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pmid:41162968

BRCAGenie: A machine learning-driven 43-gene polygenic risk score model for precision prediction of breast cancer survival.

Journal of translational medicine · 2025 doi:10.1186/s12967-025-07100-2

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Experiment

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Data

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BRCAGenie: A machine learning-driven 43-gene polygenic risk score model for precision prediction of breast cancer survival.
doi
10.1186/s12967-025-07100-2
pmid
41162968
authors
null
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Journal of translational medicine
year
2025
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Clinical and demographic characteristics of the 1031 subjects in The Cancer Genome Atlas Breast Cancer (TCGA-BRCA) cohort
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PMC12574034
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4
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Data pre-processing
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Table 1
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Clinical and demographic characteristics of the 1031 subjects in The Cancer Genome Atlas Breast Cancer (TCGA-BRCA) cohort
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[0] array · 3 items
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[1]
Characteristics
[2]
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[1] array · 1 item
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Clinical and demographic characteristics of the 1904 subjects in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) cohort
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External validation
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Table 2
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Clinical and demographic characteristics of the 1904 subjects in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) cohort
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Clinical and demographic characteristics of the 2969 subjects in the Gene Expression Omnibus (GSE96058) cohort
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External validation
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Table 3
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Clinical and demographic characteristics of the 2969 subjects in the Gene Expression Omnibus (GSE96058) cohort
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Final set of 43 genes selected to be included in the PRS after forward stepwise selection
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Final set of 43 genes selected to be included in the PRS after forward stepwise selection
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0.3120
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0.6334
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0.6467
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0.6498
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0.6566
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0.6600
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0.6655
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0.7785
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0.8609
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0.9085
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0.9389
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1.0328
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1.0401
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1.1237
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1.1537
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1.2026
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1.2867
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1.2898
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1.4623
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2.0995
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3.3420
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Genetic and clinical features included in the PRS model
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Incorporation of clinical data
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Genetic and clinical features included in the PRS model
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3.68E−03
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1.17E−07
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1.55E−05
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0.4976
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2.98E−03
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0.1377
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4.25E−01
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0.3286
