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pmid:41158216

Integrating prognosis-related genes with immune-related gene signature for development and validation of a survival stratification model for early-stage colorectal cancer.

Translational cancer research · 2025 doi:10.21037/tcr-2024-2511

Paper

partial

Experiment

partial

Data

partial

Analysis

absent

Execution

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Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
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Integrating prognosis-related genes with immune-related gene signature for development and validation of a survival stratification model for early-stage colorectal cancer.
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10.21037/tcr-2024-2511
pmid
41158216
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null
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Translational cancer research
year
2025
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Characteristics of the patients in each dataset
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[0] array · 4 items
[0]
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[1]
GSE39582 (n=566)
[2]
TCGA (n=624)
[3]
Meta-validation (n=335)
[1] array · 4 items
[0]
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[1]
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66.3 (12.8)
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164
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[0]
1
[1]
33
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105
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32
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[0]
2
[1]
264
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229
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170
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3
[1]
205
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181
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73
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[1]
60
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70
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26
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NA
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39
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34
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21
[3]
1
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45
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105
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11
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367
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425
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119
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119
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70
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26
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23
[2]
3
[3]
178
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354
[3]
36
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224
[2]
270
[3]
31
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NA
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[2]
0
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268
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Adjuvant chemotherapy
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316
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393
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[0]
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233
[2]
231
[3]
0
[24] array · 4 items
[0]
NA
[1]
17
[2]
0
[3]
335
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[0]
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[3]
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[0]
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[1]
75
[2]
189
[3]
44
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444
[2]
431
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114
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[1]
47
[2]
4
[3]
177
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39
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624
[3]
178
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Validation of the GPI as a stage-independent prognostic factor of CRC patients
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Univariate and multivariate analysis of IRGS, clinical and pathologic factors in training and validation cohorts
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0.58 (0.30–1.15)
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0.66
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[11]
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0.13 (0.02–1.08)
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0.03
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[16]
0.27 (0.03–2.74)
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0.27
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TNM stage
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0.01
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1.52 (0.17–13.36)
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0.70
[6]
[7]
1.79 (0.74–4.32)
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0.19
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[10]
[11]
[12]
[13]
3.99 (0.96–16.64)
[14]
0.04
[15]
[16]
0.35 (0.01–11.96)
[17]
0.56
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T stage
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<0.001
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[4]
2.03 (1.12–3.67)
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0.02
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[7]
1.64 (0.85–3.17)
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0.14
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[10]
[11]
[12]
[13]
2.68 (1.15–6.27)
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0.03
[15]
[16]
0.35 (0.01–11.96)
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0.26
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[0]
MMR status
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0.25
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[4]
[5]
[6]
[7]
0.61 (0.32–1.19)
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0.14
[9]
[10]
[11]
[12]
[13]
0.88 (0.38–2.04)
[14]
0.76
[15]
[16]
[17]
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[0]
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0.89
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[4]
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[12]
[13]
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[15]
[16]
[17]
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TP53 mutation
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0.27
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[8]
[9]
[10]
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[12]
[13]
2.74 (0.60–12.43)
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0.17
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KRAS mutation
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0.16
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[4]
[5]
[6]
[7]
1.02 (0.23–4.60)
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0.98
[9]
[10]
[11]
[12]
[13]
1.23 (0.53–2.87)
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0.63
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[16]
[17]
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BRAF mutation
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1.42 (0.57–3.58)
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0.45
[3]
[4]
[5]
[6]
[7]
0.00 (0.00–Inf)
[8]
0.72
[9]
[10]
[11]
[12]
[13]
2.04 (0.81–5.10)
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targets
Complete file 
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