Differential Role of CD318 in Tumor Immunity Affecting Prognosis in Colorectal Cancer Compared to Other Adenocarcinomas.

{"sci_version": "1.0", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:40725832", "kind": "science-record", "revision": 2, "content_hash": "sha256:d8a01c455bc3541c616a0b5642295987051228a76e35b77da2a88de89bbef32f", "created_at": "2026-11-01T10:25:52Z", "updated_at": "2026-11-01T14:01:45Z", "generator": {"name": "corpus-assay-engine", "converter": "sep_to_sci_v1", "source_package_schema": "urn:bntrg:sep:1.0.0"}, "paper": {"state": "partial", "title": "Differential Role of CD318 in Tumor Immunity Affecting Prognosis in Colorectal Cancer Compared to Other Adenocarcinomas.", "doi": "10.3390/jcm14145139", "pmid": "40725832", "authors": null, "journal": "Journal of clinical medicine", "year": 2025, "abstract": null, "claims": [{"id": "claim-1", "statement": "the headline numerical result the paper states for its main finding", "kind": "qualitative", "state": "blocked", "target": {"value": null, "unit": null, "tolerance": null, "source": null}, "evidence": []}], "gaps": ["abstract", "authors"]}, "experiment": {"state": "partial", "objective": "the headline numerical result the paper states for its main finding", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate and its interval from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The number a replication must land on, and the sentence it came from.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:40725832"], "outputs": ["the published estimate, its unit and its interval"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data behind the published result", "kind": "data-preparation", "state": "blocked", "blocked_on": "data:not_downloaded", "description": "The published result cannot be recomputed without the data the paper analysed.", "duration_hours": null, "parameters": {}, "inputs": [], "outputs": ["the source data with its provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the analysis programme", "kind": "analysis", "state": "blocked", "blocked_on": "no owned computational capability is bound to this experiment", "description": "Re-run the paper's analysis on the source data and produce the registered result. | SEP input not carried into the asset list: materials:the source data behind the published result in pmid:40725832", "duration_hours": null, "parameters": {}, "inputs": [], "outputs": ["the registered result"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": ["step:obtain_source_data blocked on data:not_downloaded", "step:run_analysis blocked on no owned computational capability is bound to this experiment", "step:run_analysis input 'materials:the source data behind the published result in pmid:40725832' does not resolve to a declared asset"]}, "data": {"state": "partial", "assets": [{"id": "source:pmid:40725832", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.3390/jcm14145139", "sha256": "sha256:cae4c4f60d4378166914dfe6878a1b429ed7c42cd885b061547d238ae7d1fdad", "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.3390/jcm14145139", "version": null, "note": "Source read by the package builder: full_text.", "structure": {"access_state": "full_text"}}, {"id": "asset:table:pmid:40725832:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:1db86142ae4016736e7a28025090392709deba48b74d3d4eccaa091e3de1467c", "bytes": 844, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[12]/table-wrap[1]#jcm-14-05139-t001", "version": null, "note": "Biological pathways and matching proteins involved in CD318 networks based on KEGG pathway.", "structure": {"pmcid": "PMC12295231", "section_index": 12, "section_title": "3.1. 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High Expression of CD318 in Multiple Cancers", "row_count": 17, "column_count": 8}, "table": {"label": "Table 2", "caption": "Statistical analysis of the expression of CD318 in multiple cancers along with % of five-year survival data and significance.", "rows": [["Cancer Type", "TPM Median Expression", "p Value", "% of Five-Year Survival with High Expression", "% of Five-Year Survival with Low Expression", "Protein Expression", "Significance", "Condition"], ["Breast cancer", "11.75", "0.049", "81", "93", "Low/medium", "Not prognostic", ""], ["Cervical cancer", "24.23", "0.011", "52", "75", "Medium", "Potential