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8.36E−07
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0.5750
[2]
3.32E−03
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0.4621
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8.77E−05
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0.4085
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1.73E−02
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1.16E−07
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0.6618
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1.33E−05
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0.5598
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1.83E−04
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0.8440
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2.44E−09
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3.31E−04
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0.2822
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3.62E−02
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0.7154
[2]
5.28E−07
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TMEM14B
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[2]
2.32E−02
[19] array · 3 items
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PTGES3
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0.0636
[2]
6.82E−01
[20] array · 3 items
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[2]
1.83E−04
[21] array · 3 items
[0]
NT5E
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0.2645
[2]
3.37E−02
[22] array · 3 items
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[2]
1.33E−03
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C6
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0.3617
[2]
1.37E−04
[24] array · 3 items
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ASS1
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0.0170
[2]
8.97E−01
[25] array · 3 items
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PAK6
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0.4733
[2]
3.96E−05
[26] array · 3 items
[0]
TMCO1
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− 0.0133
[2]
9.29E−01
[27] array · 3 items
[0]
CYTL1
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0.5822
[2]
1.15E−06
[28] array · 3 items
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PPFIBP2
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0.3625
[2]
4.37E−04
[29] array · 3 items
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NT5DC3
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− 0.7307
[2]
3.33E−03
[30] array · 3 items
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MTA2
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− 0.3961
[2]
6.30E−03
[31] array · 3 items
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RPS29
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[2]
5.95E−05
[32] array · 3 items
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GREB1L
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− 0.7856
[2]
2.12E−04
[33] array · 3 items
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TMEM41A
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0.5451
[2]
1.18E−04
[34] array · 3 items
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ATP6V1E1
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0.1664
[2]
2.53E−01
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0.3975
[2]
2.92E−04
[36] array · 3 items
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0.2105
[2]
4.62E−05
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0.3467
[2]
1.60E−02
[38] array · 3 items
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ZNF326
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− 0.6445
[2]
3.16E−04
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SDC3
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[2]
5.36E−02
[40] array · 3 items
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0.5090
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2.62E−03
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XG
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[2]
6.93E−01
[42] array · 3 items
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BDH1
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0.2874
[2]
3.09E−02
[43] array · 3 items
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CYP4F11
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− 0.9185
[2]
1.21E−03
[44] array · 3 items
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Age at Diagnosis
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0.0107
[2]
2.88E−01
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Model performance of our 43-gene risk score model compared with other published studies
structure object · 5 fields
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PMC12574034
