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pmid:34218797

Identification of candidate biomarkers and therapeutic agents for heart failure by bioinformatics analysis.

Vijayakrishna Kolur · Basavaraj Vastrad · Chanabasayya Vastrad · Shivakumar Kotturshetti · Anandkumar Tengli

BMC cardiovascular disorders · 2021 doi:10.1186/s12872-021-02146-8

Paper

complete

Experiment

partial

Data

partial

Analysis

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pmid:34218797

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science-record

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https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json

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2026-11-01T15:41:41Z

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2026-11-01T22:47:00Z

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paper object · 10 fields

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title

Identification of candidate biomarkers and therapeutic agents for heart failure by bioinformatics analysis.

doi

10.1186/s12872-021-02146-8

pmid

34218797

authors array · 5 items

[0]

Vijayakrishna Kolur

[1]

Basavaraj Vastrad

[2]

Chanabasayya Vastrad

[3]

Shivakumar Kotturshetti

[4]

Anandkumar Tengli

journal

BMC cardiovascular disorders

year

2021

abstract

INTRODUCTION: Heart failure (HF) is a heterogeneous clinical syndrome and affects millions of people all over the world. HF occurs when the cardiac overload and injury, which is a worldwide complaint. The aim of this study was to screen and verify hub genes involved in developmental HF as well as to explore active drug molecules. METHODS: The expression profiling by high throughput sequencing of GSE141910 dataset was downloaded from the Gene Expression Omnibus (GEO) database, which contained 366 samples, including 200 heart failure samples and 166 non heart failure samples. The raw data was integrated to find differentially expressed genes (DEGs) and were further analyzed with bioinformatics analysis. Gene ontology (GO) and REACTOME enrichment analyses were performed via ToppGene; protein-protein interaction (PPI) networks of the DEGs was constructed based on data from the HiPPIE interactome database; modules analysis was performed; target gene-miRNA regulatory network and target gene-TF regulatory network were constructed and analyzed; hub genes were validated; molecular docking studies was performed. RESULTS: A total of 881 DEGs, including 442 up regulated genes and 439 down regulated genes were observed. Most of the DEGs were significantly enriched in biological adhesion, extracellular matrix, signaling receptor binding, secretion, intrinsic component of plasma membrane, signaling receptor activity, extracellular matrix organization and neutrophil degranulation. The top hub genes ESR1, PYHIN1, PPP2R2B, LCK, TP63, PCLAF, CFTR, TK1, ECT2 and FKBP5 were identified from the PPI network. Module analysis revealed that HF was associated with adaptive immune system and neutrophil degranulation. The target genes, miRNAs and TFs were identified from the target gene-miRNA regulatory network and target gene-TF regulatory network. Furthermore, receiver operating characteristic (ROC) curve analysis and RT-PCR analysis revealed that ESR1, PYHIN1, PPP2R2B, LCK, TP63, PCLAF, CFTR, TK1, ECT2 and FKBP5 might serve as prognostic, diagnostic biomarkers and therapeutic target for HF. The predicted targets of these active molecules were then confirmed. CONCLUSION: The current investigation identified a series of key genes and pathways that might be involved in the progression of HF, providing a new understanding of the underlying molecular mechanisms of HF.

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DEGs of dataset GSE141910 between HF groups and non heart failure groups were respectively analyzed using the limma package in R [21].

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sections[4] "Identification of DEGs in HF" paragraph 2

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DEGs of dataset GSE141910 between HF groups and non heart failure groups were respectively analyzed using the limma package in R [21].

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The enriched GO terms of the up and down regulated differentially expressed genes

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PMC8256614

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Functional enrichment analysis

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Table 2

caption

The enriched GO terms of the up and down regulated differentially expressed genes

rows array · 15 items

[0] array · 9 items

[0]

GO ID

[1]

CATEGORY

[2]

GO Name

[3]

P Value

[4]

FDR B&H

[5]

FDR B&Y

[6]

Bonferroni

[7]

Gene Count

[8]

Gene

[1] array · 1 item

[0]

Up regulated genes

[2] array · 9 items

[0]

GO:0022610

[1]

[2]

biological adhesion

[3]

1.32E−13

[4]

3.37E−10

[5]

3.08E−09

[6]

6.75E−10

[7]

[8]

[3] array · 9 items

[0]

GO:0002682

[1]

[2]

regulation of immune system process

[3]

2.20E−10

[4]

2.25E−07

[5]

2.05E−06

[6]

1.12E−06

[7]

[8]

[4] array · 9 items

[0]

GO:0031012

[1]

[2]

extracellular matrix

[3]

1.09E−20

[4]

2.77E−18

[5]

1.89E−17

[6]

5.54E−18

[7]

[8]

[5] array · 9 items

[0]

GO:0009986

[1]

[2]

cell surface

[3]

5.07E−17

[4]

8.61E−15

[5]

5.86E−14

[6]

2.58E−14

[7]

[8]

[6] array · 9 items

[0]

GO:0005102

[1]

[2]

signaling receptor binding

[3]

1.36E−09

[4]

5.99E−07

[5]

4.41E−06

[6]

1.20E−06

[7]

[8]

[7] array · 9 items

[0]

GO:0098772

[1]

[2]

molecular function regulator

[3]

3.79E−04

[4]

1.59E−02

[5]

1.17E−01

[6]

3.34E−01

[7]

[8]

[8] array · 1 item

[0]

Down regulated genes

[9] array · 9 items

[0]

GO:0046903

[1]

[2]

secretion

[3]

1.07E−11

[4]

5.64E−08

[5]

5.16E−07

[6]

5.64E−08

[7]

[8]

[10] array · 9 items

[0]

GO:0006952

[1]

[2]

defense response

[3]

1.04E−06

[4]

1.63E−04

[5]

1.49E−03

[6]

5.50E−03

[7]

[8]

[11] array · 9 items

[0]

GO:0031226

[1]

[2]

intrinsic component of plasma membrane

[3]

1.74E−10

[4]

4.55E−08

[5]

3.11E−07

[6]

9.10E−08

[7]

[8]

[12] array · 9 items

[0]

GO:0098805

[1]

[2]

whole membrane

[3]

1.91E−03

[4]

4.99E−02

[5]

3.41E−01

[6]

9.97E−01

[7]

[8]

[13] array · 9 items

[0]

GO:0038023

[1]

[2]

signaling receptor activity

[3]

2.36E−04

[4]

1.97E−02

[5]

1.49E−01

[6]

2.53E−01

[7]

[8]

[14] array · 9 items

[0]

GO:0060089

[1]

[2]

molecular transducer activity

[3]

4.71E−04

[4]

2.10E−02

[5]

1.59E−01

[6]

5.04E−01

[7]

[8]

EREG, OPN4, CLEC7A, FCER1G, FCGR3A, AGTR1, CCR1, ADGRF5, ADGRF4, MERTK, IL17RB, CNR1, SELE, FLT3, MYOT, ANPEP, P2RY12, ANXA3, FPR1, CR1, LGR5, SIGLEC7, MARCO, PALLD, IL10, GABRR2, IL15RA, GPR82, DNER, PAQR5, GPR84, IL20RA, STOX1, SSTR2, SSTR5, IL18R1, BLM, CDKL5, LYVE1, IL1R2, NECTIN1, ADGRD1, GPR4, GPR12, NPTX2, GPR183, GPRC5A, PKHD1L1, RGR, S1PR3, EDNRB, TGFBR3, TLR2, SERPINE1, IL1RL1, LGR6, CALCRL, OSMR

row_count

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section[14]/table-wrap[1]#Tab2

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The enriched pathway terms of the up and down regulated differentially expressed genes

structure object · 5 fields

pmcid

PMC8256614

section_index

section_title

Functional enrichment analysis

row_count

column_count

table object · 8 fields

label

Table 3

caption

The enriched pathway terms of the up and down regulated differentially expressed genes

rows array · 17 items

[0] array · 8 items

[0]

Pathway ID

[1]

Pathway name

[2]

P-value

[3]

FDR B&H

[4]

FDR B&Y

[5]

Bonferroni

[6]

Gene count

[7]

Gene

[1] array · 1 item

[0]

Up regulated genes

[2] array · 8 items

[0]

1270244

[1]

Extracellular matrix organization

[2]

3.33E−08

[3]

1.80E−05

[4]

1.23E−04

[5]

1.80E−05

[6]

[7]

COL22A1, MFAP4, CMA1, COL14A1, COL1A1, COL8A2, COL9A1, COL9A2, COL10A1, FMOD, COL16A1, COMP, HAPLN1, ADAMTS14, CTSG, ASPN, ITGAL, ITGB7, CAPN6, TGFB2, P3H2, TLL2, LTBP2, LUM

[3] array · 8 items

[0]

1269201

[1]

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

[2]

8.13E−06

[3]

7.31E−04

[4]

5.03E−03

[5]

4.39E−03

[6]

[7]

SH2D1B, SLAMF7, SIGLEC8, ITGAL, ITGB7, KLRB1, CD1C, CD3D, CD3E, CD3G, CD247, CD40LG, SH2D1A

[4] array · 8 items

[0]

1269544

[1]

GPCR ligand binding

[2]

3.92E−04

[3]

1.51E−02

[4]

1.04E−01

[5]

2.12E−01

[6]

[7]

GNG8, PENK, F2RL2, AGTR2, APLNR, CXCL9, CCR7, CXCL11, OXER1, HTR2A, HTR2B, WNT10B, WNT9A, ACKR4, CRHBP, S1PR5, FZD2, CX3CR1, CXCL10, MCHR1, LHCGR, GPR68

[5] array · 8 items

[0]

1268749

[1]

Metabolism of Angiotensinogen to Angiotensins

[2]

5.26E−04

[3]

1.85E−02

[4]

1.27E−01

[5]

2.84E−01

[6]

[7]

CMA1, CTSG, ACE, GZMH

[6] array · 8 items

[0]

1269868

[1]

Muscle contraction

[2]

3.44E−02

[3]

4.03E−01

[4]

1.00E+00

[5]

1.00E+00

[6]

[7]

KCNIP1, RYR3, SCN2B, ATP1A4, ATP1B2, MYL1, KCNK17, NPPA, TNNI1

[7] array · 8 items

[0]

1269340

[1]

Hemostasis

[2]

6.57E−02

[3]

5.21E−01

[4]

1.00E+00

[5]

1.00E+00

[6]

[7]

GNG8, CEACAM3, F2RL2, SERPINE2, APOA1, GNA14, PDE5A, ATP1B2, IL2RB, CTSW, ISLR, ITGAL, LCK, TGFB2, LEFTY2, RASGRP1, CD2, P2RX6, CD48, HBB

[8] array · 8 items

[0]

1269171

[1]

Adaptive Immune System

[2]

1.32E−01

[3]

6.87E−01

[4]

1.00E+00

[5]

1.00E+00

[6]

[7]

NRG1, HLA-DQA1, ZAP70, SH2D1B, CARD11, SLAMF7, SIGLEC8, ITGAL, ITGB7, ASB18, IER3, MRC2, KLRB1, LCK, RASGRP1, CD1C, CD3D, CD3E, CD3G, CD247, FBXL16, CD40LG, SH2D1A

[9] array · 1 item

[0]

Down regulated genes

[10] array · 8 items

[0]

1457780

[1]

Neutrophil degranulation

[2]

4.82E−06

[3]

3.14E−03

[4]

2.22E−02

[5]

3.14E−03

[6]

[7]

SERPINA3, HK3, ACP3, HMOX2, CHI3L1, S100A8, S100A9, FCER1G, MGST1, HP, FGR, ALOX5, ANPEP, FPR1, CR1, ARG1, SLC11A1, SIGLEC9, GPR84, HPSE, PTX3, CRISPLD2, CD177, SIGLEC14, RNASE2, TLR2, ELANE, MCEMP1

[11] array · 8 items

[0]

1269907

[1]

SLC-mediated transmembrane transport

[2]

6.91E−04

[3]

4.74E−02

[4]

3.35E−01

[5]

4.51E−01

[6]

[7]

HK3, SLC7A11, SLC4A7, SLC1A1, SLC2A1, SLC5A1, SLC11A1, SLC22A16, SLCO2A1, SLCO4A1, GCKR, LCN15, SLC9A7, SLC25A18, SLC38A4, RHAG

[12] array · 8 items

[0]

1269545

[1]

Class A/1 (Rhodopsin-like receptors)

[2]

8.72E−04

[3]

4.74E−02

[4]

3.35E−01

[5]

5.69E−01

[6]

[7]

OPN4, SAA1, AGTR1, CCR1, CNR1, P2RY12, FPR1, SSTR2, SSTR5, KNG1, GPR4, GPR183, RGR, S1PR3, EDN1, EDN2, EDNRB

[13] array · 8 items

[0]

1269340

[1]

Hemostasis

[2]

2.18E−03

[3]

7.11E−02

[4]

5.02E−01

[5]

1.00E+00

[6]

[7]

SERPINA3, CD109, SLC7A11, F5, F8, F13A1, SERPINB8, FCER1G, FGR, MERTK, SERPINF2, SELE, P2RY12, APOB, KIF18B, ATP2A2, NHLRC2, KNG1, PDE11A, CD177, DOCK9, GRB7, GRB14, THBS1, SERPINE1, SERPINA5

[14] array · 8 items

[0]

1269903

[1]

Transmembranetransport of small molecules

[2]

4.89E−03

[3]

1.28E−01

[4]

9.01E−01

[5]

1.00E+00

[6]

[7]

HK3, TRPC4, CFTR, HMOX2, SLC7A11, ABCB1, SLC4A7, AQP3, AQP4, SLC1A1, SLC2A1, SLC5A1, SLC11A1, SLC22A16, SLCO2A1, ATP2A2, GABRR2, SLCO4A1, GCKR, LCN15, SLC9A7, WNK3, SLC25A18, SLC38A4, RHAG, STEAP3

[15] array · 8 items

[0]

1269203

[1]

Innate Immune System

[2]

9.62E−03

[3]

1.96E−01

[4]

1.00E+00

[5]

1.00E+00

[6]

[7]

[16] array · 8 items

[0]

1269310

[1]

Cytokine Signaling in Immune system

[2]

8.42E−02

[3]

4.76E−01

[4]

1.00E+00

[5]

1.00E+00

[6]

[7]

EREG, MARK3, F13A1, SAA1, FGF5, CCR1, FGF10, ALOX5, IL17RB, FLT3, FPR1, SAMHD1, IL10, IL15RA, IL20RA, BCL6, IL18R1, IL1R2, SOCS3, LBP, IRAK3, IL1RL1, OSMR

row_count

column_count

numeric_cells

header_rows

locator

section[14]/table-wrap[2]#Tab3

[8] object · 16 fields

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Topology table for up and down regulated genes

structure object · 5 fields

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PMC8256614

section_index

section_title

Protein–protein interaction (PPI) network and module analysis

row_count

325

column_count

table object · 8 fields

label

Table 4

caption

Topology table for up and down regulated genes

rows array · 325 items

[0] array · 6 items

[0]

Regulation

[1]

Node

[2]

Degree

[3]

Betweenness

[4]

Stress

[5]

Closeness

[1] array · 6 items

[0]

[1]

ESR1

[2]

1094

[3]

0.250896

[4]

7.4E+08

[5]

0.392769

[2] array · 6 items

[0]

[1]

PYHIN1

[2]

342

[3]

0.054258

[4]

1.1E+08

[5]

0.339882

[3] array · 6 items

[0]

[1]

PPP2R2B

[2]

199

[3]

0.023115

[4]

35,268,762

[5]

0.346839

[4] array · 6 items

[0]

[1]

LCK

[2]

162

[3]

0.033618

[4]

18,589,354

[5]

0.353915

[5] array · 6 items

[0]

[1]

TP63

[2]

142

[3]

0.018577

[4]

39,426,608

[5]

0.319664

[6] array · 6 items

[0]

[1]

CD247

[2]

129

[3]

0.013832

[4]

18,625,274

[5]

0.317784

[7] array · 6 items

[0]

[1]

PTN

[2]

105

[3]

0.016638

[4]

36,892,166

[5]

0.300662

[8] array · 6 items

[0]

[1]

APLNR

[2]

103

[3]

0.016611

[4]

40,715,208

[5]

0.288093

[9] array · 6 items

[0]

[1]

APOA1

[2]

100

[3]

0.018834

[4]

13,935,332

[5]

0.315866

[10] array · 6 items

[0]

[1]

CENPA

[2]

[3]

0.009846

[4]

31,131,318

[5]

0.301786

[11] array · 6 items

[0]

[1]

SKAP1

[2]

[3]

0.01599

[4]

10,109,482

[5]

0.313338

[12] array · 6 items

[0]

[1]

FSCN1

[2]

[3]

0.010226

[4]

9,387,016

[5]

0.335367

[13] array · 6 items

[0]

[1]

SCN2B

[2]

[3]

0.01089

[4]

24,233,242

[5]

0.284756

[14] array · 6 items

[0]

[1]

TMEM30B

[2]

[3]

0.016411

[4]

10,490,230

[5]

0.270807

[15] array · 6 items

[0]

[1]

FOXS1

[2]

[3]

0.009408

[4]

26,398,078

[5]

0.293247

[16] array · 6 items

[0]

[1]

COL1A1

[2]

[3]

0.010472

[4]

9,315,670

[5]

0.308098

[17] array · 6 items

[0]

[1]

ZAP70

[2]

[3]

0.007096

[4]

5,315,196

[5]

0.317614

[18] array · 6 items

[0]

[1]

UCHL1

[2]

[3]

0.009753

[4]

9,381,024

[5]

0.331525

[19] array · 6 items

[0]

[1]

HBB

[2]

[3]

0.009984

[4]

14,209,592

[5]

0.304767

[20] array · 6 items

[0]

[1]

NRG1

[2]

[3]

0.01151

[4]

13,449,066

[5]

0.29526

[21] array · 6 items

[0]

[1]

LEF1

[2]

[3]

0.007998

[4]

18,260,094

[5]

0.290744

[22] array · 6 items

[0]

[1]

NT5E

[2]

[3]

0.009599

[4]

11,470,634

[5]

0.301563

[23] array · 6 items

[0]

[1]

MDK

[2]

[3]

0.006889

[4]

7,533,352

[5]

0.305822

[24] array · 6 items

[0]

[1]

ISLR

[2]

[3]

0.010139

[4]

9,992,806

[5]

0.294012

[25] array · 6 items

[0]

[1]

FATE1

[2]

[3]

0.011609

[4]

9,248,788

[5]

0.281581

[26] array · 6 items

[0]

[1]

LRRC15

[2]

[3]

0.010069

[4]

4,772,792

[5]

0.299094

[27] array · 6 items

[0]

[1]

MATN2

[2]

[3]

0.004491

[4]

9,580,600

[5]

0.286792

[28] array · 6 items

[0]

[1]

LIPH

[2]

[3]

0.008197

[4]

6,873,658

[5]

0.282347

[29] array · 6 items

[0]

[1]

MYOC

[2]

[3]

0.005138

[4]

12,313,276

[5]

0.291029

[30] array · 6 items

[0]

[1]

SCARA3

[2]

[3]

0.006492

[4]

11,494,220

[5]

0.290151

[31] array · 6 items

[0]

[1]

NPPA

[2]

[3]

0.009502

[4]

4,868,574

[5]

0.307143

[32] array · 6 items

[0]

[1]

CD83

[2]

[3]

0.005149

[4]

5,484,906

[5]

0.272841

[33] array · 6 items

[0]

[1]

COL14A1

[2]

[3]

0.006129

[4]

5,699,128

[5]

0.292893

[34] array · 6 items

[0]

[1]

CTSG

[2]

[3]

0.003821

[4]

1,913,996

[5]

0.296155

[35] array · 6 items

[0]

[1]

SFRP4

[2]

[3]

0.004006

[4]

7,876,966

[5]

0.282518

[36] array · 6 items

[0]

[1]

TRAF3IP3

[2]

[3]

0.006447

[4]

4,263,002

[5]

0.290602

[37] array · 6 items

[0]

[1]

CLEC11A

[2]

[3]

0.005085

[4]

3,520,012

[5]

0.283596

[38] array · 6 items

[0]

[1]

ATP1B4

[2]

[3]

0.005722

[4]

2,476,482

[5]

0.245939

[39] array · 6 items

[0]

[1]

CD3E

[2]

[3]

0.003892

[4]

1,537,326

[5]

0.297624

[40] array · 6 items

[0]

[1]

SH2D1A

[2]

[3]

0.003969

[4]

2,117,220

[5]

0.308113

[41] array · 6 items

[0]

[1]

DDX3Y

[2]

[3]

0.003754

[4]

1,632,916

[5]

0.32095

[42] array · 6 items

[0]

[1]

PRPH

[2]

[3]

