", "0.001", "− 1.25586", "2.04E−05", "Immune gene", "Down-Regulated"], ["S100A2", "1.1", "1.1", "1.2", "0.00042", "1.255099", "0.000157", "Immune gene", "Up-Regulated"], ["IGLV7-46", "1.1", "1", "1.1", "0.023", "− 1.2377", "0.004049", "Immune gene", "Down-Regulated"], ["IGKV6-21", "1.1", "1", "1.2", "0.035", "− 1.36368", "0.006348", "Immune gene", "Down-Regulated"]], "row_count": 157, "column_count": 9, "numeric_cells": 972, "header_rows": 1, "locator": "section[4]/table-wrap[1]#Tab1"}}], "gaps": ["asset:source:pmid:40531258 not verified"]}, "analysis": {"state": "absent", "methods": [], "targets": [], "gaps": ["method", "targets"]}, "capability": {"state": "absent", "requirements": [], "gaps": ["capability"]}, "readiness": {"state": "partial", "tier": null, "blocking_axis": null, "blocked_on": null, "axes": {}, "can_run": {"dsl_operations": [], "assets": ["source:pmid:40531258", "asset:table:pmid:40531258:1"], "steps": ["read_published_estimate"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": ["xml"], "capabilities": [], "data_gaps": ["source:pmid:40531258"]}, "gaps": ["corpus_record_absent"]}, "review": {"state": 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