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25
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Discussion
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Table 6
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Model performance of our 43-gene risk score model compared with other published studies
rows array · 14 items
[0] array · 4 items
[0]
Study
[1]
Gene Number
[2]
Three-year AUC(t)
[3]
Five-year AUC(t)
[1] array · 4 items
[0]
Construct ceRNA network and risk model of breast cancer using machine learning methods under the mechanism of Cuproptosis [19]
[1]
4
[2]
0.604
[3]
0.550
[2] array · 4 items
[0]
Establishment of a novel CNV-related prognostic signature predicting prognosis in patients with breast cancer [59]
[1]
9
[2]
0.630
[3]
0.580
[3] array · 4 items
[0]
Construction and validation of a newly prognostic signature for CRISPR-Cas9-based cancer dependency map genes in breast cancer [27]
[1]
6
[2]
0.649
[3]
0.618
[4] array · 4 items
[0]
Identification of a 6-gene signature for the survival prediction of breast cancer patients based on integrated multi-omics data analysis [60]
[1]
6
[2]
0.660
[3]
0.630
[5] array · 4 items
[0]
A novel hypoxia- and lactate metabolism-related signature to predict prognosis and immunotherapy responses for breast cancer by integrating machine learning and bioinformatic analyses [26]
[1]
5
[2]
0.671
[3]
0.638
[6] array · 4 items
[0]
A novel disulfidptosis-associated expression pattern in breast cancer based on machine learning [22]
[1]
4
[2]
0.687
[3]
0.644
[7] array · 4 items
[0]
Insights into a Machine Learning-Based Palmitoylation-Related Gene Model for Predicting the Prognosis and Treatment Response of Breast Cancer Patients [28]
[1]
11
[2]
0.743
[3]
0.644
[8] array · 4 items
[0]
Identification of prognostic genes for breast cancer related to systemic lupus erythematosus by integrated analysis and machine learning [32]
[1]
3
[2]
0.690
[3]
0.690
[9] array · 4 items
[0]
Development of a Ten-lncRNA Signature Prognostic Model for Breast Cancer Survival: A Study with the TCGA Database [61]
[1]
10
[2]
0.717
[3]
0.717
[10] array · 4 items
[0]
A six-long non-coding RNAs signature as a potential prognostic marker for survival prediction of ER-positive breast cancer patients [62]
[1]
6
[2]
0.725
[3]
0.717
[11] array · 4 items
[0]
Integration of Bioinformatics and Machine Learning to Identify CD8 + T Cell-Related Prognostic Signature to Predict Clinical Outcomes and Treatment Response in Breast Cancer Patients [23]
[1]
2
[2]
0.754
[3]
0.727
[12] array · 4 items
[0]
Development and validation of a prognostic model and gene co-expression networks for breast carcinoma based on scRNA-seq and bulk-seq data [34]
[1]
10
[2]
0.772
[3]
0.736
[13] array · 4 items
[0]
43-gene risk score model in our study
[1]
43
[2]
0.736
[3]
0.751
locator
section[25]/table-wrap[1]#Tab6
[7] object · 16 fields
id
asset:table:pmid:41162968:7
role
table
format
jats-table
media_type
application/vnd.jats.table+json
uri
null
sha256
sha256:a1696a43bd8c9b558a3f90395df74bbaead69378d6e3bdb01ee5e6d2d9d98011
bytes
3369
access
open
state
verified
reader
read_table
reader_status
available
identifier
section[25]/table-wrap[2]#Tab7
version
null
note
Summary of literature review of the 43 genes identified in our study
structure object · 5 fields
pmcid
PMC12574034
section_index
25
section_title
Discussion
row_count
44
column_count
6
table object · 8 fields
label
Table 7
caption
Summary of literature review of the 43 genes identified in our study
rows array · 44 items
[0] array · 6 items
[0]
Gene name
[1]
Gene Symbol
[2]
PRSCoefficient
[3]
Good/poor prognostic marker (PRS)
[4]
Good/poor prognostic marker (Lit search)
[5]
References
[1] array · 6 items
[0]
C–C Motif Chemokine Receptor 7
[1]
CCR7
[2]
3.3420
[3]
[4]
[5]
[70–72]
[2] array · 6 items
[0]
Tubulin Delta 1
[1]
TUBD1
[2]
2.0995
[3]
[4]
[5]
[73, 74]
[3] array · 6 items
[0]
Inorganic Pyrophosphatase 2
[1]
PPA2
[2]
1.4623
[3]
[4]
[5]
[75, 76]
[4] array · 6 items
[0]
Ectodysplasin A2 Receptor
[1]
EDA2R
[2]
1.2898
[3]
[4]
[5]
[77, 78]
[5] array · 6 items
[0]
Phosphofructokinase, Liver Type
[1]
PFKL
[2]
1.2867
[3]
[4]
[5]
[79, 80]
[6] array · 6 items
[0]
Peroxidasin Like
[1]
PXDNL
[2]
1.2026
[3]
[4]
[5]
[81, 82]
[7] array · 6 items
[0]
Cation Channel Sperm Associated 3
[1]
CATSPER3
[2]
1.1537
[3]
[4]
[5]
[83]
[8] array · 6 items
[0]
Phosphoglycerate Kinase 1
[1]
PGK1
[2]
1.1237
[3]
[4]
[5]
[84–88]
[9] array · 6 items
[0]
Exocyst Complex Component 1
[1]
EXOC1
[2]
1.0401
[3]
[4]
[5]
[27, 89]
[10] array · 6 items
[0]
Transient Receptor Potential Cation Channel Subfamily M Member 2
[1]
TRPM2
[2]
1.0328
[3]
[4]
[5]
[90–92]
[11] array · 6 items
[0]
Globoside Alpha-1,3-N-Acetylgalactosaminyltransferase 1
[1]
GBGT1
[2]
0.9389
[3]
[4]
[5]
[93]
[12] array · 6 items
[0]
Ring Finger Protein 135
[1]
RNF135
[2]