0.001871

[4]

1,994,266

[5]

0.301494

[43] array · 6 items

[0]

[1]

BIRC7

[2]

[3]

0.004835

[4]

2,567,254

[5]

0.28549

[44] array · 6 items

[0]

[1]

CARD11

[2]

[3]

0.002249

[4]

2,510,852

[5]

0.292173

[45] array · 6 items

[0]

[1]

RXRG

[2]

[3]

0.002394

[4]

7,134,478

[5]

0.26225

[46] array · 6 items

[0]

[1]

CCL22

[2]

[3]

0.005706

[4]

3,916,024

[5]

0.281423

[47] array · 6 items

[0]

[1]

CD27

[2]

[3]

0.003915

[4]

2,076,446

[5]

0.294263

[48] array · 6 items

[0]

[1]

GZMB

[2]

[3]

0.003277

[4]

6,141,522

[5]

0.285602

[49] array · 6 items

[0]

[1]

THY1

[2]

[3]

0.003561

[4]

1,793,684

[5]

0.291509

[50] array · 6 items

[0]

[1]

CHRNA3

[2]

[3]

0.004247

[4]

3,415,720

[5]

0.236631

[51] array · 6 items

[0]

[1]

LSP1

[2]

[3]

0.003371

[4]

5,734,010

[5]

0.281836

[52] array · 6 items

[0]

[1]

IL2RB

[2]

[3]

0.002351

[4]

1,938,172

[5]

0.305808

[53] array · 6 items

[0]

[1]

HTR2B

[2]

[3]

0.004018

[4]

2,165,998

[5]

0.27434

[54] array · 6 items

[0]

[1]

DLGAP1

[2]

[3]

0.003816

[4]

6,072,882

[5]

0.277754

[55] array · 6 items

[0]

[1]

TRIM17

[2]

[3]

0.002943

[4]

5,543,810

[5]

0.275137

[56] array · 6 items

[0]

[1]

CTNNA2

[2]

[3]

0.003554

[4]

3,511,510

[5]

0.30254

[57] array · 6 items

[0]

[1]

SERPINE2

[2]

[3]

0.002577

[4]

3,031,536

[5]

0.27426

[58] array · 6 items

[0]

[1]

CD1E

[2]

[3]

0.003282

[4]

3,419,392

[5]

0.255229

[59] array · 6 items

[0]

[1]

MRC2

[2]

[3]

0.003395

[4]

2,950,548

[5]

0.296276

[60] array · 6 items

[0]

[1]

C1QTNF2

[2]

[3]

0.003203

[4]

2,505,388

[5]

0.270147

[61] array · 6 items

[0]

[1]

SH2D1B

[2]

[3]

0.001864

[4]

1,043,570

[5]

0.29028

[62] array · 6 items

[0]

[1]

BRINP1

[2]

[3]

0.001516

[4]

4,402,948

[5]

0.27726

[63] array · 6 items

[0]

[1]

PDIA2

[2]

[3]

0.001967

[4]

2,895,182

[5]

0.286453

[64] array · 6 items

[0]

[1]

CHD5

[2]

[3]

0.001918

[4]

5,223,636

[5]

0.286503

[65] array · 6 items

[0]

[1]

FAP

[2]

[3]

0.003531

[4]

5,820,086

[5]

0.268583

[66] array · 6 items

[0]

[1]

IL31RA

[2]

[3]

0.002073

[4]

1,606,954

[5]

0.263603

[67] array · 6 items

[0]

[1]

GAP43

[2]

[3]

0.002745

[4]

2,793,268

[5]

0.279858

[68] array · 6 items

[0]

[1]

CD5

[2]

[3]

0.001695

[4]

655,904

[5]

0.295861

[69] array · 6 items

[0]

[1]

UBASH3A

[2]

[3]

0.001652

[4]

1,347,264

[5]

0.290951

[70] array · 6 items

[0]

[1]

ROBO2

[2]

[3]

0.002959

[4]

3,726,616

[5]

0.267048

[71] array · 6 items

[0]

[1]

ITGB7

[2]

[3]

0.002686

[4]

3,351,660

[5]

0.276124

[72] array · 6 items

[0]

[1]

HTR2A

[2]

[3]

0.002571

[4]

2,472,010

[5]

0.275833

[73] array · 6 items

[0]

[1]

MOXD1

[2]

[3]

0.002391

[4]

2,492,756

[5]

0.259926

[74] array · 6 items

[0]

[1]

ASB18

[2]

[3]

9.77E−04

[4]

3,202,162

[5]

0.273001

[75] array · 6 items

[0]

[1]

CD2

[2]

[3]

0.002221

[4]

926,408

[5]

0.287954

[76] array · 6 items

[0]

[1]

BCL11B

[2]

[3]

8.18E−04

[4]

1,888,298

[5]

0.28836

[77] array · 6 items

[0]

[1]

STAT4

[2]

[3]

0.001786

[4]

2,435,506

[5]

0.277166

[78] array · 6 items

[0]

[1]

NGEF

[2]

[3]

0.001809

[4]

1,548,206

[5]

0.277636

[79] array · 6 items

[0]

[1]

SMPD3

[2]

[3]

0.002518

[4]

2,175,774

[5]

0.281

[80] array · 6 items

[0]

[1]

FZD2

[2]

[3]

0.003673

[4]

3,239,390

[5]

0.250335

[81] array · 6 items

[0]

[1]

DUSP15

[2]

[3]

0.001253

[4]

2,474,532

[5]

0.284472

[82] array · 6 items

[0]

[1]

CD3D

[2]

[3]

0.001725

[4]

1,111,132

[5]

0.288589

[83] array · 6 items

[0]

[1]

SYT17

[2]

[3]

0.002549

[4]

2,482,574

[5]

0.285802

[84] array · 6 items

[0]

[1]

FCGR3B

[2]

[3]

0.002748

[4]

1,492,022

[5]

0.282286

[85] array · 6 items

[0]

[1]

EGR2

[2]

[3]

0.002934

[4]

3,438,856

[5]

0.266406

[86] array · 6 items

[0]

[1]

ZBP1

[2]

[3]

0.001876

[4]

2,664,938

[5]

0.26006

[87] array · 6 items

[0]

[1]

CAMK4

[2]

[3]

0.001773

[4]

3,472,134

[5]

0.272716

[88] array · 6 items

[0]

[1]

DMC1

[2]

[3]

0.002511

[4]

4,659,098

[5]

0.254277

[89] array · 6 items

[0]

[1]

GDNF

[2]

[3]

0.002515

[4]

3,274,958

[5]

0.244751

[90] array · 6 items

[0]

[1]

FCN1

[2]

[3]

0.002571

[4]

1,243,380

[5]

0.236742

[91] array · 6 items

[0]

[1]

LUM

[2]

[3]

0.002276

[4]

1,515,870

[5]

0.283903

[92] array · 6 items

[0]

[1]

GZMA

[2]

[3]

0.001051

[4]

3,258,230

[5]

0.276498

[93] array · 6 items

[0]

[1]

TGFB2

[2]

[3]

0.002259

[4]

1,632,566

[5]

0.277119

[94] array · 6 items

[0]

[1]

SLAMF7

[2]

[3]

0.00211

[4]

1,035,482

[5]

0.271708

[95] array · 6 items

[0]

[1]

MS4A1

[2]

[3]

0.002857

[4]

1,169,078

[5]

0.288398

[96] array · 6 items

[0]

[1]

ETV4

[2]

[3]

0.001747

[4]

1,674,080

[5]

0.301883

[97] array · 6 items

[0]

[1]

GLI2

[2]

[3]

0.001398

[4]

2,977,194

[5]

0.285902

[98] array · 6 items

[0]

[1]

PHLDA1

[2]

[3]

4.37E−04

[4]

818,256

[5]

0.298194

[99] array · 6 items

[0]

[1]

COL8A2

[2]

[3]

0.00147

[4]

1,089,762

[5]

0.273835

[100] array · 6 items

[0]

[1]

GABRD

[2]

[3]

0.002826

[4]

2,629,544

[5]

0.25748

[101] array · 6 items

[0]

[1]

LMF1

[2]

[3]

0.004342

[4]

2,024,228

[5]

0.265132

[102] array · 6 items

[0]

[1]

F2RL2

[2]

[3]

0.001554

[4]

790,338

[5]

0.282933

[103] array · 6 items

[0]

[1]

LYPD1

[2]

[3]

0.003123

[4]

3,995,458

[5]

0.266276

[104] array · 6 items

[0]

[1]

CAPN6

[2]

[3]

0.001415

[4]

3,046,736

[5]

0.267802

[105] array · 6 items

[0]

[1]

SOX8

[2]

[3]

0.003361

[4]

2,763,024

[5]

0.251306

[106] array · 6 items

[0]

[1]

IER3

[2]

[3]

0.001921

[4]

3,613,164

[5]

0.282982

[107] array · 6 items

[0]

[1]

BEX1

[2]

[3]

0.001034

[4]

1,286,206

[5]

0.273606

[108] array · 6 items

[0]

[1]

COLQ

[2]

[3]

0.001173

[4]

1,414,826

[5]

0.261234

[109] array · 6 items

[0]

[1]

NTM

[2]

[3]

0.00284

[4]

2,486,684

[5]

0.275102

[110] array · 6 items

[0]

[1]

RPS4Y1

[2]

[3]

0.001013

[4]

1,200,768

[5]

0.287713

[111] array · 6 items

[0]

[1]

FERMT1

[2]

[3]

0.001713

[4]

4,279,868

[5]

0.270315

[112] array · 6 items

[0]

[1]

RGS17

[2]

[3]

0.002928

[4]

3,868,106

[5]

0.249895

[113] array · 6 items

[0]

[1]

TNNI1

[2]

[3]

0.001349

[4]

1,550,004

[5]

0.266765

[114] array · 6 items

[0]

[1]

MYOZ1

[2]

[3]

0.00128

[4]

2,111,156

[5]

0.283203

[115] array · 6 items

[0]

[1]

KLHDC8A

[2]

[3]

0.001147

[4]

7,007,508

[5]

0.251036

[116] array · 6 items

[0]

[1]

MYL1

[2]

[3]

7.90E−04

[4]

1,213,666

[5]

0.289945

[117] array · 6 items

[0]

[1]

DIO2

[2]

[3]

0.001161

[4]

1,959,228

[5]

0.279416

[118] array · 6 items

[0]

[1]

ITGAL

[2]

[3]

0.001182

[4]

1,521,116

[5]

0.271527

[119] array · 6 items

[0]

[1]

CRABP2

[2]

[3]

4.13E−04

[4]

675,182

[5]

0.272171

[120] array · 6 items

[0]

[1]

HSH2D

[2]

[3]

0.001425

[4]

889,856

[5]

0.26034

[121] array · 6 items

[0]

[1]

CD48

[2]

[3]

[4]

[5]

0.265422

[122] array · 6 items

[0]

[1]

CD3G

[2]

[3]

[4]

[5]

0.23833

[123] array · 6 items

[0]

[1]

LY9

[2]

[3]

[4]

[5]

0.240141

[124] array · 6 items

[0]

[1]

SIT1

[2]

[3]

[4]

[5]

0.264221

[125] array · 6 items

[0]

[1]

ATP1A4

[2]

[3]

1.16E−04

[4]

79,140

[5]

0.235049

[126] array · 6 items

[0]

[1]

FMOD

[2]

[3]

3.96E−05

[4]

20,526

[5]

0.240707

[127] array · 6 items

[0]

[1]

CCDC80

[2]

[3]

3.58E−05

[4]

499,704

[5]

0.288908

[128] array · 6 items

[0]

[1]

CCR7

[2]

[3]

[4]

[5]

0.244312

[129] array · 6 items

[0]

[1]

KCNIP1

[2]

[3]

[4]

[5]

0.219995

[130] array · 6 items

[0]

[1]

CD6

[2]

[3]

[4]

[5]

0.22832

[131] array · 6 items

[0]

[1]

FCRL3

[2]

[3]

[4]

[5]

0.241062

[132] array · 6 items

[0]

[1]

SERTAD4

[2]

[3]

[4]

[5]

0.257531

[133] array · 6 items

[0]

[1]

PRF1

[2]

[3]

[4]

[5]

0.222162

[134] array · 6 items

[0]

[1]

C1QTNF9

[2]

[3]

[4]

[5]

0.226548

[135] array · 6 items

[0]

[1]

OPCML

[2]

[3]

[4]

[5]

0.215756

[136] array · 6 items

[0]

[1]

ESM1

[2]

[3]

[4]

[5]

0.213551

[137] array · 6 items

[0]

[1]

CD40LG

[2]

[3]

[4]

[5]

0.240053

[138] array · 6 items

[0]

[1]

S1PR5

[2]

[3]

[4]

[5]

0.24224

[139] array · 6 items

[0]

[1]

AGTR2

[2]

[3]

[4]

[5]

0.259256

[140] array · 6 items

[0]

[1]

NPPB

[2]

[3]

[4]

[5]

0.211726

[141] array · 6 items

[0]

[1]

SCG5

[2]

[3]

[4]

[5]

0.238721

[142] array · 6 items

[0]

[1]

PDE5A

[2]

[3]

[4]

[5]

0.243548

[143] array · 6 items

[0]

[1]

RYR3

[2]

[3]

[4]

[5]

0.274755

[144] array · 6 items

[0]

[1]

RASEF

[2]

[3]

[4]

[5]

0.274755

[145] array · 6 items

[0]

[1]

PODXL2

[2]

[3]

[4]

[5]

0.213106

[146] array · 6 items

[0]

[1]

OGN

[2]

[3]

[4]

[5]

0.226548

[147] array · 6 items

[0]

[1]

PLCH2

[2]

[3]

[4]

[5]

0.238721

[148] array · 6 items

[0]

[1]

SCG2

[2]

[3]

[4]

[5]

0.267704

[149] array · 6 items

[0]

[1]

P3H2

[2]

[3]

[4]

[5]

0.207132

[150] array · 6 items

[0]

[1]

C12orf75

[2]

[3]

[4]

[5]

0.217608

[151] array · 6 items

[0]

[1]

ACE

[2]

[3]

[4]

[5]

0.241159

[152] array · 6 items

[0]

[1]

GNA14

[2]

[3]

[4]

[5]

0.217608

[153] array · 6 items

[0]

[1]

HDC

[2]

[3]

[4]

[5]

0.216614

[154] array · 6 items

[0]

[1]

CMA1

[2]

[3]

[4]

[5]

0.226713

[155] array · 6 items

[0]

[1]

CEACAM3

[2]

[3]

[4]

[5]

0.265519

[156] array · 6 items

[0]

Down

[1]

PCLAF

[2]

817

[3]

0.135529

[4]

4.95E+08

[5]

0.365547

[157] array · 6 items

[0]

Down

[1]

CFTR

[2]

800

[3]

0.168404

[4]

4.5E+08

[5]

0.378823

[158] array · 6 items

[0]

Down

[1]

TK1

[2]

188

[3]

0.034997

[4]

43,663,230

[5]

0.331089

[159] array · 6 items

[0]

Down

[1]

ECT2

[2]

164

[3]

0.020509

[4]

39,431,940

[5]

0.325989

[160] array · 6 items

[0]

Down

[1]

FKBP5

[2]

157

[3]

0.028064

[4]

15,963,868

[5]

0.346288

[161] array · 6 items

[0]

Down

[1]

ANLN

[2]

153

[3]

0.021564

[4]

38,168,832

[5]

0.325066

[162] array · 6 items

[0]

Down

[1]

ATP2A2

[2]

148

[3]

0.027131

[4]

19,656,040

[5]

0.363859

[163] array · 6 items

[0]

Down

[1]

BCL6

[2]

142

[3]

0.022279

[4]

29,419,916

[5]

0.314181

[164] array · 6 items

[0]

Down

[1]

TOP2A

[2]

132

[3]

0.018571

[4]

16,838,266

[5]

0.361426

[165] array · 6 items

[0]

Down

[1]

ZBTB16

[2]

132

[3]

0.025165

[4]

14,500,206

[5]

0.349976

[166] array · 6 items

[0]

Down

[1]

S100A9

[2]

124

[3]

0.01355

[4]

11,186,464

[5]

0.352219

[167] array · 6 items

[0]

Down

[1]

CEP55

[2]

123

[3]

0.019583

[4]

21,505,878

[5]

0.316891

[168] array · 6 items

[0]

Down

[1]

BLM

[2]

108

[3]

0.014259

[4]

18,458,556

[5]

0.321945

[169] array · 6 items

[0]

Down

[1]

AGTR1

[2]

100

[3]

0.019518

[4]

14,083,216

[5]

0.313564

[170] array · 6 items

[0]

Down

[1]

SAMHD1

[2]

[3]

0.011463

[4]

12,340,270

[5]

0.337357

[171] array · 6 items

[0]

Down

[1]

S100A8

[2]

[3]

0.011637

[4]

8,662,548

[5]

0.361486

[172] array · 6 items

[0]

Down

[1]

GRAP2

[2]

[3]

0.011721

[4]

16,819,438

[5]

0.305936

[173] array · 6 items

[0]

Down

[1]

CBS

[2]

[3]

0.011248

[4]

20,466,334

[5]

0.301591

[174] array · 6 items

[0]

Down

[1]

SOCS3

[2]

[3]

0.011071

[4]

9,067,820

[5]

0.324888

[175] array · 6 items

[0]

Down

[1]

GFI1B

[2]

[3]

0.011791

[4]

21,469,034

[5]

0.299012

[176] array · 6 items

[0]

Down

[1]

APOB

[2]

[3]

0.014102

[4]

9,290,092

[5]

0.319133

[177] array · 6 items

[0]

Down

[1]

PCK1

[2]

[3]

0.004102

[4]

12,732,476

[5]

0.305408

[178] array · 6 items

[0]

Down

[1]

MARK3

[2]

[3]

0.008497

[4]

19,265,788

[5]

0.304512

[179] array · 6 items

[0]

Down

[1]

HMOX2

[2]

[3]

0.011098

[4]

15,258,770

[5]

0.312053

[180] array · 6 items

[0]

Down

[1]

PCNT

[2]

[3]

0.011297

[4]

9,190,430

[5]

0.312261

[181] array · 6 items

[0]

Down

[1]

PIK3C2A

[2]

[3]

0.005568

[4]

8,768,122

[5]

0.313053

[182] array · 6 items

[0]

Down

[1]

KIF14

[2]

[3]

0.01035

[4]

12,506,564

[5]

0.304668

[183] array · 6 items

[0]

Down

[1]

WASF1

[2]

[3]

0.009478

[4]

18,219,554

[5]

0.29633

[184] array · 6 items

[0]

Down

[1]

ARNTL

[2]

[3]

0.00974

[4]

19,494,854

[5]

0.295526

[185] array · 6 items

[0]

Down

[1]

ALOX5

[2]

[3]

0.010921

[4]

7,343,824

[5]

0.306424

[186] array · 6 items

[0]

Down

[1]

MCM10

[2]

[3]

0.006773

[4]

8,807,396

[5]

0.306438

[187] array · 6 items

[0]

Down

[1]

THBS1

[2]

[3]

0.008915

[4]

6,203,038

[5]

0.312694

[188] array · 6 items

[0]

Down

[1]

VSIG4

[2]

[3]

0.010353

[4]

10,534,518

[5]

0.302037

[189] array · 6 items

[0]

Down

[1]

WWC1

[2]

[3]

0.007241

[4]

14,604,594

[5]

0.301647

[190] array · 6 items

[0]

Down

[1]

MELK

[2]

[3]

0.008554

[4]

18,629,232

[5]

0.283953

[191] array · 6 items

[0]

Down

[1]

P2RY12

[2]

[3]

0.008962

[4]

9,063,088

[5]

0.286641

[192] array · 6 items

[0]

Down

[1]

PPL

[2]

[3]

0.007851

[4]

16,137,388

[5]

0.297313

[193] array · 6 items

[0]

Down

[1]

MYBL2

[2]

[3]

0.006189

[4]

16,766,208

[5]

0.291964

[194] array · 6 items

[0]

Down

[1]

FAM107A

[2]

[3]

0.006172

[4]

12,510,302

[5]

0.289688

[195] array · 6 items

[0]

Down

[1]

GRIP1

[2]

[3]

0.008069

[4]

3,384,760

[5]

0.320055

[196] array · 6 items

[0]

Down

[1]

ELF3

[2]

[3]

0.004945

[4]

7,205,142

[5]

0.309118

[197] array · 6 items

[0]

Down

[1]

PALLD

[2]

[3]

0.00509

[4]

15,467,012

[5]

0.293274

[198] array · 6 items

[0]

Down

[1]

CTH

[2]

[3]

0.007754

[4]

5,179,060

[5]

0.296908

[199] array · 6 items

[0]

Down

[1]

