A metabolomics study reveals potential plasma biomarkers for predicting post-infarction left ventricular remodeling: findings from the metabolights database.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:41480425", "kind": "science-record", "revision": 4, "content_hash": "sha256:c9e8f35aabd279fc2bf07a56dc9735fcab9a044049140b5618f1d8de474c993b", "created_at": "2026-11-01T20:31:27Z", "updated_at": "2026-11-01T22:57:40Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "A metabolomics study reveals potential plasma biomarkers for predicting post-infarction left ventricular remodeling: findings from the metabolights database.", "doi": "10.3389/fcvm.2025.1723330", "pmid": "41480425", "authors": ["Daqiu Chen", "Yanqing Wu", "Zhanxiong Xie", "Jing Li", "Shunxiang Luo", "Shanghua Xu"], "journal": "Frontiers in cardiovascular medicine", "year": 2025, "abstract": "Background: Left ventricular remodeling (LVR) after ST-segment elevation myocardial infarction (STEMI) is a major determinant of adverse prognosis, yet reliable early biomarkers remain limited.\nMethods: This secondary analysis of publicly available metabolomic data from the MetaboLights database aimed to explore metabolic signatures associated with left ventricular remodeling (LVR) following STEMI patients. Key differential metabolites were identified through an integrated approach combining multivariate screening (PLS-DA with VIP >1.0) and univariate validation (Log2FC, FDR, Cohen's d). The robustness of principal findings was further verified by bootstrap resampling. These metabolites subsequently underwent comprehensive evaluation through univariate testing, ROC analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment.\nResults: Exploratory analysis revealed distinct differences in plasma metabolic profiles between patients with and without LVR. Notably, levels of threonine, glycine, and histidine were observed to be lower in the LVR group, with their respective AUCs of 0.785, 0.748, and 0.745 suggesting potential predictive value. Pathway analysis suggested an enrichment of these metabolites in processes such as amino acid metabolism and energy regulation, which might be linked to disruptions in oxidative stress, inflammatory, and fibrotic pathways.\nConclusions: In summary, our preliminary findings suggest that threonine, glycine, and histidine may merit further investigation as potential biomarkers for post-STEMI LVR, and their association with key pathophysiological pathways hints at possible mechanistic roles. Given the absence of clinical and demographic data, combined with the small and imbalanced sample (6 LVR vs. 55 Non-LVR patients), our findings should be interpreted as exploratory and hypothesis-generating. Their clinical predictive utility requires validation in larger, independent prospective cohorts.", "claims": [{"id": "claim-method", "statement": "Intergroup differences were assessed using the Wilcoxon rank-sum test, with p-values adjusted for multiple comparisons via the Benjamini-Hochberg false discovery rate (FDR).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:41480425", "locator": "sections[8] \"Statistical analysis and metabolite screening\" paragraph 4", "quote": "Intergroup differences were assessed using the Wilcoxon rank-sum test, with p-values adjusted for multiple comparisons via the Benjamini-Hochberg false discovery rate (FDR)."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets presented in this study can be found in online repositories. 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The names of the repository/repositories and accession number(s) can be found in the article/Supplementary Material."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Lower plasma levels of threonine, glycine, and histidine distinguished patients with post-STEMI left ventricular remodeling and showed potential predictive value.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:41480425", "locator": "sections[0] \"Abstract\" paragraph 3", "quote": "Exploratory analysis revealed distinct differences in plasma metabolic profiles between patients with and without LVR."}, {"asset": "source:pmid:41480425", "locator": "sections[0] \"Abstract\" paragraph 3", "quote": "Notably, levels of threonine, glycine, and histidine were observed to be lower in the LVR group, with their respective AUCs of 0.785, 0.748, and 0.745 suggesting potential predictive value."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "partial", "objective": "Lower plasma levels of threonine, glycine, and histidine distinguished patients with post-STEMI left ventricular remodeling and showed potential predictive value.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:41480425"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "blocked", "blocked_on": "data:accession_absent", "description": "The GEO series accession resolves and its sample accessions are listed. 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