0.9085
[3]
[4]
[5]
[94, 95]
[13] array · 6 items
[0]
P21 (RAC1) Activated Kinase 6
[1]
PAK6
[2]
0.8609
[3]
[4]
[5]
[96, 97]
[14] array · 6 items
[0]
Transmembrane And Coiled-Coil Domains 1
[1]
TMCO1
[2]
0.7987
[3]
[4]
[5]
[98, 99]
[15] array · 6 items
[0]
Argininosuccinate Synthase 1
[1]
ASS1
[2]
0.7785
[3]
[4]
[5]
[100–103]
[16] array · 6 items
[0]
5'-Nucleotidase Ecto
[1]
NT5E
[2]
0.7425
[3]
[4]
[5]
[104–107]
[17] array · 6 items
[0]
Malignant T-Cell Amplified Sequence 1
[1]
MCTS1
[2]
0.7264
[3]
[4]
[5]
[108–110]
[18] array · 6 items
[0]
Complement C6
[1]
C6
[2]
0.7013
[3]
[4]
[5]
[111]
[19] array · 6 items
[0]
PPFIA Binding Protein 2
[1]
PPFIBP2
[2]
0.6724
[3]
[4]
[5]
[112–114]
[20] array · 6 items
[0]
HOX Transcript Antisense RNA
[1]
HOTAIR
[2]
0.6655
[3]
[4]
[5]
[115–119]
[21] array · 6 items
[0]
Transmembrane Protein 41A
[1]
TMEM41A
[2]
0.6600
[3]
[4]
[5]
[120]
[22] array · 6 items
[0]
Surfeit 6
[1]
SURF6
[2]
0.6566
[3]
[4]
[5]
[121]
[23] array · 6 items
[0]
ATPase H + Transporting V1 Subunit E1
[1]
ATP6V1E1
[2]
0.6498
[3]
[4]
[5]
[122]
[24] array · 6 items
[0]
Cytokine Like 1
[1]
CYTL1
[2]
0.6467
[3]
[4]
[5]
[123–125]
[25] array · 6 items
[0]
ALX Homeobox 4
[1]
ALX4
[2]
0.6334
[3]
[4]
[5]
[126–130]
[26] array · 6 items
[0]
3-Hydroxybutyrate Dehydrogenase 1
[1]
BDH1
[2]
0.6032
[3]
[4]
[5]
[131, 132]
[27] array · 6 items
[0]
Secretogranin II
[1]
SCG2
[2]
0.3120
[3]
[4]
[5]
[133–136]
[28] array · 6 items
[0]
Xg Glycoprotein
[1]
XG
[2]
− 0.4343
[3]
[4]
[5]
[29] array · 6 items
[0]
Syndecan 3
[1]
SDC3
[2]
− 0.6365
[3]
[4]
[5]
[137]
[30] array · 6 items
[0]
Metastasis Associated 1 Family Member 2
[1]
MTA2
[2]
− 0.8020
[3]
[4]
[5]
[138–141]
[31] array · 6 items
[0]
Zinc Finger Protein 326
[1]
ZNF326
[2]
− 0.8347
[3]
[4]
[5]
[142–146]
[32] array · 6 items
[0]
Prostaglandin E Synthase 3
[1]
PTGES3
[2]
− 0.9675
[3]
[4]
[5]
[147–150]
[33] array · 6 items
[0]
5'-Nucleotidase Domain Containing 3
[1]
NT5DC3
[2]
− 1.1261
[3]
[4]
[5]
[151, 152]
[34] array · 6 items
[0]
Ribosomal Protein S29
[1]
RPS29
[2]
− 1.1681
[3]
[4]
[5]
[153, 154]
[35] array · 6 items
[0]
Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3F
[1]
APOBEC3F
[2]
− 1.2551
[3]
[4]
[5]
[155, 156]
[36] array · 6 items
[0]
Growth Regulation By Estrogen In Breast Cancer 1 Like
[1]
GREB1L
[2]
− 1.2990
[3]
[4]
[5]
[157]
[37] array · 6 items
[0]
Cytochrome P450 Family 4 Subfamily F Member 11
[1]
CYP4F11
[2]
− 1.4646
[3]
[4]
[5]
[158–160]
[38] array · 6 items
[0]
Solute Carrier Family 16 Member 13
[1]
SLC16A13
[2]
− 1.5049
[3]
[4]
[5]
[161, 162]
[39] array · 6 items
[0]
Transmembrane Protein 14B
[1]
TMEM14B
[2]
− 1.6914
[3]
[4]
[5]
[34, 163]
[40] array · 6 items
[0]
Brain Expressed X-Linked 5
[1]
BEX5
[2]
− 1.7170
[3]
[4]
[5]
[164]
[41] array · 6 items
[0]
Ribosomal Protein S6 Kinase B1
[1]
RPS6KB1
[2]
− 2.0842
[3]
[4]
[5]
[165–167]
[42] array · 6 items
[0]
NUMB Like Endocytic Adaptor Protein
[1]
NUMBL
[2]
− 2.6098
[3]
[4]
[5]
[168]
[43] array · 6 items
[0]
Endoplasmic Reticulum Protein 27
[1]
ERP27
[2]
− 2.6490
[3]
[4]
[5]
[169–172]
locator
section[25]/table-wrap[2]#Tab7
gaps array · 1 item
[0]
asset:source:pmid:41162968 not verified
analysis object · 4 fields
state
absent
methods array · 0 items
targets array · 0 items
gaps array · 2 items
[0]
method
[1]
targets
capability object · 3 fields
state
absent
requirements array · 0 items
gaps array · 1 item
[0]
capability
readiness object · 8 fields
state
partial
tier
null
blocked_on
null
axes object · 0 fields
can_run object · 3 fields
dsl_operations array · 0 items
assets array · 8 items
[0]
source:pmid:41162968
[1]
asset:table:pmid:41162968:1
[2]
asset:table:pmid:41162968:2
[3]
asset:table:pmid:41162968:3
[4]
asset:table:pmid:41162968:4
[5]
asset:table:pmid:41162968:5
[6]
asset:table:pmid:41162968:6
[7]
asset:table:pmid:41162968:7
steps array · 1 item
[0]
read_published_estimate
must_build object · 5 fields
dsl_operations array · 0 items
converters array · 0 items
readers array · 1 item
[0]
xml
capabilities array · 0 items
data_gaps array · 1 item
[0]
source:pmid:41162968
gaps array · 1 item
[0]
corpus_record_absent
review object · 5 fields
state
partial
machine_critique object · 7 fields
status
blocked
providers array · 0 items
target_providers array · 0 items
agreement
false
disagreements array · 0 items
agreement_basis object · 2 fields
policy
decisive_fields
decisive_fields array · 4 items
[0]
work_type
[1]
number_stated
[2]
parent_value
[3]
unit
blinded
true
human_critique object · 5 fields
status
not_run
reviewer
null
signed_at
null
conflict_checked
false
commentary
null
stages array · 7 items
[0] object · 4 fields
key
target_materials
status
pending
reason
null
evidence
null
[1] object · 4 fields
key
independent_readings
status
blocked
reason
The independent readings are incomplete or disagree; the source evidence must resolve the difference.