EIF4EBP1

[2]

[3]

0.005367

[4]

9,748,852

[5]

0.303946

[200] array · 6 items

[0]

Down

[1]

KNG1

[2]

[3]

0.007017

[4]

4,204,766

[5]

0.304243

[201] array · 6 items

[0]

Down

[1]

GLUL

[2]

[3]

0.00728

[4]

10,616,752

[5]

0.30116

[202] array · 6 items

[0]

Down

[1]

SLC2A1

[2]

[3]

0.004557

[4]

8,307,646

[5]

0.303974

[203] array · 6 items

[0]

Down

[1]

[2]

[3]

0.006741

[4]

3,398,298

[5]

0.314741

[204] array · 6 items

[0]

Down

[1]

RPGR

[2]

[3]

0.004441

[4]

10,097,488

[5]

0.29384

[205] array · 6 items

[0]

Down

[1]

TLR2

[2]

[3]

0.00754

[4]

8,322,330

[5]

0.294595

[206] array · 6 items

[0]

Down

[1]

GRB7

[2]

[3]

0.004147

[4]

4,832,846

[5]

0.308113

[207] array · 6 items

[0]

Down

[1]

PPEF1

[2]

[3]

0.001983

[4]

3,327,232

[5]

0.298276

[208] array · 6 items

[0]

Down

[1]

TXNRD1

[2]

[3]

0.00627

[4]

2,860,122

[5]

0.328561

[209] array · 6 items

[0]

Down

[1]

NAMPT

[2]

[3]

0.005035

[4]

10,420,710

[5]

0.290538

[210] array · 6 items

[0]

Down

[1]

BMP7

[2]

[3]

0.007622

[4]

4,442,306

[5]

0.286981

[211] array · 6 items

[0]

Down

[1]

CA14

[2]

[3]

0.005218

[4]

4,884,858

[5]

0.279189

[212] array · 6 items

[0]

Down

[1]

CCR1

[2]

[3]

0.008305

[4]

11,217,842

[5]

0.27812

[213] array · 6 items

[0]

Down

[1]

CDC45

[2]

[3]

0.004479

[4]

3,231,162

[5]

0.30618

[214] array · 6 items

[0]

Down

[1]

ARG1

[2]

[3]

0.004931

[4]

2,347,856

[5]

0.32381

[215] array · 6 items

[0]

Down

[1]

SPC24

[2]

[3]

0.005356

[4]

6,589,710

[5]

0.294834

[216] array · 6 items

[0]

Down

[1]

FGR

[2]

[3]

0.003434

[4]

3,020,950

[5]

0.303452

[217] array · 6 items

[0]

Down

[1]

KIF5C

[2]

[3]

0.004876

[4]

2,365,086

[5]

0.319586

[218] array · 6 items

[0]

Down

[1]

IL1R2

[2]

[3]

0.006825

[4]

9,489,620

[5]

0.289265

[219] array · 6 items

[0]

Down

[1]

SERPINA3

[2]

[3]

0.005518

[4]

4,047,110

[5]

0.293168

[220] array · 6 items

[0]

Down

[1]

DEPDC1B

[2]

[3]

0.002978

[4]

9,632,346

[5]

0.260838

[221] array · 6 items

[0]

Down

[1]

SLC4A7

[2]

[3]

0.006314

[4]

2,752,106

[5]

0.316232

[222] array · 6 items

[0]

Down

[1]

SERPINA5

[2]

[3]

0.003604

[4]

13,750,404

[5]

0.273206

[223] array · 6 items

[0]

Down

[1]

MPP3

[2]

[3]

0.008262

[4]

9,328,402

[5]

0.297003

[224] array · 6 items

[0]

Down

[1]

NCEH1

[2]

[3]

0.009405

[4]

3,554,728

[5]

0.304214

[225] array · 6 items

[0]

Down

[1]

SLC1A1

[2]

[3]

0.008678

[4]

2,278,154

[5]

0.320573

[226] array · 6 items

[0]

Down

[1]

CLSPN

[2]

[3]

0.003668

[4]

3,801,300

[5]

0.294343

[227] array · 6 items

[0]

Down

[1]

BCAT1

[2]

[3]

0.0052

[4]

9,066,238

[5]

0.269657

[228] array · 6 items

[0]

Down

[1]

MYH6

[2]

[3]

0.005049

[4]

1,731,786

[5]

0.308578

[229] array · 6 items

[0]

Down

[1]

IL20RA

[2]

[3]

0.005252

[4]

8,769,348

[5]

0.267901

[230] array · 6 items

[0]

Down

[1]

HOOK1

[2]

[3]

0.005558

[4]

7,195,380

[5]

0.279177

[231] array · 6 items

[0]

Down

[1]

FLT3

[2]

[3]

0.002948

[4]

1,938,440

[5]

0.292408

[232] array · 6 items

[0]

Down

[1]

ADAMTS4

[2]

[3]

0.005524

[4]

2,338,476

[5]

0.307519

[233] array · 6 items

[0]

Down

[1]

CAMSAP3

[2]

[3]

0.003339

[4]

4,795,892

[5]

0.29578

[234] array · 6 items

[0]

Down

[1]

PLA2G2A

[2]

[3]

0.003637

[4]

1,686,594

[5]

0.300565

[235] array · 6 items

[0]

Down

[1]

FOSL1

[2]

[3]

0.004151

[4]

10,955,318

[5]

0.269402

[236] array · 6 items

[0]

Down

[1]

NQO1

[2]

[3]

0.001945

[4]

5,351,260

[5]

0.289201

[237] array · 6 items

[0]

Down

[1]

ELANE

[2]

[3]

0.005024

[4]

2,289,646

[5]

0.302834

[238] array · 6 items

[0]

Down

[1]

KCND3

[2]

[3]

0.002555

[4]

9,153,178

[5]

0.28203

[239] array · 6 items

[0]

Down

[1]

EPN3

[2]

[3]

0.005073

[4]

7,423,282

[5]

0.280302

[240] array · 6 items

[0]

Down

[1]

GPR183

[2]

[3]

0.003642

[4]

4,243,792

[5]

0.256783

[241] array · 6 items

[0]

Down

[1]

CD109

[2]

[3]

0.006381

[4]

3,655,940

[5]

0.303565

[242] array · 6 items

[0]

Down

[1]

TUBA3E

[2]

[3]

0.003459

[4]

6,711,886

[5]

0.289048

[243] array · 6 items

[0]

Down

[1]

TGFBR3

[2]

[3]

0.005143

[4]

1,983,082

[5]

0.267386

[244] array · 6 items

[0]

Down

[1]

NID1

[2]

[3]

0.004536

[4]

1,702,236

[5]

0.311503

[245] array · 6 items

[0]

Down

[1]

STEAP3

[2]

[3]

0.004665

[4]

2,788,716

[5]

0.285365

[246] array · 6 items

[0]

Down

[1]

AMD1

[2]

[3]

0.005714

[4]

3,154,782

[5]

0.29099

[247] array · 6 items

[0]

Down

[1]

EDNRB

[2]

[3]

0.003092

[4]

7,273,156

[5]

0.265368

[248] array · 6 items

[0]

Down

[1]

IL17RB

[2]

[3]

0.004227

[4]

6,381,040

[5]

0.261527

[249] array · 6 items

[0]

Down

[1]

SLC19A2

[2]

[3]

0.004653

[4]

2,505,974

[5]

0.281302

[250] array · 6 items

[0]

Down

[1]

SLC22A16

[2]

[3]

0.004545

[4]

3,831,872

[5]

0.240618

[251] array · 6 items

[0]

Down

[1]

PHACTR3

[2]

[3]

0.002193

[4]

6,417,862

[5]

0.280976

[252] array · 6 items

[0]

Down

[1]

LAPTM5

[2]

[3]

0.003298

[4]

2,735,158

[5]

0.274317

[253] array · 6 items

[0]

Down

[1]

ANGPTL4

[2]

[3]

0.003467

[4]

1,447,446

[5]

0.325163

[254] array · 6 items

[0]

Down

[1]

PPM1E

[2]

[3]

0.002894

[4]

5,733,032

[5]

0.270427

[255] array · 6 items

[0]

Down

[1]

E2F2

[2]

[3]

0.002816

[4]

5,508,320

[5]

0.28041

[256] array · 6 items

[0]

Down

[1]

SERPINE1

[2]

[3]

0.001474

[4]

2,497,574

[5]

0.271302

[257] array · 6 items

[0]

Down

[1]

ACPP

[2]

[3]

0.003084

[4]

2,749,550

[5]

0.291223

[258] array · 6 items

[0]

Down

[1]

KRT7

[2]

[3]

0.002861

[4]

1,288,592

[5]

0.315774

[259] array · 6 items

[0]

Down

[1]

SERPINB8

[2]

[3]

0.002944

[4]

3,167,812

[5]

0.28186

[260] array · 6 items

[0]

Down

[1]

FREM2

[2]

[3]

0.003954

[4]

3,395,758

[5]

0.276661

[261] array · 6 items

[0]

Down

[1]

RNF157

[2]

[3]

0.002172

[4]

6,196,626

[5]

0.265551

[262] array · 6 items

[0]

Down

[1]

PPIP5K2

[2]

[3]

0.003886

[4]

8,572,108

[5]

0.270014

[263] array · 6 items

[0]

Down

[1]

[2]

[3]

0.002839

[4]

4,879,016

[5]

0.274836

[264] array · 6 items

[0]

Down

[1]

TUBAL3

[2]

[3]

0.002055

[4]

1,052,840

[5]

0.318915

[265] array · 6 items

[0]

Down

[1]

ELL2

[2]

[3]

0.003971

[4]

6,281,508

[5]

0.255859

[266] array · 6 items

[0]

Down

[1]

GRB14

[2]

[3]

0.002326

[4]

3,092,024

[5]

0.28378

[267] array · 6 items

[0]

Down

[1]

IRAK3

[2]

[3]

0.00257

[4]

6,900,170

[5]

0.265897

[268] array · 6 items

[0]

Down

[1]

MANEA

[2]

[3]

0.004508

[4]

5,075,608

[5]

0.263869

[269] array · 6 items

[0]

Down

[1]

CLEC7A

[2]

[3]

0.004246

[4]

4,293,212

[5]

0.277095

[270] array · 6 items

[0]

Down

[1]

KLF10

[2]

[3]

0.001607

[4]

3,013,994

[5]

0.281339

[271] array · 6 items

[0]

Down

[1]

GNMT

[2]

[3]

0.00165

[4]

3,015,768

[5]

0.269136

[272] array · 6 items

[0]

Down

[1]

ART3

[2]

[3]

0.002904

[4]

2,401,360

[5]

0.255748

[273] array · 6 items

[0]

Down

[1]

LRRC8E

[2]

[3]

0.003739

[4]

4,188,308

[5]

0.288665

[274] array · 6 items

[0]

Down

[1]

SLA

[2]

[3]

0.001714

[4]

1,003,510

[5]

0.289329

[275] array · 6 items

[0]

Down

[1]

CLEC4G

[2]

[3]

0.002667

[4]

2,376,260

[5]

0.277495

[276] array · 6 items

[0]

Down

[1]

TUBB4A

[2]

[3]

1.28E−04

[4]

181,440

[5]

0.250652

[277] array · 6 items

[0]

Down

[1]

CD38

[2]

[3]

[4]

[5]

0.268176

[278] array · 6 items

[0]

Down

[1]

FCGR3A

[2]

[3]

1.01E−04

[4]

73,756

[5]

0.268385

[279] array · 6 items

[0]

Down

[1]

[2]

[3]

8.10E−07

[4]

708

[5]

0.248641

[280] array · 6 items

[0]

Down

[1]

EHF

[2]

[3]

7.11E−06

[4]

4180

[5]

0.254842

[281] array · 6 items

[0]

Down

[1]

KIAA1549

[2]

[3]

4.16E−04

[4]

193,604

[5]

0.261391

[282] array · 6 items

[0]

Down

[1]

S100A3

[2]

[3]

1.84E−05

[4]

45,822

[5]

0.254376

[283] array · 6 items

[0]

Down

[1]

ADH1B

[2]

[3]

3.40E−05

[4]

28,184

[5]

0.233546

[284] array · 6 items

[0]

Down

[1]

PAPSS2

[2]

[3]

1.05E−05

[4]

8726

[5]

0.251868

[285] array · 6 items

[0]

Down

[1]

PTX3

[2]

[3]

[4]

[5]

0.19143

[286] array · 6 items

[0]

Down

[1]

IL15RA

[2]

[3]

[4]

[5]

0.234199

[287] array · 6 items

[0]

Down

[1]

EDN1

[2]

[3]

[4]

[5]

0.209723

[288] array · 6 items

[0]

Down

[1]

SERPINF2

[2]

[3]

[4]

[5]

0.232451

[289] array · 6 items

[0]

Down

[1]

ZNF366

[2]

[3]

[4]

[5]

0.282018

[290] array · 6 items

[0]

Down

[1]

ACR

[2]

[3]

[4]

[5]

0.214588

[291] array · 6 items

[0]

Down

[1]

MATN3

[2]

[3]

[4]

[5]

0.222881

[292] array · 6 items

[0]

Down

[1]

CNR1

[2]

[3]

[4]

[5]

0.216205

[293] array · 6 items

[0]

Down

[1]

LBP

[2]

[3]

[4]

[5]

0.240053

[294] array · 6 items

[0]

Down

[1]

ALOX5AP

[2]

[3]

[4]

[5]

0.23456

[295] array · 6 items

[0]

Down

[1]

SCGN

[2]

[3]

[4]

[5]

0.23353

[296] array · 6 items

[0]

Down

[1]

MAMDC2

[2]

[3]

[4]

[5]

0.248745

[297] array · 6 items

[0]

Down

[1]

CDKL5

[2]

[3]

[4]

[5]

0.219891

[298] array · 6 items

[0]

Down

[1]

CENPM

[2]

[3]

[4]

[5]

0.231833

[299] array · 6 items

[0]

Down

[1]

KCNIP2

[2]

[3]

[4]

[5]

0.219995

[300] array · 6 items

[0]

Down

[1]

CPM

[2]

[3]

[4]

[5]

0.24533

[301] array · 6 items

[0]

Down

[1]

GPSM2

[2]

[3]

[4]

[5]

0.245855

[302] array · 6 items

[0]

Down

[1]

LSAMP

[2]

[3]

[4]

[5]

0.215756

[303] array · 6 items

[0]

Down

[1]

KCNK3

[2]

[3]

[4]

[5]

0.219353

[304] array · 6 items

[0]

Down

[1]

ALOX15B

[2]

[3]

[4]

[5]

0.234981

[305] array · 6 items

[0]

Down

[1]

ST6GALNAC3

[2]

[3]

[4]

[5]

0.233263

[306] array · 6 items

[0]

Down

[1]

GPRC5A

[2]

[3]

[4]

[5]

0.274755

[307] array · 6 items

[0]

Down

[1]

SLC31A2

[2]

[3]

[4]

[5]

0.215287

[308] array · 6 items

[0]

Down

[1]

MARVELD2

[2]

[3]

[4]

[5]

0.218671

[309] array · 6 items

[0]

Down

[1]

SNTG2

[2]

[3]

[4]

[5]

0.229

[310] array · 6 items

[0]

Down

[1]

TRHDE

[2]

[3]

[4]

[5]

0.208786

[311] array · 6 items

[0]

Down

[1]

SIGLEC7

[2]

[3]

[4]

[5]

0.245229

[312] array · 6 items

[0]

Down

[1]

SMTNL2

[2]

[3]

[4]

[5]

0.265519

[313] array · 6 items

[0]

Down

[1]

ANXA3

[2]

[3]

[4]

[5]

0.274755

[314] array · 6 items

[0]

Down

[1]

F13A1

[2]

[3]

[4]

[5]

0.248745

[315] array · 6 items

[0]

Down

[1]

ANKRD7

[2]

[3]

[4]

[5]

0.233438

[316] array · 6 items

[0]

Down

[1]

KCNS2

[2]

[3]

[4]

[5]

0.219721

[317] array · 6 items

[0]

Down

[1]

SIGLEC9

[2]

[3]

[4]

[5]

0.227565

[318] array · 6 items

[0]

Down

[1]

SIGLEC10

[2]

[3]

[4]

[5]

0.282018

[319] array · 6 items

[0]

Down

[1]

C20orf197

[2]

[3]

[4]

[5]

0.282018

[320] array · 6 items

[0]

Down

[1]

SCGB1D2

[2]

[3]

[4]

[5]

0.226548

[321] array · 6 items

[0]

Down

[1]

IL1RL1

[2]

[3]

[4]

[5]

0.21698

[322] array · 6 items

[0]

Down

[1]

PLIN2

[2]

[3]

[4]

[5]

0.241935

[323] array · 6 items

[0]

Down

[1]

CD163

[2]

[3]

[4]

[5]

0.239403

[324] array · 6 items

[0]

Down

[1]

HPR

[2]

[3]

[4]

[5]

0.240053

row_count

325

column_count

numeric_cells

1351

header_rows

locator

section[15]/table-wrap[1]#Tab4

[9] object · 16 fields

asset:table:pmid:34218797:9

role

table

format

jats-table

media_type

application/vnd.jats.table+json

uri

null

sha256

sha256:d40d246e9267cdecbb667151bf6fc24dd1163f94c5e35a99f6a9287292c2dc92

bytes

2113

access

open

state

verified

reader

read_table

reader_status

available

identifier

section[16]/table-wrap[1]#Tab5

version

null

note

miRNA—target gene and TF—target gene interaction

structure object · 5 fields

pmcid

PMC8256614

section_index

section_title

Target gene—miRNA regulatory network construction

row_count

column_count

table object · 8 fields

label

Table 5

caption

miRNA—target gene and TF—target gene interaction

rows array · 30 items

[0] array · 8 items

[0]

Regulation

[1]

Target Genes

[2]

Degree

[3]

MicroRNA

[4]

Regulation

[5]

Target Genes

[6]

Degree

[7]

[1] array · 8 items

[0]

[1]

FSCN1

[2]

[3]

hsa-mir-4533

[4]

[5]

FSCN1

[6]

[7]

ESRRA

[2] array · 8 items

[0]

[1]

ESR1

[2]

[3]

hsa-mir-548ac

[4]

[5]

APOA1

[6]

[7]

RERE

[3] array · 8 items

[0]

[1]

TMEM30B

[2]

[3]

hsa-mir-548i

[4]

[5]

COL1A1

[6]

[7]

HMG20B

[4] array · 8 items

[0]

[1]

SCN2B

[2]

[3]

hsa-mir-5585-3p

[4]

[5]

HBB

[6]

[7]

THRAP3

[5] array · 8 items

[0]

[1]

CENPA

[2]

[3]

hsa-mir-6750-3p

[4]

[5]

LCK

[6]

[7]

ATF1

[6] array · 8 items

[0]

[1]

APOA1

[2]

[3]

hsa-mir-6722-5p

[4]

[5]

FOXS1

[6]

[7]

YBX1

[7] array · 8 items

[0]

[1]

PPP2R2B

[2]

[3]

hsa-mir-149-3p

[4]

[5]

CENPA

[6]

[7]

SAP30

[8] array · 8 items

[0]

[1]

TP63

[2]

[3]

hsa-mir-1178-3p

[4]

[5]

SCN2B

[6]

[7]

RCOR2

[9] array · 8 items

[0]

[1]

PYHIN1

[2]

[3]

hsa-mir-205-3p

[4]

[5]

TMEM30B

[6]

[7]

ZNF24

[10] array · 8 items

[0]

[1]

APLNR

[2]

[3]

hsa-mir-10b-5p

[4]

[5]

APLNR

[6]

[7]

FOXJ2

[11] array · 8 items

[0]

[1]

PTN

[2]

[3]

hsa-mir-155-5p

[4]

[5]

NRG1

[6]

[7]

SUZ12

[12] array · 8 items

[0]

[1]

LCK

[2]

[3]

hsa-mir-335-5p

[4]

[5]

PTN

[6]

[7]

L3MBTL2

[13] array · 8 items

[0]

[1]

CD247

[2]

[3]

hsa-mir-346

[4]

[5]

UCHL1

[6]

[7]

MAZ

[14] array · 8 items

[0]

Down

[1]

FKBP5

[2]

[3]

hsa-mir-200c-3p

[4]

[5]

ESR1

[6]

[7]

EZH2

[15] array · 8 items

[0]

Down

[1]

PCLAF

[2]

[3]

hsa-mir-1273g-3p

[4]

[5]

ZAP70

[6]

[7]

ZFX

[16] array · 8 items

[0]

Down

[1]

CEP55

[2]

[3]

hsa-mir-1244

[4]

Down

[5]

SOCS3

[6]

[7]

MXD3

[17] array · 8 items

[0]

