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pmid:40591160

Identification and validation of NEIL2 as a prognostic biomarker and potential therapeutic target in cervical cancer.

Discover oncology · 2025 doi:10.1007/s12672-025-02924-2

Paper

partial

Experiment

partial

Data

partial

Analysis

absent

Execution

absent

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Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
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pmid:40591160
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science-record
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paper object · 10 fields
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title
Identification and validation of NEIL2 as a prognostic biomarker and potential therapeutic target in cervical cancer.
doi
10.1007/s12672-025-02924-2
pmid
40591160
authors
null
journal
Discover oncology
year
2025
abstract
null
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the headline numerical result the paper states for its main finding
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the headline numerical result the paper states for its main finding
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The number a replication must land on, and the sentence it came from.
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the published estimate, its unit and its interval
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the source data with its provenance
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Re-run the paper's analysis on the source data and produce the registered result. | SEP input not carried into the asset list: materials:the source data behind the published result in pmid:40591160
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Primer sequences of NEIL2 and an internal reference
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PMC12214186
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12
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Reagents and materials
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Table 1
caption
Primer sequences of NEIL2 and an internal reference
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[0] array · 3 items
[0]
Gene name
[1]
Forward sequences
[2]
Reverse sequences
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[0]
NEIL2
[1]
CAGAGCCAAGAAAGCCAACAAG
[2]
TGGTCCAGCAGTGTATAGCAGA
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[0]
GAPDH
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CGAAGGTGGAGTCAACGGATTT
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Comparison of the clinicopathological characteristics of cervical cancer patients with high and low NEIL2 expression
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29
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Clinicopathological characteristics of groups with high and low NEIL2 expression
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Table 2
caption
Comparison of the clinicopathological characteristics of cervical cancer patients with high and low NEIL2 expression
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N
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73
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34 (46.6)
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0.002**
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[1]
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39 (53.4)
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[0]
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[2]
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[3]
36 (52.2)
[4]
0.380
[5] array · 4 items
[0]
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[1]
47 (24.0)
[2]
13 (18.8)
[3]
[6] array · 4 items
[0]
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[1]
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[2]
15 (21.7)
[3]
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[0]
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[1]
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[2]
5 (7.2)
[3]
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[2]
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[3]
25 (86.2)
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27 (64.3)
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0.505
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34 (59.6)
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46 (29.7)
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15 (26.3)
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[1]
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[2]
6 (10.5)
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[0]
T4
[1]
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2 (3.5)
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[2]
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[3]
35 (54.7)
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0.383
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[3]
31 (49.2)
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1
[19] array · 4 items
[0]
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[1]
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32 (50.8)
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[3]
16 (21.9)
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0.001***
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[0]
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185 (93.4)
[2]
57 (78.1)
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Results of the univariate and multivariate analysis of the independent prognosis
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pmcid
PMC12214186
section_index
30
section_title
Univariate and multivariate Cox regression analysis of patient outcomes
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Table 3
caption
Results of the univariate and multivariate analysis of the independent prognosis
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[0]
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[2]
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[3]
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[4]
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[5]
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[0]
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Hazard ratio (95% CI)
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[1]
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[2]
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[5]
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[2]
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[2]
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pathologic_T
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[2]
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[1]
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[2]
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[21] array · 6 items
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[2]
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[0]
NEIL2 expression
[23] array · 6 items
[0]
NEIL2 low expression
[1]
198
[2]
Reference
[3]
[4]
[5]
[24] array · 6 items
[0]
NEIL2 high expression
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73
[2]
0.422(0.209−0.854)
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0.016*
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0.121(0.016−0.924)
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Differential expression of NEIL2 in cervical cancer and normal tissues
structure object · 5 fields
pmcid
PMC12214186
section_index
35
section_title
Expression levels of NEIL2 in clinical samples
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Table 4
caption
Differential expression of NEIL2 in cervical cancer and normal tissues
rows array · 2 items
[0] array · 4 items
[0]
Gene
[1]
Normal
[2]
CC
[3]
P value
[1] array · 4 items
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NEIL2
[1]
1.5077 ± 1.2286
[2]
0.1999 ± 0.2574
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0.0481
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section[35]/table-wrap[1]#Tab4
gaps array · 1 item
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