prognostic", "Unfavorable"], ["Colorectal cancer", "19.72", "0.0052", "79", "52", "High/medium", "Potential prognostic", "Favorable"], ["Endometrial cancer", "13.47", "0.47", "68", "56", "Low/medium", "Not prognostic", ""], ["Glioma", "2.02", "0.98", "0", "13", "Low", "Not prognostic", ""], ["Head and neck cancer", "27.76", "0.008", "42", "52", "Low/medium", "Not prognostic", ""], ["Liver cancer", "0.23", "0.014", "44", "63", "Low", "Not prognostic", ""], ["Lung adenocarcinoma", "12.31", "9.2 × 10−6", "27", "46", "Medium", "Validated prognostic", "Unfavorable"], ["Lung squamous cell carcinoma", "18.51", "0.027", "39", "52", "Medium", "Not prognostic", ""], ["Melanoma cancer", "1.75", "0.058", "29(3 yr)", "57(3 yr)", "Low", "Not prognostic", ""], ["Ovarian cancer", "9.87", "0.005", "24", "37", "Low/medium", "Not prognostic", ""], ["Pancreatic cancer", "21.32", "0.00028", "16", "53", "Medium", "Potential prognostic", "Unfavorable"], ["Prostate cancer", "6.38", "0.069", "100", "97", "Low/medium", "Not prognostic", ""], ["Renal cancer", "4.59", "0.001", "49", "67", "Low", "Not prognostic", ""], ["Stomach cancer", "21.29", "0.021", "38", "34", "Low/medium", "Not prognostic", ""], ["Bladder Urothelial Carcinoma", "15.46", "0.15", "5", "4", "Low/medium", "Not prognostic", ""]], "row_count": 17, "column_count": 8, "numeric_cells": 64, "header_rows": 1, "locator": "section[13]/table-wrap[1]#jcm-14-05139-t002"}}], "gaps": ["asset:source:pmid:40725832 not verified"]}, "analysis": {"state": "absent", "methods": [], "targets": [], "gaps": ["method", "targets"]}, "capability": {"state": "absent", "requirements": [], "gaps": ["capability"]}, "readiness": {"state": "partial", "tier": null, "blocking_axis": null, "blocked_on": null, "axes": {}, "can_run": {"dsl_operations": [], "assets": ["source:pmid:40725832", "asset:table:pmid:40725832:1", "asset:table:pmid:40725832:2"], "steps": ["read_published_estimate"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": ["xml"], "capabilities": [], "data_gaps": ["source:pmid:40725832"]}, "gaps": ["corpus_record_absent"]}, "review": {"state": "partial", "machine_critique": {"status": "blocked", "providers": [{"provider": "minimax", "model": "MiniMax-M3.1-Flash", "prompt_version": "full-text-reading-v1", "prompt_hash": "81499e2b7eec414664ba727dccb4e7fda791d7505437cfe8eb62c2dcb259ce26", "source_hash": "cae4c4f60d4378166914dfe6878a1b429ed7c42cd885b061547d238ae7d1fdad", "raw_response_sha256": "sha256:24519e1a8197124fa779bc648f8e6bbb54a912993e359c61a4f6f27582029db1", "raw_response_chars": 5109}, {"provider": "minimax_alt", "model": "MiniMax-M3", "prompt_version": "full-text-reading-v1", "prompt_hash": "78e2fff6a38494526262200389a62eaf07d0a936def56a38c6cef1bf6845ca58", "source_hash": "cae4c4f60d4378166914dfe6878a1b429ed7c42cd885b061547d238ae7d1fdad", "raw_response_sha256": "sha256:0ae7cc209eca77b9fdebe32f9f3fe3357b7e31de4530cbe55432bc2fac2c31a0", "raw_response_chars": 31610}], "target_providers": [{"provider": "minimax", "model": "MiniMax-M3.1-Flash", "prompt_version": "replication-target-v2", "prompt_hash": "c74cd2aceb14f9ef86ccbc6184f17c771255a86f1a787f682e08414fd8604905", "source_hash": "cae4c4f60d4378166914dfe6878a1b429ed7c42cd885b061547d238ae7d1fdad", "raw_response": "{\"parent_value\":0,\"unit\":\"\",\"evidence\":\"\",\"target_result\":\"The paper states that CD318 expression correlates with a favorable prognosis in colorectal cancer (COAD) but unfavorable outcomes in cervical, lung, and pancreatic adenocarcinomas; it gives no numerical value for this main finding.\",\"number_stated\":false}", "reading": {"parent_value": 0, "unit": "", "evidence": "", "target_result": "The paper states that CD318 expression correlates with a favorable prognosis in colorectal cancer (COAD) but unfavorable outcomes in cervical, lung, and pancreatic adenocarcinomas; it gives no numerical value for this main finding.", "number_stated": false, "source_locator": null}, "recorded_at": "2026-10-31T15:22:40.244085+00:00"}, {"provider": "minimax_alt", "model": "MiniMax-M3", "prompt_version": "replication-target-v2", "prompt_hash": "06a3cfeaf9adccb84febd52022db1a7574f1e6fa1dea9d1d2a628819d175467e", "source_hash": "cae4c4f60d4378166914dfe6878a1b429ed7c42cd885b061547d238ae7d1fdad", "raw_response": "<think>We need answer JSON object. 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