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pmid:41476086

CKAP2, miR-941, miR-548 and LINC02577 as biomarkers for early diagnosis in colorectal cancer.

Scientific reports · 2025 doi:10.1038/s41598-025-30520-5

Paper

partial

Experiment

partial

Data

partial

Analysis

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Execution

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Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
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pmid:41476086
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science-record
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2026-11-01T10:25:54Z
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paper object · 10 fields
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title
CKAP2, miR-941, miR-548 and LINC02577 as biomarkers for early diagnosis in colorectal cancer.
doi
10.1038/s41598-025-30520-5
pmid
41476086
authors
null
journal
Scientific reports
year
2025
abstract
null
claims array · 1 item
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the headline numerical result the paper states for its main finding
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qualitative
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authors
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the headline numerical result the paper states for its main finding
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The number a replication must land on, and the sentence it came from.
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source:pmid:41476086
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the published estimate, its unit and its interval
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the source data with its provenance
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no owned computational capability is bound to this experiment
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Re-run the paper's analysis on the source data and produce the registered result. | SEP input not carried into the asset list: materials:the source data behind the published result in pmid:41476086
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https://doi.org/10.1038/s41598-025-30520-5
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Clinicopathological features of 61 colorectal cancer patients.
structure object · 5 fields
pmcid
PMC12780276
section_index
9
section_title
Sample collection
row_count
27
column_count
3
table object · 8 fields
label
Table 1
caption
Clinicopathological features of 61 colorectal cancer patients.
rows array · 27 items
[0] array · 2 items
[0]
[1]
Patients (%)
[1] array · 2 items
[0]
Age (mean ± SD)
[1]
56 ± 13 years old
[2] array · 2 items
[0]
Size (mean ± SD)
[1]
4.9 ± 2.2 cm
[3] array · 3 items
[0]
Sex
[1]
Male
[2]
30(49.2%)
[4] array · 2 items
[0]
Female
[1]
31(50.8%)
[5] array · 3 items
[0]
Location
[1]
Rectosigmoid
[2]
37(60.7%)
[6] array · 2 items
[0]
Descending
[1]
4(6.6%)
[7] array · 2 items
[0]
Ascending
[1]
17(27.9%)
[8] array · 2 items
[0]
Transverse
[1]
3(4.9%)
[9] array · 3 items
[0]
Grade
[1]
I
[2]
30(49.2%)
[10] array · 2 items
[0]
II
[1]
31(50.8%)
[11] array · 2 items
[0]
III
[1]
0
[12] array · 3 items
[0]
Stage
[1]
I
[2]
13(21.3%)
[13] array · 2 items
[0]
II
[1]
25(41.0%)
[14] array · 2 items
[0]
III
[1]
22(36.1%)
[15] array · 2 items
[0]
IV
[1]
1(1.6%)
[16] array · 3 items
[0]
T
[1]
T1/T2
[2]
15(24.6%)
[17] array · 2 items
[0]
T3
[1]
35(57.4%)
[18] array · 2 items
[0]
T4
[1]
11(18.0%)
[19] array · 3 items
[0]
N
[1]
N0/N1
[2]
56(91.8%)
[20] array · 2 items
[0]
N2/N3
[1]
5(8.2%)
[21] array · 3 items
[0]
Size
[1]
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[2]
32(52.5%)
[22] array · 2 items
[0]
> 5
[1]
29(47.5%)
[23] array · 3 items
[0]
Lymphovascular invasion
[1]
Negative
[2]
45(73.8%)
[24] array · 2 items
[0]
Positive
[1]
16(26.2%)
[25] array · 3 items
[0]
Perineural invasion
[1]
Negative
[2]
51(83.6%)
[26] array · 2 items
[0]
Positive
[1]
10(16.4%)
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section[9]/table-wrap[1]#Tab1
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Primer sequences.
structure object · 5 fields
pmcid
PMC12780276
section_index
10
section_title
Real-Time RT-PCR and statistical analysis
row_count
4
column_count
2
table object · 8 fields
label
Table 2
caption
Primer sequences.
rows array · 4 items
[0] array · 2 items
[0]
Primer
[1]
Sequence
[1] array · 2 items
[0]
LINC00294
[1]
F:TGTGTTGTCCTCCAGAATCGR:CCAACCAAGAGCCAACAAAG
[2] array · 2 items
[0]
LINC02577
[1]
F:GCCGACCTCCTATCTCATCCR:GACTCATCACTCCAACTTCTGC
[3] array · 2 items
[0]
CKAP2
[1]
F :ACCAGTTGGGTCTTTTTGGACR:TCTTCTTTTGGACATCCCTCATT
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section[10]/table-wrap[1]#Tab2
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correlation between clinicopathologic features of 61 CRC patients and gene expression of microRNAs.