Down

[1]

ATP2A2

[2]

[3]

hsa-mir-4789-3p

[4]

Down

[5]

BCL6

[6]

[7]

ARID4B

[18] array · 8 items

[0]

Down

[1]

TK1

[2]

[3]

hsa-mir-766-3p

[4]

Down

[5]

FKBP5

[6]

[7]

CBFB

[19] array · 8 items

[0]

Down

[1]

ZBTB16

[2]

[3]

hsa-mir-1976

[4]

Down

[5]

ANLN

[6]

[7]

TAF7

[20] array · 8 items

[0]

Down

[1]

SAMHD1

[2]

[3]

hsa-mir-3124-3p

[4]

Down

[5]

ATP2A2

[6]

[7]

CREM

[21] array · 8 items

[0]

Down

[1]

TOP2A

[2]

[3]

hsa-mir-186-5p

[4]

Down

[5]

CBS

[6]

[7]

IKZF1

[22] array · 8 items

[0]

Down

[1]

BCL6

[2]

[3]

hsa-mir-339-5p

[4]

Down

[5]

BLM

[6]

[7]

ZNF501

[23] array · 8 items

[0]

Down

[1]

ECT2

[2]

[3]

hsa-mir-132-3p

[4]

Down

[5]

ECT2

[6]

[7]

KLF16

[24] array · 8 items

[0]

Down

[1]

CFTR

[2]

[3]

hsa-mir-145-5p

[4]

Down

[5]

CEP55

[6]

[7]

FOSL2

[25] array · 8 items

[0]

Down

[1]

S100A9

[2]

[3]

hsa-mir-4679

[4]

Down

[5]

GRAP2

[6]

[7]

CEBPD

[26] array · 8 items

[0]

Down

[1]

AGTR1

[2]

[3]

hsa-mir-410-3p

[4]

Down

[5]

ZBTB16

[6]

[7]

TRIM28

[27] array · 8 items

[0]

Down

[1]

ANLN

[2]

[3]

hsa-mir-503-5p

[4]

Down

[5]

S100A8

[6]

[7]

STAT3

[28] array · 8 items

[0]

Down

[1]

BLM

[2]

[3]

hsa-mir-193b-3p

[4]

Down

[5]

S100A9

[6]

[7]

CEBPG

[29] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

AGTR1

[6]

[7]

EZH2

row_count

column_count

numeric_cells

104

header_rows

locator

section[16]/table-wrap[1]#Tab5

[10] object · 16 fields

asset:table:pmid:34218797:10

role

table

format

jats-table

media_type

application/vnd.jats.table+json

uri

null

sha256

sha256:848c0dbc1a78a523ff7254e102bab3b7e2a0a579d69f16124916986e39bc2598

bytes

806

access

open

state

verified

reader

read_table

reader_status

available

identifier

section[10]/table-wrap[1]#Tab1

version

null

note

The sequences of primers for quantitative RT-PCR

structure object · 5 fields

pmcid

PMC8256614

section_index

section_title

RT-PCR analysis

row_count

column_count

table object · 8 fields

label

Table 1

caption

The sequences of primers for quantitative RT-PCR

rows array · 11 items

[0] array · 3 items

[0]

Genes

[1]

Forward primers

[2]

Reverse primers

[1] array · 3 items

[0]

ESR1

[1]

CCTCTGGCTACCATTATGGG

[2]

AGTCATTGTGTCCTTGAATGC

[2] array · 3 items

[0]

PYHIN1

[1]

GCAAGATCAGTACGACAGAG

[2]

AGATAACTGAGCAACCTGTG

[3] array · 3 items

[0]

PPP2R2B

[1]

ACCAGAGACTATCTGACCG

[2]

GTAGTCATGAACCTGGTATGTC

[4] array · 3 items

[0]

LCK

[1]

CTAGTCCGGCTTTATGCAG

[2]

AAATCTACTAGGCTCCCGT

[5] array · 3 items

[0]

TP63

[1]

ATTCAATGAGGGACAGATTGC

[2]

GGGTCTTCTACATACTGGGC

[6] array · 3 items

[0]

PCLAF

[1]

GACCAATATAAACTGTGGCGGG

[2]

CCAGGGTAAACAAGGAGACGTT

[7] array · 3 items

[0]

CFTR

[1]

CTGTGGCCTTGGTTTACTG

[2]

CTCTGATCTCTGTACTTCACCA

[8] array · 3 items

[0]

TK1

[1]

AGATTCAGGTGATTCTCGGG

[2]

ACTTGTACTGGGCGATCTG

[9] array · 3 items

[0]

ECT2

[1]

GCTGTATTGTACGAGTATGCT

[2]

GTCACCAATTTGACAAGCTC

[10] array · 3 items

[0]

FKBP5

[1]

CCTAAGTTTGGCATTGACCC

[2]

CCAAGATTCTTTGGCCTTCTC

row_count

column_count

numeric_cells

header_rows

locator

section[10]/table-wrap[1]#Tab1

[11] object · 16 fields

asset:table:pmid:34218797:11

role

table

format

jats-table

media_type

application/vnd.jats.table+json

uri

null

sha256

sha256:039e3c101909fdc467734aa90b6724fe12ab39ff52eed20c608fec81eb075919

bytes

5846

access

open

state

verified

reader

read_table

reader_status

available

identifier

section[20]/table-wrap[1]#Tab6

version

null

note

Docking results of Designed Molecules on Over Expressed Proteins

structure object · 5 fields

pmcid

PMC8256614

section_index

section_title

Identification of candidate small molecules

row_count

column_count

table object · 8 fields

label

Table 6

caption

Docking results of Designed Molecules on Over Expressed Proteins

rows array · 38 items

[0] array · 6 items

[0]

Sl. No/Code

[1]

Over expressed gene: ESR1

[2]

Over expressed gene: LCK

[3]

Over expressed gene: PPP2R2B

[4]

Over expressed gene: PYHIN 1

[5]

Over expressed gene: TP63

[1] array · 5 items

[0]

PDB: 4PXM

[1]

PDB:1KSW

[2]

PDB: 2HV7

[3]

PDB: 3VD8

[4]

PDB: 6RU6

[2] array · 15 items

[0]

Total Score

[1]

Crash(-Ve)

[2]

Polar

[3]

Total Score

[4]

Crash(-Ve)

[5]

Polar

[6]

Total Score

[7]

Crash(−Ve)

[8]

Polar

[9]

Total Score

[10]

Crash(−Ve)

[11]

Polar

[12]

Total Score

[13]

Crash(−Ve)

[14]

Polar

[3] array · 16 items

[0]

HIM1

[1]

5.097

[2]

− 4.375

[3]

0.114

[4]

4.258

[5]

− 1.555

[6]

1.784

[7]

4.904

[8]

− 0.870

[9]

0.004

[10]

5.794

[11]

− 0.514

[12]

3.828

[13]

5.770

[14]

− 1.440

[15]

2.231

[4] array · 16 items

[0]

HIM2

[1]

4.057

[2]

− 6.172

[3]

0.039

[4]

4.624

[5]

− 0.997

[6]

1.959

[7]

4.906

[8]

− 0.468

[9]

1.517

[10]

5.052

[11]

− 0.780

[12]

3.415

[13]

5.414

[14]

− 1.529

[15]

2.444

[5] array · 16 items

[0]

HIM3

[1]

5.353

[2]

− 5.309

[3]

0.161

[4]

4.578

[5]

− 1.492

[6]

1.790

[7]

5.042

[8]

− 1.845

[9]

1.073

[10]

5.680

[11]

− 0.804

[12]

3.956

[13]

5.350

[14]

− 1.170

[15]

2.316

[6] array · 16 items

[0]

HIM4

[1]

3.976

[2]

− 5.132

[3]

0.167

[4]

3.839

[5]

− 1.635

[6]

1.196

[7]

6.328

[8]

− 1.172

[9]

1.128

[10]

4.966

[11]

− 0.666

[12]

1.818

[13]

5.627

[14]

− 1.416

[15]

2.320

[7] array · 16 items

[0]

HIM5

[1]

2.707

[2]

− 7.759

[3]

0.179

[4]

4.067

[5]

− 0.997

[6]

1.987

[7]

5.254

[8]

− 0.674

[9]

1.618

[10]

4.563

[11]

− 1.068

[12]

2.935

[13]

5.698

[14]

− 1.240

[15]

2.485

[8] array · 16 items

[0]

HIM6

[1]

5.948

[2]

− 3.902

[3]

1.796

[4]

5.229

[5]

− 0.707

[6]

3.656

[7]

6.766

[8]

− 1.424

[9]

1.858

[10]

6.670

[11]

− 0.941

[12]

5.519

[13]

6.218

[14]

− 1.468

[15]

2.578

[9] array · 16 items

[0]

HIM7

[1]

5.019

[2]

− 7.055

[3]

0.203

[4]

4.382

[5]

− 2.443

[6]

3.329

[7]

6.028

[8]

− 0.629

[9]

1.660

[10]

5.374

[11]

− 1.876

[12]

0.670

[13]

6.627

[14]

− 1.484

[15]

2.579

[10] array · 16 items

[0]

HIM8

[1]

4.429

[2]

− 3.983

[3]

0.344

[4]

4.150

[5]

− 4.382

[6]

4.210

[7]

6.794

[8]

− 1.279

[9]

1.129

[10]

5.468

[11]

− 0.769

[12]

3.444

[13]

5.842

[14]

− 2.088

[15]

2.272

[11] array · 16 items

[0]

HIM9

[1]

3.722

[2]

− 5.956

[3]

0.197

[4]

4.051

[5]

− 2.006

[6]

0.002

[7]

6.116

[8]

− 0.597

[9]

1.717

[10]

5.407

[11]

− 0.565

[12]

1.370

[13]

5.877

[14]

− 2.054

[15]

0.792

[12] array · 16 items

[0]

HIM10

[1]

6.771

[2]

− 3.977

[3]

1.836

[4]

5.176

[5]

− 3.512

[6]

4.023

[7]

5.332

[8]

− 1.378

[9]

3.349

[10]

6.071

[11]

− 0.923

[12]

3.854

[13]

5.825

[14]

− 0.966

[15]

3.672

[13] array · 16 items

[0]

HIM11

[1]

3.775

[2]

− 6.079

[3]

0.898

[4]

6.998

[5]

− 2.086

[6]

3.842

[7]

8.678

[8]

− 1.065

[9]

2.876

[10]

5.087

[11]

− 0.881

[12]

1.854

[13]

5.948

[14]

− 1.015

[15]

1.202

[14] array · 16 items

[0]

HIM12

[1]

0.190

[2]

− 8.149

[3]

0.022

[4]

5.302

[5]

− 2.305

[6]

3.475

[7]

5.227

[8]

− 1.636

[9]

0.710

[10]

7.322

[11]

− 1.128

[12]

4.099

[13]

6.237

[14]

− 2.562

[15]

2.171

[15] array · 16 items

[0]

HIM13

[1]

4.523

[2]

− 4.537

[3]

0.014

[4]

4.840

[5]

− 0.664

[6]

3.305

[7]

6.181

[8]

− 2.966

[9]

3.523

[10]

5.281

[11]

− 0.503

[12]

3.981

[13]

5.905

[14]

− 1.136

[15]

2.218

[16] array · 16 items

[0]

HIM14

[1]

5.247

[2]

− 3.183

[3]

0.000

[4]

4.888

[5]

− 1.296

[6]

2.563

[7]

5.037

[8]

− 0.377

[9]

1.647

[10]

7.057

[11]

− 0.799

[12]

4.256

[13]

6.116

[14]

− 1.366

[15]

2.438

[17] array · 16 items

[0]

HIM15

[1]

4.633

[2]

− 4.173

[3]

0.180

[4]

3.756

[5]

− 0.710

[6]

2.072

[7]

5.188

[8]

− 1.559

[9]

1.143

[10]

5.570

[11]

− 1.125

[12]

3.718

[13]

6.238

[14]

− 1.708

[15]

2.443

[18] array · 16 items

[0]

HIM16

[1]

4.588

[2]

− 2.883

[3]

0.000

[4]

6.027

[5]

− 1.099

[6]

3.903

[7]

5.606

[8]

− 0.987

[9]

4.197

[10]

5.661

[11]

− 0.926

[12]

2.751

[13]

7.263

[14]

− 1.533

[15]

4.212

[19] array · 16 items

[0]

HIM17

[1]

3.944

[2]

− 4.806

[3]

0.236

[4]

5.329

[5]

− 0.590

[6]

2.798

[7]

4.830

[8]

− 1.682

[9]

1.617

[10]

6.234

[11]

− 0.830

[12]

3.912

[13]

5.366

[14]

− 1.257

[15]

3.022

[20] array · 16 items

[0]

HTZ1

[1]

0.593

[2]

− 7.518

[3]

[4]

4.221

[5]

− 0.692

[6]

1.975

[7]

3.993

[8]

− 0.539

[9]

0.003

[10]

5.284

[11]

− 0.566

[12]

1.432

[13]

5.227

[14]

− 1.045

[15]

0.903

[21] array · 16 items

[0]

HTZ2

[1]

− 1.770

[2]

− 8.477

[3]

0.000

[4]

4.055

[5]

− 1.438

[6]

2.877

[7]

4.388

[8]

− 1.665

[9]

1.170

[10]

4.100

[11]

− 0.546

[12]

3.017

[13]

4.563

[14]

− 0.976

[15]

1.266

[22] array · 16 items

[0]

HTZ3

[1]

4.649

[2]

− 5.870

[3]

0.148

[4]

5.104

[5]

− 0.861

[6]

3.922

[7]

4.243

[8]

− 1.539

[9]

1.933

[10]

5.304

[11]

− 1.370

[12]

1.398

[13]

5.138

[14]

− 1.217

[15]

1.930

[23] array · 16 items

[0]

HTZ4

[1]

− 3.169

[2]

− 12.002

[3]

0.482

[4]

4.173

[5]

− 1.898

[6]

1.864

[7]

4.654

[8]

− 1.627

[9]

1.128

[10]

5.163

[11]

− 0.745

[12]

1.304

[13]

5.084

[14]

− 1.143

[15]

1.018

[24] array · 16 items

[0]

HTZ5

[1]

4.021

[2]

− 12.325

[3]

0.246

[4]

3.215

[5]

− 1.481

[6]

4.232

[7]

3.256

[8]

− 6.374

[9]

2.317

[10]

2.382

[11]

− 5.263

[12]

1.238

[13]

4.623

[14]

− 0.951

[15]

1.280

[25] array · 16 items

[0]

HTZ6

[1]

6.605

[2]

− 3.866

[3]

1.6487

[4]

4.004

[5]

− 1.104

[6]

2.851

[7]

5.834

[8]

− 1.310

[9]

3.111

[10]

5.286

[11]

− 1.530

[12]

1.436

[13]

6.336

[14]

− 2.326

[15]

3.781

[26] array · 16 items

[0]

HTZ7

[1]

4.977

[2]

− 5.434

[3]

0.655

[4]

5.197

[5]

− 2.040

[6]

3.250

[7]

5.352

[8]

− 1.371

[9]

1.172

[10]

6.138

[11]

− 1.734

[12]

1.627

[13]

4.908

[14]

− 1.057

[15]

1.335

[27] array · 16 items

[0]

HTZ8

[1]

1.025

[2]

− 8.223

[3]

0.000

[4]

3.549

[5]

− 1.310

[6]

2.403

[7]

4.024

[8]

− 3.825

[9]

2.440

[10]

4.980

[11]

− 0.593

[12]

1.474

[13]

5.164

[14]

− 1.291

[15]

0.999

[28] array · 16 items

[0]

HTZ9

[1]

3.386

[2]

− 7.041

[3]

0.194

[4]

5.567

[5]

− 1.622

[6]

3.057

[7]

6.792

[8]

− 2.581

[9]

1.088

[10]

5.794

[11]

− 0.683

[12]

1.774

[13]

6.053

[14]

− 1.408

[15]

1.037

[29] array · 16 items

[0]

HTZ10

[1]

4.744

[2]

− 5.463

[3]

0.837

[4]

4.520

[5]

− 2.469

[6]

[7]

7.758

[8]

− 1.518

[9]

3.765

[10]

5.345

[11]

− 1.133

[12]

3.661

[13]

7.507

[14]

− 2.080

[15]

4.086

[30] array · 16 items

[0]

HTZ11

[1]

2.991

[2]

− 6.177

[3]

[4]

3.453

[5]

− 0.721

[6]

1.266

[7]

4.841

[8]

− 1.738

[9]

0.045

[10]

4.368

[11]

− 0.805

[12]

1.074

[13]

6.176

[14]

− 1.380

[15]

1.511

[31] array · 16 items

[0]

HTZ12

[1]

4.810

[2]

− 6.157

[3]

0.275

[4]

5.296

[5]

− 2.814

[6]

3.605

[7]

5.138

[8]

− 1.840

[9]

2.189

[10]

5.083

[11]

− 0.870

[12]

1.536

[13]

5.592

[14]

− 1.321

[15]

1.525

[32] array · 16 items

[0]

HTZ13

[1]

4.868

[2]

− 3.837

[3]

[4]

4.863

[5]

− 0.535

[6]

2.405

[7]

4.656

[8]

− 0.681

[9]

3.152

[10]

4.246

[11]

− 2.335

[12]

0.529

[13]

6.404

[14]

− 0.975

[15]

2.954

[33] array · 16 items

[0]

HTZ14

[1]

5.646

[2]

− 3.473

[3]

[4]

4.948

[5]

− 0.801

[6]

2.324

[7]

4.953

[8]

− 1.672

[9]

1.066

[10]

5.058

[11]

− 1.174

[12]

1.121

[13]

5.114

[14]

− 1.299

[15]

1.296

[34] array · 16 items

[0]

HTZ15

[1]

3.428

[2]

− 4.957

[3]

0.348

[4]

3.949

[5]

− 0.614

[6]

1.873

[7]

4.049

[8]

− 0.787

[9]

1.224

[10]

4.796

[11]

− 1.066

[12]

1.489

[13]

3.510

[14]

− 0.607

[15]

0.461

[35] array · 16 items

[0]

HTZ16

[1]

4.227

[2]

− 4.787

[3]

0.298

[4]

4.654

[5]

− 1.534

[6]

2.096

[7]

6.143

[8]

− 1.204

[9]

2.879

[10]

4.854

[11]

− 0.994

[12]

1.564

[13]

7.102

[14]

− 0.917

[15]

3.001

[36] array · 16 items

[0]

HTZ17

[1]

3.784

[2]

− 5.018

[3]

0.380

[4]

3.661

[5]

− 0.897

[6]

1.676

[7]

4.016

[8]

− 1.179

[9]

1.384

[10]

4.039

[11]

− 0.569

[12]

2.706

[13]

4.256

[14]

− 1.040

[15]

1.236

[37] array · 16 items

[0]

HTZSTD

[1]

4.722

[2]

− 1.084

[3]

1.063

[4]

3.319

[5]

− 0.890

[6]

3.033

[7]

3.564

[8]

− 0.272

[9]

2.367

[10]

3.394

[11]

− 0.882

[12]

1.169

[13]

4.237

[14]

− 0.801

[15]

1.855

row_count

column_count

numeric_cells

548

header_rows

locator

section[20]/table-wrap[1]#Tab6

gaps array · 0 items

analysis object · 4 fields

state

complete

methods array · 2 items

[0] object · 10 fields

method-1

family

differential_expression

specific

limma_voom

label

Differential expression analysis

dsl_operations array · 3 items

[0]

normalise_counts

[1]

differential_expression_fit

[2]

fdr_bh

missing_operations array · 0 items

expressible

true

parameters object · 0 fields

data_shapes array · 1 item

[0]

count_matrix_with_condition

evidence object · 3 fields

score

band

verbatim

quote

DEGs of dataset GSE141910 between HF groups and non heart failure groups were respectively analyzed using the limma package in R [21].

