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pmid:40657397

Ginsenoside Rh7 affects β-catenin nuclear translocation by inhibiting SHCBP1 expression, thereby inhibiting epithelial-mesenchymal transition in gastric cancer cells.

International journal of medical sciences · 2025 doi:10.7150/ijms.112622

Paper

partial

Experiment

partial

Data

partial

Analysis

absent

Execution

absent

Execution evidence has not yet been added to this .science file. Explore its methods, data and open questions to plan the next step.
Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
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pmid:40657397
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science-record
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2026-11-01T10:25:51Z
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2026-11-01T10:25:51Z
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sep_to_sci_v1
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paper object · 10 fields
state
partial
title
Ginsenoside Rh7 affects β-catenin nuclear translocation by inhibiting SHCBP1 expression, thereby inhibiting epithelial-mesenchymal transition in gastric cancer cells.
doi
10.7150/ijms.112622
pmid
40657397
authors
null
journal
International journal of medical sciences
year
2025
abstract
null
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claim-1
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the headline numerical result the paper states for its main finding
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qualitative
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blocked
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null
unit
null
tolerance
null
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null
evidence array · 0 items
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[0]
abstract
[1]
authors
experiment object · 8 fields
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partial
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the headline numerical result the paper states for its main finding
steps array · 3 items
[0] object · 13 fields
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read_published_estimate
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1
name
Read the published estimate and its interval from the source
kind
other
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complete
blocked_on
null
description
The number a replication must land on, and the sentence it came from.
parameters object · 0 fields
inputs array · 1 item
[0]
source:pmid:40657397
outputs array · 1 item
[0]
the published estimate, its unit and its interval
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obtain_source_data
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The published result cannot be recomputed without the data the paper analysed.
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[0]
the source data with its provenance
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no owned computational capability is bound to this experiment
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Re-run the paper's analysis on the source data and produce the registered result. | SEP input not carried into the asset list: materials:the source data behind the published result in pmid:40657397
parameters object · 0 fields
inputs array · 0 items
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the registered result
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step:run_analysis input 'materials:the source data behind the published result in pmid:40657397' does not resolve to a declared asset
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partial
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source:pmid:40657397
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xml
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application/xml
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null
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Source read by the package builder: full_text.
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asset:source:pmid:40657397 not verified
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[1]
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read_published_estimate
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xml
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source:pmid:40657397
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corpus_record_absent
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partial
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parent_value
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false
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null
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raw_response
