Prognostic value of the Geriatric Nutritional Risk Index in sepsis-associated acute kidney injury: a retrospective cohort study.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:41356822", "kind": "science-record", "revision": 3, "content_hash": "sha256:6619394b7e24e4d4253e613c93cf3e4645301eba2afcacfca0b4d4ce34a3c4fd", "created_at": "2026-11-01T20:31:22Z", "updated_at": "2026-11-01T22:15:08Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Prognostic value of the Geriatric Nutritional Risk Index in sepsis-associated acute kidney injury: a retrospective cohort study.", "doi": "10.3389/fnut.2025.1635568", "pmid": "41356822", "authors": ["Guangqin Ren", "Huali Tang", "Xue Guo", "Yunxue He", "Zhengrong Ding", "Zhiwei Li", "Cong Zhou", "Bin Li", "Huibing Chen", "Lijuan Dong"], "journal": "Frontiers in nutrition", "year": 2025, "abstract": "Background: The Geriatric Nutritional Risk Index (GNRI) is a simple and objective tool for assessing nutritional status. It has shown prognostic value in patients with acute kidney injury (AKI). However, evidence in sepsis-associated AKI (S-AKI) remains limited, especially among patients receiving continuous renal replacement therapy (CRRT).\nMethods: This retrospective cohort study included 773 critically ill S-AKI patients who received CRRT, using data from the publicly available Dryad database. Patients were stratified into tertiles based on GNRI values. Cox proportional hazards models were employed to assess the association between GNRI and 28-day and 90-day all-cause mortality, with the lowest tertile serving as the reference group. Kaplan-Meier survival analyses were used to compare cumulative mortality across GNRI strata.\nResults: Among 773 patients, the 28-day and 90-day mortality rates were 61.7% and 73.0%, respectively. After adjusting for multiple confounders, higher GNRI scores were independently associated with lower all-cause mortality. Compared to the lowest GNRI group, the highest tertile showed significantly reduced mortality risks (28-day HR = 0.53; 95% CI: 0.47-0.75; p < 0.001; 90-day HR = 0.50; 95% CI: 0.41-0.63; p < 0.001). The association remained robust in subgroup analyses and was particularly pronounced in patients aged ≥65 years.\nConclusion: GNRI independently predicts short-term mortality in critically ill S-AKI patients on CRRT. It is simple, objective, and integrates nutritional and inflammatory status. It can assist early risk stratification and nutritional assessment.", "claims": [{"id": "claim-method", "statement": "Cox proportional hazards regression models were used to evaluate the association between GNRI and mortality.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:41356822", "locator": "sections[7] \"Statistical analysis\" paragraph 2", "quote": "Cox proportional hazards regression models were used to evaluate the association between GNRI and mortality."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The original contributions presented in this study are included in this article/Supplementary material, further inquiries can be directed to the corresponding authors.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:41356822", "locator": "sections[18] \"Data availability statement\" paragraph 2", "quote": "The original contributions presented in this study are included in this article/Supplementary material, further inquiries can be directed to the corresponding authors."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Compared to the lowest GNRI group, the highest tertile showed significantly reduced mortality risks (28-day HR = 0.53; 95% CI: 0.47–0.75; p < 0.001; 90-day HR = 0.50; 95% CI: 0.41–0.63; p < 0.001).", "kind": "quantitative", "target": {"value": 95.0, "unit": "per cent", "tolerance": null, "source": "Compared to the lowest GNRI group, the highest tertile showed significantly reduced mortality risks (28-day HR = 0.53; 95% CI: 0.47–0.75; p < 0.001; 90-day HR = 0.50; 95% CI: 0.41–0.63; p < 0.001)."}, "evidence": [{"asset": "source:pmid:41356822", "locator": "sections[0] \"Abstract\" paragraph 3", "quote": "Compared to the lowest GNRI group, the highest tertile showed significantly reduced mortality risks (28-day HR = 0.53; 95% CI: 0.47–0.75; p < 0.001; 90-day HR = 0.50; 95% CI: 0.41–0.63; p < 0.001)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "partial", "objective": "Compared to the lowest GNRI group, the highest tertile showed significantly reduced mortality risks (28-day HR = 0.53; 95% CI: 0.47–0.75; p < 0.001; 90-day HR = 0.50; 95% CI: 0.41–0.63; p < 0.001).", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:41356822"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "blocked", "blocked_on": "data:accession_absent", "description": "The GEO series accession resolves and its sample accessions are listed. 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