[1] object · 10 fields

method-2

family

network_analysis

specific

ppi_network

label

Network / pathway analysis

dsl_operations array · 3 items

[0]

build_graph

[1]

centrality_scores

[2]

pathway_enrich

missing_operations array · 0 items

expressible

true

parameters object · 0 fields

data_shapes array · 1 item

[0]

edge_list

evidence object · 3 fields

score

0.7

band

medium

quote

protein-protein interaction

targets array · 0 items

gaps array · 0 items

capability object · 3 fields

state

complete

requirements array · 1 item

[0] object · 6 fields

capability_id

capability:computational_analysis

label

Computational analysis platform

assay_families array · 9 items

[0]

meta_analysis

[1]

machine_learning

[2]

survival_analysis

[3]

statistical_regression

[4]

pca

[5]

molecular_docking

[6]

network_analysis

[7]

differential_expression

[8]

gwas

availability_state

owned

tier_unlocked

candidate

Automated Assays Laravel application and simulated adapters

gaps array · 0 items

readiness object · 8 fields

state

blocked

tier

blocking_axis

data

blocked_on

data:accession_absent

axes object · 3 fields

method object · 5 fields

tier

expressible

true

required_operations array · 3 items

[0]

normalise_counts

[1]

differential_expression_fit

[2]

fdr_bh

missing_operations array · 0 items

basis

The paper names the method it used and the corpus's method extractor maps it onto the DSL catalogue: limma_voom.

capability object · 4 fields

tier

capability_id

capability:computational_analysis

availability_state

owned

basis

The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here.

data object · 6 fields

tier

reachable

false

accessions array · 0 items

resolved_accessions array · 0 items

statements array · 0 items

basis

The paper names no accession to its source data, so the data has to come from the authors.

can_run object · 3 fields

dsl_operations array · 3 items

[0]

normalise_counts

[1]

differential_expression_fit

[2]

fdr_bh

assets array · 12 items

[0]

source:pmid:34218797

[1]

asset:table:pmid:34218797:1

[2]

asset:table:pmid:34218797:2

[3]

asset:table:pmid:34218797:3

[4]

asset:table:pmid:34218797:4

[5]

asset:table:pmid:34218797:5

[6]

asset:table:pmid:34218797:6

[7]

asset:table:pmid:34218797:7

[8]

asset:table:pmid:34218797:8

[9]

asset:table:pmid:34218797:9

[10]

asset:table:pmid:34218797:10

[11]

asset:table:pmid:34218797:11

steps array · 1 item

[0]

run_analysis

must_build object · 5 fields

dsl_operations array · 0 items

converters array · 0 items

readers array · 0 items

capabilities array · 0 items

data_gaps array · 1 item

[0]

data:geo:None

gaps array · 1 item

[0]

data:accession_absent

review object · 5 fields

state

partial

machine_critique object · 5 fields

kind

extraction_review

reader object · 5 fields

model

MiniMax-M3.1-Flash

provider

minimax

provider_family

minimax

read_at

2026-10-31T19:39:47Z

independence

single_reader

evidence_check object · 2 fields

method

verbatim

availability

null

calls

usage object · 3 fields

prompt_tokens

68038

completion_tokens

970

cached_tokens

44800

human_critique

null

stages array · 1 item

[0] object · 4 fields

extraction

state

complete

reader

MiniMax-M3.1-Flash

provider

minimax

gaps array · 3 items

[0]

review.independent_reader

[1]

review.machine_critique

[2]

review.human_critique

execution object · 5 fields

state

absent

status

not_run

mode

null

runs array · 0 items

gaps array · 1 item

[0]

execution.not_run

provenance object · 7 fields

entities array · 3 items

[0] object · 3 fields

pmid:34218797

type

paper

label

pmid:34218797

[1] object · 3 fields

source:pmid:34218797

type

manuscript

label

PMID 34218797 full text

[2] object · 3 fields

data:geo:None

type

dataset

label

GEO None

activities array · 3 items

[0] object · 4 fields

activity-reading-sci-2026-11-01

type

classification

used array · 3 items

[0] object · 3 fields

pmid:34218797

type

paper

label

pmid:34218797

[1] object · 3 fields

source:pmid:34218797

type

manuscript

label

PMID 34218797 full text

[2] object · 3 fields

data:geo:None

type

dataset

label

GEO None

agent

agent:corpus-assay-engine

[1] object · 4 fields

activity-read-34218797

type

extraction

used array · 1 item

[0]

source:pmid:34218797

agent

agent:minimax-reader

[2] object · 4 fields

activity-resolve-None

type

accession_resolution

used array · 1 item

[0]

data:geo:None

agent

agent:corpus-assay-engine

agents array · 2 items

[0] object · 3 fields

agent:corpus-assay-engine

type

software

label

Corpus assay engine

[1] object · 3 fields

agent:minimax-reader

type

software

label

MiniMax literature reader

source_run_id

reading-sci-2026-11-01

dsl_catalogue_fingerprint

343fb30756ba6ec3

capability_table_fingerprint

2cb3e42f047d2ecf

snapshot_id

ba34b49490d9bfaf

lineage object · 4 fields

parent_id

pmid:34218797

parent_hash

sha256:e6bf6ace0392e9822ef4350372a36c0a6b1bbe69d469a6ff10f1aa0a6a91e8cd

fork_of

null

generation

gaps array · 5 items

[0]

execution.not_run

[1]

review.human_critique

[2]

review.independent_reader

[3]

review.machine_critique

[4]

step:obtain_source_data blocked on data:accession_absent

assays array · 1 item

[0] object · 11 fields

role

analysis

definition_id

differential_expression

definition_version

f2132e96ae6c7a4e

definition_digest

null

required_operations array · 3 items

[0]

normalise_counts

[1]

differential_expression_fit

[2]

fdr_bh

support_state

supported

source_hashes object · 1 field

dsl_catalogue

f2132e96ae6c7a4e

confidence

evidence array · 1 item

[0]

DEGs of dataset GSE141910 between HF groups and non heart failure groups were respectively analyzed using the limma package in R [21].

