Genetic overlap between sarcoidosis and lung cancer: a combined in silico and in vitro approach.

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"sha256:813a84fd08a0ac21096601c14040007e56f7abe2e6b4026bf3fe546410d23bc6", "raw_response_chars": 58101}], "target_providers": [{"provider": "minimax", "model": "MiniMax-M3.1-Flash", "prompt_version": "replication-target-v2", "prompt_hash": "8a3493ade84b67aa8f2547e4163c89f3968aa7e6126f8487dd0fb1c8dfc73edd", "source_hash": "302a24eeb0a081e84fd01cf1102c37fe35fd804cbd830da04506fbf1ef89b834", "raw_response": "{\"parent_value\":12,\"unit\":\"DEGs\",\"evidence\":\"Twelve DEGs—SALL4, WNT10A, RASAL1, CAMK2B, GADD45B, KLF4, OLR1, CSF3, WIF1, RAMP3, AGER, and PRKAG3—were consistently dysregulated in both diseases.\",\"target_result\":\"The study identified 12 DEGs consistently dysregulated in both sarcoidosis and lung cancer.\",\"number_stated\":true}", "reading": {"parent_value": 12, "unit": "DEGs", "evidence": "Twelve DEGs—SALL4, WNT10A, RASAL1, CAMK2B, GADD45B, KLF4, OLR1, CSF3, WIF1, RAMP3, AGER, and PRKAG3—were consistently dysregulated in both diseases.", "target_result": "The study identified 12 DEGs consistently dysregulated in both sarcoidosis and lung cancer.", "number_stated": true, "source_locator": "chars 801-949 of source sha256 302a24eeb0a081e84fd01cf1102c37fe35fd804cbd830da04506fbf1ef89b834"}, "recorded_at": "2026-10-31T15:29:04.888356+00:00"}, {"provider": "minimax_alt", "model": "MiniMax-M3", "prompt_version": "replication-target-v2", "prompt_hash": "9c5f6cf10d3fd45243a04bde32dff083edf47785b8041e7557ce3e1b2cb508de", "source_hash": "302a24eeb0a081e84fd01cf1102c37fe35fd804cbd830da04506fbf1ef89b834", "raw_response": "<think>We need answer JSON only. Need identify single numerical result headline for main finding registered target. Source abstract highlights twelve DEGs consistently dysregulated in both diseases. Likely headline number = 12, unit \"DEGs\" perhaps paper prints \"Twelve DEGs\" in abstract. But question asks numerical result replication must reproduce, value paper states for registered target, unit paper prints, exact contiguous quote containing number. Target \"headline numerical result paper states for main finding.\" Candidate: twelve common DEGs. Need report headline number only. Is number 12 stated in prose as word Twelve and list. Unit? The paper prints \"Twelve DEGs\". parent_value number 12, unit likely \"DEGs\". Evidence exact contiguous quotation must contain number. They insist exact, contiguous quotation, number can be word? Schema parent numeric. Evidence should quote whole clause. \"Twelve DEGs—SALL4,...—were consistently dysregulated in both diseases.\" This is exact. Unit \"DEGs\" perhaps. target_result likely \"Twelve common differentially expressed genes (DEGs) were consistently dysregulated in both diseases.\" Need no paraphrase? target_result can state. Could choose interaction score 1.795? Main finding could be 12 DEGs. Headline numerical result likely count 12. The phrase \"headline numerical result\" perhaps benchmark task where registered target abstract target and seek result. Need determine unit exact paper prints. In abstract: \"Twelve DEGs—...\" So unit DEGs. Evidence exact contiguous. parent_value 12.\n\nCould evidence use Conclusion: \"The present study advances current knowledge by identifying twelve DEGs common to both sarcoidosis and LC, suggesting a shared pathogenic mechanism between these diseases.\" This explicitly links main finding and target. Number written word \"twelve\"; acceptable exact quote contains number? likely yes. They request value paper itself states and exact quote contains number. Number may be word. Could quote abstract sentence with \"Twelve DEGs...\" Better attribution and list. They say when text links by list or wording, quote whole clause. Use full exact sentence.\n\nNeed target_result headline perhaps \"Twelve DEGs were consistently dysregulated in both diseases.\" number_stated true. unit \"DEGs\". JSON valid no extra. Ensure em dash and accents okay.