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pmid:40980067
Prognostic significance and pathogenesis of RFC3 gene expression in diffuse large B-cell lymphoma.
PeerJ · 2025 doi:10.7717/peerj.20001
Paper
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Experiment
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Data
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Analysis
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Complete file
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These datasets include pharmacogenomic profiles of cancer cell lines exposed to a range of therapeutic agents for different RFC3 expression levels.\",\n \"publicly_downloadable\": false\n },\n {\n \"repository\": \"Supplemental Files\",\n \"accession\": \"unknown\",\n \"data_description\": \"Raw data underlying the study.\",\n \"evidence\": \"The raw data is available in the Supplemental Files.\",\n \"publicly_downloadable\": false\n }\n ],\n \"availability_statement\": \"The raw data is available in the Supplemental Files.\",\n \"data_on_request\": false,\n \"source_claims\": [\n \"RFC3 expression was significantly upregulated in DLBCL.\",\n \"High RFC3 expression was closely associated with poor prognosis, adverse clinical features, and adverse tumor microenvironment characteristics in DLBCL patients.\",\n \"RFC3 expression was validated via immunohistochemistry (IHC) in DLBCL samples.\",\n \"Survival analysis was conducted using the Kaplan–Meier method.\",\n \"The chi-square test 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GSE12453) and The Cancer Genome Atlas (TCGA).\",\n \"RFC3 expression was validated via immunohistochemistry (IHC) in DLBCL samples.\",\n \"Survival analysis was conducted using the Kaplan–Meier method.\",\n \"The chi-square test was used to assess the association between RFC3 expression and clinical characteristics of DLBCL.\",\n \"Gene Set Enrichment Analysis (GSEA) was employed to identify tumor signaling pathways associated with RFC3.\",\n \"RFC3 expression was significantly upregulated in DLBCL.\",\n \"High RFC3 expression was closely associated with poor prognosis, adverse clinical features, and adverse tumor microenvironment characteristics in DLBCL patients.\",\n \"The immunotherapy response was predicted using the IMvigor210 cohort through the IMvigor210CoreBiologics R package (Nickles & Bourgon, 2019).\",\n \"For this analysis, we obtained drug response data from the Genomics of Drug Sensitivity in Cancer (GDSC) data version 1 and 2 and the Cancer Therapeutics Response Portal, 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