order_basis

analysis_only

assay:1

Complete file

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:34218797", "kind": "science-record", "revision": 8, "content_hash": "sha256:c5e03d5706e921ed08ca150b099cb010c705c45505cdf0245aa2bb41a9edd626", "created_at": "2026-11-01T15:41:41Z", "updated_at": "2026-11-01T22:47:00Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Identification of candidate biomarkers and therapeutic agents for heart failure by bioinformatics analysis.", "doi": "10.1186/s12872-021-02146-8", "pmid": "34218797", "authors": ["Vijayakrishna Kolur", "Basavaraj Vastrad", "Chanabasayya Vastrad", "Shivakumar Kotturshetti", "Anandkumar Tengli"], "journal": "BMC cardiovascular disorders", "year": 2021, "abstract": "INTRODUCTION: Heart failure (HF) is a heterogeneous clinical syndrome and affects millions of people all over the world. HF occurs when the cardiac overload and injury, which is a worldwide complaint. The aim of this study was to screen and verify hub genes involved in developmental HF as well as to explore active drug molecules.\nMETHODS: The expression profiling by high throughput sequencing of GSE141910 dataset was downloaded from the Gene Expression Omnibus (GEO) database, which contained 366 samples, including 200 heart failure samples and 166 non heart failure samples. The raw data was integrated to find differentially expressed genes (DEGs) and were further analyzed with bioinformatics analysis. Gene ontology (GO) and REACTOME enrichment analyses were performed via ToppGene; protein-protein interaction (PPI) networks of the DEGs was constructed based on data from the HiPPIE interactome database; modules analysis was performed; target gene-miRNA regulatory network and target gene-TF regulatory network were constructed and analyzed; hub genes were validated; molecular docking studies was performed.\nRESULTS: A total of 881 DEGs, including 442 up regulated genes and 439 down regulated genes were observed. Most of the DEGs were significantly enriched in biological adhesion, extracellular matrix, signaling receptor binding, secretion, intrinsic component of plasma membrane, signaling receptor activity, extracellular matrix organization and neutrophil degranulation. The top hub genes ESR1, PYHIN1, PPP2R2B, LCK, TP63, PCLAF, CFTR, TK1, ECT2 and FKBP5 were identified from the PPI network. Module analysis revealed that HF was associated with adaptive immune system and neutrophil degranulation. The target genes, miRNAs and TFs were identified from the target gene-miRNA regulatory network and target gene-TF regulatory network. Furthermore, receiver operating characteristic (ROC) curve analysis and RT-PCR analysis revealed that ESR1, PYHIN1, PPP2R2B, LCK, TP63, PCLAF, CFTR, TK1, ECT2 and FKBP5 might serve as prognostic, diagnostic biomarkers and therapeutic target for HF. The predicted targets of these active molecules were then confirmed.\nCONCLUSION: The current investigation identified a series of key genes and pathways that might be involved in the progression of HF, providing a new understanding of the underlying molecular mechanisms of HF.", "claims": [{"id": "claim-method", "statement": "DEGs of dataset GSE141910 between HF groups and non heart failure groups were respectively analyzed using the limma package in R [21].", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:34218797", "locator": "sections[4] \"Identification of DEGs in HF\" paragraph 2", "quote": "DEGs of dataset GSE141910 between HF groups and non heart failure groups were respectively analyzed using the limma package in R [21]."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "partial", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:34218797"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "blocked", "blocked_on": "data:accession_absent", "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": [], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": [], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": ["step:obtain_source_data blocked on data:accession_absent"]}, "data": {"state": "partial", "assets": [{"id": "source:pmid:34218797", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.1186/s12872-021-02146-8", "sha256": "sha256:eb8184a8e33ad721f7e081c5dd5f18e4146e484293f23173dac9eb0cf61a7758", "bytes": 58982, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.1186/s12872-021-02146-8", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC8256614", "source": "europe_pmc_fulltext", "coverage": "whole_body_without_references", "text_hash_scope": "rendered_section_body"}}, {"id": "asset:table:pmid:34218797:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:fc6e85b6cad727bfd46ed9fd450f44efba00a2b712c35d01a273dfc99f819d90", "bytes": 7015, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[14]/table-wrap[1]#Tab2", "version": null, "note": "The enriched GO terms of the up and down regulated differentially expressed genes", "structure": {"pmcid": "PMC8256614", "section_index": 5, "section_title": "Functional enrichment analysis", "row_count": 15, "column_count": 9}, "table": {"label": "Table 2", "caption": "The enriched GO terms of the up and down regulated differentially expressed genes", "rows": [["GO ID", "CATEGORY", "GO Name", "P Value", "FDR B&H", "FDR B&Y", "Bonferroni", "Gene Count", "Gene"], ["Up regulated genes"], ["GO:0022610", "BP", "biological adhesion", "1.32E−13", "3.37E−10", "3.08E−09", "6.75E−10", "72", "HLA-DQA1, DACT2, CD83, MDK, UBASH3A, ITGBL1, FAP, MFAP4, SERPINE2, NRXN2, COL14A1, CCR7, ALOX15, COL1A1, LAMB4, COL8A2, STAB2, COL16A1, COMP, TBX21, FERMT1, XG, CCDC80, APOA1, PODXL2, ZAP70, HAPLN1, TENM4, SKAP1, CNTNAP2, PDE5A, CARD11, CTNNA2, SLAMF7, ATP1B2, CX3CR1, LRRC15, IDO1, MYOC, SIGLEC8, ISLR, SMOC2, ITGAL, ITGB7, FREM1, PTN, KIRREL3, NTM, GLI2, FBLN7, DPT, NT5E, ECM2, LCK, OMG, OPCML, TGFB2, RASGRP1, CD2, CD3E, THBS4, CD5, CD6, THY1, TIGIT, CD27, CD40LG, ROBO2, GREM1, LY9, HBB, LEF1"], ["GO:0002682", "BP", "regulation of immune system process", "2.20E−10", "2.25E−07", "2.05E−06", "1.12E−06", "72", "IL34, HLA-DQA1, ESR1, TLR7, CD83, IL17D, MDK, UBASH3A, TNFRSF4, PYHIN1, ZBP1, FCER1A, MS4A2, FCER2, FCN1, CCR7, SMPD3, CCL24, SCARA3, ALOX15, COL1A1, IL31RA, TBX21, XG, CXCL14, APOA1, ZAP70, SH2D1B, SKAP1, PDE5A, CARD11, SLAMF7, CTSG, CX3CR1, IDO1, CXCL10, ITGAL, ACE, SIT1, ITGB7, PTN, TBC1D10C, FCRL3, BPI, GLI2, KLRB1, NPPA, CAMK4, LCK, TGFB2, RASGRP1, CD1C, CD1E, CD2, CD3D, CD3E, THBS4, CD3G, CD247, CD5, CD6, THY1, TIGIT, MS4A1, CD27, GPR68, CD40LG, CD48, GREM1, SH2D1A, LEF1, LRRC17"], ["GO:0031012", "CC", "extracellular matrix", "1.09E−20", "2.77E−18", "1.89E−17", "5.54E−18", "52", "MATN2, COL22A1, MDK, COLQ, MFAP4, SERPINE2, HMCN2, AEBP1, FCN1, CMA1, CTHRC1, COL14A1, SCARA3, COL1A1, LAMB4, COL8A2, COL9A1, COL9A2, COL10A1, MXRA5, FMOD, COL16A1, COMP, CCDC80, APOA1, HAPLN1, CTSG, ADAMTSL2, LRRC15, ASPN, MYOC, NDP, SMOC2, FREM1, PTN, SSC5D, SULF1, DPT, NPPA, ADAMTSL1, ECM2, OGN, ITIH5, TGFB2, LEFTY2, EYS, THBS4, P3H2, LTBP2, GREM1, LUM, LRRC17"], ["GO:0009986", "CC", "cell surface", "5.07E−17", "8.61E−15", "5.86E−14", "2.58E−14", "63", "HYAL4, NRG1, HLA-DQA1, CD83, TNFRSF4, ITGBL1, FAP, SERPINE2, FCER1A, MS4A2, FCER2, FCN1, CXCL9, CCR7, IL31RA, SFRP4, STAB2, DUOX2, APOA1, ACKR4, FCRL6, SCUBE2, CNTNAP2, SLAMF7, CTSG, IL2RB, CX3CR1, LRRC15, CXCL10, NDP, ITGAL, ACE, ITGB7, GFRA3, PTN, PROM1, SSC5D, FCRL3, SULF1, MRC2, NTM, CLEC9A, NT5E, TGFB2, LHCGR, CD1C, HHIP, CD1E, CD2, CD3D, CD3E, CD3G, CD5, CD6, THY1, TIGIT, MS4A1, CD27, CD40LG, CD48, ROBO2, GREM1, LY9"], ["GO:0005102", "MF", "signaling receptor binding", "1.36E−09", "5.99E−07", "4.41E−06", "1.20E−06", "73", "IL34, NRG1, HLA-DQA1, ESR1, GDF6, PENK, TAC4, KDM5D, IL17D, MDK, ITGBL1, FAP, SERPINE2, FCER2, NRXN2, FCN1, CLEC11A, UCHL1, AGTR2, CXCL9, NGEF, CTHRC1, C1QTNF2, CCL22, CCL24, CXCL11, COL16A1, COMP, WNT10B, WNT9A, CXCL14, APOA1, FCRL6, GNA14, OASL, RASL11B, LRRC15, CXCL10, ADAM18, MYOC, SYTL2, NDP, ACE, GDNF, ITGB7, GFRA3, PTN, LYPD1, SCG2, NPPA, NPPB, MCHR1, ECM2, CMTM2, ESM1, LCK, OGN, TGFB2, LEFTY2, CD2, CD3E, THBS4, CD3G, THY1, TIGIT, MS4A1, C1QTNF9, CD40LG, LTB, GREM1, SYTL1, LEF1, LGI1"], ["GO:0098772", "MF", "molecular function regulator", "3.79E−04", "1.59E−02", "1.17E−01", "3.34E−01", "58", "IL34, NRG1, ESR1, GDF6, PENK, TAC4, IL17D, MDK, KCNIP1, SERPINE2, MYOZ1, NRXN2, CLEC11A, SCN2B, AGTR2, CXCL9, NGEF, CCL22, CCL24, CXCL11, HTR2B, PI16, SCG5, WNT10B, WNT9A, CXCL14, APOA1, LRRC55, PPP2R2B, ATP1B2, CXCL10, NDP, BIRC7, GDNF, PTN, TBC1D10C, LYPD1, SCG2, NPPA, NPPB, AZIN2, CMTM2, OGN, RGS4, ITIH5, TGFB2, LEFTY2, RASGRP1, THBS4, THY1, CD27, C1QTNF9, CD40LG, RGS17, LTB, GREM1, LEF1, INKA1"], ["Down regulated genes"], ["GO:0046903", "BP", "secretion", "1.07E−11", "5.64E−08", "5.16E−07", "5.64E−08", "78", "SERPINA3, HK3, SYN3, ACP3, TRPC4, CFTR, CD109, HMOX2, CHI3L1, F5, F8, F13A1, S100A8, S100A9, SAA1, FCER1G, MGST1, PIK3C2A, HP, AGTR1, PLA2G2A, CCR1, FGF10, C1QTNF1, PLA2G4F, FGR, MERTK, SERPINF2, ALOX5, SYT13, IL17RB, CNR1, ALOX15B, FLT3, ANPEP, P2RY12, ANXA3, FPR1, CR1, SLC1A1, SLC2A1, ARG1, ARNTL, SLC11A1, SLC22A16, LGI3, NSG1, ATP2A2, IL10, SIGLEC9, GPR84, NHLRC2, SSTR5, HPSE, KCNB1, IL1R2, PTX3, GLUL, SYN2, BANK1, WNK3, KNG1, CRISPLD2, CACNA1E, CD177, SIGLEC14, EDN1, EDN2, EDNRB, THBS1, RNASE2, CD38, TLR2, SERPINE1, ELANE, STEAP3, IL1RL1, MCEMP1"], ["GO:0006952", "BP", "defense response", "1.04E−06", "1.63E−04", "1.49E−03", "5.50E−03", "65", "SERPINA3, EREG, VSIG4, TMIGD3, CLEC7A, RAET1E, CHI3L1, F8, CD163, S100A8, S100A9, SAA1, FCER1G, HP, HPR, AGTR1, PLA2G2A, CCR1, FGR, SERPINF2, ALOX5, ALOX5AP, IL17RB, CNR1, SELE, ADAMTS4, ANXA3, FPR1, APOB, SAMHD1, CR1, FCN3, AQP4, ARG1, SLC11A1, MARCO, IL10, BCL6, IL18R1, GGT5, IL1R2, PTX3, SIGLEC10, KNG1, CACNA1E, CD177, SOCS3, SIGLEC14, ADAMTS5, LBP, S1PR3, EDN1, EDNRB, FOSL1, THBS1, RNASE2, NAMPT, TLR2, SERPINE1, ELANE, IRAK3, ELF3, IL1RL1, CALCRL, OSMR"], ["GO:0031226", "CC", "intrinsic component of plasma membrane", "1.74E−10", "4.55E−08", "3.11E−07", "9.10E−08", "74", "TPO, EREG, OPN4, TRPC4, CFTR, TMIGD3, KCNIP2, CD163, FCER1G, SCN3A, AGTR1, CCR1, C1QTNF1, MERTK, SYT13, IL17RB, CNR1, TRHDE, SELE, LRRC8E, FLT3, SLC4A7, P2RY12, SLC31A2, CR1, LGR5, AQP3, AQP4, SLC1A1, SLC2A1, SLC5A1, MSR1, SLC11A1, SIGLEC7, ART3, SLCO2A1, ATP2A2, MARCO, GABRR2, SIGLEC9, SLCO4A1, GPR84, SSTR2, SSTR5, IL18R1, LAPTM5, GGT5, SLC52A3, LYVE1, KCNA7, KCNB1, KCND3, NECTIN1, KCNK1, KCNK3, KCNS2, ADGRD1, CACNA1E, GPR4, GPR12, SLC38A4, GPR183, GPRC5A, RGR, S1PR3, RHAG, EDNRB, TGFBR3, TLR2, LGR6, CALCRL, OSMR, HAS2, CDH16"], ["GO:0098805", "CC", "whole membrane", "1.91E−03", "4.99E−02", "3.41E−01", "9.97E−01", "51", "EREG, SYN3, ACP3, TRPC4, CFTR, CD109, HMOX2, CD163, FCER1G, MGST1, PLA2G4F, GPAT2, MOG, CNR1, SELE, ANPEP, P2RY12, ANXA3, FPR1, APOB, SCGN, CR1, AQP4, SLC1A1, SLC2A1, ARG1, MSR1, SLC11A1, NSG1, RAB39A, MARCO, SIGLEC9, GPR84, HPSE, LAPTM5, KCND3, SYN2, SLC9A7, WASF1, CD177, SIGLEC14, GRB14, STEAP4, EDNRB, GRIP1, CD38, TLR2, STEAP3, HAS2, SERPINA5, MCEMP1"], ["GO:0038023", "MF", "signaling receptor activity", "2.36E−04", "1.97E−02", "1.49E−01", "2.53E−01", "55", "EREG, OPN4, CLEC7A, FCER1G, FCGR3A, AGTR1, CCR1, ADGRF5, ADGRF4, MERTK, IL17RB, CNR1, SELE, FLT3, MYOT, ANPEP, P2RY12, ANXA3, FPR1, CR1, LGR5, SIGLEC7, MARCO, PALLD, IL10, GABRR2, IL15RA, GPR82, DNER, PAQR5, GPR84, IL20RA, SSTR2, SSTR5, IL18R1, LYVE1, IL1R2, NECTIN1, ADGRD1, GPR4, GPR12, NPTX2, GPR183, GPRC5A, PKHD1L1, RGR, S1PR3, EDNRB, TGFBR3, TLR2, SERPINE1, IL1RL1, LGR6, CALCRL, OSMR"], ["GO:0060089", "MF", "molecular transducer activity", "4.71E−04", "2.10E−02", "1.59E−01", "5.04E−01", "58", "EREG, OPN4, CLEC7A, FCER1G, FCGR3A, AGTR1, CCR1, ADGRF5, ADGRF4, MERTK, IL17RB, CNR1, SELE, FLT3, MYOT, ANPEP, P2RY12, ANXA3, FPR1, CR1, LGR5, SIGLEC7, MARCO, PALLD, IL10, GABRR2, IL15RA, GPR82, DNER, PAQR5, GPR84, IL20RA, STOX1, SSTR2, SSTR5, IL18R1, BLM, CDKL5, LYVE1, IL1R2, NECTIN1, ADGRD1, GPR4, GPR12, NPTX2, GPR183, GPRC5A, PKHD1L1, RGR, S1PR3, EDNRB, TGFBR3, TLR2, SERPINE1, IL1RL1, LGR6, CALCRL, OSMR"]], "row_count": 15, "column_count": 9, "numeric_cells": 84, "header_rows": 1, "locator": "section[14]/table-wrap[1]#Tab2"}}, {"id": "asset:table:pmid:34218797:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:91dd15a29c48fafce4f82db7422df3ec793ebc8e8f2c7f61de90d6638775df68", "bytes": 3889, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[14]/table-wrap[2]#Tab3", "version": null, "note": "The enriched pathway terms of the up and down regulated differentially expressed genes", "structure": {"pmcid": "PMC8256614", "section_index": 5, "section_title": "Functional enrichment analysis", "row_count": 17, "column_count": 8}, "table": {"label": "Table 3", "caption": "The enriched pathway terms of the up and down regulated differentially expressed genes", "rows": [["Pathway ID", "Pathway name", "P-value", "FDR B&H", "FDR B&Y", "Bonferroni", "Gene count", "Gene"], ["Up regulated genes"], ["1270244", "Extracellular matrix organization", "3.33E−08", "1.80E−05", "1.23E−04", "1.80E−05", "24", "COL22A1, MFAP4, CMA1, COL14A1, COL1A1, COL8A2, COL9A1, COL9A2, COL10A1, FMOD, COL16A1, COMP, HAPLN1, ADAMTS14, CTSG, ASPN, ITGAL, ITGB7, CAPN6, TGFB2, P3H2, TLL2, LTBP2, LUM"], ["1269201", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "8.13E−06", "7.31E−04", "5.03E−03", "4.39E−03", "13", "SH2D1B, SLAMF7, SIGLEC8, ITGAL, ITGB7, KLRB1, CD1C, CD3D, CD3E, CD3G, CD247, CD40LG, SH2D1A"], ["1269544", "GPCR ligand binding", "3.92E−04", "1.51E−02", "1.04E−01", "2.12E−01", "22", "GNG8, PENK, F2RL2, AGTR2, APLNR, CXCL9, CCR7, CXCL11, OXER1, HTR2A, HTR2B, WNT10B, WNT9A, ACKR4, CRHBP, S1PR5, FZD2, CX3CR1, CXCL10, MCHR1, LHCGR, GPR68"], ["1268749", "Metabolism of Angiotensinogen to Angiotensins", "5.26E−04", "1.85E−02", "1.27E−01", "2.84E−01", "4", "CMA1, CTSG, ACE, GZMH"], ["1269868", "Muscle contraction", "3.44E−02", "4.03E−01", "1.00E+00", "1.00E+00", "9", "KCNIP1, RYR3, SCN2B, ATP1A4, ATP1B2, MYL1, KCNK17, NPPA, TNNI1"], ["1269340", "Hemostasis", "6.57E−02", "5.21E−01", "1.00E+00", "1.00E+00", "20", "GNG8, CEACAM3, F2RL2, SERPINE2, APOA1, GNA14, PDE5A, ATP1B2, IL2RB, CTSW, ISLR, ITGAL, LCK, TGFB2, LEFTY2, RASGRP1, CD2, P2RX6, CD48, HBB"], ["1269171", "Adaptive Immune System", "1.32E−01", "6.87E−01", "1.00E+00", "1.00E+00", "23", "NRG1, HLA-DQA1, ZAP70, SH2D1B, CARD11, SLAMF7, SIGLEC8, ITGAL, ITGB7, ASB18, IER3, MRC2, KLRB1, LCK, RASGRP1, CD1C, CD3D, CD3E, CD3G, CD247, FBXL16, CD40LG, SH2D1A"], ["Down regulated genes"], ["1457780", "Neutrophil degranulation", "4.82E−06", "3.14E−03", "2.22E−02", "3.14E−03", "28", "SERPINA3, HK3, ACP3, HMOX2, CHI3L1, S100A8, S100A9, FCER1G, MGST1, HP, FGR, ALOX5, ANPEP, FPR1, CR1, ARG1, SLC11A1, SIGLEC9, GPR84, HPSE, PTX3, CRISPLD2, CD177, SIGLEC14, RNASE2, TLR2, ELANE, MCEMP1"], ["1269907", "SLC-mediated transmembrane transport", "6.91E−04", "4.74E−02", "3.35E−01", "4.51E−01", "16", "HK3, SLC7A11, SLC4A7, SLC1A1, SLC2A1, SLC5A1, SLC11A1, SLC22A16, SLCO2A1, SLCO4A1, GCKR, LCN15, SLC9A7, SLC25A18, SLC38A4, RHAG"], ["1269545", "Class A/1 (Rhodopsin-like receptors)", "8.72E−04", "4.74E−02", "3.35E−01", "5.69E−01", "17", "OPN4, SAA1, AGTR1, CCR1, CNR1, P2RY12, FPR1, SSTR2, SSTR5, KNG1, GPR4, GPR183, RGR, S1PR3, EDN1, EDN2, EDNRB"], ["1269340", "Hemostasis", "2.18E−03", "7.11E−02", "5.02E−01", "1.00E+00", "26", "SERPINA3, CD109, SLC7A11, F5, F8, F13A1, SERPINB8, FCER1G, FGR, MERTK, SERPINF2, SELE, P2RY12, APOB, KIF18B, ATP2A2, NHLRC2, KNG1, PDE11A, CD177, DOCK9, GRB7, GRB14, THBS1, SERPINE1, SERPINA5"], ["1269903", "Transmembranetransport of small molecules", "4.89E−03", "1.28E−01", "9.01E−01", "1.00E+00", "26", "HK3, TRPC4, CFTR, HMOX2, SLC7A11, ABCB1, SLC4A7, AQP3, AQP4, SLC1A1, SLC2A1, SLC5A1, SLC11A1, SLC22A16, SLCO2A1, ATP2A2, GABRR2, SLCO4A1, GCKR, LCN15, SLC9A7, WNK3, SLC25A18, SLC38A4, RHAG, STEAP3"], ["1269203", "Innate Immune System", "9.62E−03", "1.96E−01", "1.00E+00", "1.00E+00", "42", "SERPINA3, EREG, HK3, MARK3, ACP3, CLEC7A, HMOX2, CHI3L1, S100A8, S100A9, SAA1, FCER1G, MGST1, FCGR3A, HP, GRAP2, PLA2G2A, FGF5, FGF10, FGR, ALOX5, ANPEP, FPR1, APOB, CR1, FCN3, ARG1, SLC11A1, SIGLEC9, GPR84, HPSE, PTX3, WASF1, CRISPLD2, CD177, SIGLEC14, LBP, RNASE2, TLR2, ELANE, IRAK3, MCEMP1"], ["1269310", "Cytokine Signaling in Immune system", "8.42E−02", "4.76E−01", "1.00E+00", "1.00E+00", "23", "EREG, MARK3, F13A1, SAA1, FGF5, CCR1, FGF10, ALOX5, IL17RB, FLT3, FPR1, SAMHD1, IL10, IL15RA, IL20RA, BCL6, IL18R1, IL1R2, SOCS3, LBP, IRAK3, IL1RL1, OSMR"]], "row_count": 17, "column_count": 8, "numeric_cells": 98, "header_rows": 1, "locator": "section[14]/table-wrap[2]#Tab3"}}, {"id": "asset:table:pmid:34218797:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:d40d246e9267cdecbb667151bf6fc24dd1163f94c5e35a99f6a9287292c2dc92", "bytes": 2113, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[16]/table-wrap[1]#Tab5", "version": null, "note": "miRNA—target gene and TF—target gene interaction", "structure": {"pmcid": "PMC8256614", "section_index": 7, "section_title": "Target gene—miRNA regulatory network construction", "row_count": 30, "column_count": 8}, "table": {"label": "Table 5", "caption": "miRNA—target gene and TF—target gene interaction", "rows": [["Regulation", "Target Genes", "Degree", "MicroRNA", "Regulation", "Target