structure object · 5 fields
pmcid
PMC12780276
section_index
10
section_title
Real-Time RT-PCR and statistical analysis
row_count
29
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12
table object · 8 fields
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Table 3
caption
correlation between clinicopathologic features of 61 CRC patients and gene expression of microRNAs.
rows array · 29 items
[0] array · 7 items
[0]
[1]
miR-941
[2]
P-value
[3]
Confidence interval
[4]
miR-548
[5]
P-value
[6]
Confidence interval
[1] array · 7 items
[0]
[1]
Downregulated
[2]
Normal
[3]
Upregulated
[4]
Downregulated
[5]
Normal
[6]
Upregulated
[2] array · 12 items
[0]
Age
[1]
Mean
[2]
53 ± 13
[3]
55 ± 14
[4]
60 ± 11
[5]
[6]
[7]
59 ± 14
[8]
54 ± 12
[9]
54 ± 12
[10]
[11]
[3] array · 12 items
[0]
Size
[1]
Mean
[2]
5.2 ± 2.1
[3]
4.4 ± 1.6
[4]
4.7 ± 2.6
[5]
P = 0.018*
[6]
[0.613–6.367]
[7]
4.7 ± 2.3
[8]
5.0 ± 2.7
[9]
5.0 ± 1.8
[10]
P = 0.040**
[11]
[0.073–5.102]
[4] array · 12 items
[0]
Age
[1]
< 50
[2]
14 (70.0%)
[3]
2(10.0%)
[4]
4(20.0%)
[5]
[6]
[7]
7(35.0%)
[8]
6(30.0%)
[9]
7(35.0%)
[10]
[11]
[5] array · 7 items
[0]
> 50
[1]
13 (31.7%)
[2]
7 (17.1%)
[3]
21 (51.2%)
[4]
16 (39.0%)
[5]
11 (26.8%)
[6]
14 (34.1%)
[6] array · 12 items
[0]
Gender
[1]
Male
[2]
10 (33.3%)
[3]
6 (20.0%)
[4]
14 (46.7%)
[5]
[6]
[7]
13 (43.3%)
[8]
10 (33.3%)
[9]
7 (23.3%)
[10]
[11]
[7] array · 7 items
[0]
Female
[1]
17 (54.8%)
[2]
3 (9.7%)
[3]
11 (35.5%)
[4]
10 (32.3%)
[5]
7 (22.6%)
[6]
14 (45.2%)
[8] array · 12 items
[0]
Location
[1]
Rectosigmoid
[2]
16 (43.2%)
[3]
3 (8.1%)
[4]
18 (48.6%)
[5]
[6]
[7]
13 (35.1%)
[8]
8 (21.6%)
[9]
16 (43.2%)
[10]
[11]
[9] array · 7 items
[0]
Descending
[1]
1 (25.0%)
[2]
2 (50.0%)
[3]
1 (25.0%)
[4]
2 (50.0%)
[5]
1 (25.0%)
[6]
1 (25.0%)
[10] array · 7 items
[0]
Ascending
[1]
8 (47.1%)
[2]
3 (17.6%)
[3]
6 (35.3%)
[4]
6 (35.3%)
[5]
7 (41.2%)
[6]
4 (23.5%)
[11] array · 7 items
[0]
Transverse
[1]
2 (66.7%)
[2]
1 (33.3%)
[3]
0
[4]
2 (66.7%)
[5]
1 (33.3%)
[6]
0 (0.0%)
[12] array · 12 items
[0]
Grade
[1]
I
[2]
13 (43.3%)
[3]
5 (16.7%)
[4]
12 (40.0%)
[5]
P = 0.028**
[6]
[-10.1 – (-0.474)]
[7]
13 (43.3%)
[8]
8 (26.7%)
[9]
9 (30.0%)
[10]
[11]
[13] array · 7 items
[0]
II
[1]
14 (45.2%)
[2]
4 (12.9%)
[3]
13 (41.9%)
[4]
10 (32.3%)
[5]
9 (29.0%)
[6]
12 (38.7%)
[14] array · 12 items
[0]
Stage
[1]
I
[2]
7 (53.8%)
[3]
1 (7.7%)
[4]
5 (38.5%)
[5]
[6]
[7]
7 (53.8%)
[8]
2 (15.4%)
[9]
4 (30.8%)
[10]
[11]
[15] array · 7 items
[0]
II
[1]
10 (40.0%)
[2]
5 (20.0%)
[3]
10 (40.0%)
[4]
6 (24.0%)
[5]
8 (32.0%)
[6]
11 (44.0%)
[16] array · 7 items
[0]
III
[1]
10 (45.5%)
[2]
3 (13.6%)
[3]
9 (40.9%)
[4]
10 (45.5%)
[5]
6 (27.3%)
[6]
6 (27.3%)
[17] array · 9 items
[0]
IV
[1]
0
[2]
0
[3]
1 (100.0%)
[4]
[5]
0
[6]
1 (100.0%)
[7]
0
[8]
[18] array · 12 items
[0]
T
[1]
T1/T2
[2]
9 (60.0%)
[3]
1 (6.7%)
[4]
5 (33.3%)
[5]
P = 0.043**
[6]
[0.311–13.052]
[7]
9 (60.0%)
[8]
2 (13.3%)
[9]
4 (26.7%)
[10]
P = 0.044****
[11]
[19] array · 7 items
[0]
T3
[1]
14 (40.0%)
[2]
7(20.0%)
[3]
14 (40.0%)
[4]
12 (34.3%)
[5]
11 (31.4%)
[6]
12 (34.3%)