evidence object · 1 field
provider_errors array · 4 items
[0] object · 4 fields
provider
minimax
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[1] object · 4 fields
provider
minimax_alt
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[2] object · 4 fields
provider
minimax
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[3] object · 4 fields
provider
minimax_alt
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[2] object · 4 fields
key
source_resolution
status
pending
reason
null
evidence
null
[3] object · 4 fields
key
protocol_reconstruction
status
pending
reason
null
evidence
null
[4] object · 4 fields
key
control_execution
status
pending
reason
null
evidence
null
[5] object · 4 fields
key
control_comparison
status
pending
reason
null
evidence
null
[6] object · 4 fields
key
publication
status
pending
reason
null
evidence
null
gaps array · 3 items
[0]
review.human_critique
[1]
review.machine_critique.blocked
[2]
review.machine_critique.providers
execution object · 5 fields
state
absent
status
not_run
mode
null
runs array · 0 items
gaps array · 1 item
[0]
execution.not_run
provenance object · 7 fields
entities array · 1 item
[0] object · 3 fields
id
package:9c51aef71106c06759f1e65e8ae2eba45994a011695979f083f2a0ce689b1457
type
sep_package
label
SEP v1 package for pmid:41162968
activities array · 1 item
[0] object · 4 fields
id
activity:conversion:pmid:41162968
type
conversion
used array · 1 item
[0]
package:9c51aef71106c06759f1e65e8ae2eba45994a011695979f083f2a0ce689b1457
agent
agent:corpus-assay-engine
agents array · 1 item
[0] object · 3 fields
id
agent:corpus-assay-engine
type
software
label
Corpus assay engine
source_run_id
run-20261023T122449232913
dsl_catalogue_fingerprint
343fb30756ba6ec3
capability_table_fingerprint
2cb3e42f047d2ecf
snapshot_id
ba34b49490d9bfaf
lineage object · 4 fields
parent_id
pmid:41162968
parent_hash
sha256:15f35e134b4d8b4a3198922effc99acc0f80786ae7c76f12ab42d44ae32ad6f6
fork_of
null
gaps array · 14 items
[0]
abstract
[1]
asset:source:pmid:41162968 not verified
[2]
authors
[3]
capability
[4]
corpus_record_absent
[5]
execution.not_run
[6]
method
[7]
review.human_critique
[8]
review.machine_critique.blocked
[9]
review.machine_critique.providers
[10]
step:obtain_source_data blocked on data:not_downloaded
[11]
step:run_analysis blocked on no owned computational capability is bound to this experiment
[12]
step:run_analysis input 'materials:the source data behind the published result in pmid:41162968' does not resolve to a declared asset
[13]
targets
Complete file
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"8.36E−07"], ["PFKL", "0.5750", "3.32E−03"], ["RNF135", "0.4621", "8.77E−05"], ["EXOC1", "0.4085", "1.73E−02"], ["APOBEC3F", "− 0.7288", "1.16E−07"], ["EDA2R", "0.6618", "1.33E−05"], ["PGK1", "0.5598", "1.83E−04"], ["CATSPER3", "0.8440", "2.44E−09"], ["SLC16A13", "− 0.6982", "3.31E−04"], ["TRPM2", "0.2822", "3.62E−02"], ["GBGT1", "0.7154", "5.28E−07"], ["TMEM14B", "− 0.4823", "2.32E−02"], ["PTGES3", "0.0636", "6.82E−01"], ["ERP27", "− 1.1711", "1.83E−04"], ["NT5E", "0.2645", "3.37E−02"], ["BEX5", "− 0.6013", "1.33E−03"], ["C6", "0.3617", "1.37E−04"], ["ASS1", "0.0170", "8.97E−01"], ["PAK6", "0.4733", "3.96E−05"], ["TMCO1", "− 0.0133", "9.29E−01"], ["CYTL1", "0.5822", "1.15E−06"], ["PPFIBP2", "0.3625", "4.37E−04"], ["NT5DC3", "− 