Interactions Among Tumor Subtype, PPARγ Expression, and Adipose Proliferation Shape Outcomes in Breast Cancer.

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"sha256:c2c007845f223793aec6508e08676fb58a6d8d643b233f435c2427da7435f774", "raw_response_chars": 3272}, {"provider": "minimax_alt", "model": "MiniMax-M3", "prompt_version": "full-text-reading-v1", "prompt_hash": "796692e85a3d986d456fedaeab394e45e97b295352bc3ea5c9e65e6f2e77547a", "source_hash": "fdbf17b9222dd0fcb1d0cf4c6ba80874ac0dcb89b64b62dbae22e2021fbc3f9e", "raw_response_sha256": "sha256:5053b579407e535a154308eb54ae5bf5468b7f35954247d9009efd2ca6ca32a0", "raw_response_chars": 47419}], "target_providers": [{"provider": "minimax", "model": "MiniMax-M3.1-Flash", "prompt_version": "replication-target-v2", "prompt_hash": "a22250eabe105788b65812067d58d2452e50f1c9fc79528072759baf537cc6a2", "source_hash": "fdbf17b9222dd0fcb1d0cf4c6ba80874ac0dcb89b64b62dbae22e2021fbc3f9e", "raw_response": "{\"parent_value\":6.903,\"unit\":\"FPKM\",\"evidence\":\"Kaplan-Meier analysis revealed that high PPARγ expression (≥6.903 FPKM) was significantly associated with both improved overall and disease-specific survival, particularly in premenopausal patients.\",\"target_result\":\"High PPARγ expression was associated with improved overall and disease-specific survival, particularly in premenopausal patients.\",\"number_stated\":true}", "reading": {"parent_value": 6.903, "unit": "FPKM", "evidence": "Kaplan-Meier analysis revealed that high PPARγ expression (≥6.903 FPKM) was significantly associated with both improved overall and disease-specific survival, particularly in premenopausal patients.", "target_result": "High PPARγ expression was associated with improved overall and disease-specific survival, particularly in premenopausal patients.", "number_stated": true, "source_locator": "chars 801-999 of source sha256 fdbf17b9222dd0fcb1d0cf4c6ba80874ac0dcb89b64b62dbae22e2021fbc3f9e"}, "recorded_at": "2026-10-31T15:21:09.452766+00:00"}, {"provider": "minimax_alt", "model": "MiniMax-M3", "prompt_version": "replication-target-v2", "prompt_hash": "599995a6a4e436e2be186c616e36f561d294c3c46e225eb1da59e5d9bab95e55", "source_hash": "fdbf17b9222dd0fcb1d0cf4c6ba80874ac0dcb89b64b62dbae22e2021fbc3f9e", "raw_response": "<think>We need answer JSON object only. Need identify single numerical result replication registered target headline main finding. Source has many numbers. Main finding likely high PPARγ expression cutoff ≥6.903 FPKM associated improved survival. Asked headline number only, value paper states for registered target. Need determine exact quote contiguous clause attaching number to target. Likely abstract: \"Kaplan-Meier analysis revealed that high PPARγ expression (≥6.903 FPKM) was significantly associated with both improved overall and disease-specific survival, particularly in premenopausal patients.\" Number 6.903 FPKM. Evidence must exact contiguous quotation contains number, don't shorten; attribution via wording. Should quote whole clause perhaps exact sentence. parent_value 6.903, unit FPKM, target_result perhaps concise \"High PPARγ expression (≥6.903 FPKM) was significantly associated with improved overall and disease-specific survival, particularly in premenopausal patients.\" Evidence exact full sentence. Could headline numerical result alternatively cohort sample size 1094? Registered target \"headline numerical result the paper states for its main finding\". They want number replication has to reproduce, likely threshold 6.903 FPKM. Need ensure target_result perhaps state headline. JSON escaping gamma unicode okay. Evidence exact contiguous. They say report headline number only: value paper itself states. target_result likely describe. Need no prose outside JSON. Use >=? Unit paper prints FPKM. Evidence exact quotation, don't shorten it. We can quote sentence exactly. parent_value numerical 6.903. number true.\n\nCould the headline number be 0.705 vs 0.776 for postmenopausal lower visceral SUVmean, another main finding? Title interactions and abstract reports both key results. But \"single numerical result that a replication of the registered target has to reproduce\", registered target headline numerical result paper states for main finding. Main finding probably cutoff of PPARγ expression? Abstract main sentence first numerical result 6.903 FPKM. They may expect 6.903 FPKM. Let's inspect wording. \"Kaplan-Meier analysis revealed that high PPARγ expression (≥6.903 FPKM) was significantly associated...\" Thus value tied to main prognostic finding. The other imaging result lower visceral SUVmean (0.705 vs 0.776) perhaps second finding but no unit printed (SUVmean likely numeric metric), title broad. \"headline numerical result\" likely threshold.