Identifying myosin heavy chain 11 as a predictive biomarker of prostate cancer progression and antiandrogen resistance.

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"sha256:626ce52258ff4f780dcd9b05040a47843066dcb32f8b42d0af8da70f0a25b2ca", "raw_response_chars": 4009}, {"provider": "minimax_alt", "model": "MiniMax-M3", "prompt_version": "full-text-reading-v1", "prompt_hash": "c0dae4559bc7adb3cd49d81ed7c100743977c3c10e6b330526e7b1bb1bac568d", "source_hash": "8a05b23515f6538304a6fdd81d89e7f96b9693dff34298e87670507a10f60369", "raw_response_sha256": "sha256:4c460c09aea386bd83b87b93bcd02a314d1dc97a8549655cf11712bfd278debd", "raw_response_chars": 53316}], "target_providers": [{"provider": "minimax", "model": "MiniMax-M3.1-Flash", "prompt_version": "replication-target-v2", "prompt_hash": "f593c3d500bacf1942a5dd8d367538e788a9403d660fd4e5cfad8231524b2fc1", "source_hash": "8a05b23515f6538304a6fdd81d89e7f96b9693dff34298e87670507a10f60369", "raw_response": "{\"parent_value\":54,\"unit\":\"differentially expressed genes\",\"evidence\":\"The present study identified 54 differentially expressed genes common to all three resistant lines, of which nine hub genes were confirmed using protein-protein interaction network analysis.\",\"target_result\":\"The study identified 54 differentially expressed genes common to all three antiandrogen-resistant cell lines.\",\"number_stated\":true}", "reading": {"parent_value": 54, "unit": "differentially expressed genes", "evidence": "The present study identified 54 differentially expressed genes common to all three resistant lines, of which nine hub genes were confirmed using protein-protein interaction network analysis.", "target_result": "The study identified 54 differentially expressed genes common to all three antiandrogen-resistant cell lines.", "number_stated": true, "source_locator": "chars 823-1013 of source sha256 8a05b23515f6538304a6fdd81d89e7f96b9693dff34298e87670507a10f60369"}, "recorded_at": "2026-10-31T15:15:45.826214+00:00"}, {"provider": "minimax_alt", "model": "MiniMax-M3", "prompt_version": "replication-target-v2", "prompt_hash": "eb46fb0aded3597ff9a3e189beba8154c63626e58c02a4ada8bd31cb7347842d", "source_hash": "8a05b23515f6538304a6fdd81d89e7f96b9693dff34298e87670507a10f60369", "raw_response": "<think>We need answer JSON only. Need identify single numerical result replication registered target headline numerical result paper main finding. Source abstract says identified 54 DEGs common all three, nine hub genes confirmed, MYH11 emerged key gene. Headline numerical result likely 54? Need infer target: \"the headline numerical result the paper itself states for its main finding\". We need number stated for registered target. Could be 54 differentially expressed genes common to all three resistant lines. Need exact contiguous quotation containing number. Unit printed perhaps \"genes\". Evidence quote whole clause, likely \"The present study identified 54 differentially expressed genes common to all three resistant lines, of which nine hub genes were confirmed using protein-protein interaction network analysis.\" Number 54 and unit \"genes\". Headline number perhaps 54. Need target_result state likely \"54 differentially expressed genes common to all three resistant lines\". Exact evidence. Could question be designed to avoid picking nine? \"single numerical result that a replication of the registered target has to reproduce.\" Registered target broad \"headline numerical result paper states for its main finding\". The headline is likely 54 common DEGs. The paper title and abstract focus MYH11, but no numeric result for MYH11 itself. Yet asks \"number the paper itself states for the registered target, not value calculated...\" They likely expect 54 genes. Let's inspect wording: \"Read supplied paper text and find the single numerical result that a replication of the registered target has to reproduce. Report the headline number only: the value the paper itself states for the registered target... REGISTERED TARGET: the headline numerical result the paper states for its main finding\". Main finding numerical result in abstract: 54 DEGs common all three, nine hub genes. Which is \"headline numerical result\"? Maybe 54 as first and key count. They insist unit as printed. So parent_value 54, unit \"differentially expressed genes\" or \"genes\". Evidence exact clause. target_result can describe \"54 differentially expressed genes common to all three resistant lines\". Number_stated true.\n\nNeed ensure valid JSON no markdown.</think>\n\n{\"parent_value\":54,\"unit\":\"differentially expressed genes\",\"evidence\":\"The present study identified 54 differentially expressed genes common to all three resistant lines, of which nine hub genes were confirmed using protein-protein interaction network analysis.