[20] array · 7 items
[0]
T4
[1]
4 (36.4%)
[2]
1 (9.1%)
[3]
6 (54.5%)
[4]
2 (18.2%)
[5]
4 (36.4%)
[6]
5 (45.5%)
[21] array · 12 items
[0]
N
[1]
N0/N1
[2]
26 (46.4%)
[3]
8 (14.3%)
[4]
22 (39.3%)
[5]
[6]
[7]
21 (37.5%)
[8]
15 (26.8%)
[9]
20 (35.7%)
[10]
P = 0.033***
[11]
[22] array · 7 items
[0]
N2/N3
[1]
1 (20.0%)
[2]
1 (20.0%)
[3]
3 (60.0%)
[4]
2 (40.0%)
[5]
2 (40.0%)
[6]
1 (20.0%)
[23] array · 12 items
[0]
Size
[1]
< 5
[2]
11 (34.4%)
[3]
4 (12.5%)
[4]
17 (53.1%)
[5]
[6]
[7]
13 (40.6%)
[8]
7 (21.9%)
[9]
12 (37.5%)
[10]
[11]
[24] array · 7 items
[0]
> 5
[1]
16 (55.2%)
[2]
5 (17.2%)
[3]
8 (27.6%)
[4]
10 (34.5%)
[5]
10 (34.5%)
[6]
9 (31.0%)
[25] array · 12 items
[0]
Perineural invasion
[1]
Negative
[2]
21 (41.2%)
[3]
6 (11.8%)
[4]
24 (47.1%)
[5]
[6]
[7]
21 (41.2%)
[8]
13 (25.5%)
[9]
17 (33.3%)
[10]
[11]
[26] array · 7 items
[0]
Positive
[1]
6 (60.0%)
[2]
3 (30.0%)
[3]
1 (10.0%)
[4]
2 (20.0%)
[5]
4 (40.0%)
[6]
4 (40.0%)
[27] array · 12 items
[0]
Lymphovascular invasion
[1]
Negative
[2]
21 (46.7%)
[3]
7 (15.6%)
[4]
17 (37.8%)
[5]
[6]
[7]
18 (40.0%)
[8]
11 (24.4%)
[9]
16 (35.6%)
[10]
[11]
[28] array · 7 items
[0]
Positive
[1]
6 (37.5%)
[2]
2 (12.5%)
[3]
8 (50.0%)
[4]
5 (31.3%)
[5]
6 (37.5%)
[6]
5 (31.3%)
locator
section[10]/table-wrap[2]#Tab3
[4] object · 16 fields
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asset:table:pmid:41476086:4
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correlation between clinicopathologic features of 61 CRC patients and gene expression of CKAP2, LINC00294 and LINC02577
structure object · 5 fields
pmcid
PMC12780276
section_index
17
section_title
Association between genes and clinicopathological features
row_count
29
column_count
15
table object · 8 fields
label
Table 4
caption
correlation between clinicopathologic features of 61 CRC patients and gene expression of CKAP2, LINC00294 and LINC02577
rows array · 29 items
[0] array · 8 items
[0]
[1]
CKAP2
[2]
P-value
[3]
Confidence interval
[4]
LINC02577
[5]
P-value
[6]
Confidence interval
[7]
LINC00294
[1] array · 10 items
[0]
[1]
Downregulated
[2]
Normal
[3]
Upregulated
[4]
Downregulated
[5]
Normal
[6]
Upregulated
[7]
Downregulated
[8]
Normal
[9]
Upregulated
[2] array · 15 items
[0]
Age
[1]
Mean
[2]
61 ± 14
[3]
56 ± 14
[4]
54 ± 11
[5]
[6]
[7]
57 ± 14
[8]
58 ± 14
[9]
54 ± 12
[10]
[11]
[12]
60 ± 12
[13]
54 ± 13
[14]
55 ± 13
[3] array · 15 items
[0]
Size
[1]
Mean
[2]
4.3 ± 1.4
[3]
4.8 ± 2
[4]
5.4 ± 2.9
[5]
P = 0.025***
[6]
[7]
4.5 ± 2.4
[8]
5.0 ± 2.2
[9]
5.2 ± 2.2
[10]
[11]
[12]
5.5 ± 3.2
[13]
4.7 ± 2
[14]
4.7 ± 1.3
[4] array · 15 items
[0]
Age
[1]
< 50
[2]
2(10.0%)
[3]
9(45.0%)
[4]
9(45.0%)
[5]
[6]
[7]
7(35.0%)
[8]
3(15.0%)
[9]
10(50.0%)
[10]
[11]
[12]
4(20.0%)
[13]
11(55.0%)
[14]
5(25.0%)
[5] array · 10 items
[0]
> 50
[1]
8(19.5%)
[2]
23(56.1%)
[3]
10(24.4%)
[4]
11(26.8%)
[5]
13(31.7%)
[6]
17(41.5%)
[7]
13(31.7%)
[8]
17(41.5%)
[9]
11(26.8%)
[6] array · 15 items
[0]
Gender
[1]
Male
[2]
6(20.0%)
[3]
12(40.0%)
[4]
12(40.0%)
[5]
[6]
[7]
10(33.3%)
[8]
8(26.7%)
[9]
12(40.0%)
[10]
[11]
[12]
9(30.0%)
[13]