0.7307", "3.33E−03"], ["MTA2", "− 0.3961", "6.30E−03"], ["RPS29", "− 0.7609", "5.95E−05"], ["GREB1L", "− 0.7856", "2.12E−04"], ["TMEM41A", "0.5451", "1.18E−04"], ["ATP6V1E1", "0.1664", "2.53E−01"], ["HOTAIR", "0.3975", "2.92E−04"], ["SCG2", "0.2105", 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breast cancer by integrating machine learning and bioinformatic analyses [26]", "5", "0.671", "0.638"], ["A novel disulfidptosis-associated expression pattern in breast cancer based on machine learning [22]", "4", "0.687", "0.644"], ["Insights into a Machine Learning-Based Palmitoylation-Related Gene Model for Predicting the Prognosis and Treatment Response of Breast Cancer Patients [28]", "11", "0.743", "0.644"], ["Identification of prognostic genes for breast cancer related to systemic lupus erythematosus by integrated analysis and machine learning [32]", "3", "0.690", "0.690"], ["Development of a Ten-lncRNA Signature Prognostic Model for Breast Cancer Survival: A Study with the TCGA Database [61]", "10", "0.717", "0.717"], ["A six-long non-coding RNAs signature as a potential prognostic marker for survival prediction of ER-positive breast cancer patients [62]", "6", "0.725", "0.717"], ["Integration of Bioinformatics and Machine Learning to Identify CD8 + T Cell-Related Prognostic Signature to Predict Clinical Outcomes and Treatment Response in Breast Cancer Patients [23]", "2", "0.754", "0.727"], ["Development and validation of a prognostic model and gene co-expression networks for breast carcinoma based on scRNA-seq and bulk-seq data [34]", "10", "0.772", "0.736"], ["43-gene risk score model in our study", "43", "0.736", "0.751"]], "row_count": 14, "column_count": 4, "numeric_cells": 52, "header_rows": 1, "locator": "section[25]/table-wrap[1]#Tab6"}}, {"id": "asset:table:pmid:41162968:7", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:a1696a43bd8c9b558a3f90395df74bbaead69378d6e3bdb01ee5e6d2d9d98011", "bytes": 3369, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[25]/table-wrap[2]#Tab7", "version": null, "note": "Summary of literature review of the 43 genes identified in our study", "structure": {"pmcid": "PMC12574034", 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"ATP6V1E1", "0.6498", "", "", "[122]"], ["Cytokine Like 1", "CYTL1", "0.6467", "", "", "[123–125]"], ["ALX Homeobox 4", "ALX4", "0.6334", "", "", "[126–130]"], ["3-Hydroxybutyrate Dehydrogenase 1", "BDH1", "0.6032", "", "", "[131, 132]"], ["Secretogranin II", "SCG2", "0.3120", "", "", "[133–136]"], ["Xg Glycoprotein", "XG", "− 0.4343", "", "", ""], ["Syndecan 3", "SDC3", "− 0.6365", "", "", "[137]"], ["Metastasis Associated 1 Family Member 2", "MTA2", "− 0.8020", "", "", "[138–141]"], ["Zinc Finger Protein 326", "ZNF326", "− 0.8347", "", "", "[142–146]"], ["Prostaglandin E Synthase 3", "PTGES3", "− 0.9675", "", "", "[147–150]"], ["5'-Nucleotidase Domain Containing 3", "NT5DC3", "− 1.1261", "", "", "[151, 152]"], ["Ribosomal Protein S29", "RPS29", "− 1.1681", "", "", "[153, 154]"], ["Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3F", "APOBEC3F", "− 1.2551", "", "", "[155, 156]"], ["Growth Regulation By Estrogen In Breast Cancer 1 Like", "GREB1L", "− 1.2990", "", "", "[157]"], 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