Genes", "Degree", "TF"], ["Up", "FSCN1", "99", "hsa-mir-4533", "Up", "FSCN1", "62", "ESRRA"], ["Up", "ESR1", "72", "hsa-mir-548ac", "Up", "APOA1", "48", "RERE"], ["Up", "TMEM30B", "64", "hsa-mir-548i", "Up", "COL1A1", "21", "HMG20B"], ["Up", "SCN2B", "46", "hsa-mir-5585-3p", "Up", "HBB", "16", "THRAP3"], ["Up", "CENPA", "35", "hsa-mir-6750-3p", "Up", "LCK", "15", "ATF1"], ["Up", "APOA1", "22", "hsa-mir-6722-5p", "Up", "FOXS1", "14", "YBX1"], ["Up", "PPP2R2B", "14", "hsa-mir-149-3p", "Up", "CENPA", "10", "SAP30"], ["Up", "TP63", "12", "hsa-mir-1178-3p", "Up", "SCN2B", "5", "RCOR2"], ["Up", "PYHIN1", "5", "hsa-mir-205-3p", "Up", "TMEM30B", "5", "ZNF24"], ["Up", "APLNR", "2", "hsa-mir-10b-5p", "Up", "APLNR", "4", "FOXJ2"], ["Up", "PTN", "1", "hsa-mir-155-5p", "Up", "NRG1", "2", "SUZ12"], ["Up", "LCK", "1", "hsa-mir-335-5p", "Up", "PTN", "2", "L3MBTL2"], ["Up", "CD247", "1", "hsa-mir-346", "Up", "UCHL1", "2", "MAZ"], ["Down", "FKBP5", "88", "hsa-mir-200c-3p", "Up", "ESR1", "1", "EZH2"], ["Down", "PCLAF", "62", "hsa-mir-1273g-3p", "Up", "ZAP70", "1", "ZFX"], ["Down", "CEP55", "57", "hsa-mir-1244", "Down", "SOCS3", "48", "MXD3"], ["Down", "ATP2A2", "55", "hsa-mir-4789-3p", "Down", "BCL6", "44", "ARID4B"], ["Down", "TK1", "45", "hsa-mir-766-3p", "Down", "FKBP5", "43", "CBFB"], ["Down", "ZBTB16", "43", "hsa-mir-1976", "Down", "ANLN", "38", "TAF7"], ["Down", "SAMHD1", "26", "hsa-mir-3124-3p", "Down", "ATP2A2", "35", "CREM"], ["Down", "TOP2A", "17", "hsa-mir-186-5p", "Down", "CBS", "31", "IKZF1"], ["Down", "BCL6", "13", "hsa-mir-339-5p", "Down", "BLM", "19", "ZNF501"], ["Down", "ECT2", "13", "hsa-mir-132-3p", "Down", "ECT2", "15", "KLF16"], ["Down", "CFTR", "9", "hsa-mir-145-5p", "Down", "CEP55", "10", "FOSL2"], ["Down", "S100A9", "7", "hsa-mir-4679", "Down", "GRAP2", "10", "CEBPD"], ["Down", "AGTR1", "5", "hsa-mir-410-3p", "Down", "ZBTB16", "4", "TRIM28"], ["Down", "ANLN", "5", "hsa-mir-503-5p", "Down", "S100A8", "3", "STAT3"], ["Down", "BLM", "3", "hsa-mir-193b-3p", "Down", "S100A9", "2", "CEBPG"], ["", "", "", "", "Down", "AGTR1", "1", "EZH2"]], "row_count": 30, "column_count": 8, "numeric_cells": 104, "header_rows": 1, "locator": "section[16]/table-wrap[1]#Tab5"}}, {"id": "asset:table:pmid:34218797:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:848c0dbc1a78a523ff7254e102bab3b7e2a0a579d69f16124916986e39bc2598", "bytes": 806, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[10]/table-wrap[1]#Tab1", "version": null, "note": "The sequences of primers for quantitative RT-PCR", "structure": {"pmcid": "PMC8256614", "section_index": 10, "section_title": "RT-PCR analysis", "row_count": 11, "column_count": 3}, "table": {"label": "Table 1", "caption": "The sequences of primers for quantitative RT-PCR", "rows": [["Genes", "Forward primers", "Reverse primers"], ["ESR1", "CCTCTGGCTACCATTATGGG", "AGTCATTGTGTCCTTGAATGC"], ["PYHIN1", "GCAAGATCAGTACGACAGAG", "AGATAACTGAGCAACCTGTG"], ["PPP2R2B", "ACCAGAGACTATCTGACCG", "GTAGTCATGAACCTGGTATGTC"], ["LCK", "CTAGTCCGGCTTTATGCAG", "AAATCTACTAGGCTCCCGT"], ["TP63", "ATTCAATGAGGGACAGATTGC", "GGGTCTTCTACATACTGGGC"], ["PCLAF", "GACCAATATAAACTGTGGCGGG", "CCAGGGTAAACAAGGAGACGTT"], ["CFTR", "CTGTGGCCTTGGTTTACTG", "CTCTGATCTCTGTACTTCACCA"], ["TK1", "AGATTCAGGTGATTCTCGGG", "ACTTGTACTGGGCGATCTG"], ["ECT2", "GCTGTATTGTACGAGTATGCT", "GTCACCAATTTGACAAGCTC"], ["FKBP5", "CCTAAGTTTGGCATTGACCC", "CCAAGATTCTTTGGCCTTCTC"]], "row_count": 11, "column_count": 3, "numeric_cells": 1, "header_rows": 1, "locator": "section[10]/table-wrap[1]#Tab1"}}, {"id": "asset:table:pmid:34218797:5", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:039e3c101909fdc467734aa90b6724fe12ab39ff52eed20c608fec81eb075919", "bytes": 5846, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[20]/table-wrap[1]#Tab6", "version": null, "note": "Docking results of Designed Molecules on Over Expressed Proteins", "structure": {"pmcid": "PMC8256614", "section_index": 11, "section_title": "Identification of candidate small molecules", "row_count": 38, "column_count": 16}, "table": {"label": "Table 6", "caption": "Docking results of Designed Molecules on Over Expressed Proteins", "rows": [["Sl. No/Code", "Over expressed gene: ESR1", "Over expressed gene: LCK", "Over expressed gene: PPP2R2B", "Over expressed gene: PYHIN 1", "Over expressed gene: TP63"], ["PDB: 4PXM", "PDB:1KSW", "PDB: 2HV7", "PDB: 3VD8", "PDB: 6RU6"], ["Total Score", "Crash(-Ve)", "Polar", "Total Score", "Crash(-Ve)", "Polar", "Total Score", "Crash(−Ve)", "Polar", "Total Score", "Crash(−Ve)", "Polar", "Total Score", "Crash(−Ve)", "Polar"], ["HIM1", "5.097", "− 4.375", "0.114", "4.258", "− 1.555", "1.784", "4.904", "− 0.870", "0.004", "5.794", "− 0.514", "3.828", "5.770", "− 1.440", "2.231"], ["HIM2", "4.057", "− 6.172", "0.039", "4.624", "− 0.997", "1.959", "4.906", "− 0.468", "1.517", "5.052", "− 0.780", "3.415", "5.414", "− 1.529", "2.444"], ["HIM3", "5.353", "− 5.309", "0.161", "4.578", "− 1.492", "1.790", "5.042", "− 1.845", "1.073", "5.680", "− 0.804", "3.956", "5.350", "− 1.170", "2.316"], ["HIM4", "3.976", "− 5.132", "0.167", "3.839", "− 1.635", "1.196", "6.328", "− 1.172", "1.128", "4.966", "− 0.666", "1.818", "5.627", "− 1.416", "2.320"], ["HIM5", "2.707", "− 7.759", "0.179", "4.067", "− 0.997", "1.987", "5.254", "− 0.674", "1.618", "4.563", "− 1.068", "2.935", "5.698", "− 1.240", "2.485"], ["HIM6", "5.948", "− 3.902", "1.796", "5.229", "− 0.707", "3.656", "6.766", "− 1.424", "1.858", "6.670", "− 0.941", "5.519", "6.218", "− 1.468", "2.578"], ["HIM7", "5.019", "− 7.055", "0.203", "4.382", "− 2.443", "3.329", "6.028", "− 0.629", "1.660", "5.374", "− 1.876", "0.670", "6.627", "− 1.484", "2.579"], ["HIM8", "4.429", "− 3.983", "0.344", "4.150", "− 4.382", "4.210", "6.794", "− 1.279", "1.129", "5.468", "− 0.769", "3.444", "5.842", "− 2.088", "2.272"], ["HIM9", "3.722", "− 5.956", "0.197", "4.051", "− 2.006", "0.002", "6.116", "− 0.597", "1.717", "5.407", "− 0.565", "1.370", "5.877", "− 2.054", "0.792"], ["HIM10", "6.771", "− 3.977", "1.836", "5.176", "− 3.512", "4.023", "5.332", "− 1.378", "3.349", "6.071", "− 0.923", "3.854", "5.825", "− 0.966", "3.672"], ["HIM11", "3.775", "− 6.079", "0.898", "6.998", "− 2.086", "3.842", "8.678", "− 1.065", "2.876", "5.087", "− 0.881", "1.854", "5.948", "− 1.015", "1.202"], ["HIM12", "0.190", "− 8.149", "0.022", "5.302", "− 2.305", "3.475", "5.227", "− 1.636", "0.710", "7.322", "− 1.128", "4.099", "6.237", "− 2.562", "2.171"], ["HIM13", "4.523", "− 4.537", "0.014", "4.840", "− 0.664", "3.305", "6.181", "− 2.966", "3.523", "5.281", "− 0.503", "3.981", "5.905", "− 1.136", "2.218"], ["HIM14", "5.247", "− 3.183", "0.000", "4.888", "− 1.296", "2.563", "5.037", "− 0.377", "1.647", "7.057", "− 0.799", "4.256", "6.116", "− 1.366", "2.438"], ["HIM15", "4.633", "− 4.173", "0.180", "3.756", "− 0.710", "2.072", "5.188", "− 1.559", "1.143", "5.570", "− 1.125", "3.718", "6.238", "− 1.708", "2.443"], ["HIM16", "4.588", "− 2.883", "0.000", "6.027", "− 1.099", "3.903", "5.606", "− 0.987", "4.197", "5.661", "− 0.926", "2.751", "7.263", "− 1.533", "4.212"], ["HIM17", "3.944", "− 4.806", "0.236", "5.329", "− 0.590", "2.798", "4.830", "− 1.682", "1.617", "6.234", "− 0.830", "3.912", "5.366", "− 1.257", "3.022"], ["HTZ1", "0.593", "− 7.518", "0", "4.221", "− 0.692", "1.975", "3.993", "− 0.539", "0.003", "5.284", "− 0.566", "1.432", "5.227", "− 1.045", "0.903"], ["HTZ2", "− 1.770", "− 8.477", "0.000", "4.055", "− 1.438", "2.877", "4.388", "− 1.665", "1.170", "4.100", "− 0.546", "3.017", "4.563", "− 0.976", "1.266"], ["HTZ3", "4.649", "− 5.870", "0.148", "5.104", "− 0.861", "3.922", "4.243", "− 1.539", "1.933", "5.304", "− 1.370", "1.398", "5.138", "− 1.217", "1.930"], ["HTZ4", "− 3.169", "− 12.002", "0.482", "4.173", "− 1.898", "1.864", "4.654", "− 1.627", "1.128", "5.163", "− 0.745", "1.304", "5.084", "− 1.143", "1.018"], ["HTZ5", "4.021", "− 12.325", "0.246", "3.215", "− 1.481", "4.232", "3.256", "− 6.374", "2.317", "2.382", "− 5.263", "1.238", "4.623", "− 0.951", "1.280"], ["HTZ6", "6.605", "− 3.866", "1.6487", "4.004", "− 1.104", "2.851", "5.834", "− 1.310", "3.111", "5.286", "− 1.530", "1.436", "6.336", "− 2.326", "3.781"], ["HTZ7", "4.977", "− 5.434", "0.655", "5.197", "− 2.040", "3.250", "5.352", "− 1.371", "1.172", "6.138", "− 1.734", "1.627", "4.908", "− 1.057", "1.335"], ["HTZ8", "1.025", "− 8.223", "0.000", "3.549", "− 1.310", "2.403", "4.024", "− 3.825", "2.440", "4.980", "− 0.593", "1.474", "5.164", "− 1.291", "0.999"], ["HTZ9", "3.386", "− 7.041", "0.194", "5.567", "− 1.622", "3.057", "6.792", "− 2.581", "1.088", "5.794", "− 0.683", "1.774", "6.053", "− 1.408", "1.037"], ["HTZ10", "4.744", "− 5.463", "0.837", "4.520", "− 2.469", "3", "7.758", "− 1.518", "3.765", "5.345", "− 1.133", "3.661", "7.507", "− 2.080", "4.086"], ["HTZ11", "2.991", "− 6.177", "0", "3.453", "− 0.721", "1.266", "4.841", "− 1.738", "0.045", "4.368", "− 0.805", "1.074", "6.176", "− 1.380", "1.511"], ["HTZ12", "4.810", "− 6.157", "0.275", "5.296", "− 2.814", "3.605", "5.138", "− 1.840", "2.189", "5.083", "− 0.870", "1.536", "5.592", "− 1.321", "1.525"], ["HTZ13", "4.868", "− 3.837", "0", "4.863", "− 0.535", "2.405", "4.656", "− 0.681", "3.152", "4.246", "− 2.335", "0.529", "6.404", "− 0.975", "2.954"], ["HTZ14", "5.646", "− 3.473", "0", "4.948", "− 0.801", "2.324", "4.953", "− 1.672", "1.066", "5.058", "− 1.174", "1.121", "5.114", "− 1.299", "1.296"], ["HTZ15", "3.428", "− 4.957", "0.348", "3.949", "− 0.614", "1.873", "4.049", "− 0.787", "1.224", "4.796", "− 1.066", "1.489", "3.510", "− 0.607", "0.461"], ["HTZ16", "4.227", "− 4.787", "0.298", "4.654", "− 1.534", "2.096", "6.143", "− 1.204", "2.879", "4.854", "− 0.994", "1.564", "7.102", "− 0.917", "3.001"], ["HTZ17", "3.784", "− 5.018", "0.380", "3.661", "− 0.897", "1.676", "4.016", "− 1.179", "1.384", "4.039", "− 0.569", "2.706", "4.256", "− 1.040", "1.236"], ["HTZSTD", "4.722", "− 1.084", "1.063", "3.319", "− 0.890", "3.033", "3.564", "− 0.272", "2.367", "3.394", "− 0.882", "1.169", "4.237", "− 0.801", "1.855"]], "row_count": 38, "column_count": 16, "numeric_cells": 548, "header_rows": 3, "locator": "section[20]/table-wrap[1]#Tab6"}}, {"id": "asset:table:pmid:34218797:6", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:fc6e85b6cad727bfd46ed9fd450f44efba00a2b712c35d01a273dfc99f819d90", "bytes": 7015, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[14]/table-wrap[1]#Tab2", "version": null, "note": "The enriched GO terms of the up and down regulated differentially expressed genes", "structure": {"pmcid": "PMC8256614", "section_index": 14, "section_title": "Functional enrichment analysis", "row_count": 15, "column_count": 9}, "table": {"label": "Table 2", "caption": "The enriched GO terms of the up and down regulated differentially expressed genes", "rows": [["GO ID", "CATEGORY", "GO Name", "P Value", "FDR B&H", "FDR B&Y", "Bonferroni", "Gene Count", "Gene"], ["Up regulated genes"], ["GO:0022610", "BP", "biological adhesion", "1.32E−13", "3.37E−10", "3.08E−09", "6.75E−10", "72", "HLA-DQA1, DACT2, CD83, MDK, UBASH3A, ITGBL1, FAP, MFAP4, SERPINE2, NRXN2, COL14A1, CCR7, ALOX15, COL1A1, LAMB4, COL8A2, STAB2, COL16A1, COMP, TBX21, FERMT1, XG, CCDC80, APOA1, PODXL2, ZAP70, HAPLN1, TENM4, SKAP1, CNTNAP2, PDE5A, CARD11, CTNNA2, SLAMF7, ATP1B2, CX3CR1, LRRC15, IDO1, MYOC, SIGLEC8, ISLR, SMOC2, ITGAL, ITGB7, FREM1, PTN, KIRREL3, NTM, GLI2, FBLN7, DPT, NT5E, ECM2, LCK, OMG, OPCML, TGFB2, RASGRP1, CD2, CD3E, THBS4, CD5, CD6, THY1, TIGIT, CD27, CD40LG, ROBO2, GREM1, LY9, HBB, LEF1"], ["GO:0002682", "BP", "regulation of immune system process", "2.20E−10", "2.25E−07", "2.05E−06", "1.12E−06", "72", "IL34, HLA-DQA1, ESR1, TLR7, CD83, IL17D, MDK, UBASH3A, TNFRSF4, PYHIN1, ZBP1, FCER1A, MS4A2, FCER2, FCN1, CCR7, SMPD3, CCL24, SCARA3, ALOX15, COL1A1, IL31RA, TBX21, XG, CXCL14, APOA1, ZAP70, SH2D1B, SKAP1, PDE5A, CARD11, SLAMF7, CTSG, CX3CR1, IDO1, CXCL10, ITGAL, ACE, SIT1, ITGB7, PTN, TBC1D10C, FCRL3, BPI, GLI2, KLRB1, NPPA, CAMK4, LCK, TGFB2, RASGRP1, CD1C, CD1E, CD2, CD3D, CD3E, THBS4, CD3G, CD247, CD5, CD6, THY1, TIGIT, MS4A1, CD27, GPR68, CD40LG, CD48, GREM1, SH2D1A, LEF1, LRRC17"], ["GO:0031012", "CC", "extracellular matrix", "1.09E−20", "2.77E−18", "1.89E−17", "5.54E−18", "52", "MATN2, COL22A1, MDK, COLQ, MFAP4, SERPINE2, HMCN2, AEBP1, FCN1, CMA1, CTHRC1, COL14A1, SCARA3, COL1A1, LAMB4, COL8A2, COL9A1, COL9A2, COL10A1, MXRA5, FMOD, COL16A1, COMP, CCDC80, APOA1, HAPLN1, CTSG, ADAMTSL2, LRRC15, ASPN, MYOC, NDP, SMOC2, FREM1, PTN, SSC5D, SULF1, DPT, NPPA, ADAMTSL1, ECM2, OGN, ITIH5, TGFB2, LEFTY2, EYS, THBS4, P3H2, LTBP2, GREM1, LUM, LRRC17"], ["GO:0009986", "CC", "cell surface", "5.07E−17", "8.61E−15", "5.86E−14", "2.58E−14", "63", "HYAL4, NRG1, HLA-DQA1, CD83, TNFRSF4, ITGBL1, FAP, SERPINE2, FCER1A, MS4A2, FCER2, FCN1, CXCL9, CCR7, IL31RA, SFRP4, STAB2, DUOX2, APOA1, ACKR4, FCRL6, SCUBE2, CNTNAP2, SLAMF7, CTSG, IL2RB, CX3CR1, LRRC15, CXCL10, NDP, ITGAL, ACE, ITGB7, GFRA3, PTN, PROM1, SSC5D, FCRL3, SULF1, MRC2, NTM, CLEC9A, NT5E, TGFB2, LHCGR, CD1C, HHIP, CD1E, CD2, CD3D, CD3E, CD3G, CD5, CD6, THY1, TIGIT, MS4A1, CD27, CD40LG, CD48, ROBO2, GREM1, LY9"], ["GO:0005102", "MF", "signaling receptor binding", "1.36E−09", "5.99E−07", "4.41E−06", "1.20E−06", "73", "IL34, NRG1, HLA-DQA1, ESR1, GDF6, PENK, TAC4, KDM5D, IL17D, MDK, ITGBL1, FAP, SERPINE2, FCER2, NRXN2, FCN1, CLEC11A, UCHL1, AGTR2, CXCL9, NGEF, CTHRC1, C1QTNF2, CCL22, CCL24, CXCL11, COL16A1, COMP, WNT10B, WNT9A, CXCL14, APOA1, FCRL6, GNA14, OASL, RASL11B, LRRC15, CXCL10, ADAM18, MYOC, SYTL2, NDP, ACE, GDNF, ITGB7, GFRA3, PTN, LYPD1, SCG2, NPPA, NPPB, MCHR1, ECM2, CMTM2, ESM1, LCK, OGN, TGFB2, LEFTY2, CD2, CD3E, THBS4, CD3G, THY1, TIGIT, MS4A1, C1QTNF9, CD40LG, LTB, GREM1, SYTL1, LEF1, LGI1"], ["GO:0098772", "MF", "molecular function regulator", "3.79E−04", "1.59E−02", "1.17E−01", "3.34E−01", "58", "IL34, NRG1, ESR1, GDF6, PENK, TAC4, IL17D, MDK, KCNIP1, SERPINE2, MYOZ1, NRXN2, CLEC11A, SCN2B, AGTR2, CXCL9, NGEF, CCL22, CCL24, CXCL11, HTR2B, PI16, SCG5, WNT10B, WNT9A, CXCL14, APOA1, LRRC55, PPP2R2B, ATP1B2, CXCL10, NDP, BIRC7, GDNF, PTN, TBC1D10C, LYPD1, SCG2, NPPA, NPPB, AZIN2, CMTM2, OGN, RGS4, ITIH5, TGFB2, LEFTY2, RASGRP1, THBS4, THY1, CD27, C1QTNF9, CD40LG, RGS17, LTB, GREM1, LEF1, INKA1"], ["Down regulated genes"], ["GO:0046903", "BP", "secretion", "1.07E−11", "5.64E−08", "5.16E−07", "5.64E−08", "78", "SERPINA3, HK3, SYN3, ACP3, TRPC4, CFTR, CD109, HMOX2, CHI3L1, F5, F8, F13A1, S100A8, S100A9, SAA1, FCER1G, MGST1, PIK3C2A, HP, AGTR1, PLA2G2A, CCR1, FGF10, C1QTNF1, PLA2G4F, FGR, MERTK, SERPINF2, ALOX5, SYT13, IL17RB, CNR1, ALOX15B, FLT3, ANPEP, P2RY12, ANXA3, FPR1, CR1, SLC1A1, SLC2A1, ARG1, ARNTL, SLC11A1, SLC22A16, LGI3, NSG1, ATP2A2, IL10, SIGLEC9, GPR84, NHLRC2, SSTR5, HPSE, KCNB1, IL1R2, PTX3, GLUL, SYN2, BANK1, WNK3, KNG1, CRISPLD2, CACNA1E, CD177, SIGLEC14, EDN1, EDN2, EDNRB, THBS1, RNASE2, CD38, TLR2, SERPINE1, ELANE, STEAP3, IL1RL1, MCEMP1"], ["GO:0006952", "BP", "defense response", "1.04E−06", "1.63E−04", "1.49E−03", "5.50E−03", "65", "SERPINA3, EREG, VSIG4, TMIGD3, CLEC7A, RAET1E, CHI3L1, F8, CD163, S100A8, S100A9, SAA1, FCER1G, HP, HPR, AGTR1, PLA2G2A, CCR1, FGR, SERPINF2, ALOX5, ALOX5AP, IL17RB, CNR1, SELE, ADAMTS4, ANXA3, FPR1, APOB, SAMHD1, CR1, FCN3, AQP4, ARG1, SLC11A1, MARCO, IL10, BCL6, IL18R1, GGT5, IL1R2, PTX3, SIGLEC10, KNG1, CACNA1E, CD177, SOCS3, SIGLEC14, ADAMTS5, LBP, S1PR3, EDN1, EDNRB, FOSL1, THBS1, RNASE2, NAMPT, TLR2, SERPINE1, ELANE, IRAK3, ELF3, IL1RL1, CALCRL, OSMR"], ["GO:0031226", "CC", "intrinsic component of plasma membrane", "1.74E−10", "4.55E−08", "3.11E−07", "9.10E−08", "74", "TPO, EREG, OPN4, TRPC4, CFTR, TMIGD3, KCNIP2, CD163, FCER1G, SCN3A, AGTR1, CCR1, C1QTNF1, MERTK, SYT13, IL17RB, CNR1, TRHDE, SELE, LRRC8E, FLT3, SLC4A7, P2RY12, SLC31A2, CR1, LGR5, AQP3, AQP4, SLC1A1, SLC2A1, SLC5A1, MSR1, SLC11A1, SIGLEC7, ART3, SLCO2A1, ATP2A2, MARCO, GABRR2, SIGLEC9, SLCO4A1, GPR84, SSTR2, SSTR5, IL18R1, LAPTM5, GGT5, SLC52A3, LYVE1, KCNA7, KCNB1, KCND3, NECTIN1, KCNK1, KCNK3, KCNS2, ADGRD1, CACNA1E, GPR4, GPR12, SLC38A4, GPR183, GPRC5A, RGR, S1PR3, RHAG, EDNRB, TGFBR3, TLR2, LGR6, CALCRL, OSMR, HAS2, CDH16"], ["GO:0098805", "CC", "whole membrane", "1.91E−03", "4.99E−02", "3.41E−01", "9.97E−01", "51", "EREG, SYN3, ACP3, TRPC4, CFTR, CD109, HMOX2, CD163, FCER1G, MGST1, PLA2G4F, GPAT2, MOG, CNR1, SELE, ANPEP, P2RY12, ANXA3, FPR1, APOB, SCGN, CR1, AQP4, SLC1A1, SLC2A1, ARG1, MSR1, SLC11A1, NSG1, RAB39A, MARCO, SIGLEC9, GPR84, HPSE, LAPTM5, KCND3, SYN2, SLC9A7, WASF1, CD177, SIGLEC14, GRB14, STEAP4, EDNRB, GRIP1, CD38, TLR2, STEAP3, HAS2, SERPINA5, MCEMP1"], ["GO:0038023", "MF", "signaling receptor activity", "2.36E−04", "1.97E−02", "1.49E−01", "2.53E−01", "55", "EREG, OPN4, CLEC7A, FCER1G, FCGR3A, AGTR1, CCR1, ADGRF5, ADGRF4, MERTK, IL17RB, CNR1, SELE, FLT3, MYOT, ANPEP, P2RY12, ANXA3, FPR1, CR1, LGR5, SIGLEC7, MARCO, PALLD, IL10, GABRR2, IL15RA, GPR82, DNER, PAQR5, GPR84, IL20RA, SSTR2, SSTR5, IL18R1, LYVE1, IL1R2, NECTIN1, ADGRD1, GPR4, GPR12, NPTX2, GPR183, GPRC5A, PKHD1L1, RGR, S1PR3, EDNRB, TGFBR3, TLR2, SERPINE1, IL1RL1, LGR6, CALCRL, OSMR"], ["GO:0060089", "MF", "molecular transducer activity", "4.71E−04", "2.10E−02", "1.59E−01", "5.04E−01", "58", "EREG, OPN4, CLEC7A, FCER1G, FCGR3A, AGTR1, CCR1, ADGRF5, ADGRF4, MERTK, IL17RB, CNR1, SELE, FLT3, MYOT, ANPEP, P2RY12, ANXA3, FPR1, CR1, LGR5, SIGLEC7, MARCO, PALLD, IL10, GABRR2, IL15RA, GPR82, DNER, PAQR5, GPR84, IL20RA, STOX1, SSTR2, SSTR5, IL18R1, BLM, CDKL5, LYVE1, IL1R2, NECTIN1, ADGRD1, GPR4, GPR12, NPTX2, GPR183, GPRC5A, PKHD1L1, RGR, S1PR3, EDNRB, TGFBR3, TLR2, SERPINE1, IL1RL1, LGR6, CALCRL, OSMR"]], "row_count": 15, "column_count": 9, "numeric_cells": 84, "header_rows": 1, "locator": "section[14]/table-wrap[1]#Tab2"}}, {"id": "asset:table:pmid:34218797:7", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:91dd15a29c48fafce4f82db7422df3ec793ebc8e8f2c7f61de90d6638775df68", "bytes": 3889, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[14]/table-wrap[2]#Tab3", "version": null, "note": "The