14(46.7%)
[14]
7(23.3%)
[7] array · 10 items
[0]
Female
[1]
4(12.9%)
[2]
20(64.5%)
[3]
7(22.6%)
[4]
8(25.8%)
[5]
8(25.8%)
[6]
15(48.4%)
[7]
8(25.8%)
[8]
14(45.2%)
[9]
9(29.0%)
[8] array · 15 items
[0]
Location
[1]
Rectosigmoid
[2]
8(21.6%)
[3]
21(56.8%)
[4]
8(21.6%)
[5]
[6]
[7]
11(29.7%)
[8]
8(21.6%)
[9]
18(48.6%)
[10]
[11]
[12]
10(27.0%)
[13]
17(45.9%)
[14]
10(27.0%)
[9] array · 10 items
[0]
Descending
[1]
1(25.0%)
[2]
2(50.0%)
[3]
1(25.0%)
[4]
1(25.0%)
[5]
0
[6]
3(75.0%)
[7]
1(25.0%)
[8]
3(75.0%)
[9]
0
[10] array · 10 items
[0]
Ascending
[1]
1(5.9%)
[2]
6(35.3%)
[3]
10(58.8%)
[4]
6(35.3%)
[5]
6(35.3%)
[6]
5(29.4%)
[7]
6(35.3%)
[8]
6(35.3%)
[9]
5(29.4%)
[11] array · 10 items
[0]
Transverse
[1]
0
[2]
3(100%)
[3]
0
[4]
0
[5]
2(66.6%)
[6]
1(33.3%)
[7]
0
[8]
2(66.6%)
[9]
1(33.3%)
[12] array · 15 items
[0]
Grade
[1]
I
[2]
9(30.0%)
[3]
13(43.3%)
[4]
8(26.7%)
[5]
[6]
[7]
8(26.7%)
[8]
8(26.7%)
[9]
14(46.7%)
[10]
[11]
[12]
8(26.7%)
[13]
15(50.0%)
[14]
7(23.3%)
[13] array · 10 items
[0]
II
[1]
1(3.2%)
[2]
19(61.3%)
[3]
11(35.5%)
[4]
10(32.3%)
[5]
8(25.8%)
[6]
13(41.9%)
[7]
9(29.0%)
[8]
13(41.9%)
[9]
9(29.0%)
[14] array · 15 items
[0]
Stage
[1]
I
[2]
2(15.4%)
[3]
7(53.8%)
[4]
4(30.8%)
[5]
[6]
[7]
3(23.1%)
[8]
5(38.5%)
[9]
5(38.5%)
[10]
P = 0.028*
[11]
[0.349- 5.527]
[12]
3(23.1%)
[13]
6(46.2%)
[14]
4(30.8%)
[15] array · 10 items
[0]
II
[1]
4(16.0%)
[2]
15(60.0%)
[3]
6(24.0%)
[4]
6(24.0%)
[5]
7(28.0%)
[6]
12(48.0%)
[7]
8(32.0%)
[8]
13(52.0%)
[9]
4(16.0%)
[16] array · 10 items
[0]
III
[1]
4(18.2%)
[2]
10(45.5%)
[3]
8(36.4%)
[4]
9(40.9%)
[5]
4(18.2%)
[6]
9(40.9%)
[7]
5(22.7%)
[8]
9(40.9%)
[9]
8(36.4%)
[17] array · 10 items
[0]
IV
[1]
0
[2]
0
[3]
1(100.0%)
[4]
0
[5]
0
[6]
1(100.0%)
[7]
1(100.0%)
[8]
0
[9]
0
[18] array · 15 items
[0]
T
[1]
T1/T2
[2]
3(20.0%)
[3]
8(53.3%)
[4]
4(26.7%)
[5]
P = 0.005**
[6]
[-2.777 – (-0.478)]
[7]
4(26.7%)
[8]
6(40.0%)
[9]
5(33.3%)
[10]
P = 0.035**
[11]
[-7.755 – (-0.275)]
[12]
5(33.3%)
[13]
6(40.0%)
[14]
4(26.7%)
[19] array · 10 items
[0]
T3
[1]
3(8.6%)
[2]
19(54.3%)
[3]
13(37.1%)
[4]
8(22.9%)
[5]
9(25.7%)
[6]
18(51.4%)
[7]
8(22.9%)
[8]
17(48.6%)
[9]
10(28.6%)
[20] array · 10 items
[0]
T4
[1]
4(36.4%)
[2]
5(45.5%)
[3]
2(18.2%)
[4]
6(54.5%)
[5]
1(9.1%)
[6]
4(36.4%)
[7]
4(36.4%)
[8]
5(45.5%)
[9]
2(18.2%)
[21] array · 15 items
[0]
N
[1]
N0/N1
[2]
8(14.3%)
[3]
30(53.6%)
[4]
18(32.1%)
[5]
[6]
[7]
16(28.6%)
[8]
16(28.6%)
[9]
24(42.9%)
[10]
P = 0.028*
[11]
[-5.527 –(-0.349)]
[12]
15(26.8%)
[13]
26(46.4%)
[14]
15(26.8%)
[22] array · 10 items
[0]
N2/N3
[1]
2(40.0%)
[2]
2(40.0%)
[3]
1(20.0%)
[4]
2(40.0%)
[5]
0
[6]
3(60.0%)
[7]
2(40.0%)
[8]
2(40.0%)
[9]
1(20.0%)
[23] array · 15 items
[0]
Size
[1]
< 5
[2]
8(25.0%)
[3]
15(46.9%)
[4]
9(28.1%)
[5]
[6]
[7]
10(31.3%)
[8]
8(25.0%)
[9]
14(43.8%)
[10]
[11]
[12]
8(25.0%)
[13]
16(50.0%)
[14]
8(25.0%)
[24] array · 10 items
[0]
> 5
[1]
2(6.9%)
[2]
17(58.6%)
[3]
10(34.5%)
[4]
8(27.6%)
[5]
8(27.6%)
[6]
13(44.8%)
[7]
9(31.0%)
[8]
12(41.4%)
[9]
8(27.6%)
[25] array · 15 items
[0]
Perineural invasion
[1]
Negative
[2]
10(19.6%)
[3]
25(49.0%)
[4]