\",\"target_result\":\"54 differentially expressed genes common to all three antiandrogen-resistant cell lines\",\"number_stated\":true}", "reading": {"parent_value": 54, "unit": "differentially expressed genes", "evidence": "The present study identified 54 differentially expressed genes common to all three resistant lines, of which nine hub genes were confirmed using protein-protein interaction network analysis.", "target_result": "54 differentially expressed genes common to all three antiandrogen-resistant cell lines", "number_stated": true, "source_locator": "chars 823-1013 of source sha256 8a05b23515f6538304a6fdd81d89e7f96b9693dff34298e87670507a10f60369"}, "recorded_at": "2026-10-31T15:15:45.553918+00:00"}], "agreement": false, "disagreements": {"target_result": {"minimax": "The study identified 54 differentially expressed genes common to all three antiandrogen-resistant cell lines, of which nine hub genes were confirmed using protein-protein interaction network analysis; MYH11 emerged as a key gene associated with prostate cancer progression and patient prognosis.", "minimax_alt": "The present study identified 54 differentially expressed genes common to all three resistant lines, of which nine hub genes were confirmed using protein-protein interaction network analysis. Among these, myosin heavy chain 11 (MYH11) emerged as a key gene associated with both PCa progression and patient prognosis.", "decisive": false}, "physical_methods": {"minimax": ["Functional assays in C4-2 and LNCaP cells", "Protein-protein interaction network analysis"], "minimax_alt": ["Functional assays in C4-2 and LNCaP cells"], "decisive": false}, "analysis_methods": {"minimax": ["RNA-sequencing data analysis", "Gene Expression Profiling Interactive Analysis (GEPIA)", "Disease-free survival assessment using TCGA data", "Protein-protein interaction network analysis"], "minimax_alt": ["RNA-sequencing differential-expression analysis of LNCaP cell lines resistant to bicalutamide, enzalutamide, and apalutamide", "Protein-protein interaction network analysis", "Gene Expression Profiling Interactive Analysis (GEPIA) of patient survival and disease-free survival using TCGA data", "Unpaired, two-tailed Student's t-test for two-group differences", "One-way ANOVA followed by the Scheffe post hoc test for differences among ≥3 groups"], "decisive": false}, "statistical_method": {"minimax": "Unpaired, two-tailed Student's t-test for differences between two groups; one-way ANOVA followed by the Scheffe post hoc test for differences among three or more groups.", "minimax_alt": "", "decisive": true}}, "agreement_basis": {"policy": "decisive_fields", "decisive_fields": ["work_type", "number_stated", "parent_value", "unit"]}, "blinded": true}, "human_critique": {"status": "not_run", "reviewer": null, "signed_at": null, "conflict_checked": false, "commentary": null}, "stages": [{"key": "target_materials", "status": "pending", "reason": null, "evidence": null}, {"key": "independent_readings", "status": "blocked", "reason": "The independent readings are incomplete or disagree; the source evidence must resolve the difference.", "evidence": {"provider_errors": []}}, {"key": "source_resolution", "status": "pending", "reason": null, "evidence": null}, {"key": "protocol_reconstruction", "status": "pending", "reason": null, "evidence": null}, {"key": "control_execution", "status": "pending", "reason": null, "evidence": null}, {"key": "control_comparison", "status": "pending", "reason": null, "evidence": null}, {"key": "publication", "status": "pending", "reason": null, "evidence": null}], "gaps": ["review.human_critique", "review.machine_critique.blocked"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "package:080afe8ea0ed5033960beb8ab19aaecc6b52c0697589f9afef6583965945ffe6", "type": "sep_package", "label": "SEP v1 package for pmid:41467068"}], "activities": [{"id": "activity:conversion:pmid:41467068", "type": "conversion", "used": ["package:080afe8ea0ed5033960beb8ab19aaecc6b52c0697589f9afef6583965945ffe6"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:minimax", "type": "model", "label": "minimax"}, {"id": "agent:minimax_alt", "type": "model", "label": "minimax_alt"}, {"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}], "source_run_id": "run-20261023T122449232913", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "60f41891-83be-4baf-808c-9db7126ddc76", "parent_hash": "080afe8ea0ed5033960beb8ab19aaecc6b52c0697589f9afef6583965945ffe6", "fork_of": null, "generation": 1}, "gaps": ["abstract", "asset:source:pmid:41467068 not verified", "authors", "capability", "corpus_record_absent", "execution.not_run", "method", "review.human_critique", "review.machine_critique.blocked", "step:obtain_source_data blocked on data:not_downloaded", "step:run_analysis blocked on no owned computational capability is bound to this experiment", "step:run_analysis input 'materials:the source data behind the published result in pmid:41467068' does not resolve to a declared asset", "targets"]}