<think>We need answer JSON only. Need interpret task. Need find single numerical result replication of registered target main finding. Source text seems abstract/results no specific quantitative headline number except counts and thresholds, no effect size/IC50 etc. "headline numerical result the paper states for its main finding" likely no number stated. Need set false parent_value 0 unit empty evidence empty, target_result state what text states instead. Need ensure target result string perhaps describe qualitative findings. Exact source wording perhaps can quote? User says if no number for registered target, set number_stated false, leave parent_value at 0, leave unit and evidence empty, and say in target_result what text does state instead. So target_result can paraphrase? "The text states qualitatively that..." Need no invented source. We can quote exact wording, perhaps full conclusion sentence. JSON valid. Since no headline numerical result for main finding. We need maybe registered target means main finding headline numerical result. Text states effects but no numerical magnitude. Thus: {"parent_value":0,"unit":"","evidence":"","target_result":"The text states that ginsenoside Rh7 suppresses GC progression by regulating SHCBP1-mediated β-catenin nuclear translocation, thereby inhibiting EMT, proliferation, migration, and invasion, but it gives no numerical result for this main finding.","number_stated":false} Is target_result asked "what text does state instead" perhaps quote exact clause. Use source exact wording: "Ginsenoside Rh7 suppresses GC progression by regulating SHCBP1-mediated β-catenin nuclear translocation, thereby inhibiting EMT, proliferation, migration, and invasion." This is exact contiguous. Then mention no number? target_result could state exact quote + no numerical magnitude. Need only headline number? Since absent. Let's answer.</think> {"parent_value":0,"unit":"","evidence":"","target_result":"The text states that “Ginsenoside Rh7 suppresses GC progression by regulating SHCBP1-mediated β-catenin nuclear translocation, thereby inhibiting EMT, proliferation, migration, and invasion,” but reports no numerical result for this main finding.","number_stated":false}
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The text states that “Ginsenoside Rh7 suppresses GC progression by regulating SHCBP1-mediated β-catenin nuclear translocation, thereby inhibiting EMT, proliferation, migration, and invasion,” but reports no numerical result for this main finding.
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false
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null
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Ginsenoside Rh7 inhibited GC cell invasion, migration, and proliferation dose-dependently by downregulating SHCBP1 expression; the supplied text does not state a numerical effect magnitude for this headline finding.
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false
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[0]
Transcriptome sequencing
[1]
Immunoprecipitation (IP)
[2]
Transwell assays
[3]
Cell counting kit-8 (CCK-8) assays
[4]
Colony assays
[5]
In vivo tumor models
[6]
Rescue experiments involving SHCBP1 overexpression
minimax_alt array · 7 items
[0]
Transcriptome sequencing
[1]
Immunoprecipitation (IP)
[2]
Transwell assays
[3]
Cell counting kit-8 (CCK-8) assays
[4]
Colony assays
[5]
In vivo tumor models
[6]
SHCBP1-overexpression rescue experiments
decisive
false
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minimax array · 9 items
[0]
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[1]
Differential expression analysis using the Limma package
[2]
Intersection analysis
[3]
Protein-protein interaction (PPI) network analysis
[4]
MNC (Maximum Neighborhood Component) ranking
[5]
DMNC (Density of Maximum Neighborhood Component) ranking
[6]
Topological analysis
[7]
Kaplan-Meier (KM) method
[8]
Log-rank test
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[0]
Weighted gene co-expression network analysis (WGCNA)
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Differential expression analysis using the Limma package in R
[2]
Venn diagram overlap and intersection analysis
[3]
Protein-protein interaction (PPI) network analysis using STRING
[4]
cytoHubba topological ranking using MNC (Maximum Neighborhood Component) and DMNC (Density of Maximum Neighborhood Component)
[5]
Boxplot gene-expression analysis using Sangerbox
[6]
Transcriptome-sequencing expression analysis
[7]
Student's t-test
[8]
Analysis of variance (ANOVA) with Tukey's post hoc test
[9]
Kaplan-Meier (KM) method and log-rank test
decisive
false
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minimax
minimax_alt
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true
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decisive_fields
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null
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null
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target_materials