16(31.4%)
[5]
[6]
[7]
15(29.4%)
[8]
15(29.4%)
[9]
21(41.2%)
[10]
[11]
[12]
15(29.4%)
[13]
22(43.1%)
[14]
14(27.5%)
[26] array · 11 items
[0]
Positive
[1]
0
[2]
7(70.0%)
[3]
3(30.0%)
[4]
3(30.0%)
[5]
1(10.0%)
[6]
6(60.0%)
[7]
[8]
2(20.0%)
[9]
6(60.0%)
[10]
2(20.0%)
[27] array · 15 items
[0]
Lymphovascular invasion
[1]
Negative
[2]
9(20.0%)
[3]
20(44.4%)
[4]
16(35.6%)
[5]
[6]
[7]
13(28.9%)
[8]
10(22.2%)
[9]
22(48.9%)
[10]
[11]
[12]
12(26.7%)
[13]
19(42.2%)
[14]
14(31.1%)
[28] array · 10 items
[0]
Positive
[1]
1(6.3%)
[2]
12(75.0%)
[3]
3(18.8%)
[4]
5(31.3%)
[5]
6(37.5%)
[6]
5(31.3%)
[7]
5(31.3%)
[8]
9(56.3%)
[9]
2(12.5%)
locator
section[17]/table-wrap[1]#Tab4
gaps array · 1 item
[0]
asset:source:pmid:41476086 not verified
analysis object · 4 fields
state
absent
methods array · 0 items
targets array · 0 items
gaps array · 2 items
[0]
method
[1]
targets
capability object · 3 fields
state
absent
requirements array · 0 items
gaps array · 1 item
[0]
capability
readiness object · 8 fields
state
partial
tier
null
blocked_on
null
axes object · 0 fields
can_run object · 3 fields
dsl_operations array · 0 items
assets array · 5 items
[0]
source:pmid:41476086
[1]
asset:table:pmid:41476086:1
[2]
asset:table:pmid:41476086:2
[3]
asset:table:pmid:41476086:3
[4]
asset:table:pmid:41476086:4
steps array · 1 item
[0]
read_published_estimate
must_build object · 5 fields
dsl_operations array · 0 items
converters array · 0 items
readers array · 1 item
[0]
xml
capabilities array · 0 items
data_gaps array · 1 item
[0]
source:pmid:41476086
gaps array · 1 item
[0]
corpus_record_absent
review object · 5 fields
state
partial
machine_critique object · 7 fields
status
blocked
providers array · 0 items
target_providers array · 0 items
agreement
false
disagreements array · 0 items
agreement_basis object · 2 fields
policy
decisive_fields
decisive_fields array · 4 items
[0]
work_type
[1]
number_stated
[2]
parent_value
[3]
unit
blinded
true
human_critique object · 5 fields
status
not_run
reviewer
null
signed_at
null
conflict_checked
false
commentary
null
stages array · 7 items
[0] object · 4 fields
key
target_materials
status
pending
reason
null
evidence
null
[1] object · 4 fields
key
independent_readings
status
blocked
reason
The independent readings are incomplete or disagree; the source evidence must resolve the difference.
evidence object · 1 field
provider_errors array · 4 items
[0] object · 4 fields
provider
minimax
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[1] object · 4 fields
provider
minimax_alt
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[2] object · 4 fields
provider
minimax
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[3] object · 4 fields
provider
minimax_alt
model
null
reason
HTTP Error 429: Too Many Requests
raw_response
null
[2] object · 4 fields
key
source_resolution
status
pending
reason
null
evidence
null
[3] object · 4 fields
key
protocol_reconstruction
status
pending
reason
null
evidence
null
[4] object · 4 fields
key
control_execution
status
pending
reason
null
evidence