enriched pathway terms of the up and down regulated differentially expressed genes", "structure": {"pmcid": "PMC8256614", "section_index": 14, "section_title": "Functional enrichment analysis", "row_count": 17, "column_count": 8}, "table": {"label": "Table 3", "caption": "The enriched pathway terms of the up and down regulated differentially expressed genes", "rows": [["Pathway ID", "Pathway name", "P-value", "FDR B&H", "FDR B&Y", "Bonferroni", "Gene count", "Gene"], ["Up regulated genes"], ["1270244", "Extracellular matrix organization", "3.33E−08", "1.80E−05", "1.23E−04", "1.80E−05", "24", "COL22A1, MFAP4, CMA1, COL14A1, COL1A1, COL8A2, COL9A1, COL9A2, COL10A1, FMOD, COL16A1, COMP, HAPLN1, ADAMTS14, CTSG, ASPN, ITGAL, ITGB7, CAPN6, TGFB2, P3H2, TLL2, LTBP2, LUM"], ["1269201", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "8.13E−06", "7.31E−04", "5.03E−03", "4.39E−03", "13", "SH2D1B, SLAMF7, SIGLEC8, ITGAL, ITGB7, KLRB1, CD1C, CD3D, CD3E, CD3G, CD247, CD40LG, SH2D1A"], ["1269544", "GPCR ligand binding", "3.92E−04", "1.51E−02", "1.04E−01", "2.12E−01", "22", "GNG8, PENK, F2RL2, AGTR2, APLNR, CXCL9, CCR7, CXCL11, OXER1, HTR2A, HTR2B, WNT10B, WNT9A, ACKR4, CRHBP, S1PR5, FZD2, CX3CR1, CXCL10, MCHR1, LHCGR, GPR68"], ["1268749", "Metabolism of Angiotensinogen to Angiotensins", "5.26E−04", "1.85E−02", "1.27E−01", "2.84E−01", "4", "CMA1, CTSG, ACE, GZMH"], ["1269868", "Muscle contraction", "3.44E−02", "4.03E−01", "1.00E+00", "1.00E+00", "9", "KCNIP1, RYR3, SCN2B, ATP1A4, ATP1B2, MYL1, KCNK17, NPPA, TNNI1"], ["1269340", "Hemostasis", "6.57E−02", "5.21E−01", "1.00E+00", "1.00E+00", "20", "GNG8, CEACAM3, F2RL2, SERPINE2, APOA1, GNA14, PDE5A, ATP1B2, IL2RB, CTSW, ISLR, ITGAL, LCK, TGFB2, LEFTY2, RASGRP1, CD2, P2RX6, CD48, HBB"], ["1269171", "Adaptive Immune System", "1.32E−01", "6.87E−01", "1.00E+00", "1.00E+00", "23", "NRG1, HLA-DQA1, ZAP70, SH2D1B, CARD11, SLAMF7, SIGLEC8, ITGAL, ITGB7, ASB18, IER3, MRC2, KLRB1, LCK, RASGRP1, CD1C, CD3D, CD3E, CD3G, CD247, FBXL16, CD40LG, SH2D1A"], ["Down regulated genes"], ["1457780", "Neutrophil degranulation", "4.82E−06", "3.14E−03", "2.22E−02", "3.14E−03", "28", "SERPINA3, HK3, ACP3, HMOX2, CHI3L1, S100A8, S100A9, FCER1G, MGST1, HP, FGR, ALOX5, ANPEP, FPR1, CR1, ARG1, SLC11A1, SIGLEC9, GPR84, HPSE, PTX3, CRISPLD2, CD177, SIGLEC14, RNASE2, TLR2, ELANE, MCEMP1"], ["1269907", "SLC-mediated transmembrane transport", "6.91E−04", "4.74E−02", "3.35E−01", "4.51E−01", "16", "HK3, SLC7A11, SLC4A7, SLC1A1, SLC2A1, SLC5A1, SLC11A1, SLC22A16, SLCO2A1, SLCO4A1, GCKR, LCN15, SLC9A7, SLC25A18, SLC38A4, RHAG"], ["1269545", "Class A/1 (Rhodopsin-like receptors)", "8.72E−04", "4.74E−02", "3.35E−01", "5.69E−01", "17", "OPN4, SAA1, AGTR1, CCR1, CNR1, P2RY12, FPR1, SSTR2, SSTR5, KNG1, GPR4, GPR183, RGR, S1PR3, EDN1, EDN2, EDNRB"], ["1269340", "Hemostasis", "2.18E−03", "7.11E−02", "5.02E−01", "1.00E+00", "26", "SERPINA3, CD109, SLC7A11, F5, F8, F13A1, SERPINB8, FCER1G, FGR, MERTK, SERPINF2, SELE, P2RY12, APOB, KIF18B, ATP2A2, NHLRC2, KNG1, PDE11A, CD177, DOCK9, GRB7, GRB14, THBS1, SERPINE1, SERPINA5"], ["1269903", "Transmembranetransport of small molecules", "4.89E−03", "1.28E−01", "9.01E−01", "1.00E+00", "26", "HK3, TRPC4, CFTR, HMOX2, SLC7A11, ABCB1, SLC4A7, AQP3, AQP4, SLC1A1, SLC2A1, SLC5A1, SLC11A1, SLC22A16, SLCO2A1, ATP2A2, GABRR2, SLCO4A1, GCKR, LCN15, SLC9A7, WNK3, SLC25A18, SLC38A4, RHAG, STEAP3"], ["1269203", "Innate Immune System", "9.62E−03", "1.96E−01", "1.00E+00", "1.00E+00", "42", "SERPINA3, EREG, HK3, MARK3, ACP3, CLEC7A, HMOX2, CHI3L1, S100A8, S100A9, SAA1, FCER1G, MGST1, FCGR3A, HP, GRAP2, PLA2G2A, FGF5, FGF10, FGR, ALOX5, ANPEP, FPR1, APOB, CR1, FCN3, ARG1, SLC11A1, SIGLEC9, GPR84, HPSE, PTX3, WASF1, CRISPLD2, CD177, SIGLEC14, LBP, RNASE2, TLR2, ELANE, IRAK3, MCEMP1"], ["1269310", "Cytokine Signaling in Immune system", "8.42E−02", "4.76E−01", "1.00E+00", "1.00E+00", "23", "EREG, MARK3, F13A1, SAA1, FGF5, CCR1, FGF10, ALOX5, IL17RB, FLT3, FPR1, SAMHD1, IL10, IL15RA, IL20RA, BCL6, IL18R1, IL1R2, SOCS3, LBP, IRAK3, IL1RL1, OSMR"]], "row_count": 17, "column_count": 8, "numeric_cells": 98, "header_rows": 1, "locator": "section[14]/table-wrap[2]#Tab3"}}, {"id": "asset:table:pmid:34218797:8", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:839cfcfed9d2fc7852ecc423fbaff46f241f6bc95cf8e87698b1b153cb380dc9", "bytes": 16929, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[15]/table-wrap[1]#Tab4", "version": null, "note": "Topology table for up and down regulated genes", "structure": {"pmcid": "PMC8256614", "section_index": 15, "section_title": "Protein–protein interaction (PPI) network and module analysis", "row_count": 325, "column_count": 6}, "table": {"label": "Table 4", "caption": "Topology table for up and down regulated genes", "rows": [["Regulation", "Node", "Degree", "Betweenness", "Stress", "Closeness"], ["Up", "ESR1", "1094", "0.250896", "7.4E+08", "0.392769"], ["Up", "PYHIN1", "342", "0.054258", "1.1E+08", "0.339882"], ["Up", "PPP2R2B", "199", "0.023115", "35,268,762", "0.346839"], ["Up", "LCK", "162", "0.033618", "18,589,354", "0.353915"], ["Up", "TP63", "142", "0.018577", "39,426,608", "0.319664"], ["Up", "CD247", "129", "0.013832", "18,625,274", "0.317784"], ["Up", "PTN", "105", "0.016638", "36,892,166", "0.300662"], ["Up", "APLNR", "103", "0.016611", "40,715,208", "0.288093"], ["Up", "APOA1", "100", "0.018834", "13,935,332", "0.315866"], ["Up", "CENPA", "98", "0.009846", "31,131,318", "0.301786"], ["Up", "SKAP1", "97", "0.01599", "10,109,482", "0.313338"], ["Up", "FSCN1", "88", "0.010226", "9,387,016", "0.335367"], ["Up", "SCN2B", "86", "0.01089", "24,233,242", "0.284756"], ["Up", "TMEM30B", "79", "0.016411", "10,490,230", "0.270807"], ["Up", "FOXS1", "79", "0.009408", "26,398,078", "0.293247"], ["Up", "COL1A1", "76", "0.010472", "9,315,670", "0.308098"], ["Up", "ZAP70", "75", "0.007096", "5,315,196", "0.317614"], ["Up", "UCHL1", "74", "0.009753", "9,381,024", "0.331525"], ["Up", "HBB", "72", "0.009984", "14,209,592", "0.304767"], ["Up", "NRG1", "70", "0.01151", "13,449,066", "0.29526"], ["Up", "LEF1", "61", "0.007998", "18,260,094", "0.290744"], ["Up", "NT5E", "60", "0.009599", "11,470,634", "0.301563"], ["Up", "MDK", "59", "0.006889", "7,533,352", "0.305822"], ["Up", "ISLR", "58", "0.010139", "9,992,806", "0.294012"], ["Up", "FATE1", "57", "0.011609", "9,248,788", "0.281581"], ["Up", "LRRC15", "56", "0.010069", "4,772,792", "0.299094"], ["Up", "MATN2", "54", "0.004491", "9,580,600", "0.286792"], ["Up", "LIPH", "54", "0.008197", "6,873,658", "0.282347"], ["Up", "MYOC", "49", "0.005138", "12,313,276", "0.291029"], ["Up", "SCARA3", "49", "0.006492", "11,494,220", "0.290151"], ["Up", "NPPA", "46", "0.009502", "4,868,574", "0.307143"], ["Up", "CD83", "43", "0.005149", "5,484,906", "0.272841"], ["Up", "COL14A1", "41", "0.006129", "5,699,128", "0.292893"], ["Up", "CTSG", "40", "0.003821", "1,913,996", "0.296155"], ["Up", "SFRP4", "40", "0.004006", "7,876,966", "0.282518"], ["Up", "TRAF3IP3", "38", "0.006447", "4,263,002", "0.290602"], ["Up", "CLEC11A", "38", "0.005085", "3,520,012", "0.283596"], ["Up", "ATP1B4", "38", "0.005722", "2,476,482", "0.245939"], ["Up", "CD3E", "37", "0.003892", "1,537,326", "0.297624"], ["Up", "SH2D1A", "37", "0.003969", "2,117,220", "0.308113"], ["Up", "DDX3Y", "37", "0.003754", "1,632,916", "0.32095"], ["Up", "PRPH", "37", "0.001871", "1,994,266", "0.301494"], ["Up", "BIRC7", "35", "0.004835", "2,567,254", "0.28549"], ["Up", "CARD11", "35", "0.002249", "2,510,852", "0.292173"], ["Up", "RXRG", "35", "0.002394", "7,134,478", "0.26225"], ["Up", "CCL22", "34", "0.005706", "3,916,024", "0.281423"], ["Up", "CD27", "33", "0.003915", "2,076,446", 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"5,075,608", "0.263869"], ["Down", "CLEC7A", "25", "0.004246", "4,293,212", "0.277095"], ["Down", "KLF10", "24", "0.001607", "3,013,994", "0.281339"], ["Down", "GNMT", "24", "0.00165", "3,015,768", "0.269136"], ["Down", "ART3", "24", "0.002904", "2,401,360", "0.255748"], ["Down", "LRRC8E", "24", "0.003739", "4,188,308", "0.288665"], ["Down", "SLA", "23", "0.001714", "1,003,510", "0.289329"], ["Down", "CLEC4G", "23", "0.002667", "2,376,260", "0.277495"], ["Down", "TUBB4A", "5", "1.28E−04", "181,440", "0.250652"], ["Down", "CD38", "4", "0", "0", "0.268176"], ["Down", "FCGR3A", "4", "1.01E−04", "73,756", "0.268385"], ["Down", "F5", "3", "8.10E−07", "708", "0.248641"], ["Down", "EHF", "2", "7.11E−06", "4180", "0.254842"], ["Down", "KIAA1549", "2", "4.16E−04", "193,604", "0.261391"], ["Down", "S100A3", "2", "1.84E−05", "45,822", "0.254376"], ["Down", "ADH1B", "2", "3.40E−05", "28,184", "0.233546"], ["Down", "PAPSS2", "2", "1.05E−05", "8726", "0.251868"], ["Down", "PTX3", "1", "0", "0", 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"role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:d40d246e9267cdecbb667151bf6fc24dd1163f94c5e35a99f6a9287292c2dc92", "bytes": 2113, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[16]/table-wrap[1]#Tab5", "version": null, "note": "miRNA—target gene and TF—target gene interaction", "structure": {"pmcid": "PMC8256614", "section_index": 16, "section_title": "Target gene—miRNA regulatory network construction", "row_count": 30, "column_count": 8}, "table": {"label": "Table 5", "caption": "miRNA—target gene and TF—target gene interaction", "rows": [["Regulation", "Target Genes", "Degree", "MicroRNA", "Regulation", "Target Genes", "Degree", "TF"], ["Up", "FSCN1", "99", "hsa-mir-4533", "Up", "FSCN1", "62", "ESRRA"], ["Up", "ESR1", "72", "hsa-mir-548ac", "Up", "APOA1", "48", "RERE"], ["Up", "TMEM30B", "64", "hsa-mir-548i", "Up", "COL1A1", "21", "HMG20B"], ["Up", "SCN2B", "46", "hsa-mir-5585-3p", "Up", "HBB", "16", "THRAP3"], ["Up", "CENPA", "35", "hsa-mir-6750-3p", "Up", "LCK", "15", "ATF1"], ["Up", "APOA1", "22", "hsa-mir-6722-5p", "Up", "FOXS1", "14", "YBX1"], ["Up", "PPP2R2B", "14", "hsa-mir-149-3p", "Up", "CENPA", "10", "SAP30"], ["Up", "TP63", "12", "hsa-mir-1178-3p", "Up", "SCN2B", "5", "RCOR2"], ["Up", "PYHIN1", "5", "hsa-mir-205-3p", "Up", "TMEM30B", "5", "ZNF24"], ["Up", "APLNR", "2", "hsa-mir-10b-5p", "Up", "APLNR", "4", "FOXJ2"], ["Up", "PTN", "1", "hsa-mir-155-5p", "Up", "NRG1", "2", "SUZ12"], ["Up", "LCK", "1", "hsa-mir-335-5p", "Up", "PTN", "2", "L3MBTL2"], ["Up", "CD247", "1", "hsa-mir-346", "Up", "UCHL1", "2", "MAZ"], ["Down", "FKBP5", "88", "hsa-mir-200c-3p", "Up", "ESR1", "1", "EZH2"], ["Down", "PCLAF", "62", "hsa-mir-1273g-3p", "Up", "ZAP70", "1", "ZFX"], ["Down", "CEP55", "57", "hsa-mir-1244", "Down", "SOCS3", "48", "MXD3"], ["Down", "ATP2A2", "55", "hsa-mir-4789-3p", "Down", "BCL6", "44", "ARID4B"], ["Down", "TK1", "45", "hsa-mir-766-3p", "Down", "FKBP5", "43", "CBFB"], ["Down", "ZBTB16", "43", "hsa-mir-1976", "Down", "ANLN", "38", "TAF7"], ["Down", "SAMHD1", "26", "hsa-mir-3124-3p", "Down", "ATP2A2", "35", "CREM"], ["Down", "TOP2A", "17", "hsa-mir-186-5p", "Down", "CBS", "31", "IKZF1"], ["Down", "BCL6", "13", "hsa-mir-339-5p", "Down", "BLM", "19", "ZNF501"], ["Down", "ECT2", "13", "hsa-mir-132-3p", "Down", "ECT2", "15", "KLF16"], ["Down", "CFTR", "9", "hsa-mir-145-5p", "Down", "CEP55", "10", "FOSL2"], ["Down", "S100A9", "7", "hsa-mir-4679", "Down", "GRAP2", "10", "CEBPD"], ["Down", "AGTR1", "5", "hsa-mir-410-3p", "Down", "ZBTB16", "4", "TRIM28"], ["Down", "ANLN", "5", "hsa-mir-503-5p", "Down", "S100A8", "3", "STAT3"], ["Down", "BLM", "3", "hsa-mir-193b-3p", "Down", "S100A9", "2", "CEBPG"], ["", "", "", "", "Down", "AGTR1", "1", "EZH2"]], "row_count": 30, "column_count": 8, "numeric_cells": 104, "header_rows": 1, "locator": "section[16]/table-wrap[1]#Tab5"}}, {"id": "asset:table:pmid:34218797:10", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:848c0dbc1a78a523ff7254e102bab3b7e2a0a579d69f16124916986e39bc2598", "bytes": 806, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[10]/table-wrap[1]#Tab1", "version": null, "note": "The sequences of primers for quantitative RT-PCR", "structure": {"pmcid": "PMC8256614", "section_index": 19, "section_title": "RT-PCR analysis", "row_count": 11, "column_count": 3}, "table": {"label": "Table 1", "caption": "The sequences of primers for quantitative RT-PCR", "rows": [["Genes", "Forward primers", "Reverse primers"], ["ESR1", "CCTCTGGCTACCATTATGGG", "AGTCATTGTGTCCTTGAATGC"], ["PYHIN1", "GCAAGATCAGTACGACAGAG", "AGATAACTGAGCAACCTGTG"], ["PPP2R2B", "ACCAGAGACTATCTGACCG", "GTAGTCATGAACCTGGTATGTC"], ["LCK", "CTAGTCCGGCTTTATGCAG", "AAATCTACTAGGCTCCCGT"], ["TP63", "ATTCAATGAGGGACAGATTGC", "GGGTCTTCTACATACTGGGC"], ["PCLAF", "GACCAATATAAACTGTGGCGGG", "CCAGGGTAAACAAGGAGACGTT"], ["CFTR", "CTGTGGCCTTGGTTTACTG", "CTCTGATCTCTGTACTTCACCA"], ["TK1", "AGATTCAGGTGATTCTCGGG", "ACTTGTACTGGGCGATCTG"], ["ECT2", "GCTGTATTGTACGAGTATGCT", "GTCACCAATTTGACAAGCTC"], ["FKBP5", "CCTAAGTTTGGCATTGACCC", "CCAAGATTCTTTGGCCTTCTC"]], "row_count": 11, "column_count": 3, "numeric_cells": 1, "header_rows": 1, "locator": "section[10]/table-wrap[1]#Tab1"}}, {"id": "asset:table:pmid:34218797:11", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:039e3c101909fdc467734aa90b6724fe12ab39ff52eed20c608fec81eb075919", "bytes": 5846, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[20]/table-wrap[1]#Tab6", "version": null, "note": "Docking results of Designed Molecules on Over Expressed Proteins", "structure": {"pmcid": "PMC8256614", "section_index": 20, "section_title": "Identification of candidate small molecules", "row_count": 38, "column_count": 16}, "table": {"label": "Table 6", "caption": "Docking results of Designed Molecules on Over Expressed Proteins", "rows": [["Sl. No/Code", "Over expressed gene: ESR1", "Over expressed gene: LCK", "Over expressed gene: PPP2R2B", "Over expressed gene: PYHIN 1", "Over expressed gene: TP63"], ["PDB: 4PXM", "PDB:1KSW", "PDB: 2HV7", "PDB: 3VD8", "PDB: 6RU6"], ["Total Score", "Crash(-Ve)", "Polar", "Total Score", "Crash(-Ve)", "Polar", "Total Score", "Crash(−Ve)", "Polar", "Total Score", "Crash(−Ve)", "Polar", "Total Score", "Crash(−Ve)", "Polar"], ["HIM1", "5.097", "− 4.375", "0.114", "4.258", "− 1.555", "1.784", "4.904", "− 0.870", "0.004", "5.794", "− 0.514", "3.828", "5.770", "− 1.440", "2.231"], ["HIM2", "4.057", "− 6.172", "0.039", "4.624", "− 0.997", "1.959", "4.906", "− 0.468", "1.517", "5.052", "− 0.780", "3.415", "5.414", "− 1.529", "2.444"], ["HIM3", "5.353", "− 5.309", "0.161", "4.578", "− 1.492", "1.790", "5.042", "− 1.845", "1.073", "5.680", "− 0.804", "3.956", "5.350", "− 1.170", "2.316"], ["HIM4", "3.976", "− 5.132", "0.167", "3.839", "− 1.635", "1.196", "6.328", "− 1.172", "1.128", "4.966", "− 0.666", "1.818", "5.627", "− 1.416", "2.320"], ["HIM5", "2.707", "− 7.759", "0.179", "4.067", "− 0.997", "1.987", "5.254", "− 0.674", "1.618", "4.563", "− 1.068", "2.935", "5.698", "− 1.240", "2.485"], ["HIM6", "5.948", "− 3.902", "1.796", "5.229", "− 0.707", "3.656", "6.766", "− 1.424", "1.858", "6.670", "− 0.941", "5.519", "6.218", "− 1.468", "2.578"], ["HIM7", "5.019", "− 7.055", "0.203", "4.382", "− 2.443", "3.329", "6.028", "− 0.629", "1.660", "5.374", "− 1.876", "0.670", "6.627", "− 1.484", "2.579"], ["HIM8", "4.429", "− 3.983", "0.344", "4.150", "− 4.382", "4.210", "6.794", "− 1.279", "1.129", "5.468", "− 0.769", "3.444", "5.842", "− 2.088", "2.272"], ["HIM9", "3.722", "− 5.956", "0.197", "4.051", "− 2.006", "0.002", "6.116", "− 0.597", "1.717", "5.407", "− 0.565", "1.370", "5.877", "− 2.054", "0.792"], ["HIM10", "6.771", "− 3.977", "1.836", "5.176", "− 3.512", "4.023", "5.332", "− 1.378", "3.349", "6.071", "− 0.923", "3.854", "5.825", "− 0.966", "3.672"], ["HIM11", "3.775", "− 6.079", "0.898", "6.998", "− 2.086", "3.842", "8.678", "− 1.065", "2.876", "5.087", "− 0.881", "1.854", "5.948", "− 1.015", "1.202"], ["HIM12", "0.190", "− 8.149", "0.022", "5.302", "− 2.305", "3.475", "5.227", "− 1.636", "0.710", "7.322", "− 1.128", "4.099", "6.237", "− 2.562", "2.171"], ["HIM13", "4.523", "− 4.537", "0.014", "4.840", "− 0.664", "3.305", "6.181", "− 2.966", "3.523", "5.281", "− 0.503", "3.981", "5.905", "− 1.136", "2.218"], ["HIM14", "5.247", "− 3.183", "0.000", "4.888", "− 1.296", "2.563", "5.037", "− 0.377", "1.647", "7.057", "− 0.799", "4.256", "6.116", "− 1.366", "2.438"], ["HIM15", "4.633", "− 4.173", "0.180", "3.756", "− 0.710", "2.072", "5.188", "− 1.559", "1.143", "5.570", "− 1.125", "3.718", "6.238", "− 1.708", "2.443"], ["HIM16", "4.588", "− 2.883", "0.000", "6.027", "− 1.099", "3.903", "5.606", "− 0.987", "4.197", "5.661", "− 0.926", "2.751", "7.263", "− 1.533", "4.212"], ["HIM17", "3.944", "− 4.806", "0.236", "5.329", "− 0.590", "2.798", "4.830", "− 1.682", "1.617", "6.234", "− 0.830", "3.912", "5.366", "− 1.257", "3.022"], ["HTZ1", "0.593", "− 7.518", "0", "4.221", "− 0.692", "1.975", "3.993", "− 0.539", "0.003", "5.284", "− 0.566", "1.432", "5.227", "− 1.045", "0.903"], ["HTZ2", "− 1.770", "− 8.477", "0.000", "4.055", "− 1.438", "2.877", "4.388", "− 1.665", "1.170", "4.100", "− 0.546", "3.017", "4.563", "− 0.976", "1.266"], ["HTZ3", "4.649", "− 5.870", "0.148", "5.104", "− 0.861", "3.922", "4.243", "− 1.539", "1.933", "5.304", "− 1.370", "1.398", "5.138", "− 1.217", "1.930"], ["HTZ4", "− 3.169", "− 12.002", "0.482", "4.173", "− 1.898", "1.864", "4.654", "− 1.627", "1.128", "5.163", "− 0.745", "1.304", "5.084", "− 1.143", "1.018"], ["HTZ5", "4.021", "− 12.325", "0.246", "3.215", "− 1.481", "4.232", "3.256", "− 6.374", "2.317", "2.382", "− 5.263", "1.238", "4.623", "− 0.951", "1.280"], ["HTZ6", "6.605", "− 3.866", "1.6487", "4.004", "− 1.104", "2.851", "5.834", "− 1.310", "3.111", "5.286", "− 1.530", "1.436", "6.336", "− 2.326", "3.781"], 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