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null
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null
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step:run_analysis input 'materials:the source data behind the published result in pmid:40657397' does not resolve to a declared asset
[12]
targets
Complete file
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{"dsl_operations": [], "converters": [], "readers": ["xml"], "capabilities": [], "data_gaps": ["source:pmid:40657397"]}, "gaps": ["corpus_record_absent"]}, "review": {"state": "partial", "machine_critique": {"status": "blocked", "providers": [{"provider": "minimax", "model": "MiniMax-M3.1-Flash", "prompt_version": "full-text-reading-v1", "prompt_hash": "6cfd35bb5bfe83bbef6ce823adf9a013f2fa03102d80dfb79daf7baf9de06361", "source_hash": "281104de5489b0f3426fc2725f70326b565a490e1764cff7ebb446aa12569751", "raw_response_sha256": "sha256:c65709bbffbd868d0836330a0684e5daf3a6b4cba152930d07d6c72db624e561", "raw_response_chars": 4876}, {"provider": "minimax_alt", "model": "MiniMax-M3", "prompt_version": "full-text-reading-v1", "prompt_hash": "cb609fa59321d015062e7c057cdcc0719942cf3d918bf3ea84c7bd8882156fb3", "source_hash": "281104de5489b0f3426fc2725f70326b565a490e1764cff7ebb446aa12569751", "raw_response_sha256": "sha256:aff0f965683195febd34503af7afa7cb1bca593fc45f4c40bcc9544c75981386", "raw_response_chars": 74881}], "target_providers": [{"provider": "minimax", "model": "MiniMax-M3.1-Flash", "prompt_version": "replication-target-v2", "prompt_hash": "b9c9322be052afdb18a4d0c84cb6ec9320c3157749b750e48f663a07bf719552", "source_hash": "281104de5489b0f3426fc2725f70326b565a490e1764cff7ebb446aa12569751", "raw_response": "{\"parent_value\":0,\"unit\":\"\",\"evidence\":\"\",\"target_result\":\"The paper states that ginsenoside Rh7 inhibits gastric cancer cell invasion, migration, and proliferation dose-dependently by downregulating SHCBP1 expression, but it does not state a numerical result for this main finding.\",\"number_stated\":false}", "reading": {"parent_value": 0, "unit": "", "evidence": "", "target_result": "The paper states that ginsenoside Rh7 inhibits gastric cancer cell invasion, migration, and proliferation dose-dependently by downregulating SHCBP1 expression, but it does not state a numerical result for this main finding.", "number_stated": false, "source_locator": null}, "recorded_at": "2026-10-31T15:27:12.098915+00:00"}, {"provider": "minimax_alt", "model": "MiniMax-M3", "prompt_version": "replication-target-v2", "prompt_hash": "c497cb3f36d96039dcc5a309caf343adae7573eda1d21a45acd239279192e66e", "source_hash": "281104de5489b0f3426fc2725f70326b565a490e1764cff7ebb446aa12569751", "raw_response": "<think>We need answer JSON only. Need interpret task. Need find single numerical result replication of registered target main finding. Source text seems abstract/results no specific quantitative headline number except counts and thresholds, no effect size/IC50 etc. \"headline numerical result the paper states for its main finding\" likely no number stated. Need set false parent_value 0 unit empty evidence empty, target_result state what text states instead. Need ensure target result string perhaps describe qualitative findings. Exact source wording perhaps can quote? User says if no number for registered target, set number_stated false, leave parent_value at 0, leave unit and evidence empty, and say in target_result what text does state instead. So target_result can paraphrase? \"The text states qualitatively that...\" Need no invented source. We can quote exact wording, perhaps full conclusion sentence. JSON valid. Since no headline numerical result for main finding. We need maybe registered target means main finding headline numerical result. Text states effects but no numerical magnitude. Thus:\n{\"parent_value\":0,\"unit\":\"\",\"evidence\":\"\",\"target_result\":\"The text states that ginsenoside Rh7 suppresses GC progression by regulating SHCBP1-mediated β-catenin nuclear translocation, thereby inhibiting EMT, proliferation, migration, and invasion, but it gives no numerical result for this main finding.\",\"number_stated\":false}\nIs target_result asked \"what text does state instead\" perhaps quote exact clause. Use source exact wording: \"Ginsenoside Rh7 suppresses GC progression by regulating SHCBP1-mediated β-catenin nuclear translocation, thereby inhibiting EMT, proliferation, migration, and invasion.\" This is exact contiguous. Then mention no number? target_result could state exact quote + no numerical magnitude. Need only headline number? Since absent. Let's answer.</think>\n\n{\"parent_value\":0,\"unit\":\"\",\"evidence\":\"\",\"target_result\":\"The text states that “Ginsenoside Rh7 suppresses GC progression by regulating SHCBP1-mediated β-catenin nuclear translocation, thereby inhibiting EMT, proliferation, migration, and invasion,” but reports no numerical result for this main finding.