null
[5] object · 4 fields
key
control_comparison
status
pending
reason
null
evidence
null
[6] object · 4 fields
key
publication
status
pending
reason
null
evidence
null
gaps array · 3 items
[0]
review.human_critique
[1]
review.machine_critique.blocked
[2]
review.machine_critique.providers
execution object · 5 fields
state
absent
status
not_run
mode
null
runs array · 0 items
gaps array · 1 item
[0]
execution.not_run
provenance object · 7 fields
entities array · 1 item
[0] object · 3 fields
id
package:12cd584e56091f86fc75445c14bfa36d83a57cb885f62614c55c598e9ccf7270
type
sep_package
label
SEP v1 package for pmid:41476086
activities array · 1 item
[0] object · 4 fields
id
activity:conversion:pmid:41476086
type
conversion
used array · 1 item
[0]
package:12cd584e56091f86fc75445c14bfa36d83a57cb885f62614c55c598e9ccf7270
agent
agent:corpus-assay-engine
agents array · 1 item
[0] object · 3 fields
id
agent:corpus-assay-engine
type
software
label
Corpus assay engine
source_run_id
run-20261023T122449232913
dsl_catalogue_fingerprint
343fb30756ba6ec3
capability_table_fingerprint
2cb3e42f047d2ecf
snapshot_id
ba34b49490d9bfaf
lineage object · 4 fields
parent_id
pmid:41476086
parent_hash
sha256:0e41189685119dad0149f077fcfc704ba0b594f1cee728bdc7bfaedf33d990cc
fork_of
null
gaps array · 14 items
[0]
abstract
[1]
asset:source:pmid:41476086 not verified
[2]
authors
[3]
capability
[4]
corpus_record_absent
[5]
execution.not_run
[6]
method
[7]
review.human_critique
[8]
review.machine_critique.blocked
[9]
review.machine_critique.providers
[10]
step:obtain_source_data blocked on data:not_downloaded
[11]
step:run_analysis blocked on no owned computational capability is bound to this experiment
[12]
step:run_analysis input 'materials:the source data behind the published result in pmid:41476086' does not resolve to a declared asset
[13]
targets
Complete file
{"sci_version": "1.0", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:41476086", "kind": "science-record", "revision": 2, "content_hash": "sha256:cbd69f80308ecc53dc4f8523915bbf2dbf5e77ca3681ec0121bab42bb0b54ba2", "created_at": "2026-11-01T10:25:54Z", "updated_at": "2026-11-01T14:01:53Z", "generator": {"name": "corpus-assay-engine", "converter": "sep_to_sci_v1", "source_package_schema": "urn:bntrg:sep:1.0.0"}, "paper": {"state": "partial", "title": "CKAP2, miR-941, miR-548 and LINC02577 as biomarkers for early diagnosis in colorectal cancer.", "doi": "10.1038/s41598-025-30520-5", "pmid": "41476086", "authors": null, "journal": "Scientific reports", "year": 2025, "abstract": null, "claims": [{"id": "claim-1", "statement": "the headline numerical result the paper states for its main finding", "kind": "qualitative", "state": "blocked", "target": {"value": null, "unit": null, "tolerance": null, "source": null}, "evidence": []}], "gaps": ["abstract", "authors"]}, "experiment": {"state": "partial", "objective": "the headline numerical result the paper states for its main finding", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate and its interval from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The number a replication must land on, and the sentence it came from.