</think>\n\n{\"parent_value\":12,\"unit\":\"DEGs\",\"evidence\":\"Twelve DEGs—SALL4, WNT10A, RASAL1, CAMK2B, GADD45B, KLF4, OLR1, CSF3, WIF1, RAMP3, AGER, and PRKAG3—were consistently dysregulated in both diseases.\",\"target_result\":\"Twelve common differentially expressed genes were consistently dysregulated in both diseases.\",\"number_stated\":true}", "reading": {"parent_value": 12, "unit": "DEGs", "evidence": "Twelve DEGs—SALL4, WNT10A, RASAL1, CAMK2B, GADD45B, KLF4, OLR1, CSF3, WIF1, RAMP3, AGER, and PRKAG3—were consistently dysregulated in both diseases.", "target_result": "Twelve common differentially expressed genes were consistently dysregulated in both diseases.", "number_stated": true, "source_locator": "chars 801-949 of source sha256 302a24eeb0a081e84fd01cf1102c37fe35fd804cbd830da04506fbf1ef89b834"}, "recorded_at": "2026-10-31T15:29:07.587776+00:00"}], "agreement": true, "disagreements": {"analysis_methods": {"minimax": ["Gene expression differential-expression analysis", "Overlap analysis of differentially expressed genes", "Kaplan–Meier Plotter", "Cox regression analysis", "GEPIA violin plots", "ANOVA", "Functional enrichment analysis", "Protein–protein interaction analysis", "miRNet network analysis", "DGIdb drug–gene interaction analysis"], "minimax_alt": ["Differential-expression and overlapping-DEG analysis of GEO datasets", "GEPIA validation", "Enrichr pathway enrichment analysis", "STRING protein–protein interaction (PPI) analysis", "miRNet gene–miRNA interaction network analysis", "Degree and betweenness centrality analysis", "DGIdb drug–gene interaction analysis", "Kaplan–Meier Plotter survival assessment", "Cox regression analysis", "ANOVA"], "decisive": false}}, "agreement_basis": {"policy": "decisive_fields", "decisive_fields": ["work_type", "number_stated", "parent_value", "unit"]}, "blinded": true}, "human_critique": {"status": "not_run", "reviewer": null, "signed_at": null, "conflict_checked": false, "commentary": null}, "stages": [{"key": "target_materials", "status": "pending", "reason": null, "evidence": null}, {"key": "independent_readings", "status": "passed", "reason": "The independent readings are incomplete or disagree; the source evidence must resolve the difference.", "evidence": {"provider_errors": []}}, {"key": "source_resolution", "status": "pending", "reason": null, "evidence": null}, {"key": "protocol_reconstruction", "status": "pending", "reason": null, "evidence": null}, {"key": "control_execution", "status": "pending", "reason": null, "evidence": null}, {"key": "control_comparison", "status": "pending", "reason": null, "evidence": null}, {"key": "publication", "status": "pending", "reason": null, "evidence": null}], "gaps": ["review.human_critique", "review.machine_critique.passed"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "package:1ae89aa637e3d18b09e977e0e3797460a6fe8084650c489eb27b219837828d89", "type": "sep_package", "label": "SEP v1 package for pmid:40797277"}], "activities": [{"id": "activity:conversion:pmid:40797277", "type": "conversion", "used": ["package:1ae89aa637e3d18b09e977e0e3797460a6fe8084650c489eb27b219837828d89"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:minimax", "type": "model", "label": "minimax"}, {"id": "agent:minimax_alt", "type": "model", "label": "minimax_alt"}, {"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}], "source_run_id": "run-20261023T122449232913", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:40797277", "parent_hash": "sha256:6a81e3ca8b139aba34813e8b2db50ce9506c57fbed09c8a11e6fb2bbe914d622", "fork_of": null, "generation": 2}, "gaps": ["abstract", "asset:source:pmid:40797277 not verified", "authors", "capability", "corpus_record_absent", "execution.not_run", "method", "review.human_critique", "review.machine_critique.passed", "step:obtain_source_data blocked on data:not_downloaded", "step:run_analysis blocked on no owned computational capability is bound to this experiment", "step:run_analysis input 'materials:the source data behind the published result in pmid:40797277' does not resolve to a declared asset", "targets"]}