\",\"number_stated\":false}", "reading": {"parent_value": 0, "unit": "", "evidence": "", "target_result": "The text states that “Ginsenoside Rh7 suppresses GC progression by regulating SHCBP1-mediated β-catenin nuclear translocation, thereby inhibiting EMT, proliferation, migration, and invasion,” but reports no numerical result for this main finding.", "number_stated": false, "source_locator": null}, "recorded_at": "2026-10-31T15:27:14.265256+00:00"}], "agreement": false, "disagreements": {"target_result": {"minimax": "unclear", "minimax_alt": "Ginsenoside Rh7 inhibited GC cell invasion, migration, and proliferation dose-dependently by downregulating SHCBP1 expression; the supplied text does not state a numerical effect magnitude for this headline finding.", "decisive": false}, "physical_methods": {"minimax": ["Transcriptome sequencing", "Immunoprecipitation (IP)", "Transwell assays", "Cell counting kit-8 (CCK-8) assays", "Colony assays", "In vivo tumor models", "Rescue experiments involving SHCBP1 overexpression"], "minimax_alt": ["Transcriptome sequencing", "Immunoprecipitation (IP)", "Transwell assays", "Cell counting kit-8 (CCK-8) assays", "Colony assays", "In vivo tumor models", "SHCBP1-overexpression rescue experiments"], "decisive": false}, "analysis_methods": {"minimax": ["Weighted gene co-expression network analysis (WGCNA)", "Differential expression analysis using the Limma package", "Intersection analysis", "Protein-protein interaction (PPI) network analysis", "MNC (Maximum Neighborhood Component) ranking", "DMNC (Density of Maximum Neighborhood Component) ranking", "Topological analysis", "Kaplan-Meier (KM) method", "Log-rank test"], "minimax_alt": ["Weighted gene co-expression network analysis (WGCNA)", "Differential expression analysis using the Limma package in R", "Venn diagram overlap and intersection analysis", "Protein-protein interaction (PPI) network analysis using STRING", "cytoHubba topological ranking using MNC (Maximum Neighborhood Component) and DMNC (Density of Maximum Neighborhood Component)", "Boxplot gene-expression analysis using Sangerbox", "Transcriptome-sequencing expression analysis", "Student's t-test", "Analysis of variance (ANOVA) with Tukey's post hoc test", "Kaplan-Meier (KM) method and log-rank test"], "decisive": false}, "statistical_method": {"minimax": "", "minimax_alt": "Student's t-test and analysis of variance (ANOVA) with Tukey's post hoc test", "decisive": true}}, "agreement_basis": {"policy": "decisive_fields", "decisive_fields": ["work_type", "number_stated", "parent_value", "unit"]}, "blinded": true}, "human_critique": {"status": "not_run", "reviewer": null, "signed_at": null, "conflict_checked": false, "commentary": null}, "stages": [{"key": "target_materials", "status": "pending", "reason": null, "evidence": null}, {"key": "independent_readings", "status": "blocked", "reason": "The independent readings are incomplete or disagree; the source evidence must resolve the difference.", "evidence": {"provider_errors": []}}, {"key": "source_resolution", "status": "pending", "reason": null, "evidence": null}, {"key": "protocol_reconstruction", "status": "pending", "reason": null, "evidence": null}, {"key": "control_execution", "status": "pending", "reason": null, "evidence": null}, {"key": "control_comparison", "status": "pending", "reason": null, "evidence": null}, {"key": "publication", "status": "pending", "reason": null, "evidence": null}], "gaps": ["review.human_critique", "review.machine_critique.blocked"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "package:9e3c41a6d1602d0a4fae9affc3a2cef522674d12242dd086e279c8860bb25c45", "type": "sep_package", "label": "SEP v1 package for pmid:40657397"}], "activities": [{"id": "activity:conversion:pmid:40657397", "type": "conversion", "used": ["package:9e3c41a6d1602d0a4fae9affc3a2cef522674d12242dd086e279c8860bb25c45"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:minimax", "type": "model", "label": "minimax"}, {"id": "agent:minimax_alt", "type": "model", "label": "minimax_alt"}, {"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}], "source_run_id": "run-20261023T122449232913", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "6b013275-13b3-4b50-bcc9-f7e6c1b62228", "parent_hash": "9e3c41a6d1602d0a4fae9affc3a2cef522674d12242dd086e279c8860bb25c45", "fork_of": null, "generation": 1}, "gaps": ["abstract", "asset:source:pmid:40657397 not verified", "authors", "capability", "corpus_record_absent", "execution.not_run", "method", "review.human_critique", "review.machine_critique.blocked", "step:obtain_source_data blocked on data:not_downloaded", "step:run_analysis blocked on no owned computational capability is bound to this experiment", "step:run_analysis input 'materials:the source data behind the published result in pmid:40657397' does not resolve to a declared asset", "targets"]}