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:41476086"], "outputs": ["the published estimate, its unit and its interval"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data behind the published result", "kind": "data-preparation", "state": "blocked", "blocked_on": "data:not_downloaded", "description": "The published result cannot be recomputed without the data the paper analysed.", "duration_hours": null, "parameters": {}, "inputs": [], "outputs": ["the source data with its provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the analysis programme", "kind": "analysis", "state": "blocked", "blocked_on": "no owned computational capability is bound to this experiment", "description": "Re-run the paper's analysis on the source data and produce the registered result. | SEP input not carried into the asset list: materials:the source data behind the published result in pmid:41476086", "duration_hours": null, "parameters": {}, "inputs": [], "outputs": ["the registered result"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": ["step:obtain_source_data blocked on data:not_downloaded", "step:run_analysis blocked on no owned computational capability is bound to this experiment", "step:run_analysis input 'materials:the source data behind the published result in pmid:41476086' does not resolve to a declared asset"]}, "data": {"state": "partial", "assets": [{"id": "source:pmid:41476086", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.1038/s41598-025-30520-5", "sha256": "sha256:64d45aace3873fca3c8ce8963a633dff7b9041e5021fc6fa5f24272240858793", "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.1038/s41598-025-30520-5", "version": null, "note": "Source read by the package builder: full_text.", "structure": {"access_state": "full_text"}}, {"id": "asset:table:pmid:41476086:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:b3bf238e6ea80f5a902a0f379ab0dd786b89c792922a5d48161d938abeaaef0d", "bytes": 922, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[9]/table-wrap[1]#Tab1", "version": null, "note": "Clinicopathological features of 61 colorectal cancer patients.", "structure": {"pmcid": "PMC12780276", "section_index": 9, "section_title": "Sample collection", "row_count": 27, "column_count": 3}, "table": {"label": "Table 1", "caption": "Clinicopathological features of 61 colorectal cancer patients.", "rows": [["", "Patients (%)"], ["Age (mean ± SD)", "56 ± 13 years old"], ["Size (mean ± SD)", "4.9 ± 2.2 cm"], ["Sex", "Male", "30(49.2%)"], ["Female", "31(50.8%)"], ["Location", "Rectosigmoid", "37(60.7%)"], ["Descending", "4(6.6%)"], ["Ascending", "17(27.9%)"], ["Transverse", "3(4.9%)"], ["Grade", "I", "30(49.2%)"], ["II", "31(50.8%)"], ["III", "0"], ["Stage", "I", "13(21.3%)"], ["II", "25(41.0%)"], ["III", "22(36.1%)"], ["IV", "1(1.6%)"], ["T", "T1/T2", "15(24.6%)"], ["T3", "35(57.4%)"], ["T4", "11(18.0%)"], ["N", "N0/N1", "56(91.8%)"], ["N2/N3", "5(8.2%)"], ["Size", "< 