\n\nNeed exact evidence no ellipsis. Full sentence exact:\n\"Kaplan-Meier analysis revealed that high PPARγ expression (≥6.903 FPKM) was significantly associated with both improved overall and disease-specific survival, particularly in premenopausal patients.\"\nTarget_result could repeat. JSON valid. Ensure unit just FPKM, not ≥ FPKM because unit printed FPKM. Could \"≥6.903 FPKM\" parent value 6.903. Good.\n\nLet's formulate.</think>\n\n{\"parent_value\":6.903,\"unit\":\"FPKM\",\"evidence\":\"Kaplan-Meier analysis revealed that high PPARγ expression (≥6.903 FPKM) was significantly associated with both improved overall and disease-specific survival, particularly in premenopausal patients.\",\"target_result\":\"High PPARγ expression (≥6.903 FPKM) was significantly associated with improved overall and disease-specific survival, particularly in premenopausal patients.\",\"number_stated\":true}", "reading": {"parent_value": 6.903, "unit": "FPKM", "evidence": "Kaplan-Meier analysis revealed that high PPARγ expression (≥6.903 FPKM) was significantly associated with both improved overall and disease-specific survival, particularly in premenopausal patients.", "target_result": "High PPARγ expression (≥6.903 FPKM) was significantly associated with improved overall and disease-specific survival, particularly in premenopausal patients.", "number_stated": true, "source_locator": "chars 801-999 of source sha256 fdbf17b9222dd0fcb1d0cf4c6ba80874ac0dcb89b64b62dbae22e2021fbc3f9e"}, "recorded_at": "2026-10-31T15:21:13.346870+00:00"}], "agreement": true, "disagreements": {"target_result": {"minimax": "In 1094 primary breast cancer patients from the TCGA-BRCA cohort, high PPARγ expression (≥6.903 FPKM) was significantly associated with improved overall and disease-specific survival, particularly in premenopausal patients.", "minimax_alt": "Kaplan-Meier analysis revealed that high PPARγ expression (≥6.903 FPKM) was significantly associated with both improved overall and disease-specific survival, particularly in premenopausal patients.", "decisive": false}, "analysis_methods": {"minimax": ["Kaplan-Meier analysis", "Stratification by PPARγ expression, menopausal status, and tumor receptor subtype", "RNA-seq expression analysis"], "minimax_alt": ["Kaplan-Meier analysis", "Median-based stratification of PPARγ expression"], "decisive": false}}, "agreement_basis": {"policy": "decisive_fields", "decisive_fields": ["work_type", "number_stated", "parent_value", "unit"]}, "blinded": true}, "human_critique": {"status": "not_run", "reviewer": null, "signed_at": null, "conflict_checked": false, "commentary": null}, "stages": [{"key": "target_materials", "status": "pending", "reason": null, "evidence": null}, {"key": "independent_readings", "status": "passed", "reason": "The independent readings are incomplete or disagree; the source evidence must resolve the difference.", "evidence": {"provider_errors": []}}, {"key": "source_resolution", "status": "pending", "reason": null, "evidence": null}, {"key": "protocol_reconstruction", "status": "pending", "reason": null, "evidence": null}, {"key": "control_execution", "status": "pending", "reason": null, "evidence": null}, {"key": "control_comparison", "status": "pending", "reason": null, "evidence": null}, {"key": "publication", "status": "pending", "reason": null, "evidence": null}], "gaps": ["review.human_critique", "review.machine_critique.passed"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "package:bcca3dea98d3d4b11643211f4072a7263903fb5e8e3e134f12c351768ed29fa7", "type": "sep_package", "label": "SEP v1 package for pmid:40672515"}], "activities": [{"id": "activity:conversion:pmid:40672515", "type": "conversion", "used": ["package:bcca3dea98d3d4b11643211f4072a7263903fb5e8e3e134f12c351768ed29fa7"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:minimax", "type": "model", "label": "minimax"}, {"id": "agent:minimax_alt", "type": "model", "label": "minimax_alt"}, {"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}], "source_run_id": "run-20261023T122449232913", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "403581d6-9919-4157-9087-f2b1fc043e07", "parent_hash": "bcca3dea98d3d4b11643211f4072a7263903fb5e8e3e134f12c351768ed29fa7", "fork_of": null, "generation": 1}, "gaps": ["abstract", "asset:source:pmid:40672515 not verified", "authors", "capability", "corpus_record_absent", "execution.not_run", "method", "review.human_critique", "review.machine_critique.passed", "step:obtain_source_data blocked on data:not_downloaded", "step:run_analysis blocked on no owned computational capability is bound to this experiment", "step:run_analysis input 'materials:the source data behind the published result in pmid:40672515' does not resolve to a declared asset", "targets"]}