5", "32(52.5%)"], ["> 5", "29(47.5%)"], ["Lymphovascular invasion", "Negative", "45(73.8%)"], ["Positive", "16(26.2%)"], ["Perineural invasion", "Negative", "51(83.6%)"], ["Positive", "10(16.4%)"]], "row_count": 27, "column_count": 3, "numeric_cells": 28, "header_rows": 1, "locator": "section[9]/table-wrap[1]#Tab1"}}, {"id": "asset:table:pmid:41476086:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:bbb1a514344fc229eadecc4879ce1e4e24c8df3e7b37dfbecb0d8018fa7863c8", "bytes": 374, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[10]/table-wrap[1]#Tab2", "version": null, "note": "Primer sequences.", "structure": {"pmcid": "PMC12780276", "section_index": 10, "section_title": "Real-Time RT-PCR and statistical analysis", "row_count": 4, "column_count": 2}, "table": {"label": "Table 2", "caption": "Primer sequences.", "rows": [["Primer", "Sequence"], ["LINC00294", "F:TGTGTTGTCCTCCAGAATCGR:CCAACCAAGAGCCAACAAAG"], ["LINC02577", "F:GCCGACCTCCTATCTCATCCR:GACTCATCACTCCAACTTCTGC"], ["CKAP2", "F :ACCAGTTGGGTCTTTTTGGACR:TCTTCTTTTGGACATCCCTCATT"]], "row_count": 4, "column_count": 2, "numeric_cells": 2, "header_rows": 1, "locator": "section[10]/table-wrap[1]#Tab2"}}, {"id": "asset:table:pmid:41476086:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:2226bd8c5954da594fe12a16bed1444e6ee237217b36b11f4f933f6cd877859d", "bytes": 3047, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[10]/table-wrap[2]#Tab3", "version": null, "note": "correlation between clinicopathologic features of 61 CRC patients and gene expression of microRNAs.", "structure": {"pmcid": "PMC12780276", "section_index": 10, "section_title": "Real-Time RT-PCR and statistical analysis", "row_count": 29, "column_count": 12}, "table": {"label": "Table 3", "caption": "correlation between clinicopathologic features of 61 CRC patients and gene expression of microRNAs.", "rows": [["", "miR-941", "P-value", "Confidence interval", "miR-548", "P-value", "Confidence interval"], ["", "Downregulated", "Normal", "Upregulated", "Downregulated", "Normal", "Upregulated"], ["Age", "Mean", "53 ± 13", "55 ± 14", "60 ± 11", "", "", "59 ± 14", "54 ± 12", "54 ± 12", "", ""], ["Size", "Mean", "5.2 ± 2.1", "4.4 ± 1.6", "4.7 ± 2.6", "P = 0.018*", "[0.613–6.367]", "4.7 ± 2.3", "5.0 ± 2.7", "5.0 ± 1.8", "P = 0.040**", "[0.073–5.102]"], ["Age", "< 50", "14 (70.0%)", "2(10.0%)", "4(20.0%)", "", "", "7(35.0%)", "6(30.0%)", "7(35.0%)", "", ""], ["> 50", "13 (31.7%)", "7 (17.1%)", "21 (51.2%)", "16 (39.0%)", "11 (26.8%)", "14 (34.1%)"], ["Gender", "Male", "10 (33.3%)", "6 (20.0%)", "14 (46.7%)", "", "", "13 (43.3%)", "10 (33.3%)", "7 (23.3%)", "", ""], ["Female", "17 (54.8%)", "3 (9.7%)", "11 (35.5%)", "10 (32.3%)", "7 (22.6%)", "14 (45.2%)"], ["Location", "Rectosigmoid", "16 (43.2%)", "3 (8.1%)", "18 (48.6%)", "", "", "13 (35.1%)", "8 (21.6%)", "16 (43.2%)", "", ""], ["Descending", "1 (25.0%)", "2 (50.0%)", "1 (25.0%)", "2 (50.0%)", "1 (25.0%)", "1 (25.0%)"], 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